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公开(公告)号：US20220227787A1
公开(公告)日：2022-07-21
申请号：US17558130
申请日：2021-12-21
Applicant: Gilead Sciences, Inc.
Inventor： Daniel H. Byun , Eda Y. Canales , Laurent P. Debien , Petr Jansa , Rick A. Lee , Jennifer A. Loyer-Drew , Stephane Perreault , Hyung-Jung Pyun , Roland D. Saito , Michael S. Sangi , Adam J. Schrier , Marina E. Shatskikh , James G. Taylor , Jennifer A. Treiberg , Joshua J. Van Veldhuizen , Lianhong Xu
IPC: C07D519/00
Abstract: The present disclosure relates to novel compounds for use in therapeutic treatement of a disease associated with peptidylarginine deiminases (PADs), such as peptidylarginine deiminase type 4 (PAD4). The present disclosure also relates to processes and intermediates for the preparation of such compounds, methods of using such compounds and pharmaceutical compositions comprising the compounds described herein.
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公开(公告)号：US20190008858A1
公开(公告)日：2019-01-10
申请号：US16005111
申请日：2018-06-11
Applicant: Gilead Sciences, Inc.
Inventor： Kyla Bjornson , Eda Canales , Jeromy J. Cottell , Kapil K. Karki , Ashley A. Katana , Darryl Kato , Tetsuya Kobayashi , John O. Link , Ruben Martinez , Barton W. Phillips , Hyung-jung Pyun , Michael Sangi , Adam J. Schrier , Dustin Siegel , James G. Taylor , Chinh V. Tran , Teresa A. Trejo Martin , Randall W. Vivian , Zheng-Yu Yang , Jeff Zablocki , Sheila Zipfel
IPC: A61K31/498 , C07K5/08 , A61K31/10 , C07K5/083 , C07D498/22 , C07D498/16 , C07D403/14 , C07D241/36 , A61K45/06 , A61K38/21 , A61K38/06 , C07K5/087 , A61K31/519 , A61K31/506 , A61K31/4985 , A61K31/4745 , A61K31/401 , A61K38/00
CPC classification number: A61K31/498 , A61K31/10 , A61K31/401 , A61K31/4745 , A61K31/4985 , A61K31/506 , A61K31/519 , A61K38/00 , A61K38/06 , A61K38/21 , A61K45/06 , C07D241/36 , C07D403/14 , C07D498/16 , C07D498/22 , C07K5/08 , C07K5/0808 , C07K5/0812 , C07K5/0827 , A61K2300/00
Abstract: Compounds of Formula I are disclosed As well as pharmaceutically acceptable salts thereof. Methods of using said compounds and pharmaceutical compositions containing said compounds are also disclosed.
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公开(公告)号：US20170210756A1
公开(公告)日：2017-07-27
申请号：US15227527
申请日：2016-08-03
Applicant: Gilead Sciences, Inc.
Inventor： Amy Cagulada , Johann Chan , Lina Chan , Denise A. Colby , Kapil Kumar Karki , Darryl Kato , Katie Ann Keaton , Sudha Kondapally , Christopher Levins , Adam Littke , Ruben Martinez , Dominika Pcion , Troy Reynolds , Bruce Ross , Michael Sangi , Adam J. Schrier , Pamela Seng , Dustin Siegel , Nathan Shapiro , Donald Tang , James G. Taylor , Jonathan Tripp , Andrew W. Waltman , Lawrence Yu
IPC: C07D498/18 , C07C271/34 , C07C255/61 , C07C205/57 , C07C233/09 , C07C251/12 , C07D403/12 , C07D241/44
CPC classification number: C07D498/18 , C07C51/09 , C07C205/57 , C07C209/00 , C07C227/02 , C07C233/09 , C07C251/12 , C07C255/61 , C07C271/34 , C07C2601/02 , C07D241/44 , C07D403/12 , C07D453/02 , C07D498/16 , C07K5/0808
Abstract: The present disclosure provides processes for the preparation of a compound of formula I: which is useful as an antiviral agent. The disclosure also provides compounds and processes for the preparation of the compounds that are synthetic intermediates to the compound of formula I.
