公开(公告)号：US10975287B2

公开(公告)日：2021-04-13

申请号：US16091945

申请日：2017-04-05

Applicant: GlaxoSmithKline Intellectual Property Development Limited

Inventor： Adam Kenneth Charnley ,  Michael G. Darcy ,  Jason W. Dodson ,  Terry V. Hughes ,  Yue Li ,  Yiqian Lian ,  Neysa Nevins ,  Joshi M. Ramanjulu

IPC: C07D401/14 ,  C07D403/12 ,  A61P31/18 ,  C09K8/508 ,  C09K8/512 ,  C09K8/516 ,  E21B33/13 ,  E21B47/10 ,  C07D403/14 ,  C07D413/14

Abstract: Disclosed are compounds having the formula: wherein Ra, R1, R2, R3, R4, R5, R6, R7, and R8, are as defined herein, or a salt, particularly a pharmaceutically acceptable salt, thereof.

公开(公告)号：US11970480B2

公开(公告)日：2024-04-30

申请号：US17663749

申请日：2022-05-17

Applicant: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED

Inventor： Adam Kenneth Charnley ,  Michael G. Darcy ,  Jason W. Dodson ,  Xiaoyang Dong ,  Terry V. Hughes ,  Jianxing Kang ,  Lara Kathryn Leister ,  Yiqian Lian ,  Yue Li ,  John F. Mehlmann ,  Neysa Nevins ,  Joshi M. Ramanjulu ,  Joseph J. Romano ,  Gren Z. Wang ,  Guosen Ye ,  Daohua Zhang

IPC: C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D487/22 ,  C07D493/10 ,  C07D498/18 ,  C07F9/6558

CPC classification number: C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D487/22 ,  C07D493/10 ,  C07D498/18 ,  C07F9/65583

Abstract: Disclosed are compounds having the formula:






wherein q, r, s, A, B, C, RA1, RA2, RB1, RB2, RC1, RC2, R3, R4, R5, R6, R14, R15, R16, and R17, are as defined herein, or a tautomer thereof, or a salt, particularly a pharmaceutically acceptable salt, thereof.

公开(公告)号：US11976057B2

公开(公告)日：2024-05-07

申请号：US17492978

申请日：2021-10-04

Applicant: GlaxoSmithKline Intellectual Property Development Limited

Inventor： Edward Brnardic ,  Michael Bury ,  Rodolfo Cadilla ,  Jon Collins ,  Yu Guo ,  Anthony Handlon ,  Huijie Li ,  Yue Li ,  Daniel Paone ,  Christie Schulte ,  Barry Shearer ,  Maben Ying ,  Guosen Ye ,  Huichang Zhang ,  Millard Hurst Lambert, III

IPC: C07D401/14 ,  A61P17/00 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

CPC classification number: C07D401/14 ,  A61P17/00 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

Abstract: This invention relates to novel compounds according to Formula (I) which are antagonists of MrgX2, to pharmaceutical compositions containing them, and to their use in therapy for the treatment of MrgX2-mediated diseases and disorders.