公开(公告)号：US09878090B2

公开(公告)日：2018-01-30

申请号：US14971715

申请日：2015-12-16

申请人： CFD Research Corporation

发明人： Sivaramakrishnan Krishnamoorthy ,  Guiren Wang ,  Jianjun Feng ,  Yi Wang

IPC分类号： A61M5/142 ,  B01F13/00 ,  B01L3/00 ,  B01L99/00 ,  B08B7/00 ,  B08B9/00 ,  F04B19/00 ,  F04B19/24 ,  G01N30/00

CPC分类号： A61M5/14244 ,  A61M2205/0244 ,  B01F13/0079 ,  B01F13/0081 ,  B01L3/5027 ,  B01L99/00 ,  B01L2300/1833 ,  B01L2400/0415 ,  B01L2400/0442 ,  B01L2400/0493 ,  B01L2400/0496 ,  B08B7/0064 ,  B08B9/00 ,  F04B19/006 ,  F04B19/24 ,  G01N2030/0035 ,  G01N2030/0065

摘要： A micropump that pumps liquid using electrothermally-induced flow is described, along with a corresponding self-regulating pump and infusion pump. The micropump has applications in microfluidic systems, such as biochips. The self-regulating infusion pump is useful for administration of large and small volumes of liquids such as drugs to patients and can be designed for a wide range of flow rates by combining multiple micropumps in one infusion pump system. The micropump uses electrode sequences on opposing surfaces of a flow chamber that are staggered with respect to each other. The opposing surfaces include staggered electrodes that have the same phase and same electrode sequence. As such electrodes with the same phase are staggered and not eclipsed.

公开(公告)号：US09259735B2

公开(公告)日：2016-02-16

申请号：US14317356

申请日：2014-06-27

申请人： HandyLab, Inc.

发明人： Kalyan Handique ,  Karthik Ganesan ,  Sundaresh N. Brahmasandra

IPC分类号： B01L7/00 ,  B01F13/00 ,  B01J19/00 ,  B01L3/00 ,  G01N1/40 ,  G01N35/10

CPC分类号： B01L7/52 ,  B01F13/0071 ,  B01F13/0079 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00828 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00835 ,  B01J2219/00837 ,  B01J2219/0086 ,  B01J2219/00862 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00936 ,  B01J2219/00943 ,  B01J2219/00945 ,  B01J2219/00961 ,  B01J2219/0097 ,  B01J2219/00986 ,  B01L3/502784 ,  B01L3/502792 ,  B01L2200/0605 ,  B01L2200/0673 ,  B01L2200/14 ,  B01L2300/0816 ,  B01L2400/0442 ,  B01L2400/0493 ,  B01L2400/0677 ,  G01N1/4077 ,  G01N35/1083 ,  Y10T436/12 ,  Y10T436/25 ,  Y10T436/2575

摘要： The present invention provides control methods, control systems, and control software for microfluidic devices that operate by moving discrete micro-droplets through a sequence of determined configurations. Such microfluidic devices are preferably constructed in a hierarchical and modular fashion which is reflected in the preferred structure of the provided methods and systems. In particular, the methods are structured into low-level device component control functions, middle-level actuator control functions, and high-level micro-droplet control functions. Advantageously, a microfluidic device may thereby be instructed to perform an intended reaction or analysis by invoking micro-droplet control function that perform intuitive tasks like measuring, mixing, heating, and so forth. The systems are preferably programmable and capable of accommodating microfluidic devices controlled by low voltages and constructed in standardized configurations. Advantageously, a single control system can thereby control numerous different reactions in numerous different microfluidic devices simply by loading different easily understood micro-droplet programs.

公开(公告)号：US20140377850A1

公开(公告)日：2014-12-25

申请号：US14317356

申请日：2014-06-27

申请人： HandyLab, Inc.

发明人： Kalyan Handique ,  Karthik Ganesan ,  Sundaresh N. Brahmasandra

IPC分类号： B01L7/00 ,  B01L3/00

CPC分类号： B01L7/52 ,  B01F13/0071 ,  B01F13/0079 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00828 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00835 ,  B01J2219/00837 ,  B01J2219/0086 ,  B01J2219/00862 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00936 ,  B01J2219/00943 ,  B01J2219/00945 ,  B01J2219/00961 ,  B01J2219/0097 ,  B01J2219/00986 ,  B01L3/502784 ,  B01L3/502792 ,  B01L2200/0605 ,  B01L2200/0673 ,  B01L2200/14 ,  B01L2300/0816 ,  B01L2400/0442 ,  B01L2400/0493 ,  B01L2400/0677 ,  G01N1/4077 ,  G01N35/1083 ,  Y10T436/12 ,  Y10T436/25 ,  Y10T436/2575

