公开(公告)号：US10975287B2

公开(公告)日：2021-04-13

申请号：US16091945

申请日：2017-04-05

Applicant: GlaxoSmithKline Intellectual Property Development Limited

Inventor： Adam Kenneth Charnley ,  Michael G. Darcy ,  Jason W. Dodson ,  Terry V. Hughes ,  Yue Li ,  Yiqian Lian ,  Neysa Nevins ,  Joshi M. Ramanjulu

IPC: C07D401/14 ,  C07D403/12 ,  A61P31/18 ,  C09K8/508 ,  C09K8/512 ,  C09K8/516 ,  E21B33/13 ,  E21B47/10 ,  C07D403/14 ,  C07D413/14

Abstract: Disclosed are compounds having the formula: wherein Ra, R1, R2, R3, R4, R5, R6, R7, and R8, are as defined herein, or a salt, particularly a pharmaceutically acceptable salt, thereof.

公开(公告)号：US10730907B2

公开(公告)日：2020-08-04

申请号：US16523150

申请日：2019-07-26

Applicant: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED

Inventor： Jerry Adams ,  Yiqian Lian

IPC: A61K31/7084 ,  C07H21/04 ,  C07H21/00 ,  A61K39/39 ,  C07F9/6574 ,  C07H21/02 ,  A61K39/00

Abstract: A compound of Formula (I) wherein Y1, Y2, X1, X2, R1, R2, R3, R4, R5, R6, R8, and R9 are as defined herein; and pharmaceutically acceptable salts and tautomers thereof, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, in the treatment of diseases in which modulation of STING (Stimulator of Interferon Genes) is beneficial, for example inflammation, allergic and autoimmune diseases, infectious diseases, cancer, pre-cancerous syndromes and as vaccine adjuvants.

公开(公告)号：US11970480B2

公开(公告)日：2024-04-30

申请号：US17663749

申请日：2022-05-17

Applicant: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED

Inventor： Adam Kenneth Charnley ,  Michael G. Darcy ,  Jason W. Dodson ,  Xiaoyang Dong ,  Terry V. Hughes ,  Jianxing Kang ,  Lara Kathryn Leister ,  Yiqian Lian ,  Yue Li ,  John F. Mehlmann ,  Neysa Nevins ,  Joshi M. Ramanjulu ,  Joseph J. Romano ,  Gren Z. Wang ,  Guosen Ye ,  Daohua Zhang

IPC: C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D487/22 ,  C07D493/10 ,  C07D498/18 ,  C07F9/6558

CPC classification number: C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D487/22 ,  C07D493/10 ,  C07D498/18 ,  C07F9/65583

Abstract: Disclosed are compounds having the formula:






wherein q, r, s, A, B, C, RA1, RA2, RB1, RB2, RC1, RC2, R3, R4, R5, R6, R14, R15, R16, and R17, are as defined herein, or a tautomer thereof, or a salt, particularly a pharmaceutically acceptable salt, thereof.

公开(公告)号：US20200002370A1

公开(公告)日：2020-01-02

申请号：US16523150

申请日：2019-07-26

Applicant: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED

Inventor： Jerry ADAMS ,  Yiqian Lian

IPC: C07H21/04 ,  C07H21/00 ,  A61K39/39 ,  C07F9/6574 ,  C07H21/02 ,  A61K31/7084

Abstract: A compound of Formula (I) wherein Y1, Y2, X1, X2, R1, R2, R3, R4, R5, R6, R8, and R9 are as defined herein; and pharmaceutically acceptable salts and tautomers thereof, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, in the treatment of diseases in which modulation of STING (Stimulator of Interferon Genes) is beneficial, for example inflammation, allergic and autoimmune diseases, infectious diseases, cancer, pre-cancerous syndromes and as vaccine adjuvants.

公开(公告)号：US10364266B2

公开(公告)日：2019-07-30

申请号：US15979729

申请日：2018-05-15

Applicant: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED

Inventor： Jerry Adams ,  Yiqian Lian

IPC: C07H21/02 ,  C07H21/04 ,  C07F9/6574 ,  A61K39/39 ,  C07H21/00 ,  A61K31/7084 ,  A61K39/00

Abstract: A compound of Formula (I) wherein Y1, Y2, X1, X2, R1, R2, R3, R4, R5, R6, R8, and R9 are as defined herein; and pharmaceutically acceptable salts and tautomers thereof, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, in the treatment of diseases in which modulation of STING (Stimulator of Interferon Genes) is beneficial, for example inflammation, allergic and autoimmune diseases, infectious diseases, cancer, pre-cancerous syndromes and as vaccine adjuvants.

公开(公告)号：US20170233430A1

公开(公告)日：2017-08-17

申请号：US15586634

申请日：2017-05-04

Applicant: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED

Inventor： Jerry Adams ,  Yiqian Lian

IPC: C07H21/04 ,  A61K31/7084 ,  A61K39/39

CPC classification number: C07H21/04 ,  A61K31/7084 ,  A61K39/39 ,  A61K2039/55511 ,  C07F9/65746 ,  C07H21/00 ,  C07H21/02

Abstract: A compound of Formula (I) wherein Y1, Y2, X1, X2, R1, R2, R3, R4, R5, R6, R8, and R9 are as defined herein; and pharmaceutically acceptable salts and tautomers thereof, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, in the treatment of diseases in which modulation of STING (Stimulator of Interferon Genes) is beneficial, for example inflammation, allergic and autoimmune diseases, infectious diseases, cancer, pre-cancerous syndromes and as vaccine adjuvants.

公开(公告)号：US09994607B2

公开(公告)日：2018-06-12

申请号：US15586634

申请日：2017-05-04

Applicant: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED

Inventor： Jerry Adams ,  Yiqian Lian

IPC: C07H21/04 ,  A61K39/39 ,  A61K31/7084 ,  C07H21/02 ,  C07F9/6574 ,  A61K39/00

CPC classification number: C07H21/04 ,  A61K31/7084 ,  A61K39/39 ,  A61K2039/55511 ,  C07F9/65746 ,  C07H21/00 ,  C07H21/02

Abstract: A compound of Formula (I) wherein Y1, Y2, X1, X2, R1, R2, R3, R4, R5, R6, R8, and R9 are as defined herein; and pharmaceutically acceptable salts and tautomers thereof, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, in the treatment of diseases in which modulation of STING (Stimulator of Interferon Genes) is beneficial, for example inflammation, allergic and autoimmune diseases, infectious diseases, cancer, pre-cancerous syndromes and as vaccine adjuvants.

公开(公告)号：US09718848B2

公开(公告)日：2017-08-01

申请号：US15368921

申请日：2016-12-05

Applicant: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED

Inventor： Jerry Adams ,  Kevin J. Duffy ,  Yiqian Lian

IPC: C07H21/02 ,  C07H21/04 ,  C07F9/6574 ,  A61K39/39 ,  A61K39/00

CPC classification number: C07H21/04 ,  A61K31/7084 ,  A61K39/39 ,  A61K2039/55511 ,  C07F9/65746 ,  C07H21/00 ,  C07H21/02

Abstract: A compound of Formula (I) wherein Y1, Y2, X1, X2, R1, R2, R3, R4, R5, R6, R8, and R9 are as defined herein; and pharmaceutically acceptable salts and tautomers thereof, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, in the treatment of diseases in which modulation of STING (Stimulator of Interferon Genes) is beneficial, for example inflammation, allergic and autoimmune diseases, infectious diseases, cancer, pre-cancerous syndromes and as vaccine adjuvants.