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    Bacteria Identification by Phage Induced Impedance Fluctuation Analysis
    1.
    发明申请
    Bacteria Identification by Phage Induced Impedance Fluctuation Analysis 审中-公开
    噬菌体诱导阻抗波动分析的细菌鉴定

    公开(公告)号：US20120252003A1

    公开(公告)日：2012-10-04

    申请号：US13075250

    申请日：2011-03-30

    申请人： Gabor Schmera ,  Laszlo Kish

    发明人： Gabor Schmera ,  Laszlo Kish

    IPC分类号： C12Q1/70 ,  C12M1/42

    CPC分类号： G01N33/48735

    摘要： Methods for detection and identification of bacteria within a sample include the step of inserting a pair of electrodes into the sample. A first impedance across the electrodes is established with a first AC voltage source having a first frequency. A phage is introduced into the sample, and impedance fluctuations that are caused by ion release by the bacteria due to the phage introduction are measured. The use of impedance fluctuations instead of voltage fluctuations to detect and identify bacteria minimizes 1/f noise effects and increases system sensitivity. To further increase system sensitivity by eliminating thermal noise, a second impedance across the electrodes can be established using a second AC voltage source at a second frequency. Second impedance fluctuations are cross-correlated to the first impedance fluctuations, and the cross-correlation results are analyzed to determine whether or not bacteria are present in the sample based on phage electrical activity.

    摘要翻译： 用于检测和鉴定样品中的细菌的方法包括将一对电极插入样品中的步骤。 利用具有第一频率的第一AC电压源建立电极两端的第一阻抗。 样品中引入了噬菌体，测量了由于引入噬菌体而导致细菌离子释放引起的阻抗波动。 使用阻抗波动代替电压波动来检测和识别细菌可以最大限度地降低1 / f噪声影响并提高系统灵敏度。 为了通过消除热噪声来进一步提高系统灵敏度，可以使用第二频率的第二AC电压源来建立电极两端的第二阻抗。 第二阻抗波动与第一阻抗波动相互关联，并且分析互相关结果以基于噬菌体电活动来确定样品中是否存在细菌。

    Bacteria identification by phage induced impedance fluctuation analysis
    2.
    发明授权
    Bacteria identification by phage induced impedance fluctuation analysis 有权

    公开(公告)号：US09645101B2

    公开(公告)日：2017-05-09

    申请号：US13936631

    申请日：2013-07-08

    申请人： Gabor Schmera ,  Laszlo Kish

    发明人： Gabor Schmera ,  Laszlo Kish

    IPC分类号： G01N27/02 ,  G01N33/569 ,  G01N33/487

    CPC分类号： G01N27/021 ,  G01N33/48735 ,  G01N33/56911

    摘要： Methods for detection and identification of bacteria within a sample include the step of inserting a pair of electrodes into the sample. A first impedance across the electrodes is established with a first AC voltage source having a first frequency. A phage is introduced into the sample, and impedance fluctuations that are caused by ion release by the bacteria due to the phage introduction are measured. The use of impedance fluctuations instead of voltage fluctuations to detect and identify bacteria minimizes 1/f noise effects and increases system sensitivity. To further increase system sensitivity by eliminating thermal noise, a second impedance across the electrodes can be established using a second AC voltage source at a second frequency. Second impedance fluctuations are cross-correlated to the first impedance fluctuations, and the cross-correlation results are analyzed to determine whether or not bacteria are present in the sample based on phage electrical activity.

    Bacteria Identification by Phage Induced Impedance Fluctuation Analysis
    3.
    发明申请
    Bacteria Identification by Phage Induced Impedance Fluctuation Analysis 有权
    噬菌体诱导阻抗波动分析的细菌鉴定

    公开(公告)号：US20130295556A1

    公开(公告)日：2013-11-07

    申请号：US13936631

    申请日：2013-07-08

    申请人： Gabor Schmera ,  Laszlo Kish

    发明人： Gabor Schmera ,  Laszlo Kish

    IPC分类号： G01N27/02

    CPC分类号： G01N27/021 ,  G01N33/48735 ,  G01N33/56911

    摘要： Methods for detection and identification of bacteria within a sample include the step of inserting a pair of electrodes into the sample. A first impedance across the electrodes is established with a first AC voltage source having a first frequency. A phage is introduced into the sample, and impedance fluctuations that are caused by ion release by the bacteria due to the phage introduction are measured. The use of impedance fluctuations instead of voltage fluctuations to detect and identify bacteria minimizes 1/f noise effects and increases system sensitivity. To further increase system sensitivity by eliminating thermal noise, a second impedance across the electrodes can be established using a second AC voltage source at a second frequency. Second impedance fluctuations are cross-correlated to the first impedance fluctuations, and the cross-correlation results are analyzed to determine whether or not bacteria are present in the sample based on phage electrical activity.

    摘要翻译： 用于检测和鉴定样品中的细菌的方法包括将一对电极插入样品中的步骤。 利用具有第一频率的第一AC电压源建立电极两端的第一阻抗。 样品中引入了噬菌体，测量了由于引入噬菌体而导致细菌离子释放引起的阻抗波动。 使用阻抗波动代替电压波动来检测和识别细菌可以最大限度地降低1 / f噪声影响并提高系统灵敏度。 为了通过消除热噪声来进一步提高系统灵敏度，可以使用第二频率的第二AC电压源来建立电极两端的第二阻抗。 第二阻抗波动与第一阻抗波动相互关联，并且分析互相关结果以基于噬菌体电活动来确定样品中是否存在细菌。