公开(公告)号：US20220204566A1

公开(公告)日：2022-06-30

申请号：US17565796

申请日：2021-12-30

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Stefano COLLOCA ,  Virginia AMMENDOLA ,  Fabiana GRAZIOLI ,  Alessandra Franz VITELLI ,  Alfredo NICOSIA ,  Riccardo CORTESE

IPC: C07K14/005 ,  C12N15/86 ,  C07K14/075 ,  C07K14/75 ,  A61K39/12 ,  C12N15/861 ,  A61K39/155 ,  A61K39/21 ,  C12N7/00

Abstract: There is provided inter alia an isolated polynucleotide, wherein the polynucleotide encodes a polypeptide selected from the group consisting of: (a) a polypeptide having the amino acid sequence according to SEQ ID NO: 1, (b) a functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 1, wherein the functional derivative has an amino acid sequence which is at least 80% identical over its entire length to the amino acid sequence of SEQ ID NO: 1, and (c) a polypeptide having the amino acid sequence according to SEQ ID NO: 3.

公开(公告)号：US20210060150A1

公开(公告)日：2021-03-04

申请号：US16986413

申请日：2020-08-06

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Stefano COLLOCA ,  Virginia AMMENDOLA ,  Fabiana GRAZIOLI ,  Alessandra VITELLI ,  Alfredo NICOSIA ,  Riccardo CORTESE

IPC: A61K39/04 ,  C12N15/86 ,  A61K39/12 ,  C12N7/00 ,  A61P31/06 ,  A61K35/761 ,  C07K14/005 ,  C07K14/35 ,  A61K9/00 ,  A61K39/39 ,  A61K45/00 ,  C12N15/85

Abstract: There is provided adenoviral vectors encoding a mycobacterial antigen derived from a chimp adenovirus, and to related aspects.

公开(公告)号：US20220220157A1

公开(公告)日：2022-07-14

申请号：US17583511

申请日：2022-01-25

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Virginia AMMENDOLA ,  Stefano COLLOCA ,  Riccardo CORTESE ,  Fabiana GRAZIOLI ,  Alfredo NICOSIA ,  Alessandra VITELLI

IPC: C07K14/005 ,  C12N15/86 ,  C07K14/075 ,  C07K14/75 ,  A61K39/12 ,  C12N15/861 ,  A61K39/155 ,  A61K39/21 ,  C12N7/00

Abstract: There is provided inter alia an isolated polynucleotide, wherein the polynucleotide encodes a polypeptide selected from the group consisting of: (a) a polypeptide having the amino acid sequence according to SEQ ID NO: 1, (b) a functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 1, wherein the functional derivative has an amino acid sequence which is at least 80% identical over its entire length to the amino acid sequence of SEQ ID NO: 1, and (c) a polypeptide having the amino acid sequence according to SEQ ID NO: 3.

公开(公告)号：US20180216081A1

公开(公告)日：2018-08-02

申请号：US15747545

申请日：2016-07-25

Applicant: GLAXOSMITHKLINE BIOLOGICALS, SA

Inventor： Stefano COLLOCA ,  Virginia AMMENDOLA ,  Fabiana GRAZIOLI ,  Alessandra VITELLI ,  Alfredo NICOSIA ,  Riccardo CORTESE

IPC: C12N7/00 ,  C12N15/86 ,  C07K14/005 ,  A61K35/761 ,  C07K14/35 ,  A61K39/04 ,  A61P31/06

CPC classification number: A61K39/04 ,  A61K9/0019 ,  A61K35/761 ,  A61K39/12 ,  A61K39/39 ,  A61K45/05 ,  A61K2039/5256 ,  A61K2039/545 ,  A61P31/06 ,  C07K14/005 ,  C07K14/35 ,  C12N7/00 ,  C12N15/85 ,  C12N15/86 ,  C12N2710/10321 ,  C12N2710/10341 ,  C12N2710/10343 ,  C12N2740/16234 ,  C12N2760/18534

Abstract: There is provided adenoviral vectors encoding a mycobacterial antigen derived from a chimp adenovirus, and to related aspects.

公开(公告)号：US20180170972A1

公开(公告)日：2018-06-21

申请号：US15735839

申请日：2016-06-10

Applicant: GLAXOSMITHKLINE BIOLOGICALS, SA

Inventor： Stefano COLLOCA ,  Virginia AMMENDOLA ,  Fabiana GRAZIOLI ,  Alessandra Franz VITELLI ,  Alfredo NICOSIA ,  Riccardo CORTESE

IPC: C07K14/005 ,  C12N7/00 ,  A61K39/21 ,  A61K39/155

Abstract: There is provided inter alia an isolated polynucleotide, wherein the polynucleotide encodes a polypeptide selected from the group consisting of: (a) a polypeptide having the amino acid sequence according to SEQ ID NO: 1, (b) a functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 1, wherein the functional derivative has an amino acid sequence which is at least 80% identical over its entire length to the amino acid sequence of SEQ ID NO: 1, and (c) a polypeptide having the amino acid sequence according to SEQ ID NO: 3.