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公开(公告)号：US10220030B2
公开(公告)日：2019-03-05
申请号：US15811712
申请日：2017-11-14
发明人： Michael Jonathan Bury , Linda N. Casillas , Adam Kenneth Charnley , Pamela A. Haile , Robert W. Marquis, Jr. , John F. Mehlmann , Joseph J. Romano , Robert R. Singhaus, Jr. , Gren Z. Wang
IPC分类号： A61K31/4709 , C07D401/12 , C07D405/14 , C07D417/12 , C07D215/44 , C07D405/12 , C07D417/14 , C07D471/04 , A61K31/4706
摘要： Disclosed are compounds having the formula: wherein R1, R2, R3 and Z are as defined herein, and methods of making and using the same.
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公开(公告)号：US10981901B1
公开(公告)日：2021-04-20
申请号：US16091189
申请日：2017-04-05
发明人： Joseph J. Romano , Jianxing Kang
IPC分类号： C07D413/14 , C07D403/14
摘要： Disclosed are compounds having the formula: wherein q, r, s, A, B, C, RA1, RA2, RB1, RB2, RC1, RC2, R3, R4, R5, R6, R14, R15, R16, and R17, are as defined herein, or a tautomer thereof, or a salt, particularly a pharmaceutically acceptable salt, thereof.
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公开(公告)号：US11970480B2
公开(公告)日：2024-04-30
申请号：US17663749
申请日：2022-05-17
发明人： Adam Kenneth Charnley , Michael G. Darcy , Jason W. Dodson , Xiaoyang Dong , Terry V. Hughes , Jianxing Kang , Lara Kathryn Leister , Yiqian Lian , Yue Li , John F. Mehlmann , Neysa Nevins , Joshi M. Ramanjulu , Joseph J. Romano , Gren Z. Wang , Guosen Ye , Daohua Zhang
IPC分类号： C07D403/14 , C07D405/14 , C07D413/14 , C07D487/22 , C07D493/10 , C07D498/18 , C07F9/6558
CPC分类号： C07D403/14 , C07D405/14 , C07D413/14 , C07D487/22 , C07D493/10 , C07D498/18 , C07F9/65583
摘要： Disclosed are compounds having the formula:
wherein q, r, s, A, B, C, RA1, RA2, RB1, RB2, RC1, RC2, R3, R4, R5, R6, R14, R15, R16, and R17, are as defined herein, or a tautomer thereof, or a salt, particularly a pharmaceutically acceptable salt, thereof.-
公开(公告)号：US10189820B2
公开(公告)日：2019-01-29
申请号：US15730664
申请日：2018-01-03
发明人： John F. Mehlmann , Joseph J. Romano
IPC分类号： A61K31/5355 , C07D403/14 , C07D405/14 , C07D413/14 , C07D487/22 , C07D493/10 , C07D498/18 , C07F9/6558
摘要： Disclosed are compounds having the formula: wherein q, r, s, A, B, C, RA1, RA2, RB1, RB2, RC1, RC2, R3, R4, R5, R6, R14, R15, R16, and R17, are as defined herein, or a tautomer thereof, or a salt, particularly a pharmaceutically acceptable salt, thereof.
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公开(公告)号：US09994529B2
公开(公告)日：2018-06-12
申请号：US15431942
申请日：2017-02-14
发明人： Michael Jonathan Bury , Linda N. Casillas , Adam K. Charnley , Michael P. Demartino , Xiaoyang Dong , Patrick M. Eidam , Pamela A. Haile , Robert W. Marquis, Jr. , Joshi M. Ramanjulu , Joseph J. Romano , Ami Lakdawala Shah , Robert R. Singhaus, Jr. , Gren Wang
IPC分类号： C07D239/94 , C07D403/12 , C07D417/12 , C07D417/14 , C07D471/04
CPC分类号： C07D239/94 , C07D403/12 , C07D417/12 , C07D417/14 , C07D471/04
摘要： Disclosed are compounds having the formula: wherein R1, R2, R3, and Z are as defined herein, and methods of making and using the same.
