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公开(公告)号：US10185088B2
公开(公告)日：2019-01-22
申请号：US15533670
申请日：2015-12-18
Applicant: GE HEALTHCARE BIO-SCIENCES AB
Inventor： Hanno Ehring , Siavash Yazdanfar , Mikael Anders Hornqvist , Zhangyi Zhong , Ying Mao
Abstract: Disclosed is an optical fiber arrangement for inducing coupling among propagation modes of light, said arrangement comprising a multimode optical fiber (30) having an input end (32) for receiving light and an output end (31) for emitting light, with a coupling inducing section (33) extending from said input end to said output end, and a holder (80) on which the optical fiber is arranged, wherein said multimode optical fiber has a non-circular cross section. Disclosed also is a system for measuring the absorption or determining the concentration of a substance, said system comprising at least one optical fiber arrangement.
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公开(公告)号：US10094770B2
公开(公告)日：2018-10-09
申请号：US15200722
申请日：2016-07-01
Applicant: GE HEALTHCARE BIO-SCIENCES AB
Inventor： Hanno Ehring
Abstract: The present invention relates to a flow cell (10) comprising a fluid inlet (16) and a fluid outlet (18) separated by a sample flow-through chamber (12) comprising at least one UV-transparent window (22′), wherein the at least one UV-transparent window (22′) is made of a polymer material and has been subjected to Gamma radiation sterilisation. In one aspect, the flow cell is combustible.
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公开(公告)号：US09404862B2
公开(公告)日：2016-08-02
申请号：US13891340
申请日：2013-05-10
Applicant: GE HEALTHCARE BIO-SCIENCES AB
Inventor： Hanno Ehring
CPC classification number: G01N21/33 , A61L2/08 , A61L2202/11 , G01N21/05 , G01N21/59 , G01N30/74 , G01N33/48707 , G01N2021/0346 , G01N2201/062
Abstract: The present invention relates to a flow cell (10) comprising a fluid inlet (16) and a fluid outlet (18) separated by a sample flow-through chamber (12) comprising at least one UV-transparent window (22′), wherein the at least one UV-transparent window (22′) is made of a polymer material and has been subjected to Gamma radiation sterilization. In one aspect, the flow cell is combustible.
Abstract translation: 本发明涉及包括流体入口（16）和流体出口（18）的流动池，流体出口（18）由包括至少一个UV透明窗（22'）的样品流通室（12）分离，其中 所述至少一个UV透明窗（22'）由聚合物材料制成，并且已进行伽马辐射灭菌。 在一个方面，流动池是可燃的。
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4.发明授权Methods and apparatus for measuring the light absorbance of a substance in a solution 有权用于测量溶液中物质的吸光度的方法和装置公开(公告)号：US09322772B2
公开(公告)日：2016-04-26
申请号：US14404860
申请日：2013-05-30
Applicant: GE HEALTHCARE BIO-SCIENCES AB
Inventor： Hanno Ehring , Fredrik Lars Jarhede , Erik Ostlund
CPC classification number: G01N21/33 , G01N21/3151 , G01N30/74 , G01N2021/3181 , G01N2030/8827 , G01N2201/062
Abstract: Disclosed is an apparatus for measuring the absorbance of a substance in a solution, comprising: i) a sample cell (30) of known path length (b) for containing said solution (S), said cell being transparent to light of a predefined wavelength spectrum; ii) plural LED's each being independently operable by means of a controller (25) each for emitting light, within said predefined wavelength spectrum, along a light path; iii) a band pass filter (22) in the light path; iv) a beam splitter (24) for dividing light from said source propagating along the path into a first portion and a second portion, said first portion being directable by the beam splitter toward a reference detector (42) and said second portion being directable into the cell (30); v) a reference detector (42) for detecting the intensity of said first portion of light directed by said beam splitter; and vi) a sample detector (40) for detecting the intensity of the second portion propagating from the cell; the apparatus allowing a sample in the cell to be inexpensively subjected to more than one wavelength of light for quicker or more accurate analysis.
Abstract translation: 公开了一种用于测量溶液中物质的吸光度的装置，包括：i）用于容纳所述溶液（S）的已知路径长度（b）的样品池（30），所述池对于预定波长的光是透明的 光谱; ii）多个LED各自可以通过控制器（25）独立操作，每个控制器用于沿所述光路在所述预定波长光谱内发射光; iii）光路中的带通滤波器（22）; iv）用于将沿着路径传播的光源的光分离成第一部分和第二部分的分束器（24），所述第一部分可被分束器引向参考检测器（42），并且所述第二部分可被引导到 电池（30）; v）用于检测由所述分束器引导的所述第一部分光的强度的参考检测器（42） 和vi）用于检测从单元传播的第二部分的强度的样本检测器（40） 允许细胞中的样品经济地经受多于一个波长的光的装置，用于更快或更准确的分析。
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公开(公告)号：US20190310182A1
公开(公告)日：2019-10-10
申请号：US16464759
申请日：2017-11-30
Applicant: GE Healthcare Bio-Sciences AB
Inventor： Hanno Ehring , Mats Lundkvist , David Carl Martin Bergman , Andreas Marcstrom
Abstract: The invention relates to an optical flow cell comprising a housing forming an enclosed and elongated fluid channel arranged along a first axis, an inlet arranged to connect a first outer surface area of the housing to a first end of the fluid channel and an outlet arranged to connect a second outer surface area to a second end of the fluid channel, a first light guide and a second light guide concentrically arranged along a second axis and on opposite side walls of the fluid channel. The invention further relates to a corresponding method to produce an optical flow cell.
