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公开(公告)号：US10717711B2
公开(公告)日：2020-07-21
申请号：US16286920
申请日：2019-02-27
Inventor： Adam K. Charnley , Xiaoyang Dong
IPC: C07D239/94 , C07D403/12 , C07D417/12 , C07D417/14 , C07D471/04
Abstract: Disclosed are compounds having the formula: wherein R1, R2, R3, and Z are as defined herein, and methods of making and using the same.
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Patent Agency Ranking
公开(公告)号：US09650364B2
公开(公告)日：2017-05-16
申请号：US14762905
申请日：2014-02-19
Inventor： Linda N. Casillas , Adam Kenneth Charnley , Xiaoyang Dong , Pamela A. Haile , Michael P. Demartino , John F. Mehlmann
IPC: C07D403/12 , C07D405/14 , A61K9/20 , A61K9/48
CPC classification number: C07D403/12 , A61K9/2054 , A61K9/4866 , C07D405/14
Abstract: Disclosed are compounds that are inhibitors of RIP2 kinase and methods of making and using the same.
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![Triazole-substituted imidazo[1,2-a]pyrimidines as cGAS inhibitors](/abs-image/US/2025/03/11/US12247033B2/abs.jpg.150x150.jpg)
公开(公告)号：US12247033B2
公开(公告)日：2025-03-11
申请号：US18586620
申请日：2024-02-26
Inventor： Adam K. Charnley , Janos Botyanszki , Xiaoyang Dong , Philip Gareth Humphreys , Bryan Wayne King , Kimberly Katherine Marcus , Joseph Pero , Alexander Joseph Reif , Daohua Zhang , Attiq Rahman , Kenneth Allen Newlander , Kenneth Wiggall , Joshi Ramanjulu
IPC: C07D487/04 , C07D403/14 , C07D471/04 , C07D471/14 , C07F9/6561
Abstract: The present invention relates to compounds of Formula (I), compositions containing them, and to their use in the treatment of various disorders, in particular autoimmune, autoinflammatory or immune-mediated conditions, such as systemic lupus erythematosus (SLE), cutaneous lupus erythematosus (CLE) and lupus nephritis.
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![TRIAZOLE-SUBSTITUTED IMIDAZO[1,2-A]PYRIMIDINES AS CGAS INHIBITORS](/abs-image/US/2025/03/20/US20250092053A1/abs.jpg.150x150.jpg)
公开(公告)号：US20250092053A1
公开(公告)日：2025-03-20
申请号：US18966276
申请日：2024-12-03
Inventor： Adam K. CHARNLEY , Janos Botyanszki , Xiaoyang Dong , Philip Gareth Humphreys , Bryan Wayne King , Kimberly Katherine Marcus , Joseph Pero , Alexander Joseph Reif , Daohua Zhang , Attiq Rahman , Kenneth Allen Newlander , Kenneth Wiggall , Joshi Ramanjulu
IPC: C07D487/04 , C07D403/14 , C07D471/04 , C07D471/14 , C07F9/6561
Abstract: The present invention relates to compounds of Formula (I), compositions containing them, and to their use in the treatment of various disorders, in particular autoimmune, autoinflammatory or immune-mediated conditions, such as systemic lupus erythematosus (SLE), cutaneous lupus erythematosus (CLE) and lupus nephritis.
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公开(公告)号：US11970480B2
公开(公告)日：2024-04-30
申请号：US17663749
申请日：2022-05-17
Inventor： Adam Kenneth Charnley , Michael G. Darcy , Jason W. Dodson , Xiaoyang Dong , Terry V. Hughes , Jianxing Kang , Lara Kathryn Leister , Yiqian Lian , Yue Li , John F. Mehlmann , Neysa Nevins , Joshi M. Ramanjulu , Joseph J. Romano , Gren Z. Wang , Guosen Ye , Daohua Zhang
IPC: C07D403/14 , C07D405/14 , C07D413/14 , C07D487/22 , C07D493/10 , C07D498/18 , C07F9/6558
CPC classification number: C07D403/14 , C07D405/14 , C07D413/14 , C07D487/22 , C07D493/10 , C07D498/18 , C07F9/65583
Abstract: Disclosed are compounds having the formula:
wherein q, r, s, A, B, C, RA1, RA2, RB1, RB2, RC1, RC2, R3, R4, R5, R6, R14, R15, R16, and R17, are as defined herein, or a tautomer thereof, or a salt, particularly a pharmaceutically acceptable salt, thereof.-
公开(公告)号：US09994529B2
公开(公告)日：2018-06-12
申请号：US15431942
申请日：2017-02-14
Inventor： Michael Jonathan Bury , Linda N. Casillas , Adam K. Charnley , Michael P. Demartino , Xiaoyang Dong , Patrick M. Eidam , Pamela A. Haile , Robert W. Marquis, Jr. , Joshi M. Ramanjulu , Joseph J. Romano , Ami Lakdawala Shah , Robert R. Singhaus, Jr. , Gren Wang
IPC: C07D239/94 , C07D403/12 , C07D417/12 , C07D417/14 , C07D471/04
CPC classification number: C07D239/94 , C07D403/12 , C07D417/12 , C07D417/14 , C07D471/04
Abstract: Disclosed are compounds having the formula: wherein R1, R2, R3, and Z are as defined herein, and methods of making and using the same.
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