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公开(公告)号：US20100292187A1
公开(公告)日：2010-11-18
申请号：US12814755
申请日：2010-06-14
申请人： Gary M. Karp , Peter Seongwoo Hwang , James J. Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony A. Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey A. Campbell , Chunshi Li , Steven Paget , Nanjing Zhang , Xiaoyan Zhang , Jin Zhu
发明人： Gary M. Karp , Peter Seongwoo Hwang , James J. Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony A. Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey A. Campbell , Chunshi Li , Steven Paget , Nanjing Zhang , Xiaoyan Zhang , Jin Zhu
IPC分类号： A61K31/675 , A61K31/541 , A61K31/53 , A61K31/497 , A61K31/506 , A61K31/454 , A61K31/4439 , A61K31/433 , A61K31/4245 , A61K31/427 , A61K31/422 , A61K31/41 , A61K31/4196 , A61K31/4155 , A61K31/407 , A61K31/404 , C07D417/12 , C07D413/12 , C07D401/12 , C07D413/04 , C07D417/10 , C07D413/10 , C07F9/572 , C07D491/14 , C07D403/10 , C07D209/14 , C07D403/12 , C07D407/12 , C07D417/04 , C07D403/04 , C07D401/04 , A61P31/12
CPC分类号： C07D209/30 , C07D209/42 , C07D401/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D413/12 , C07D417/10 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IRES activity.
摘要翻译： 本发明提供化合物，药物组合物和使用这些化合物或组合物治疗病毒感染或影响病毒IRES活性的方法。
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公开(公告)号：US20110268698A1
公开(公告)日：2011-11-03
申请号：US13158692
申请日：2011-06-13
申请人： Gary M. KARP , Peter Seongwoo HWANG , James J. TAKASUGI , Hongyu REN , Richard Gerald WILDE , Anthony A. TURPOFF , Alexander AREFOLOV , Guangming CHEN , Jeffrey Allen CAMPBELL , Chunshi Li , Steven Paget , Nanjing Zhang , Xiaoyan Zhang , Jin Zhu
发明人： Gary M. KARP , Peter Seongwoo HWANG , James J. TAKASUGI , Hongyu REN , Richard Gerald WILDE , Anthony A. TURPOFF , Alexander AREFOLOV , Guangming CHEN , Jeffrey Allen CAMPBELL , Chunshi Li , Steven Paget , Nanjing Zhang , Xiaoyan Zhang , Jin Zhu
IPC分类号： A61K38/21
CPC分类号： C07D209/30 , C07D209/42 , C07D401/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D413/12 , C07D417/10 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IBES activity.
摘要翻译： 本发明提供化合物，药物组合物和使用这些化合物或组合物治疗病毒感染或影响病毒IBES活性的方法。
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公开(公告)号：US07781478B2
公开(公告)日：2010-08-24
申请号：US11653450
申请日：2007-01-16
申请人： Gary M. Karp , Peter Seongwoo Hwang , James J. Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony A. Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Chunshi Li , Steven Paget , Nanjing Zhang , Jin Zhu , Xiaoyan Zhang
发明人： Gary M. Karp , Peter Seongwoo Hwang , James J. Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony A. Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Chunshi Li , Steven Paget , Nanjing Zhang , Jin Zhu , Xiaoyan Zhang
IPC分类号： C07D209/10 , A61K31/404
CPC分类号： C07D209/30 , C07D209/42 , C07D401/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D413/12 , C07D417/10 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IRES activity.
摘要翻译： 本发明提供化合物，药物组合物和使用这些化合物或组合物治疗病毒感染或影响病毒IRES活性的方法。
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公开(公告)号：US07973069B2
公开(公告)日：2011-07-05
申请号：US12814755
申请日：2010-06-14
申请人： Gary M. Karp , Peter Seongwoo Hwang , James J. Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony A. Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Chunshi Li , Steven Paget , Nanjing Zhang , Jin Zhu , Xiaoyan Zhang
发明人： Gary M. Karp , Peter Seongwoo Hwang , James J. Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony A. Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Chunshi Li , Steven Paget , Nanjing Zhang , Jin Zhu , Xiaoyan Zhang
IPC分类号： C07D209/10 , A61K31/404
CPC分类号： C07D209/30 , C07D209/42 , C07D401/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D413/12 , C07D417/10 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IRES activity.
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公开(公告)号：US07772271B2
公开(公告)日：2010-08-10
申请号：US11653448
申请日：2007-01-16
申请人： Gary Mitchell Karp , Peter Seongwoo Hwang , James J. Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Chunshi Li , Steven Paget , Nanjing Zhang , Xiaoyan Zhang , Jin Zhu
发明人： Gary Mitchell Karp , Peter Seongwoo Hwang , James J. Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Chunshi Li , Steven Paget , Nanjing Zhang , Xiaoyan Zhang , Jin Zhu
IPC分类号： C07D209/10 , A61K31/404
CPC分类号： C07D209/30 , C07D209/14 , C07D209/42 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D409/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IRES activity.
