公开(公告)号：US10220030B2

公开(公告)日：2019-03-05

申请号：US15811712

申请日：2017-11-14

Applicant: GlaxoSmithKline Intellectual Property Development Limited

Inventor： Michael Jonathan Bury ,  Linda N. Casillas ,  Adam Kenneth Charnley ,  Pamela A. Haile ,  Robert W. Marquis, Jr. ,  John F. Mehlmann ,  Joseph J. Romano ,  Robert R. Singhaus, Jr. ,  Gren Z. Wang

IPC: A61K31/4709 ,  C07D401/12 ,  C07D405/14 ,  C07D417/12 ,  C07D215/44 ,  C07D405/12 ,  C07D417/14 ,  C07D471/04 ,  A61K31/4706

Abstract: Disclosed are compounds having the formula: wherein R1, R2, R3 and Z are as defined herein, and methods of making and using the same.

公开(公告)号：US11365190B2

公开(公告)日：2022-06-21

申请号：US17156893

申请日：2021-01-25

Applicant: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED

Inventor： Adam Kenneth Charnley ,  Gren Z. Wang ,  Joseph J. Romano

IPC: C07D413/14 ,  C07D403/14 ,  C07D405/14 ,  C07D487/22 ,  C07D493/10 ,  C07D498/18 ,  C07F9/6558

Abstract: Disclosed are compounds having the formula: wherein q, r, s, A, B, C, RA1, RA2, RB1, RB2, RC1, RC2, R3, R4, R5, R6, R14, R15, R16, and R17, are as defined herein, or a tautomer thereof, or a salt, particularly a pharmaceutically acceptable salt, thereof.

公开(公告)号：US20210139473A1

公开(公告)日：2021-05-13

申请号：US17156893

申请日：2021-01-25

Applicant: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED

Inventor： Adam Kenneth CHARNLEY ,  Gren Z. Wang ,  Joseph J. Romano

IPC: C07D413/14 ,  C07D403/14

Abstract: Disclosed are compounds having the formula: wherein q, r, s, A, B, C, RA1, RA2, RB1, RB2, RC1, RC2, R3, R4, R5, R6, R14, R15, R16, and R17, are as defined herein, or a tautomer thereof, or a salt, particularly a pharmaceutically acceptable salt, thereof.

公开(公告)号：US11970480B2

公开(公告)日：2024-04-30

申请号：US17663749

申请日：2022-05-17

Applicant: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED

Inventor： Adam Kenneth Charnley ,  Michael G. Darcy ,  Jason W. Dodson ,  Xiaoyang Dong ,  Terry V. Hughes ,  Jianxing Kang ,  Lara Kathryn Leister ,  Yiqian Lian ,  Yue Li ,  John F. Mehlmann ,  Neysa Nevins ,  Joshi M. Ramanjulu ,  Joseph J. Romano ,  Gren Z. Wang ,  Guosen Ye ,  Daohua Zhang

IPC: C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D487/22 ,  C07D493/10 ,  C07D498/18 ,  C07F9/6558

CPC classification number: C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D487/22 ,  C07D493/10 ,  C07D498/18 ,  C07F9/65583

Abstract: Disclosed are compounds having the formula:






wherein q, r, s, A, B, C, RA1, RA2, RB1, RB2, RC1, RC2, R3, R4, R5, R6, R14, R15, R16, and R17, are as defined herein, or a tautomer thereof, or a salt, particularly a pharmaceutically acceptable salt, thereof.