摘要： The present invention provides control methods, control systems, and control software for microfluidic devices that operate by moving discrete micro-droplets through a sequence of determined configurations. Such microfluidic devices are preferably constructed in a hierarchical and modular fashion which is reflected in the preferred structure of the provided methods and systems. In particular, the methods are structured into low-level device component control functions, middle-level actuator control functions, and high-level micro-droplet control functions. Advantageously, a microfluidic device may thereby be instructed to perform an intended reaction or analysis by invoking micro-droplet control function that perform intuitive tasks like measuring, mixing, heating, and so forth. The systems are preferably programmable and capable of accommodating microfluidic devices controlled by low voltages and constructed in standardized configurations. Advantageously, a single control system can thereby control numerous different reactions in numerous different microfluidic devices simply by loading different easily understood micro-droplet programs.

摘要翻译： 本发明提供了通过一系列确定的配置移动离散微滴来操作的微流体装置的控制方法，控制系统和控制软件。 这种微流体装置优选地以分级和模块化的方式构成，其反映在所提供的方法和系统的优选结构中。 特别地，这些方法被构造成低级器件部件控制功能，中间级执行器控制功能和高级微滴控制功能。 有利地，可以通过调用执行直观任务（如测量，混合，加热等）的微滴控制功能来指示微流体装置来执行预期的反应或分析。 该系统优选地是可编程的并且能够容纳由低电压控制并以标准化配置构造的微流体装置。 有利地，单个控制系统因此可以通过加载不同的容易理解的微液滴程序来控制许多不同微流体装置中的许多不同反应。

公开(公告)号：US08853650B2

公开(公告)日：2014-10-07

申请号：US13871622

申请日：2013-04-26

申请人： Ludwig Maximilians Universität München

发明人： Stefan Duhr ,  Phillip Baaske

IPC分类号： G01N21/64 ,  G01N21/63 ,  G01N21/62 ,  G01N21/17 ,  G01N15/14 ,  B01L3/00 ,  G01N15/00 ,  G01N15/02 ,  B01F13/00

CPC分类号： G01N33/6803 ,  B01F13/0079 ,  B01L3/502715 ,  B01L3/502761 ,  B01L2200/0668 ,  B01L2400/0442 ,  B01L2400/0451 ,  B01L2400/0454 ,  C12Q1/68 ,  G01K11/12 ,  G01N15/0205 ,  G01N15/1434 ,  G01N15/1475 ,  G01N21/171 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/6458 ,  G01N21/6486 ,  G01N33/6845 ,  G01N2015/0065 ,  G01N2015/0092 ,  G01N2015/025 ,  G01N2021/6439 ,  G01N2201/02 ,  G01N2201/06113 ,  G01N2201/0638 ,  Y10T436/143333

摘要： The present invention relates to a method and an apparatus for a fast thermo-optical characterization of particles. In particular, the present invention relates to a method and a device to measure the stability of (bio)molecules, the interaction of molecules, in particular biomolecules, with, e.g. further (bio)molecules, particularly modified (bio)molecules, particles, beads, and/or the determination of the length/size (e.g. hydrodynamic radius) of individual (bio)molecules, particles, beads and/or the determination of length/size (e.g. hydrodynamic radius).

摘要翻译： 本发明涉及用于快速热光学表征颗粒的方法和装置。 特别地，本发明涉及测量（生物）分子的稳定性，特别是生物分子与分子的相互作用的方法和装置。 进一步（生物）分子，特别是改性（生物）分子，颗粒，珠粒和/或单个（生物）分子，颗粒，珠子的长度/尺寸（例如流体动力学半径）的确定和/或长度/ 尺寸（例如流体动力学半径）。

公开(公告)号：US08697008B2

公开(公告)日：2014-04-15

申请号：US13257373

申请日：2010-03-09

申请人： Andrew Clarke ,  Nicholas J. Dartnell ,  Christopher B. Rider

发明人： Andrew Clarke ,  Nicholas J. Dartnell ,  Christopher B. Rider

IPC分类号： B01L3/00

CPC分类号： B01L3/502715 ,  B01F13/0062 ,  B01F13/0076 ,  B01F13/0079 ,  B01L2300/0861 ,  B05B7/0408 ,  B41J2/02 ,  Y10S435/808 ,  Y10S436/805 ,  Y10S436/809 ,  Y10T436/117497 ,  Y10T436/118339 ,  Y10T436/25

摘要： A method and device for periodically perturbing the flow field within a microfluidic device to provide regular droplet formation at high speed.

摘要翻译： 一种用于周期性地扰动微流体装置内的流场以提供高速度的常规液滴形成的方法和装置。

公开(公告)号：US20130280131A1

公开(公告)日：2013-10-24

申请号：US13925046

申请日：2013-06-24

申请人： Handylab, Inc.

