公开(公告)号：US20210220462A1

公开(公告)日：2021-07-22

申请号：US17270328

申请日：2019-08-22

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Cindy CASTADO ,  Nadia OUAKED ,  Steven Clement SIJMONS

IPC: A61K39/02 ,  A61K39/39 ,  A61P31/04 ,  C12N9/88

Abstract: The invention provides proteins and compositions for the treatment and prevention of disease caused by Bordetella pertussis.

公开(公告)号：US20240181037A1

公开(公告)日：2024-06-06

申请号：US18283601

申请日：2022-03-25

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA ,  CUREVAC SE

Inventor： Hans Wolfgang GROßE ,  Edith JASNY ,  Janine MÜHE ,  Ventzislav Bojidarov VASSILEV ,  Clarisse LORIN ,  Nadia OUAKED ,  Corey MALLETT ,  Ronan ROUXEL ,  Normand BLAIS

IPC: A61K39/145 ,  A61K39/00 ,  A61P31/16 ,  A61P37/04

CPC classification number: A61K39/145 ,  A61P31/16 ,  A61P37/04 ,  A61K2039/53 ,  A61K2039/6018 ,  A61K2039/6031 ,  A61K2039/6093

Abstract: The present invention relates to carrier-formulated mRNA comprising at least one coding sequence encoding an influenza HA stem polypeptide, and to related aspects.

公开(公告)号：US20210386846A1

公开(公告)日：2021-12-16

申请号：US17397379

申请日：2021-08-09

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Marie-Ange DEMOITIÉ ,  Marie-Noëlle DONNER ,  Nadia OUAKED

IPC: A61K39/04 ,  A61K35/761 ,  A61K39/12 ,  A61K39/39 ,  A61K45/00 ,  A61P31/06 ,  C07K14/005 ,  C07K14/35 ,  C12N7/00 ,  C12N15/85 ,  C12N15/86 ,  A61K9/00

Abstract: The present invention relates to methods for inducing an immune response, in particular methods for inducing an immune response against mycobacterial infections or disease comprising (i) at least one administration of a polypeptide Rv1196 related antigen and at least one administration of an adenovirus encoding a Rv1196 related antigen or (ii) at least one administration of a polypeptide Rv0125 related antigen and at least one administration of an adenovirus encoding a Rv0125 related antigen. Associated compositions, adenoviral constructs and polynucleotide sequences are also provided.

公开(公告)号：US20180250375A1

公开(公告)日：2018-09-06

申请号：US15747671

申请日：2016-07-25

Applicant: GLAXOSMITHKLINE BIOLOGICALS, SA

Inventor： Marie-Ange DEMOITIE ,  Marie-Noelle Renelle DONNER ,  Nadia OUAKED

IPC: A61K39/04 ,  A61K45/00 ,  A61K39/12 ,  A61K39/39 ,  C12N15/85 ,  A61K9/00 ,  A61P31/06

CPC classification number: A61K39/04 ,  A61K9/0019 ,  A61K35/761 ,  A61K39/12 ,  A61K39/39 ,  A61K45/05 ,  A61K2039/5256 ,  A61K2039/545 ,  A61P31/06 ,  C07K14/005 ,  C07K14/35 ,  C12N7/00 ,  C12N15/85 ,  C12N15/86 ,  C12N2710/10321 ,  C12N2710/10341 ,  C12N2710/10343 ,  C12N2740/16234 ,  C12N2760/18534

Abstract: The present invention relates to methods for inducing an immune response, in particular methods for inducing an immune response against mycobacterial infections or disease comprising (i) at least one administration of a polypeptide Rv1196 related antigen and at least one administration of an adenovirus encoding a Rv1196 related antigen or (ii) at least one administration of a polypeptide Rv0125 related antigen and at least one administration of an adenovirus encoding a Rv0125 related antigen. Associated compositions, adenoviral constructs and polynucleotide sequences are also provided.