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公开(公告)号：US11525768B2
公开(公告)日：2022-12-13
申请号：US16538616
申请日：2019-08-12
Applicant: General Electric Company
Inventor： Antonio Caiafa , Vasile Bogdan Neculaes , Allen Lawrence Garner , Andrew Soliz Torres
Abstract: In accordance with the present disclosure, exposure of a sample to one or more electric pulses via capacitive coupling is described. In certain embodiments, the sample may be a biological sample to be treated or modified using the pulsed electric fields. In certain embodiments, the electric pulses may be delivered to a load using capacitive coupling. In other embodiments, the electric pulses may be bipolar pulses.
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公开(公告)号：US11464829B2
公开(公告)日：2022-10-11
申请号：US16514662
申请日：2019-07-17
Applicant: General Electric Company
Inventor： Vasile Bogdan Neculaes , Andrew Soliz Torres , Antonio Caiafa , Brian Dun-Lan Lee , Allen Lawrence Garner
IPC: A61K38/18 , A61K35/19 , G01N33/49 , C12N13/00 , G01N33/487
Abstract: Methods and systems for releasing growth factors are disclosed. In certain embodiments, a blood sample is exposed to a sequence of one or more electric pulses to trigger release of a growth factor in the sample. In certain embodiments, the growth factor release is not accompanied by clotting within the blood sample.
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公开(公告)号：US10927345B2
公开(公告)日：2021-02-23
申请号：US15694635
申请日：2017-09-01
Applicant: General Electric Company
Inventor： Vasile Bogdan Neculaes , Juan Jose Becerra , Christine Angela Morton , Andrew Soliz Torres , Antonio Caiafa
Abstract: Methods and systems for generating a tunable or customizable activated product composition are related. In certain embodiments, one or more of electric pulse parameters, flow rate, or sample container size are varied so as to generate the activated product composition. The activated product composition may be customized or optimized based for a particular patient or procedure.
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公开(公告)号：US20170362571A1
公开(公告)日：2017-12-21
申请号：US15694635
申请日：2017-09-01
Applicant: General Electric Company
Inventor： Vasile Bogdan Neculaes , Juan Jose Becerra , Christine Angela Morton , Andrew Soliz Torres , Antonio Caiafa
CPC classification number: C12N5/0644 , C12M35/02 , C12N2529/00
Abstract: Methods and systems for generating a tunable or customizable activated product composition are related. In certain embodiments, one or more of electric pulse parameters, flow rate, or sample container size are varied so as to generate the activated product composition. The activated product composition may be customized or optimized based for a particular patient or procedure.
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公开(公告)号：US20170191052A1
公开(公告)日：2017-07-06
申请号：US14984988
申请日：2015-12-30
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Vasile Bogdan Neculaes , Andrew Soliz Torres , Steve Lambert Klopman
CPC classification number: C12N13/00 , A61K33/06 , A61K35/19 , A61K38/18 , A61K41/00 , C12N5/0644 , A61K2300/00
Abstract: The present disclosure relates to the generation of an activated platelet product in which one or more of the presence or absence of clots, the timing of clot formation (if present), and/or the mechanical strength of clots (if present) is controlled by the presence or concentration of calcium ions during the activation process. In certain embodiments, the calcium ion concentration is controlled in the presence of pulsed electric fields or a chemical activator (e.g., thrombin) as part of the activation process.
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Patent Agency Ranking
公开(公告)号：US20150203836A1
公开(公告)日：2015-07-23
申请号：US14158106
申请日：2014-01-17
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Antonio Caiafa , Vasile Bogdan Neculaes , Allen Lawrence Garner , Andrew Soliz Torres
CPC classification number: C12N13/00 , A61B5/150755 , C12M35/02 , G01N33/49 , H03K3/53
Abstract: In accordance with the present disclosure, exposure of a sample to one or more electric pulses via capacitive coupling is described. In certain embodiments, the sample may be a biological sample to be treated or modified using the pulsed electric fields. In certain embodiments, the electric pulses may be delivered to a load using capacitive coupling. In other embodiments, the electric pulses may be bipolar pulses.
