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公开(公告)号：US10359419B2
公开(公告)日：2019-07-23
申请号：US14043887
申请日：2013-10-02
Applicant: General Electric Company
Inventor： Anthony John Murray , Radislav Alexandrovich Potyrailo , Andrew David Pris , Nandini Nagraj
IPC: G01N33/53 , G01N33/532 , G01N33/58
Abstract: A method of recovering a target from a sample is provided. The method comprises the adding a substrate coupled binding element to the sample comprising the target to form a substrate coupled binding element-target complex; precipitating the complex by changing one or more environmental conditions of the substrate and recovering the target and the substrate coupled binding-element under mild conditions.
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公开(公告)号：US20180370827A1
公开(公告)日：2018-12-27
申请号：US16103886
申请日：2018-08-14
Applicant: General Electric Company
Inventor： Aditya Kumar , Anthony John Murray , Ruijie Shi , Zhaoyang Wan , Mustafa Tekin Dokucu , Vijaysai Prasad
Abstract: A method of operating a waste water treatment plant (WWTP) having at least one of an aerobic digester (AD) and a membrane bioreactor (MBR) is described. The method of operating AD is comprised of monitoring and controlling AD in real-time using an online extended Kalman filter (EKF) having a online dynamic model of AD. The EKF uses real-time AD measured data, and online dynamic model of AD to update adapted model parameters and estimate model based inferred variables for AD, which are used for AD control by AD control system having supervisory and low-level control layers. The method of operating MBR is similar to that of AD. The supervisory control ensures the WWTP satisfying the effluent quality requirement while minimize the operation cost. A WWTP having at least one of an AD or MBR is disclosed. The method of operating a WWTP can be implemented using a computer.
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公开(公告)号：US20160355426A1
公开(公告)日：2016-12-08
申请号：US15244075
申请日：2016-08-23
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Vasile Bogdan Neculaes , Stephen Robert Vasconcellos , Brian Christopher Moore , Anthony John Murray , June Klimash , Kenneth Roger Conway , Tracy Lynn Paxon , Michael Brian Salerno , Casey L. Renko
CPC classification number: C02F11/12 , C02F1/302 , C02F1/42 , C02F3/342 , C02F11/02 , C02F11/122 , C02F11/123 , C02F11/127 , C02F11/14 , Y02W10/27
Abstract: Methods for treatment of sludge with microwave irradiation for improving its dewatering are provided. In one embodiment, the method includes exposing the sludge to microwave irradiation at an absorbed power density of between about 7 W/ml and about 13 W/ml. Turbidity, total solids content and overall dewaterability are improved when the microwave irradiation treatment is combined with another method for dewatering sludge, such as enzyme treatment, conditioning with a flocculating agent and mechanical dewatering.
Abstract translation: 提供了利用微波辐射处理污泥以改善其脱水的方法。 在一个实施方案中，该方法包括以约7W / ml至约13W / ml的吸收功率密度将污泥暴露于微波照射。 当微波照射处理与另一种用于脱水污泥的方法（如酶处理，用絮凝剂调理和机械脱水）相结合时，浊度，总固体含量和总脱水性得到改善。
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公开(公告)号：US20150093839A1
公开(公告)日：2015-04-02
申请号：US14043895
申请日：2013-10-02
Applicant: General Electric Company
Inventor： Radislav Alexandrovich Potyrailo , Andrew David Pris , Nandini Nagraj , Anthony John Murray
IPC: G01N33/53
CPC classification number: G01N33/5306 , G01N33/5308 , G01N33/54306 , G01N33/54386
Abstract: A method of recovering a target from a sample is provided. The method of recovering the target follows different steps. The steps include providing a binding element, wherein the binding elements are immobilized on a solid support, adding the sample comprising the target to the binding element to form a binding element-target complex; washing the binding element-target complex; and eluting the target from the binding element-target complex. The system for reversible detection of target in a range from 2 to 1,000,000 bind/release cycles is also provided.
Abstract translation: 提供了从样品中回收靶的方法。 恢复目标的方法遵循不同的步骤。 所述步骤包括提供结合元件，其中所述结合元件固定在固体支持物上，将包含所述靶的样品添加到所述结合元件以形成结合元件 - 目标复合物; 洗涤结合元素 - 目标复合物; 并从结合元件 - 目标复合物洗脱目标物。 还提供了在2至1,000,000个结合/释放循环范围内可目标检测靶的系统。
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公开(公告)号：US09958441B2
公开(公告)日：2018-05-01
申请号：US15204666
申请日：2016-07-07
Applicant: General Electric Company
Inventor： An-Ping Zhang , Anthony John Murray , Rui Chen
IPC: G01N33/543 , B82Y15/00 , G01N27/327 , G01N27/414 , G01N33/545 , G01N33/53 , B82Y40/00
CPC classification number: G01N33/54373 , B82Y15/00 , B82Y40/00 , G01N27/327 , G01N27/4145 , G01N27/4146 , G01N33/545
Abstract: A biosensing FET device, comprising a plurality of nanostructured SOI channels, that is adapted to operate in solutions having a high ionic strength and provides improves sensitivity and detection. Generally, the biosensing device comprises an underlying substrate layer, an insulator and a semiconductor layer and a plurality of channels in the semiconductor layer comprising a plurality of whole or partially formed nanopores in the channels.