发明人： KALYAN HANDIQUE ,  KARTHIK GANESAN ,  SUNDARESH N. BRAHMASANDRA

IPC分类号： G01N35/10

CPC分类号： B01L7/52 ,  B01F13/0071 ,  B01F13/0079 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00828 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00835 ,  B01J2219/00837 ,  B01J2219/0086 ,  B01J2219/00862 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00936 ,  B01J2219/00943 ,  B01J2219/00945 ,  B01J2219/00961 ,  B01J2219/0097 ,  B01J2219/00986 ,  B01L3/502784 ,  B01L3/502792 ,  B01L2200/0605 ,  B01L2200/0673 ,  B01L2200/14 ,  B01L2300/0816 ,  B01L2400/0442 ,  B01L2400/0493 ,  B01L2400/0677 ,  G01N1/4077 ,  G01N35/1083 ,  Y10T436/12 ,  Y10T436/25 ,  Y10T436/2575

摘要： The present invention provides control methods, control systems, and control software for microfluidic devices that operate by moving discrete micro-droplets through a sequence of determined configurations. Such microfluidic devices are preferably constructed in a hierarchical and modular fashion which is reflected in the preferred structure of the provided methods and systems. In particular, the methods are structured into low-level device component control functions, middle-level actuator control functions, and high-level micro-droplet control functions. Advantageously, a microfluidic device may thereby be instructed to perform an intended reaction or analysis by invoking micro-droplet control function that perform intuitive tasks like measuring, mixing, heating, and so forth. The systems are preferably programmable and capable of accommodating microfluidic devices controlled by low voltages and constructed in standardized configurations. Advantageously, a single control system can thereby control numerous different reactions in numerous different microfluidic devices simply by loading different easily understood micro-droplet programs.

摘要翻译： 本发明提供了通过一系列确定的配置移动离散微滴来操作的微流体装置的控制方法，控制系统和控制软件。 这种微流体装置优选地以分级和模块化的方式构成，其反映在所提供的方法和系统的优选结构中。 特别地，这些方法被构造成低级器件部件控制功能，中间级执行器控制功能和高级微滴控制功能。 有利地，可以通过调用执行直观任务（如测量，混合，加热等）的微滴控制功能来指示微流体装置来执行预期的反应或分析。 该系统优选地是可编程的并且能够容纳由低电压控制并以标准化配置构造的微流体装置。 有利地，单个控制系统因此可以通过加载不同的容易理解的微液滴程序来控制许多不同微流体装置中的许多不同反应。

公开(公告)号：US07604394B2

公开(公告)日：2009-10-20

申请号：US11516358

申请日：2006-09-06

申请人： Sivaramakrishnan Krishnamoorthy ,  Jianjun Feng

发明人： Sivaramakrishnan Krishnamoorthy ,  Jianjun Feng

IPC分类号： B01F13/00 ,  H02K44/00 ,  C12Q1/68 ,  B03C5/02

CPC分类号： B08B7/0064 ,  B01F13/0079 ,  B01F13/0081 ,  B01L3/5027 ,  B01L99/00 ,  B01L2300/1833 ,  B01L2400/0415 ,  B01L2400/0442 ,  B01L2400/0493 ,  B08B9/00 ,  F04B19/006 ,  F04B19/24 ,  Y10S366/04 ,  Y10T137/0329 ,  Y10T137/034 ,  Y10T137/0391

摘要： Apparatus and methods are disclosed for mixing and self-cleaning elements in microfluidic systems based on electrothermally induced fluid flow. The apparatus and methods provide for the control of fluid flow in and between components in a microfluidic system to cause the removal of unwanted liquids and particulates or mixing of liquids. The geometry and position of electrodes is adjusted to generate a temperature gradient in the liquid, thereby causing a non-uniform distribution of dielectric properties within the liquid. The dielectric non-uniformity produces a body force and flow in the solution, which is controlled by element and electrode geometries, electrode placement, and the frequency and waveform of the applied voltage.

