-
公开(公告)号：US11591590B2
公开(公告)日：2023-02-28
申请号：US16850727
申请日：2020-04-16
摘要： The present disclosure relates to the generation of an activated platelet product in which one or more of the presence or absence of clots, the timing of clot formation (if present), and/or the mechanical strength of clots (if present) is controlled by the presence or concentration of calcium ions during the activation process. In certain embodiments, the calcium ion concentration is controlled in the presence of pulsed electric fields or a chemical activator (e.g., thrombin) as part of the activation process.
-
公开(公告)号：US20220037105A1
公开(公告)日：2022-02-03
申请号：US16944836
申请日：2020-07-31
IPC分类号： H01J29/68 , B29C64/273 , H01J37/30 , B29C64/153
摘要： A system for melting, sintering, or heat treating a material is provided. The system includes a cathode, an anode, and a focus coil assembly having a quadrupole magnet. The quadrupole magnet includes four poles and a yoke. The four poles are spaced apart and surround a beam cavity. Each of the four poles includes a pole face proximate the beam cavity and an end opposite the pole face. The first and third poles are aligned along an x-axis and configured to have a first magnetic polarity at their respective pole faces and a second magnetic polarity opposite the first magnetic polarity at their respective ends. The second and fourth poles are aligned along a y-axis and configured to have the second magnetic polarity at their respective pole faces and the first magnetic polarity at their respective ends. The yoke surrounds the poles and is coupled to the poles.
-
公开(公告)号：US09752120B2
公开(公告)日：2017-09-05
申请号：US14674971
申请日：2015-03-31
发明人： Vasile Bogdan Neculaes , Juan Jose Becerra , Christine Angela Morton , Andrew Soliz Torres , Antonio Caiafa
CPC分类号： C12N5/0644 , C12M35/02 , C12N2529/00
摘要： Methods and systems for generating a tunable or customizable activated product composition are related. In certain embodiments, one or more of electric pulse parameters, flow rate, or sample container size are varied so as to generate the activated product composition. The activated product composition may be customized or optimized based for a particular patient or procedure.
-
公开(公告)号：US20170000438A1
公开(公告)日：2017-01-05
申请号：US14789585
申请日：2015-07-01
发明人： Robert John Filkins , Ahmad Nadeem Ishaque , Alok Mani Srivastava , Peter William Lorraine , Holly Ann Camanzo , Xiaolei Shi , Vasile Bogdan Neculaes , Sam Joseph Camardello , Gregory Boverman , Ge Wang , Wenxiang Cong
CPC分类号： A61B6/481 , A61B6/02 , A61B6/4258 , A61B6/485 , A61B8/0808 , A61B8/481 , A61K49/0015 , A61K49/0065
摘要： The present approach generally relates to systems and methods for implementing energy modulated tomographic imaging of nanoparticles. In certain embodiments, a first energy is used to activate probe particles labeling an anatomy or tissue of interest. The probe particles, once activated, emit photons at a different rate and/or spectrum in response to an underlying physiological event, such as action potentials propagating in the labeled anatomy or tissue. The emitted photons may then be detected and used to map or image the occurrence of the physiological event.
摘要翻译： 本方法通常涉及用于实现纳米颗粒的能量调制层析成像的系统和方法。 在某些实施方案中，使用第一能量来激活标记感兴趣的解剖结构或组织的探针颗粒。 一旦被激活，探针颗粒响应于潜在的生理事件（例如在标记的解剖结构或组织中传播的动作电位）以不同的速率和/或光谱发射光子。 然后可以检测发射的光子并用于映射或成像生理事件的发生。
-
公开(公告)号：US20160367632A1
公开(公告)日：2016-12-22
申请号：US15251990
申请日：2016-08-30
发明人： Vasile Bogdan Neculaes , Andrew Soliz Torres , Antonio Caiafa , Brian Dun-Lan Lee , Allen Lawrence Garner
IPC分类号： A61K38/18 , G01N33/49 , G01N33/487 , C12N13/00
CPC分类号： A61K38/1858 , A61K35/19 , C12N13/00 , G01N33/48707 , G01N33/49
摘要： Methods and systems for releasing growth factors are disclosed. In certain embodiments, a blood sample is exposed to a sequence of one or more electric pulses to trigger release of a growth factor in the sample. In certain embodiments, the growth factor release is not accompanied by clotting within the blood sample.