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Patent Agency Ranking
公开(公告)号：US20170267716A1
公开(公告)日：2017-09-21
申请号：US15071210
申请日：2016-03-16
Applicant: General Electric Company
Inventor： Anthony John Murray , Andrew David Pris , Erik Leeming Kvam , Nandini Nagraj , Eugene Pauling Boden , Ernest William Kovacs , Louisa Ruth Carr , Rui Chen , Tiberiu Mircea Siclovan , Kelly Scott Chichak
IPC: C07K1/36 , C07K16/00 , C12N9/74 , C12N15/115 , C07K14/705
CPC classification number: C07K1/36 , C07K1/32 , C07K14/70564 , C07K16/4291 , C12N9/6429 , C12Y304/21005
Abstract: Provided herein are aptamer-polymer conjugates which are responsive to environmental stimuli and are useful in selective purification of untagged target polypeptides.
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公开(公告)号：US09765375B2
公开(公告)日：2017-09-19
申请号：US13929976
申请日：2013-06-28
Applicant: General Electric Company
Inventor： Anthony John Murray , John Richard Nelson
IPC: C12P19/34 , C12Q1/68 , C12N15/115 , C12N15/11
CPC classification number: C12P19/34 , C12N15/111 , C12N15/115 , C12N2310/16 , C12N2320/10
Abstract: Methods for developing a binding-element are provided. A mixture comprising a target molecule, a plurality of oligonucleotides and a ligase is provided, followed by binding the oligonucleotides to the target molecule to form an oligonucleotides-target molecule complex. The oligonucleotides bound to the target molecule are ligated to form the binding-element. The binding-elements are separated from the mixture.
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公开(公告)号：US20170191992A1
公开(公告)日：2017-07-06
申请号：US15465970
申请日：2017-03-22
Applicant: General Electric Company
Inventor： Radislav Alexandrovich Potyrailo , Andrew David Pris , Nandini Nagraj , Anthony John Murray
IPC: G01N33/53 , G01N33/543
CPC classification number: G01N33/5306 , G01N33/5308 , G01N33/54306 , G01N33/54386
Abstract: A method of recovering a target from a sample is provided. The method of recovering the target follows different steps. The steps include providing a binding element, wherein the binding elements are immobilized on a solid support, adding the sample comprising the target to the binding element to form a binding element-target complex; washing the binding element-target complex; and eluting the target from the binding element-target complex. The system for reversible detection of target in a range from 2 to 1,000,000 bind/release cycles is also provided.
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公开(公告)号：US20160313318A1
公开(公告)日：2016-10-27
申请号：US15204666
申请日：2016-07-07
Applicant: General Electric Company
Inventor： An-Ping Zhang , Anthony John Murray , Rui Chen
IPC: G01N33/543 , G01N33/545
CPC classification number: G01N33/54373 , B82Y15/00 , B82Y40/00 , G01N27/327 , G01N27/4145 , G01N27/4146 , G01N33/545
Abstract: A biosensing FET device, comprising a plurality of nanostructured SOI channels, that is adapted to operate in solutions having a high ionic strength and provides improves sensitivity and detection. Generally, the biosensing device comprises an underlying substrate layer, an insulator and a semiconductor layer and a plurality of channels in the semiconductor layer comprising a plurality of whole or partially formed nanopores in the channels.
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公开(公告)号：US20150093820A1
公开(公告)日：2015-04-02
申请号：US14043887
申请日：2013-10-02
Applicant: General Electric Company
Inventor： Anthony John Murray , Radislav Alexandrovich Potyrailo , Andrew David Pris , Nandini Nagraj
IPC: C12N15/115
CPC classification number: G01N33/5308 , G01N33/532 , G01N33/58
Abstract: A method of recovering a target from a sample is provided. The method comprises the adding a substrate coupled binding element to the sample comprising the target to form a substrate coupled binding element-target complex; precipitating the complex by changing one or more environmental conditions of the substrate and recovering the target and the substrate coupled binding-element under mild conditions.
Abstract translation: 提供了从样品中回收靶的方法。 该方法包括将底物耦合的结合元件添加到包含靶的样品以形成基底耦合的结合元件 - 目标复合物; 通过改变衬底的一个或多个环境条件并在温和条件下回收靶和衬底耦合的结合元件来沉淀复合物。
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