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公开(公告)号：US09617310B2
公开(公告)日：2017-04-11
申请号：US14214477
申请日：2014-03-14
Applicant: Gilead Sciences, Inc.
Inventor： Kyla L. Bjornson , Kapil K. Karki , John O. Link , Hyung-jung Pyun , Adam J. Schrier , Kirk L. Stevens , James G. Taylor , Randall W. Vivian , Jeff Zablocki , Sheila Zipfel
IPC: C07D498/22 , A61K31/437 , A61K31/519 , A61K31/4985 , A61P31/14 , C07K7/64 , C07D487/00 , C07D487/02 , C07D203/02
CPC classification number: C07K7/64 , A61K31/437 , A61K31/519 , C07D203/02 , C07D487/00 , C07D487/02 , C07D498/22
Abstract: Compounds of formula I: or pharmaceutically acceptable salts thereof, wherein the various substituents are defined herein, methods of using said compounds, and pharmaceutical compositions containing said compounds.
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公开(公告)号：US20240254118A1
公开(公告)日：2024-08-01
申请号：US18391258
申请日：2023-12-20
Applicant: Gilead Sciences, Inc.
Inventor： Megan K. Armstrong , Elbert Chin , Chienhung Chou , Laurent P. Debien , Joshua D. Farr , Pancham Lal Gupta , Chao-I Hung , Michael L. Mitchell , Prasenjit K. Mukherjee , Shaina V. Nguyen , Gregory T. Notte , Daniel Roa , Adam J. Schrier , Zheng-Yu Yang
IPC: C07D471/04 , A61K31/473 , A61K31/4741 , A61K31/4743 , A61K31/4745 , A61K31/4748 , A61K31/496 , A61K31/501 , A61K31/506 , A61K31/5355 , A61K31/5377 , A61K31/5386 , A61K31/541 , A61K31/55 , C07D401/12 , C07D491/048 , C07D513/04 , C07D519/00
CPC classification number: C07D471/04 , A61K31/473 , A61K31/4741 , A61K31/4743 , A61K31/4745 , A61K31/4748 , A61K31/496 , A61K31/501 , A61K31/506 , A61K31/5355 , A61K31/5377 , A61K31/5386 , A61K31/541 , A61K31/55 , C07D401/12 , C07D491/048 , C07D513/04 , C07D519/00
Abstract: The present disclosure relates generally to compounds that inhibit PRMT5. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through inhibiting PRMT5. The disclosure further relates to the use of the compounds for the treatment of a disease or condition associated with chromosome 9p21 deletion or MTAP null. The disclosure further relates to the use of the compounds for the treatment of cancers.
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Patent Agency Ranking
公开(公告)号：US11878965B2
公开(公告)日：2024-01-23
申请号：US17557860
申请日：2021-12-21
Applicant: Gilead Sciences, Inc.
Inventor： Daniel H. Byun , Zhenhong R. Cai , Eda Y. Canales , Laurent P. Debien , Timothy R. Hansen , Richard Huang , Petr Jansa , Rick A. Lee , Jennifer A. Loyer-Drew , Ryan McFadden , Michael L. Mitchell , Hyung-Jung Pyun , Roland D. Saito , Michael S. Sangi , Adam J. Schrier , Marina E. Shatskikh , James G. Taylor , Joshua J. Van Veldhuizen , Lianhong Xu
IPC: C07D401/04 , A61K31/437 , A61K31/454 , A61K31/501 , A61K31/506 , A61K31/5355 , A61K31/5383 , A61K45/06 , C07D401/14 , C07D519/00
CPC classification number: C07D401/04 , A61K31/437 , A61K31/454 , A61K31/501 , A61K31/506 , A61K31/5355 , A61K31/5383 , A61K45/06 , C07D401/14 , C07D519/00
Abstract: The present disclosure relates to novel compounds for use in therapeutic treatment of a disease associated with peptidylarginine deiminases (PADs), such as peptidylarginine deiminase type 4 (PAD4). The present disclosure also relates to processes and intermediates for the preparation of such compounds, methods of using such compounds and pharmaceutical compositions comprising the compounds described herein.