-
公开(公告)号：US20160355426A1
公开(公告)日：2016-12-08
申请号：US15244075
申请日：2016-08-23
发明人： Vasile Bogdan Neculaes , Stephen Robert Vasconcellos , Brian Christopher Moore , Anthony John Murray , June Klimash , Kenneth Roger Conway , Tracy Lynn Paxon , Michael Brian Salerno , Casey L. Renko
CPC分类号： C02F11/12 , C02F1/302 , C02F1/42 , C02F3/342 , C02F11/02 , C02F11/122 , C02F11/123 , C02F11/127 , C02F11/14 , Y02W10/27
摘要： Methods for treatment of sludge with microwave irradiation for improving its dewatering are provided. In one embodiment, the method includes exposing the sludge to microwave irradiation at an absorbed power density of between about 7 W/ml and about 13 W/ml. Turbidity, total solids content and overall dewaterability are improved when the microwave irradiation treatment is combined with another method for dewatering sludge, such as enzyme treatment, conditioning with a flocculating agent and mechanical dewatering.
摘要翻译： 提供了利用微波辐射处理污泥以改善其脱水的方法。 在一个实施方案中，该方法包括以约7W / ml至约13W / ml的吸收功率密度将污泥暴露于微波照射。 当微波照射处理与另一种用于脱水污泥的方法（如酶处理，用絮凝剂调理和机械脱水）相结合时，浊度，总固体含量和总脱水性得到改善。
-
公开(公告)号：US11525768B2
公开(公告)日：2022-12-13
申请号：US16538616
申请日：2019-08-12
摘要： In accordance with the present disclosure, exposure of a sample to one or more electric pulses via capacitive coupling is described. In certain embodiments, the sample may be a biological sample to be treated or modified using the pulsed electric fields. In certain embodiments, the electric pulses may be delivered to a load using capacitive coupling. In other embodiments, the electric pulses may be bipolar pulses.
-
公开(公告)号：US11464829B2
公开(公告)日：2022-10-11
申请号：US16514662
申请日：2019-07-17
发明人： Vasile Bogdan Neculaes , Andrew Soliz Torres , Antonio Caiafa , Brian Dun-Lan Lee , Allen Lawrence Garner
IPC分类号： A61K38/18 , A61K35/19 , G01N33/49 , C12N13/00 , G01N33/487
摘要： Methods and systems for releasing growth factors are disclosed. In certain embodiments, a blood sample is exposed to a sequence of one or more electric pulses to trigger release of a growth factor in the sample. In certain embodiments, the growth factor release is not accompanied by clotting within the blood sample.
-
公开(公告)号：US10927345B2
公开(公告)日：2021-02-23
申请号：US15694635
申请日：2017-09-01
发明人： Vasile Bogdan Neculaes , Juan Jose Becerra , Christine Angela Morton , Andrew Soliz Torres , Antonio Caiafa
摘要： Methods and systems for generating a tunable or customizable activated product composition are related. In certain embodiments, one or more of electric pulse parameters, flow rate, or sample container size are varied so as to generate the activated product composition. The activated product composition may be customized or optimized based for a particular patient or procedure.
-
公开(公告)号：US20170362571A1
公开(公告)日：2017-12-21
申请号：US15694635
申请日：2017-09-01
发明人： Vasile Bogdan Neculaes , Juan Jose Becerra , Christine Angela Morton , Andrew Soliz Torres , Antonio Caiafa
CPC分类号： C12N5/0644 , C12M35/02 , C12N2529/00
摘要： Methods and systems for generating a tunable or customizable activated product composition are related. In certain embodiments, one or more of electric pulse parameters, flow rate, or sample container size are varied so as to generate the activated product composition. The activated product composition may be customized or optimized based for a particular patient or procedure.
-
-
-
-
-
-
-
-
-
搜索结果
39 条记录 (耗时 0.021 秒)