摘要翻译： 公开了用于基于电热诱导流体流动的微流体系统中的混合和自清洁元件的装置和方法。 该装置和方法提供了在微流体系统中的组件之间和之间的流体流动的控制，以便除去不期望的液体和微粒或混合液体。 调节电极的几何形状和位置，以在液体中产生温度梯度，从而导致液体内介电性质的不均匀分布。 电介质非均匀性在溶液中产生体力和流动，其由元件和电极几何形状，电极布置以及施加电压的频率和波形控制。

公开(公告)号：US06869273B2

公开(公告)日：2005-03-22

申请号：US10147153

申请日：2002-05-15

申请人： Paul Crivelli

发明人： Paul Crivelli

IPC分类号： B01F5/04 ,  B01F5/06 ,  B01F13/00 ,  B01L3/00 ,  F04B19/00 ,  F04B19/24 ,  F04F5/24

CPC分类号： B01F13/0079 ,  B01F5/0415 ,  B01F5/0646 ,  B01F5/0655 ,  B01F13/0001 ,  B01F2215/0409 ,  B01F2215/0431 ,  B01F2215/045 ,  B01F2215/0454 ,  B01F2215/0477 ,  B01L3/50273 ,  B01L2300/0861 ,  B01L2400/0442 ,  B01L2400/0677 ,  F04B19/006 ,  F04B19/24 ,  F04F5/24 ,  Y10T137/2196

摘要： A microelectromechanical (MEM) device for controlled movement of a fluid. The device includes a chamber having a heating element, an inlet, and a constricted egress channel.

摘要翻译： 用于控制流体运动的微机电（MEM）装置。 该装置包括具有加热元件，入口和收缩出口的腔室。

公开(公告)号：US20170030921A1

公开(公告)日：2017-02-02

申请号：US15254456

申请日：2016-09-01

申请人： Nano Temper Technologies GmbH

发明人： Stefan DUHR ,  Philipp BAASKE

IPC分类号： G01N33/68 ,  G01K11/12 ,  C12Q1/68 ,  G01N15/14 ,  G01N21/17 ,  G01N21/64 ,  G01N15/02

CPC分类号： G01N33/6803 ,  B01F13/0079 ,  B01L3/502715 ,  B01L3/502761 ,  B01L2200/0668 ,  B01L2400/0442 ,  B01L2400/0451 ,  B01L2400/0454 ,  C12Q1/68 ,  G01K11/12 ,  G01N15/0205 ,  G01N15/1434 ,  G01N15/1475 ,  G01N21/171 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/6458 ,  G01N21/6486 ,  G01N33/6845 ,  G01N2015/0065 ,  G01N2015/0092 ,  G01N2015/025 ,  G01N2021/6439 ,  G01N2201/02 ,  G01N2201/06113 ,  G01N2201/0638 ,  Y10T436/143333

摘要： The present invention relates to a method and an apparatus for a fast thermo-optical characterisation of particles. In particular, the present invention relates to a method and a device to measure the stability of (bio)molecules, the interaction of molecules, in particular biomolecules, with, e.g. further (bio)molecules, particularly modified (bio)molecules, particles, beads, and/or the determination of the length/size (e.g. hydrodynamic radius) of individual (bio)molecules, particles, beads and/or the determination of length/size (e.g. hydrodynamic radius).

摘要翻译： 本发明涉及用于快速热光学表征颗粒的方法和装置。 特别地，本发明涉及测量（生物）分子的稳定性，特别是生物分子与分子的相互作用的方法和装置。 进一步（生物）分子，特别是改性（生物）分子，颗粒，珠粒和/或单个（生物）分子，颗粒，珠子的长度/尺寸（例如流体动力学半径）的确定和/或长度/ 尺寸（例如流体动力学半径）。

公开(公告)号：US09459211B2

公开(公告)日：2016-10-04

申请号：US14504843

申请日：2014-10-02

申请人： Ludwig Maximilians Universität München

发明人： Stefan Duhr ,  Philipp Baaske

IPC分类号： G01N21/64 ,  B01L3/00 ,  G01N15/02 ,  G01N15/14 ,  G01N21/17 ,  G01K11/12 ,  B01F13/00 ,  G01N15/00

CPC分类号： G01N33/6803 ,  B01F13/0079 ,  B01L3/502715 ,  B01L3/502761 ,  B01L2200/0668 ,  B01L2400/0442 ,  B01L2400/0451 ,  B01L2400/0454 ,  C12Q1/68 ,  G01K11/12 ,  G01N15/0205 ,  G01N15/1434 ,  G01N15/1475 ,  G01N21/171 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/6458 ,  G01N21/6486 ,  G01N33/6845 ,  G01N2015/0065 ,  G01N2015/0092 ,  G01N2015/025 ,  G01N2021/6439 ,  G01N2201/02 ,  G01N2201/06113 ,  G01N2201/0638 ,  Y10T436/143333

摘要： The present invention relates to a method and an apparatus for a fast thermo-optical characterization of particles. In particular, the present invention relates to a method and a device to measure the stability of (bio)molecules, the interaction of molecules, in particular biomolecules, with, e.g. further (bio)molecules, particularly modified (bio)molecules, particles, beads, and/or the determination of the length/size (e.g. hydrodynamic radius) of individual (bio)molecules, particles, beads and/or the determination of length/size (e.g. hydrodynamic radius).