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公开(公告)号：US20100305100A1
公开(公告)日：2010-12-02
申请号：US12828597
申请日：2010-07-01
申请人： Gary Mitchell Karp , Peter Seongwoo Hwang , James J. Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Chunshi Li , Steven Paget , Nanjing Zhang , Xiaoyan Zhang , Jin Zhu
发明人： Gary Mitchell Karp , Peter Seongwoo Hwang , James J. Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Chunshi Li , Steven Paget , Nanjing Zhang , Xiaoyan Zhang , Jin Zhu
IPC分类号： A61K31/55 , C07D209/04 , C07D417/06 , C07D405/12 , C07D271/10 , C07D403/04 , C07D263/30 , C07D401/12 , C07D239/10 , C07D215/00 , C07D223/16 , A61K31/405 , A61K31/40 , A61K31/4155 , A61K31/4245 , A61K31/427 , A61K31/42 , A61K31/4439 , A61K31/497 , A61K31/4725 , A61P31/14 , A61P31/12
CPC分类号： C07D209/30 , C07D209/14 , C07D209/42 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D409/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IRES activity.
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公开(公告)号：US08735414B2
公开(公告)日：2014-05-27
申请号：US13259717
申请日：2010-04-05
申请人： Malcolm MacCoss , F. George Njoroge , Amin Nomeir , Guangming Chen , Song Xiao Huang , Ramesh Kakarla , Gary Mitchell Karp , William Joseph Lennox , Chunshi Li , Ronggang Liu , Yalei Liu , Christie Morrill , Steven D. Paget , Sean W Smith , James Takasugi , Anthony A. Turpoff , Hongyu Ren , Nanjing Zhang , Xiaoyan Zhang , Jin Zhu
发明人： Malcolm MacCoss , F. George Njoroge , Amin Nomeir , Guangming Chen , Song Xiao Huang , Ramesh Kakarla , Gary Mitchell Karp , William Joseph Lennox , Chunshi Li , Ronggang Liu , Yalei Liu , Christie Morrill , Steven D. Paget , Sean W Smith , James Takasugi , Anthony A. Turpoff , Hongyu Ren , Nanjing Zhang , Xiaoyan Zhang , Jin Zhu
IPC分类号： A61K31/506 , C07D401/02 , C07D405/02 , C07D209/04
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The present invention is directed to compounds and forms and pharmaceutical compositions thereof useful for treating a viral infection, or for affecting viral activity by modulating viral replication.
摘要翻译： 本发明涉及用于治疗病毒感染或通过调节病毒复制影响病毒活性的化合物及其形式和药物组合物。
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公开(公告)号：US20120184574A1
公开(公告)日：2012-07-19
申请号：US13259717
申请日：2010-04-05
申请人： Malcolm Maccoss , F. George Njoroge , Amin Nomeir , Guangming Chen , Song Xiao Huang , Ramesh Kakarla , Gary Mitchell Karp , William Joseph Lennox , Chunshi Li , Ronggang Liu , Yalei Liu , Christie Morrill , Steven D. Paget , Sean W. Smith , James Takasugi , Anthony A. Turpoff , Hongyu Ren , Nanjing Zhang , Xiaoyan Zhang , Jin Zhu
发明人： Malcolm Maccoss , F. George Njoroge , Amin Nomeir , Guangming Chen , Song Xiao Huang , Ramesh Kakarla , Gary Mitchell Karp , William Joseph Lennox , Chunshi Li , Ronggang Liu , Yalei Liu , Christie Morrill , Steven D. Paget , Sean W. Smith , James Takasugi , Anthony A. Turpoff , Hongyu Ren , Nanjing Zhang , Xiaoyan Zhang , Jin Zhu
IPC分类号： A61K31/4439 , C07D401/14 , A61K31/444 , A61P31/20 , A61P31/12 , A61P31/22 , A61P31/18 , A61P31/14 , C07D401/04 , A61K31/506
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The present invention is directed to compounds and forms and pharmaceutical compositions thereof useful for treating a viral infection, or for affecting viral activity by modulating viral replication.
摘要翻译： 本发明涉及用于治疗病毒感染或通过调节病毒复制影响病毒活性的化合物及其形式和药物组合物。
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9.发明授权Substituted sulfoxide compounds, methods for preparing the same and use thereof 有权取代亚砜化合物，其制备方法及其应用公开(公告)号：US08017784B2
公开(公告)日：2011-09-13
申请号：US12126355
申请日：2008-05-23
申请人： Jingen Deng , Qin Yang , Yongle Chen , Jin Zhu , Qiwei Wang , Qiuya Huang , Xuemei Hou
发明人： Jingen Deng , Qin Yang , Yongle Chen , Jin Zhu , Qiwei Wang , Qiuya Huang , Xuemei Hou
IPC分类号： C07D401/14
CPC分类号： C07D401/14 , C07D401/12
摘要： Disclosed are an optically pure compound having formula I, its pharmaceutically acceptable salt and its pharmaceutically acceptable solvate, and a use thereof in manufacturing medicaments and pharmaceutical compositions. A process for preparing the compound defined therein is also provided.
摘要翻译： 公开了具有式I，其药学上可接受的盐及其药学上可接受的溶剂化物的光学纯的化合物及其在制备药物和药物组合物中的用途。 还提供了制备其中限定的化合物的方法。
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公开(公告)号：US20080301120A1
公开(公告)日：2008-12-04
申请号：US11806833
申请日：2007-06-04
申请人： Jin Zhu , Roger Barney
发明人： Jin Zhu , Roger Barney
CPC分类号： G06Q40/00 , G06F16/31 , G06F16/34 , G06F16/382 , G06F16/951
摘要： Data is processed at a central data processor using multiple processing steps. The data is processed for the extraction of entities. Relationships between the extracted entities are also extracted. A system map is built using one or more factors derived from the extracted entities and relationships and organized by influence relationships. Each factor is associated with one or more options.
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