公开(公告)号：US11795478B2

公开(公告)日：2023-10-24

申请号：US17742221

申请日：2022-05-11

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Virginia Ammendola ,  Stefania Capone ,  Stefano Colloca ,  Antonella Folgori ,  Rossella Merone

IPC: C12N15/86 ,  A61K39/12 ,  A61K39/21 ,  C07K14/005 ,  A61P31/18 ,  A61P31/14 ,  A61K39/00

CPC classification number: C12N15/86 ,  A61K39/12 ,  A61K39/21 ,  A61P31/14 ,  A61P31/18 ,  C07K14/005 ,  A61K2039/572 ,  C12N2710/10343 ,  C12N2740/16034 ,  C12N2740/16234 ,  C12N2760/20134

Abstract: The present invention relates to isolated polynucleotide and polypeptide sequences derived from novel chimpanzee adenovirus ChAd157, as well as to recombinant polynucleotides, vectors, adenoviruses, cells and compositions comprising said polynucleotide and polypeptide sequences.

公开(公告)号：US11702674B2

公开(公告)日：2023-07-18

申请号：US16973630

申请日：2019-06-11

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Virginia Ammendola ,  Stefania Capone ,  Stefano Colloca ,  Antonella Folgori ,  Rossella Merone

IPC: C12N15/86 ,  A61K39/235 ,  A61P37/04 ,  A61K39/21 ,  A61K39/00 ,  A61K39/12

CPC classification number: C12N15/86 ,  A61K39/235 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/5256 ,  A61P37/04 ,  C12N2710/10322 ,  C12N2710/10334 ,  C12N2710/10343 ,  C12N2740/16034 ,  C12N2740/16071

Abstract: The present invention relates to isolated polynucleotide and polypeptide sequences derived from novel chimpanzee adenovirus ChAd157, as well as to recombinant polynucleotides, vectors, adenoviruses, cells and compositions comprising said polynucleotide and polypeptide sequences.

公开(公告)号：US12264179B2

公开(公告)日：2025-04-01

申请号：US18358350

申请日：2023-07-25

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Stefania Capone ,  Antonella Folgori ,  Armin Lahm ,  Benjamin Wizel

IPC: C07K14/005 ,  A61K39/00 ,  A61K39/245 ,  C12N7/00

Abstract: The invention provides Epstein-Barr Virus antigen polynucleotides, polypeptides and vectors; as well as immunogenic compositions comprising the same. It includes the use of Epstein-Barr Virus antigen constructs to produce vaccines for treating and preventing Epstein-Barr Virus infections and Epstein-Barr Virus-associated diseases, such as multiple sclerosis, rheumatoid arthritis and systemic lupus erythematosus.

公开(公告)号：US11773139B2

公开(公告)日：2023-10-03

申请号：US16770963

申请日：2018-12-14

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Stefania Capone ,  Antonella Folgori ,  Armin Lahm ,  Benjamin Wizel

IPC: C07K14/005 ,  A61K39/245 ,  C12N7/00 ,  A61K39/00

CPC classification number: C07K14/005 ,  A61K39/245 ,  C12N7/00 ,  A61K2039/70 ,  C12N2710/16222 ,  C12N2710/16234 ,  C12N2710/16271

Abstract: The invention provides Epstein-Barr Virus antigen polynucleotides, polypeptides and vectors; as well as immunogenic compositions comprising the same. It includes the use of Epstein-Barr Virus antigen constructs to produce vaccines for treating and preventing Epstein-Barr Virus infections and Epstein-Barr Virus-associated diseases, such as multiple sclerosis, rheumatoid arthritis and systemic lupus erythematosus.

公开(公告)号：US11414679B2

公开(公告)日：2022-08-16

申请号：US16466683

申请日：2017-12-07

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Virginia Ammendola ,  Stefania Capone ,  Stefano Colloca ,  Antonella Folgori ,  Rossella Merone

IPC: C12N15/86 ,  C07K14/005 ,  A61K39/21 ,  A61K39/12 ,  A61P31/18 ,  A61P31/14 ,  A61K39/00

Abstract: The present invention relates to isolated polynucleotide and polypeptide sequences derived from novel chimpanzee adenovirus ChAd157, as well as to recombinant polynucleotides, vectors, adenoviruses, cells and compositions comprising said polynucleotide and polypeptide sequences.