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公开(公告)号：US20170290827A1
公开(公告)日：2017-10-12
申请号：US15488035
申请日：2017-04-14
Applicant: Gilead Sciences, Inc.
Inventor： Kyla Bjornson , Eda Canales , Jeromy J. Cottell , Kapil K. Karki , Ashley A. Katana , Darryl Kato , Tetsuya Kobayashi , John O. Link , Ruben Martinez , Barton W. Phillips , Hyung-Jung Pyun , Michael Sangi , Adam J. Schrier , Dustin Siegel , James G. Taylor , Chinh V. Tran , Teresa Alejandra Trejo Martin , Randall W. Vivian , Zheng-Yu Yang , Jeff Zablocki , Sheila M. Zipfel
IPC: A61K31/498 , C07D403/14 , C07D241/36 , A61K31/401 , A61K31/10
Abstract: Compounds of Formula I are disclosed As well as pharmaceutically acceptable salts thereof. Methods of using said compounds and pharmaceutical compositions containing said compounds are also disclosed.
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公开(公告)号：US20250051309A1
公开(公告)日：2025-02-13
申请号：US18754794
申请日：2024-06-26
Applicant: Gilead Sciences, Inc.
Inventor： Jason E. Anesini , James L. Bachman , Alexander J. Burckle , Christopher T. Clark , Kerry E. Jones , Zachary A. Kasun , Jennifer A. Loyer-Drew , Gregory T. Notte , Michael S. Sangi , Adam J. Schrier , Joshua J. Van Veldhuizen
IPC: C07D401/14 , A61K31/444 , A61K31/497 , A61K31/501 , A61K31/5365 , A61K31/5383 , C07D401/04 , C07D487/04 , C07D498/04
Abstract: The present disclosure relates generally to certain compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions provided herein may be used for the treatment or prevention of an autoimmune disease and/or inflammatory condition, including rheumatoid arthritis.
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公开(公告)号：US20230090053A1
公开(公告)日：2023-03-23
申请号：US17557860
申请日：2021-12-21
Applicant: Gilead Sciences, Inc.
Inventor： Daniel H. Byun , Zhenhong R. Cai , Eda Y. Canales , Laurent P. Debien , Timothy R. Hansen , Richard Huang , Petr Jansa , Rick A. Lee , Jennifer A. Loyer-Drew , Ryan McFadden , Michael L. Mitchell , Hyung-Jung Pyun , Roland D. Saito , Michael S. Sangi , Adam J. Schrier , Marina E. Shatskikh , James G. Taylor , Joshua J. Van Veldhuizen , Lianhong Xu
IPC: C07D401/04 , A61K45/06 , A61K31/437 , C07D519/00 , A61K31/5383 , C07D401/14 , A61K31/454 , A61K31/501 , A61K31/506 , A61K31/5355
Abstract: The present disclosure relates to novel compounds for use in therapeutic treatment of a disease associated with peptidylarginine deiminases (PADs), such as peptidylarginine deiminase type 4 (PAD4). The present disclosure also relates to processes and intermediates for the preparation of such compounds, methods of using such compounds and pharmaceutical compositions comprising the compounds described herein.
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公开(公告)号：US20230002412A1
公开(公告)日：2023-01-05
申请号：US17242617
申请日：2021-04-28
Applicant: Gilead Sciences, Inc.
Inventor： Eda Y. Canales , Weng K. Chang , Laurent P. Debien , Petr Jansa , Jennifer A. Loyer-Drew , Luisruben P. Martinez , Stephane Perreault , Gary B. Phillips , Hyung-Jung Pyun , Roland D. Saito , Michael S. Sangi , Adam J. Schrier , Marina E. Shatskikh , James G. Taylor , Jennifer A. Treiberg , Joshua J. Van Veldhuizen
IPC: C07D519/00 , C07D471/14 , A61K45/06
Abstract: The present disclosure relates to novel compounds for use in therapeutic treatment of a disease associated with peptidylarginine deiminases (PADs), such as peptidylarginine deiminase type 4 (PAD4). The present disclosure also relates to processes and intermediates for the preparation of such compounds, methods of using such compounds and pharmaceutical compositions comprising the compounds described herein.
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