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Patent Agency Ranking
公开(公告)号：US20180067040A1
公开(公告)日：2018-03-08
申请号：US15565268
申请日：2016-04-08
Applicant: GE HEALTHCARE BIO-SCIENCES AB
Inventor： Henrik Svanberg , Hanno Ehring , Erik Nils Ostlund
CPC classification number: G01N21/05 , G01N2021/052 , G01N2201/0664 , G01N2201/0668 , G01N2201/0813 , G01N2201/086 , G02B6/36 , G02B6/3616 , G02B6/3644 , G02B6/3825 , G02B6/3861 , G02B6/4219
Abstract: The present invention relates to an optical flow cell (1) for a measuring device, having an input light guide with a light exit surface, an output light guide with a light entrance surface, said input light guide and output light guide being integrated with a holder (30) to form optical flow cell (1), and wherein the holder (30) extends along a first axis (A) and has a through hole (31) for receiving a flow of a sample fluid, said through hole (31) being transversal to said first axis (A), and the input light guide and output light guide further are arranged in said holder (30) so that the light exit surface and the light entrance surface extend into said through hole (31) and are arranged to be in optical alignment with each other and at a first distance from each other. The invention also relates to a measuring device having at least one optical flow cell (1).
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公开(公告)号：US20200054964A1
公开(公告)日：2020-02-20
申请号：US16487607
申请日：2018-02-14
Applicant: GE Healthcare Bio-Sciences AB
Inventor： Hans Blom , Mikael Berg , Hanno Ehring , Linda Mathiasson , Helena Skoglar , Rebecka Chmielowski
Abstract: The present invention relates to a method for determining operational status of a chromatography column (1; 39, 47, 59; 107, 109, 111, 113), comprising detecting a feed signal (21; 201) representative of the composition of a feed material provided to the inlet of the column; detecting the UV absorbance in the feed material, detecting an effluent signal (23; 203, 205, 207, 209) representative of the composition of the effluent from the column; and using the feed signal and the effluent signal to determine operational status of the column. The feed signal is generated using a first UV detector having a first UV cell pathlength operating at a first UV wavelength and in the effluent signal is generated using a second UV detector having a second UV cell pathlength operating at a second UV wavelength. The method further comprising determining a first threshold value based on the detected UV absorbance in the feed material, and selecting the first UV cell pathlength and/or first UV wavelength based on the first threshold value.
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公开(公告)号：US20190317009A1
公开(公告)日：2019-10-17
申请号：US16464778
申请日：2017-11-30
Applicant: GE Healthcare Bio-Sciences AB
Inventor： Hanno Ehring , Mats Rimmo
Abstract: An optical measuring device (1; 1′; 1″; 41; 61) configured for being connected in a flow path, said optical measuring device (1; 1′; 1″; 41; 61) comprising:—a first and a second flow path connector (5, 7; 5′, 7′; 5″, 7″);—at least one flow cell part (3; 3a, 3b; 3a, 3b, 3c, 3d) provided in between the first and second flow path connectors (5, 7; 5′, 7′; 5″, 7″) such that a flow in a flow path in which the optical measuring device (1; 1′; 1″; 41; 61) can be arranged will flow through the first flow path connector (5; 5′; 5″), the at least one flow cell part (3; 3a, 3b; 3a, 3b, 3c, 3d) and through the second flow path connector (7; 7′; 7″); and—at least one releasable connection device (9) arranged for releasably connecting the at least one flow cell part (3; 3a, 3b; 3a, 3b, 3c, 3d) in between the first and second flow path connectors (5, 7; 5′, 7′; 5″, 7″).
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公开(公告)号：US20190011356A1
公开(公告)日：2019-01-10
申请号：US16130100
申请日：2018-09-13
Applicant: GE Healthcare Bio-Sciences AB
Inventor： Hanno Ehring
CPC classification number: G01N21/33 , A61L2/08 , A61L2202/11 , G01N21/05 , G01N21/59 , G01N30/74 , G01N33/48707 , G01N2021/0346 , G01N2201/062
Abstract: The present invention relates to a flow cell (10) comprising a fluid inlet (16) and a fluid outlet (18) separated by a sample flow-through chamber (12) comprising at least one UV-transparent window (22′), wherein the at least one UV-transparent window (22′) is made of a polymer material and has been subjected to Gamma radiation sterilisation. In one aspect, the flow cell is combustible.
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10.发明申请公开(公告)号：US20170356848A1
公开(公告)日：2017-12-14
申请号：US15528123
申请日：2015-11-24
Applicant: GE HEALTHCARE BIO-SCIENCES AB
Inventor： Hanno Ehring
CPC classification number: G01N21/645 , G01J3/42 , G01J3/4406 , G01J2003/421 , G01N21/05 , G01N21/33 , G01N2021/1736 , G01N2021/1738 , G01N2021/174 , G01N2021/6482 , G01N2021/6484 , G01N2021/6491 , G01N2201/0696
Abstract: Disclosed is apparatus (1) for measuring fluorescence and absorbance of a substance in a sample, said apparatus (1) comprising: a flow cell (2) for containing a sample, a first light source (3), a first conductor (5) for transmitting light from the first light source (3) to the flow cell (2) for irradiating a sample contained therein, a second conductor (7) for transmitting light from the flow cell (2) to a sample detector (9) arranged to detect an electromagnetic radiation that has passed through said cell (2), and a processing unit (16) arranged to receive a first signal (31) from a reference detector (15) and a second signal (32) from the sample detector (9) and to determine an absorbance based on said first and second signals (31,32), said apparatus (1) further comprising a second light source (4), a third conductor (6) for transmitting light from the second light source (4) to the cell (2) and wherein the sample detector (9) is further arranged to also detect fluorescence signals in the light that has passed through the flow cell (2). The invention also relates to a method for measuring the absorbance and the fluorescence of a substance in a sample.
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