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    DEVICES AND METHODS FOR BIOCHIP MULTIPLEXING
    2.
    发明申请
    DEVICES AND METHODS FOR BIOCHIP MULTIPLEXING 有权
    BIOCHIP MULTIPLEXING的装置和方法

    公开(公告)号：US20070189921A1

    公开(公告)日：2007-08-16

    申请号：US09760384

    申请日：2001-01-11

    申请人： Hau Duong ,  Gary Blackburn ,  Jon Kayyem ,  Stephen O'Connor ,  Gary Olsen ,  Robert Pietri ,  Robert Terbrueggen

    发明人： Hau Duong ,  Gary Blackburn ,  Jon Kayyem ,  Stephen O'Connor ,  Gary Olsen ,  Robert Pietri ,  Robert Terbrueggen

    IPC分类号： G01N21/00

    CPC分类号： G01N21/6452 ,  G01N35/08 ,  G01N2035/00158 ,  Y10T436/11

    摘要： The invention is directed to a method of analyzing a plurality of biochips. In particular, the method includes inserting a first biochip in to a first station of an analysis device, inserting a second biochip into a second station of the analysis device, wherein each of the first and second biochips comprise a substrate that includes an array of detection electrodes, each including a different capture binding ligand, a different target analyte, and a label, and a plurality of electrical contacts, detecting current as an indication of the presence of the labels on the first biochip and detecting current as an indication of the presence of the labels on the second biochip.

    摘要翻译： 本发明涉及分析多个生物芯片的方法。 特别地，该方法包括将第一生物芯片插入到分析装置的第一站中，将第二生物芯片插入到分析装置的第二站中，其中第一和第二生物芯片中的每一个包括基板，其包括检测阵列 电极，每个包括不同的捕获结合配体，不同的目标分析物和标签，以及多个电触点，检测电流作为第一生物芯片上标签存在的指示，并检测电流作为存在的指示 的第二个生物芯片上的标签。

    Method for kraft waste reclamation
    3.
    发明申请
    Method for kraft waste reclamation 审中-公开
    牛皮纸废物回收方法

    公开(公告)号：US20070051482A1

    公开(公告)日：2007-03-08

    申请号：US11522849

    申请日：2006-09-18

    申请人： Gary Olsen ,  John Stuever ,  Susan Stuever

    发明人： Gary Olsen ,  John Stuever ,  Susan Stuever

    IPC分类号： D21C11/14

    CPC分类号： C01F11/185 ,  C01P2004/61 ,  C09C1/021 ,  D21C11/0071 ,  D21C11/0078 ,  D21C11/12 ,  D21H17/675 ,  Y02P40/44

    摘要： A method for obtaining particulate calcium carbonate having an average particle size less than about 12 microns is provided. The method includes the steps of (1) withdrawing from a pulp mill a mixture containing calcium carbonate; (2) treating the mixture to remove contaminants contained in the mixture to produce a treated mixture containing calcium carbonate and further having a chemical composition and/or purity which substantially inhibits the fusing together of calcium carbonate particulates; (3) recovering from the treated mixture particulate calcium carbonate having an average particle size less than about 12 microns. The calcium carbonate produced has a high surface area to volume ratio and is therefore highly reactive and suitable for numerous applications such as in the treatment of soil, filler paper production, paint production, and contaminant containment in coal stack emission assemblies.

    摘要翻译： 提供了一种获得平均粒度小于约12微米的颗粒状碳酸钙的方法。 该方法包括以下步骤：（1）从纸浆厂取出含有碳酸钙的混合物; （2）处理混合物以除去混合物中所含的污染物，以产生含有碳酸钙的处理过的混合物，并且还具有基本上抑制碳酸钙颗粒的熔合在一起的化学组成和/或纯度; （3）从经处理的混合物中回收平均粒径小于约12微米的颗粒状碳酸钙。 所生产的碳酸钙具有高的表面积与体积比，因此具有高反应性，适用于许多应用，例如在煤堆排放组件中处理土壤，填料纸生产，油漆生产和污染物封存。

    Modulators of ß-amyloid peptide aggregation
    4.
    发明申请
    Modulators of ß-amyloid peptide aggregation 失效
    β-淀粉样肽聚集的调节剂

    公开(公告)号：US20050137128A1

    公开(公告)日：2005-06-23

    申请号：US10989763

    申请日：2004-11-15

    申请人： Mark Findeis ,  Kathryn Phillips ,  Gary Olsen ,  Christopher Self

    发明人： Mark Findeis ,  Kathryn Phillips ,  Gary Olsen ,  Christopher Self

    IPC分类号： G01N33/68 ,  A61K38/00 ,  A61K38/17 ,  A61P25/28 ,  A61P43/00 ,  C07K5/083 ,  C07K7/06 ,  C07K14/47 ,  A61K38/12 ,  C07K5/12

    CPC分类号： C07K14/4711 ,  A61K38/00

    摘要： Compounds that modulate natural β amyloid peptide aggregation are provided. The modulators of the invention comprise a peptide, preferably based on a β amyloid peptide, that is comprised entirely of D-amino acids. Preferably, the peptide comprises 3-5 D-amino acid residues and includes at least two D-amino acid residues independently selected from the group consisting of D-leucine, D-phenylalanine and D-valine. In a particularly preferred embodiment, the peptide is a retro-inverso isomer of a β amyloid peptide, preferably a retro-inverso isomer of Aβ17-21. In certain embodiments, the peptide is modified at the amino-terminus, the carboxy-terminus, or both. Preferred amino-terminal modifying groups alkyl groups. Preferred carboxy-terminal modifying groups include an amide group, an acetate group, an alkyl amide group, an aryl amide group or a hydroxy group. Pharmaceutical compositions comprising the compounds of the invention, and diagnostic and treatment methods for amyloidogenic diseases using the compounds of the invention, are also disclosed.

    摘要翻译： 提供调节天然β淀粉样肽聚集的化合物。 本发明的调节剂包含优选基于β-淀粉样肽的肽，其完全由D-氨基酸组成。 优选地，肽包含3-5个D-氨基酸残基，并且包括独立地选自D-亮氨酸，D-苯丙氨酸和D-缬氨酸的至少两个D-氨基酸残基。 在特别优选的实施方案中，肽是β淀粉样肽的逆反异构体，优选Abeta 17-21的逆反异构体。 在某些实施方案中，肽在氨基末端，羧基末端或两者都被修饰。 优选的氨基末端修饰基团是烷基。 优选的羧基末端修饰基团包括酰胺基，乙酸基，烷基酰胺基，芳基酰胺基或羟基。 还公开了包含本发明化合物的药物组合物，以及使用本发明化合物的淀粉样变性疾病的诊断和治疗方法。