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公开(公告)号：US10035826B2
公开(公告)日：2018-07-31
申请号：US15150204
申请日：2016-05-09
发明人： Vega Masignani , Danilo Gomes Moriel , Francesco Berlanda Scorza , Nathalie Norais , Maria Rita Fontana , Mariagrazia Pizza , Laura Serino , Herve Tettelin
IPC分类号： A61K39/02 , C07K14/245 , C07K16/12 , A61K39/108 , A61K39/00
CPC分类号： C07K14/245 , A61K39/00 , A61K39/0258 , A61K2039/505 , A61K2039/523 , C07K16/1232
摘要： Disclosed herein are various open reading frames from a strain of E. coli responsible for neonatal meningitis (MNEC), and a subset of these that is of particular interest for preparing compositions for immunizing against MNEC infections.
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2.发明授权Proteins and nucleic acids from meningitis/sepsis-associated Escherichia coli 有权来自脑膜炎/败血症相关大肠杆菌的蛋白质和核酸公开(公告)号：US09334313B2
公开(公告)日：2016-05-10
申请号：US14293967
申请日：2014-06-02
发明人： Vega Masignani , Danilo Gomes Moriel , Francesco Berlanda Scorza , Nathalie Norais , Maria Rita Fontana , Mariagrazia Pizza , Laura Serino , Herve Tettelin
IPC分类号： A61K39/108 , C07K14/245 , A61K39/00
CPC分类号： C07K14/245 , A61K39/00 , A61K39/0258 , A61K2039/505 , A61K2039/523 , C07K16/1232
摘要： Disclosed herein are various open reading frames from a strain of E. coli responsible for neonatal meningitis (MNEC), and a subset of these that is of particular interest for preparing compositions for immunizing against MNEC infections.
摘要翻译： 本文公开了来自负责新生儿脑膜炎（MNEC）的大肠杆菌菌株的各种开放阅读框，以及用于制备用于免疫针对MNEC感染的组合物特别有意义的这些的一部分。
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公开(公告)号：US10105429B2
公开(公告)日：2018-10-23
申请号：US15369405
申请日：2016-12-05
发明人： Laura Serino , Mariagrazia Pizza
IPC分类号： A61K39/108 , C07K14/245 , A61K39/00
摘要： The invention provides an immunogenic composition comprising a combination of (i) bacterial Ig-like domain protein fragment (orf405B) having the amino acid sequence set forth in SEQ ID NO:2 or a protein having at least 80% similarity thereto, and (ii) putative Lipoprotein (orf3526) having the amino acid sequence set forth in SEQ ID NO:8 or a protein having at least 80% similarity thereto.
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公开(公告)号：US09266929B2
公开(公告)日：2016-02-23
申请号：US14450075
申请日：2014-08-01
发明人： Claire Fraser , Cesira Galeotti , Guido Grandi , Erin Hickey , Vega Masignani , Marirosa Mora , Jeremy Petersen , Mariagrazia Pizza , Rino Rappuoli , Giulio Ratti , Vincenzo Scarlato , Maria Scarselli , Herve Tettelin , J. Craig Venter
IPC分类号： C12P21/00 , C12N15/00 , C12N15/09 , C07K14/22 , A61K39/095
CPC分类号： C07K14/22 , A61K38/00 , A61K39/00 , A61K39/095 , A61K2039/55505 , Y10S530/806 , Y10S530/825
摘要： The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.
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公开(公告)号：US12128094B2
公开(公告)日：2024-10-29
申请号：US17287268
申请日：2019-11-04
发明人： Mario Contorni , Mariagrazia Pizza , Anja Seubert
CPC分类号： A61K39/0018 , A61P31/04 , A61K2039/55505
摘要： The invention provides an immunogenic composition comprising OMVs and (a) acellular pertussis antigen, (b) a tetanus toxoid and (c) a diphtheria toxoid, wherein the OMVs are derived from Bordetella pertussis. The invention also provides compositions for use in a method for raising an immune response in a patient, comprising the step of administering to the patient a composition of the invention.
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公开(公告)号：US10376573B2
公开(公告)日：2019-08-13
申请号：US14407987
申请日：2013-06-14
发明人： Mariagrazia Pizza , Peter Dull , Marzia Monica Giuliani , Muhamed-Kheir Taha , Eva Hong , Ala-Eddine Deghmane
IPC分类号： A61K39/095 , A61K39/39 , A61K39/00
摘要： A method for immunizing a subject against serogroup X meningococcus by administering a vaccine comprising one, two or all three of: (i) a meningococcal fHbp antigen; (ii) a meningococcal NHBA antigen; and/or (iii) a meningococcal NadA antigen. The vaccine may also include meningococcal outer membrane vesicles.
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公开(公告)号：US09932374B2
公开(公告)日：2018-04-03
申请号：US14425037
申请日：2013-09-19
发明人： Cesira Galeotti , Rosanna Leuzzi , Mariagrazia Pizza , Maria Scarselli , Meera Unnikrishnan , Manuele Martinelli
CPC分类号： C07K14/33 , A61K39/08 , A61K2039/55505 , A61K2039/55566 , A61K2039/70 , C07K16/1282
摘要： The invention provides methods, proteins, nucleic acids and antibodies for preventing or treating a C. difficile infection in a mammal.
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公开(公告)号：US09364528B1
公开(公告)日：2016-06-14
申请号：US15015041
申请日：2016-02-03
IPC分类号： A61K39/095 , A61K39/02 , A61K39/00 , A61K39/39
CPC分类号： A61K39/095 , A61K38/164 , A61K39/00 , A61K39/02 , A61K39/39 , A61K2039/53 , A61K2039/55505 , A61K2039/70 , C07K14/22
摘要： Compositions comprising a first biological molecule from a Neisseria bacterium and a second biological molecule from a Neisseria bacterium. The term “biological molecule” includes proteins and nucleic acids. Preferred Neisseria species are N. meningitidis and N. gonorrhoeae.
摘要翻译： 组合物包含来自奈瑟氏球菌细菌的第一生物分子和来自奈顿球菌细菌的第二生物分子。 术语“生物分子”包括蛋白质和核酸。 优选的奈瑟氏菌属是脑膜炎奈瑟氏球菌和淋病奈瑟氏球菌。
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公开(公告)号：US09694063B2
公开(公告)日：2017-07-04
申请号：US14363387
申请日：2012-12-07
发明人： Maria Scarselli , Mariagrazia Pizza , Rosanna Leuzzi , Maria Arico , Manuele Martinelli , Gillian Douce
CPC分类号： A61K39/08 , A61K2039/55505 , A61K2039/55566 , A61K2039/70 , C07K14/33 , C07K2319/20
摘要： The present invention relates to recombinant fragments of C. difficile TcdA and TcdB that may be used in the development of vaccines against C. difficile associated disease. More particularly it relates to combinations comprising a ToxB-GT antigen and a TcdA antigen or a ToxA-GT antigen and a TcdB antigen.
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公开(公告)号：US09249198B2
公开(公告)日：2016-02-02
申请号：US14450082
申请日：2014-08-01
发明人： Claire Fraser , Cesira Galeotti , Guido Grandi , Erin Hickey , Vega Masignani , Marirosa Mora , Jeremy Petersen , Mariagrazia Pizza , Rino Rappuoli , Giulio Ratti , Vincenzo Scarlato , Maria Scarselli , Herve Tettelin , J. Craig Venter
CPC分类号： C07K14/22 , A61K38/00 , A61K39/00 , A61K39/095 , A61K2039/55505 , Y10S530/806 , Y10S530/825
摘要： The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.
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