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公开(公告)号：US10307374B2
公开(公告)日：2019-06-04
申请号：US15495066
申请日：2017-04-24
发明人： Luis Brito , Michelle C. Archer , Andrew Geall , Derek O'Hagan , Manmohan Singh
IPC分类号： A61K9/107 , A61K39/12 , A61K39/155 , A61K31/713 , A61K9/00 , A61K39/00
摘要： This invention generally relates to cationic oil-in-water emulsions that can be used to deliver nucleic acid molecules, such as an RNA molecule. The emulsion particles comprise an oil core and a cationic lipid. The emulsion particles have an average diameter of about 80 nm to about 180 nm, and the emulsion have an N/P ratio of at least 1.1:1.
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公开(公告)号：US10238733B2
公开(公告)日：2019-03-26
申请号：US15067216
申请日：2016-03-11
发明人： Luis Brito , Andrew Geall , Derek O'Hagan , Manmohan Singh
IPC分类号： A61K39/395 , A61K39/385 , A61K9/107 , A61K39/39 , A61K39/00
摘要： This invention generally relates to cationic oil-in-water emulsions that can be used to deliver negatively charged molecules, such as an RNA molecule. The emulsion particles comprise an oil core and a cationic lipid. The cationic lipid can interact with the negatively charged molecule thereby anchoring the molecule to the emulsion particles. The cationic emulsions described herein are particularly suitable for delivering nucleic acid molecules (such as an RNA molecule encoding an antigen) to cells and formulating nucleic acid-based vaccines.
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公开(公告)号：US20170224616A1
公开(公告)日：2017-08-10
申请号：US15495066
申请日：2017-04-24
发明人： Luis Brito , Michelle Chan , Andrew Geall , Derek O'Hagan , Manmohan Singh
CPC分类号： A61K9/107 , A61K9/0019 , A61K31/713 , A61K39/12 , A61K39/155 , A61K2039/53 , A61K2039/55566 , C12N2760/18534 , Y02A50/412 , Y02A50/489
摘要： This invention generally relates to cationic oil-in-water emulsions that can be used to deliver nucleic acid molecules, such as an RNA molecule. The emulsion particles comprise an oil core and a cationic lipid. The emulsion particles have an average diameter of about 80 nm to about 180 nm, and the emulsion have an N/P ratio of at least 1.1:1.
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公开(公告)号：US20170202960A1
公开(公告)日：2017-07-20
申请号：US15467660
申请日：2017-03-23
发明人： Luis Brito , Michelle Chan , Andrew Geall , Derek O'Hagan , Manmohan Singh
IPC分类号： A61K39/39 , A61K47/02 , A61K47/12 , C12N7/00 , A61K47/34 , A61K47/22 , A61K39/245 , A61K39/155 , A61K47/06 , A61K47/26
CPC分类号： A61K39/39 , A61K9/1075 , A61K39/12 , A61K39/155 , A61K39/245 , A61K47/02 , A61K47/06 , A61K47/12 , A61K47/22 , A61K47/24 , A61K47/26 , A61K47/34 , A61K2039/5256 , A61K2039/53 , A61K2039/55555 , A61K2039/55566 , A61K2039/575 , C12N7/00 , C12N2710/16134 , C12N2710/16171 , C12N2710/16734 , C12N2710/16771 , C12N2760/18534 , C12N2760/18571 , C12N2770/36134 , C12N2770/36143 , C12N2840/203 , Y02A50/386 , Y02A50/388 , Y02A50/412
摘要： This invention generally relates to cationic oil-in-water emulsions that contain high concentrations of cationic lipids and have a defined oil:lipid ratio. The cationic lipid can interact with the negatively charged molecule thereby anchoring the molecule to the emulsion particles. The cationic emulsions described herein are useful for delivering negatively charged molecules, such as nucleic acid molecules to cells, and for formulating nucleic acid-based vaccines.
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公开(公告)号：US10183074B2
公开(公告)日：2019-01-22
申请号：US15467660
申请日：2017-03-23
发明人： Luis Brito , Michelle Chan , Andrew Geall , Derek O'Hagan , Manmohan Singh
IPC分类号： A61K9/107 , A61K39/00 , A61K39/12 , A61K47/12 , A61K39/39 , A61K47/06 , A61K47/24 , A61K39/155 , A61K39/245 , A61K47/02 , A61K47/22 , A61K47/26 , A61K47/34 , C12N7/00
摘要： This invention generally relates to cationic oil-in-water emulsions that contain high concentrations of cationic lipids and have a defined oil:lipid ratio. The cationic lipid can interact with the negatively charged molecule thereby anchoring the molecule to the emulsion particles. The cationic emulsions described herein are useful for delivering negatively charged molecules, such as nucleic acid molecules to cells, and for formulating nucleic acid-based vaccines.
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