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公开(公告)号：US20210139473A1
公开(公告)日：2021-05-13
申请号：US17156893
申请日：2021-01-25
IPC分类号： C07D413/14 , C07D403/14
摘要： Disclosed are compounds having the formula: wherein q, r, s, A, B, C, RA1, RA2, RB1, RB2, RC1, RC2, R3, R4, R5, R6, R14, R15, R16, and R17, are as defined herein, or a tautomer thereof, or a salt, particularly a pharmaceutically acceptable salt, thereof.
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公开(公告)号：US20160060249A1
公开(公告)日：2016-03-03
申请号：US14933201
申请日：2015-11-05
发明人： Linda N. CASILLAS , Adam Kenneth Charnley , Pamela A. Haile , Terry Vincent Hughes , Robert W. Marquis, JR. , John F. Mehlmann , Michael Reilly , Joseph J. Romano , Robert R. Singhaus, JR.
IPC分类号： C07D401/12 , C07D405/14
CPC分类号： C07D401/12 , C07D405/14
摘要： Disclosed are compounds having the formula: wherein R1, R2, R3, R4 and R5 are as defined herein, and methods of making and using the same.
摘要翻译： 公开了具有下式的化合物：其中R1，R2，R3，R4和R5如本文所定义，以及制备和使用它们的方法。
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公开(公告)号：US20140256949A1
公开(公告)日：2014-09-11
申请号：US14283352
申请日：2014-05-21
发明人： Linda N. CASILLAS , Adam Kenneth Charnley , Pamela A. Haile , Terry Vincent Hughes , Robert W. Marquis, JR. , John F. Mehlmann , Michael Reilly , Joseph J. Romano , Robert R. Singhaus, JR.
IPC分类号： C07D405/14 , C07D401/12
CPC分类号： C07D401/12 , C07D405/14
摘要： Disclosed are compounds having the formula: wherein R1, R2, R3, R4 and R5 are as defined herein, and methods of making and using the same.
摘要翻译： 公开了具有下式的化合物：其中R1，R2，R3，R4和R5如本文所定义，以及制备和使用它们的方法。
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公开(公告)号：US11377440B2
公开(公告)日：2022-07-05
申请号：US16652221
申请日：2018-10-04
发明人： David T. Fosbenner , Todd L. Graybill , Jianxing Kang , Bryan W. King , Yunfeng Lan , Lara Kathryn Leister , Mukesh K. Mahajan , John F. Mehlmann , Angel I. Morales-Ramos , George Scott Pesiridis , Joshi M. Ramanjulu , Joseph J. Romano , Stuart Paul Romeril , Mark J. Schulz , Huiqiang Zhou , Junya Qu
IPC分类号： C07D403/14 , C07D401/14 , C07D405/14
摘要： Disclosed are compounds having the formula: (I) wherein q, r, s, A, B, C, RA1, RA2, RB1, RB2, RC1, RC2, R3, R4, R5, R6, R14, R15, R16, R17, Rx, and Ry are as defined herein, or a tautomer thereof, or a salt, particularly a pharmaceutically acceptable salt, thereof.
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公开(公告)号：US11365190B2
公开(公告)日：2022-06-21
申请号：US17156893
申请日：2021-01-25
IPC分类号： C07D413/14 , C07D403/14 , C07D405/14 , C07D487/22 , C07D493/10 , C07D498/18 , C07F9/6558
摘要： Disclosed are compounds having the formula: wherein q, r, s, A, B, C, RA1, RA2, RB1, RB2, RC1, RC2, R3, R4, R5, R6, R14, R15, R16, and R17, are as defined herein, or a tautomer thereof, or a salt, particularly a pharmaceutically acceptable salt, thereof.
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