公开(公告)号：US20060225688A1

公开(公告)日：2006-10-12

申请号：US11099883

申请日：2005-04-06

申请人： Gary Ward ,  Bob Powell

发明人： Gary Ward ,  Bob Powell

IPC分类号： F02F1/00

CPC分类号： F02F1/045 ,  C22C21/02 ,  F02F1/18

摘要： Cast-in-place cylinder bore liners are disclosed for use in casting of engine cylinder blocks, wherein a plurality of the cylinder bore liners are joined to form a cassette, and wherein an accuracy in positioning of each of the bore liners with respect to each other is maximized and a weight thereof is minimized.

摘要翻译： 公开了用于铸造发动机气缸体的现浇缸内衬，其中多个气缸内衬被连接以形成一个盒，并且其中每个钻孔衬套相对于每个缸套的定位精度 其他最大化并且其重量被最小化。

公开(公告)号：US06616914B2

公开(公告)日：2003-09-09

申请号：US09907393

申请日：2001-07-17

申请人： Gary Ward ,  Robert Schultz

发明人： Gary Ward ,  Robert Schultz

IPC分类号： A61K912

CPC分类号： A61K9/0075 ,  Y10S514/866

摘要： In a powder formulation for use in a dry powder inhaler, a pharmaceutical acts as its own carrier, so that use of lactose or other excipients are not needed. The dry powder formulation has a single active pharmaceutical compound having two major populations in particle size distribution: microfine particles of the active pharmaceutical, of 1-10 microns in diameter, and larger carrier particles, also of the active pharmaceutical compound. The carrier particles provide a long acting, delayed onset, and optionally therapeutic effect via the GI tract, while the microfine particles provide a fast onset effect via the lung.

摘要翻译： 在用于干粉吸入器的粉末制剂中，药物用作其自身的载体，使得不需要使用乳糖或其它赋形剂。 干粉制剂具有粒度分布为两个主要群体的单一活性药物化合物：活性药物的微细颗粒直径为1-10微米，以及较大的载体颗粒，也是活性药物化合物。 载体颗粒通过胃肠道提供长效，延迟发作和任选的治疗作用，而微细颗粒通过肺提供快速起效。

公开(公告)号：US20070228730A1

公开(公告)日：2007-10-04

申请号：US11393300

申请日：2006-03-30

申请人： Robert Sivley ,  Gary Ward ,  Doug Enderle

发明人： Robert Sivley ,  Gary Ward ,  Doug Enderle

IPC分类号： F16L25/00

CPC分类号： F16L15/004

摘要： A threaded connection for a conduit includes a pin member and a box member. The pin member includes a pin thread having a pin thread crest, a pin thread root, a pin load flank oriented at a pin load flank angle, and a pin stab flank oriented at a pin stab flank angle. The box member includes a box thread having a box thread crest, a box thread root, a box load flank oriented at a box load flank angle, and a box stab flank oriented at a box stab flank angle. At least one of the pin load flank angle, the pin stab flank angle, the box load flank angle, and the box stab flank angle varies over at least part of the threaded connection.

摘要翻译： 用于导管的螺纹连接件包括销构件和箱构件。 销构件包括具有销螺纹牙顶的销螺纹，销螺纹根部，定位在销负载侧面角处的销负载侧面，以及以针刺侧面角定向的销钉侧面。 盒构件包括具有盒形螺纹牙顶的箱形螺纹，箱形螺纹根部，定位在箱体载荷侧面角处的箱体荷载侧面和以箱形柱侧倾角定向的箱形支撑侧面。 至少一个销轴承角度，针刺侧面角度，箱体负载侧面角度以及箱体立柱侧面角度至少在螺纹连接的一部分上变化。

公开(公告)号：US20060042771A1

公开(公告)日：2006-03-02

申请号：US10929274

申请日：2004-08-30

申请人： Gary Ward

发明人： Gary Ward

IPC分类号： B22D27/04 ,  B22D30/00

CPC分类号： B22D17/2218 ,  B22C9/065 ,  B22D27/04 ,  Y10T137/87322

摘要： A system and method for thermal management of a die is disclosed wherein cooling of the die is controlled by controlling coolant flow to switch between laminar flow and turbulent flow as desired.

摘要翻译： 公开了一种用于模具的热管理的系统和方法，其中通过根据需要控制冷却剂流动以在层流和湍流之间切换来控制模具的冷却。

公开(公告)号：US06786496B2

公开(公告)日：2004-09-07

申请号：US10285796

申请日：2002-10-31

申请人： Gary Ward ,  John Lonczak

发明人： Gary Ward ,  John Lonczak

IPC分类号： A61G500

CPC分类号： A61G5/10 ,  A61G5/00 ,  A61G5/128

摘要： A barrier-free wheelchair constructed entirely of plastic or non-metal components. The device is designed to facilitate the passage of wheelchair occupants through magnetometers, such as those utilized for airport security. The present invention is non-collapsible in nature, as the device is intended for on-site usage and not for transport in vehicles and the like. Due to its materials and construction, the wheelchair of the present invention also allows for a solid non-sling seat, is pilferage resistant, and provides multiple surfaces upon which indicia, such as corporate graphics, may appear. In addition, consistent with pre-existing wheelchairs, the present invention allows for the removable attachment of a variety of accessories, including foot rests and trays.