Abstract translation: 根据本公开，描述了通过电容耦合将样本暴露于一个或多个电脉冲。 在某些实施方案中，样品可以是使用脉冲电场处理或修饰的生物样品。 在某些实施例中，电脉冲可以使用电容耦合传送到负载。 在其他实施例中，电脉冲可以是双极性脉冲。
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公开(公告)号：US20140363412A1
公开(公告)日：2014-12-11
申请号：US13912050
申请日：2013-06-06
Applicant: General Electric Company
Inventor： Vasile Bogdan Neculaes , Antonio Caiafa , Brian Duh-Lan Lee , Nicole Evelyn LaPlante , Andrew Soliz Torres , Allen Lawrence Garner
CPC classification number: A61K35/19 , A61K41/00 , A61N1/00 , C12N5/0644 , C12N13/00
Abstract: Embodiments of the disclosure relate to platelet activation and/or aggregation using electric pulses. In one embodiment, a platelet-containing sample is exposed to electric pulses. At least one of the electric pulses has a duration greater than 1 microsecond and a field strength below 50 kV/cm. In another embodiment, the electric pulses may be designed with particular field strengths and durations.
Abstract translation: 本公开的实施方案涉及使用电脉冲的血小板活化和/或聚集。 在一个实施方案中，将含血小板的样品暴露于电脉冲。 电脉冲中的至少一个具有大于1微秒的持续时间和低于50kV / cm的场强。 在另一个实施例中，电脉冲可以被设计为具有特定的场强和持续时间。
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公开(公告)号：US11591590B2
公开(公告)日：2023-02-28
申请号：US16850727
申请日：2020-04-16
Applicant: General Electric Company
Inventor： Vasile Bogdan Neculaes , Andrew Soliz Torres , Steve Lambert Klopman
Abstract: The present disclosure relates to the generation of an activated platelet product in which one or more of the presence or absence of clots, the timing of clot formation (if present), and/or the mechanical strength of clots (if present) is controlled by the presence or concentration of calcium ions during the activation process. In certain embodiments, the calcium ion concentration is controlled in the presence of pulsed electric fields or a chemical activator (e.g., thrombin) as part of the activation process.
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公开(公告)号：US20220037105A1
公开(公告)日：2022-02-03
申请号：US16944836
申请日：2020-07-31
Applicant: General Electric Company
Inventor： John Scott Price , Ye Bai , Antonio Caiafa , Vasile Bogdan Neculaes , Uwe Wiedmann
IPC: H01J29/68 , B29C64/273 , H01J37/30 , B29C64/153
Abstract: A system for melting, sintering, or heat treating a material is provided. The system includes a cathode, an anode, and a focus coil assembly having a quadrupole magnet. The quadrupole magnet includes four poles and a yoke. The four poles are spaced apart and surround a beam cavity. Each of the four poles includes a pole face proximate the beam cavity and an end opposite the pole face. The first and third poles are aligned along an x-axis and configured to have a first magnetic polarity at their respective pole faces and a second magnetic polarity opposite the first magnetic polarity at their respective ends. The second and fourth poles are aligned along a y-axis and configured to have the second magnetic polarity at their respective pole faces and the first magnetic polarity at their respective ends. The yoke surrounds the poles and is coupled to the poles.
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公开(公告)号：US09752120B2
公开(公告)日：2017-09-05
申请号：US14674971
申请日：2015-03-31
Applicant: General Electric Company
Inventor： Vasile Bogdan Neculaes , Juan Jose Becerra , Christine Angela Morton , Andrew Soliz Torres , Antonio Caiafa
CPC classification number: C12N5/0644 , C12M35/02 , C12N2529/00
Abstract: Methods and systems for generating a tunable or customizable activated product composition are related. In certain embodiments, one or more of electric pulse parameters, flow rate, or sample container size are varied so as to generate the activated product composition. The activated product composition may be customized or optimized based for a particular patient or procedure.
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