摘要翻译： 完全由塑料或非金属部件构成的无障碍轮椅。 该设备旨在促进轮椅乘员通过磁力计，例如用于机场安全的那些人。 本发明本质上是不可折叠的，因为该装置旨在用于现场使用，而不用于在车辆等中运输。 由于其材料和结构，本发明的轮椅还允许坚固的非吊索座椅，具有防盗性，并且提供多个表面，在该表面上可以出现诸如公司图形的标记。 此外，与现有的轮椅一致，本发明允许可拆卸地附接各种附件，包括脚踏板和托盘。

公开(公告)号：US06651655B1

公开(公告)日：2003-11-25

申请号：US09562798

申请日：2000-05-02

申请人： Cynthia Licalsi ,  Gary Ward ,  Bernard Greenspan ,  Clyde Witham

发明人： Cynthia Licalsi ,  Gary Ward ,  Bernard Greenspan ,  Clyde Witham

IPC分类号： A61M1500

CPC分类号： A61M15/0028 ,  A61M15/0043 ,  A61M2202/066 ,  A61M2202/30

摘要： In a method for creating an immune response, a vaccine is prepared in the form of a dry powder. The powder particles have an aerodynamic particle size range from 1-100 microns. A dose of powder is loaded into a dry powder inhaler. The dose is inhaled with an inspiratory flow rate of less than 60 liters per minute. A mucosal immune response is created via particles of the vaccine material depositing on the upper respiratory tract. A systemic immune response is created via particles of the vaccine material depositing into the deep lung. The vaccine material is size reduced by e.g., jet milling, into the desired range, yet vaccine potency is retained.

摘要翻译： 在产生免疫应答的方法中，以干燥粉末的形式制备疫苗。 粉末颗粒的空气动力学粒度范围为1-100微米。 将一剂粉末装入干粉吸入器。 吸入剂量的吸气流速小于60升/分钟。 通过沉积在上呼吸道上的疫苗材料的颗粒产生粘膜免疫应答。 通过沉积到深肺中的疫苗材料的颗粒产生全身免疫应答。 通过例如喷射研磨将疫苗材料的尺寸减小到所需的范围，但保留了疫苗效力。

公开(公告)号：US06427688B1

公开(公告)日：2002-08-06

申请号：US09495494

申请日：2000-02-01

申请人： Michael Ligotke ,  Andrew W. Gieschen ,  Robert F. Eisele ,  Thomas R. Jackson ,  Jeffrey Chen ,  Bernard Greenspan ,  Clyde Witham ,  Gary Ward

发明人： Michael Ligotke ,  Andrew W. Gieschen ,  Robert F. Eisele ,  Thomas R. Jackson ,  Jeffrey Chen ,  Bernard Greenspan ,  Clyde Witham ,  Gary Ward

IPC分类号： A61M1500

CPC分类号： A61M15/0086 ,  A61M15/0008 ,  A61M15/0031 ,  A61M15/0043 ,  A61M15/0045 ,  A61M15/0048 ,  A61M15/02 ,  A61M2202/064 ,  A61M2205/43 ,  A61M2206/16 ,  A61M2206/18

摘要： A dry powder inhaler has a dispersion chamber containing beads. A dose of dry powder is released into the chamber, or into an inlet tangentially joining into the chamber. As the patient inhales on a nosepiece or mouthpiece, air moves circularly through the dispersion chamber to drive the beads. The beads roll, bounce, and collide repeatedly with the drug particles on the chamber surfaces or on the beads. The smaller active drug particles are separated from the larger carrier particles and from each other, and a powder aerosol is created and inhaled by the patient. The beads are preferably lightweight, so that they can be rapidly accelerated and moved, even with nominal inspiration. The flow resistance of the inhaler is also reduced via the beads, allowing greater air flow and powder dispersion, without any increased effort by the patient.

摘要翻译： 干粉吸入器具有包含珠的分散室。 干粉的剂量被释放到室中，或者进入切向连接到室中的入口。 当患者在鼻梁或喉舌上吸气时，空气循环移动通过分散室以驱动珠子。 珠子与腔室表面或珠子上的药物颗粒反复滚动，反弹并碰撞。 较小的活性药物颗粒与较大的载体颗粒和彼此分离，并且由患者产生并吸入粉末气溶胶。 珠子优选是轻质的，使得它们可以被快速加速和移动，即使具有标称的灵感。 吸入器的流动阻力也通过珠子减小，允许更大的空气流动和粉末分散，而不会增加患者的任何增加的努力。

公开(公告)号：US06369115B1

公开(公告)日：2002-04-09

申请号：US09528519

申请日：2000-03-20

申请人： Gary Ward

发明人： Gary Ward

IPC分类号： A61K31045

CPC分类号： A61K9/0075 ,  A61K31/167 ,  A61K31/56 ,  Y10S514/826 ,  Y10S514/951 ,  Y10S514/97 ,  A61K2300/00

摘要： A dry powder formulation for treatment of pulmonary conditions, via inhalation, includes an effective amount of formoterol or a salt or solvate thereof, in a dry powder form, an effective amount of fluticasone, in a dry powder form, and an excipient. A method for preparing a physically stable dry powder formulation for inhalation includes the steps of micronizing a first active polar drug, a second active non-polar drug, and a polar excipient. The second non-polar active drug is first blended with the excipient to form an intermediate mixture. The intermediate mixture is then blended with the first active polar drug. The increased separation of the polar drug and polar excipient stabilizes the formulation.

摘要翻译： 用于通过吸入治疗肺部病症的干粉制剂包括有效量的福莫特罗或其盐或溶剂合物，干粉形式，有效量的氟替卡松，干粉形式和赋形剂。 制备用于吸入的物理稳定的干粉制剂的方法包括使第一活性极性药物，第二活性非极性药物和极性赋形剂微粉化的步骤。 首先将第二种非极性活性药物与赋形剂混合以形成中间体混合物。 然后将中间体混合物与第一活性极性药物混合。 极性药物和极性赋形剂的分离增加使制剂稳定。

公开(公告)号：US09424227B2

公开(公告)日：2016-08-23

申请号：US13541633

申请日：2012-07-03

申请人： Samuel H. Duncan ,  Dennis K. Ma ,  Wei-Je Huang ,  Gary Ward

发明人： Samuel H. Duncan ,  Dennis K. Ma ,  Wei-Je Huang ,  Gary Ward

IPC分类号： G06F15/173 ,  G06F15/167 ,  G06F15/16 ,  G06F15/163 ,  G06F15/17

CPC分类号： G06F15/167 ,  G06F15/16 ,  G06F15/163 ,  G06F15/17 ,  G06F15/173

摘要： Non-contiguous or tiled payload data are efficiently transferred between peers over a fabric. Specifically, a client transfers a byte enable message to a peer device via a mailbox mechanism, where the byte enable message specifies which bytes of the payload data being transferred via the data packet are to be written to the frame buffer on the peer device and which bytes are not to be written. The client transfers the non-contiguous or tiled payload payload data to the peer device. Upon receiving the payload data, the peer device writes bytes from the payload data into the target frame buffer for only those bytes enabled via the byte enable message. One advantage of the present invention is that non-contiguous or tiled data are transferred over a fabric with improved efficiency.

摘要翻译： 非连续或平铺的有效载荷数据可以通过一个结构在对等体之间有效传输。 具体来说，客户端通过邮箱机制向对等设备传送字节使能消息，其中字节使能消息指定要经由数据包传送的有效载荷数据的哪些字节将被写入对等设备上的帧缓冲器，以及哪个 字节不被写入。 客户端将非连续或平铺的有效载荷有效载荷数据传输到对等设备。 在接收到有效载荷数据时，对等设备将字节从有效载荷数据写入目标帧缓冲器，以便仅通过字节使能消息使能的字节。 本发明的一个优点在于，不连续的或平铺的数据以提高的效率在织物上传送。

公开(公告)号：US20110029413A1

公开(公告)日：2011-02-03

申请号：US12865232

申请日：2009-01-29

申请人： Israel Ben-Tzur ,  Gary Ward

发明人： Israel Ben-Tzur ,  Gary Ward

IPC分类号： G06Q10/00

CPC分类号： G06Q10/08 ,  G06Q10/087

摘要： A system for managing perishables in a supply chain, including at least one sensor module adapted to sense at least one parameter of at least one monitorable shipping unit of perishables through multiple stages in a supply chain, a plurality of sensed inputs integrator and communicators (SIICs), each communicating with the least one sensor module at least one different one of the multiple stages in the supply chain, for receiving information relating to the at least one parameter, a perishable lifecycle manager (PLM) communicating with at least some of the plurality of SIICs and a user interface providing to a user an indication of at least one of remaining lifetime prediction, supply chain link accountability and first expired, first out logistics outputs relating to the at least one monitorable shipping unit of perishables whose at least one parameter is sensed by the at least one sensor module.

摘要翻译： 一种用于管理供应链中的易腐食品的系统，包括至少一个传感器模块，其适于通过供应链中的多个阶段感测易腐食品的至少一个可监控运输单元的至少一个参数，多个感测的输入积分器和通信器（SIIC） ），每个与所述至少一个传感器模块与所述供应链中的所述多个级中的至少一个不同的传感器模块进行通信，用于接收与所述至少一个参数相关的信息;易腐坏的生命周期管理器（PLM），其与所述多个 以及用户界面，向用户提供与至少一个参数为至少一个参数的至少一个可监控运输单元相关的剩余寿命预测，供应链链接问责和首次到期先出后勤输出中的至少一个的指示， 由至少一个传感器模块感测。