摘要:
A barrier-free wheelchair constructed entirely of plastic or non-metal components. The device is designed to facilitate the passage of wheelchair occupants through magnetometers, such as those utilized for airport security. The present invention is non-collapsible in nature, as the device is intended for on-site usage and not for transport in vehicles and the like. Due to its materials and construction, the wheelchair of the present invention also allows for a solid non-sling seat, is pilferage resistant, and provides multiple surfaces upon which indicia, such as corporate graphics, may appear. In addition, consistent with pre-existing wheelchairs, the present invention allows for the removable attachment of a variety of accessories, including foot rests and trays.
摘要:
In a powder formulation for use in a dry powder inhaler, a pharmaceutical acts as its own carrier, so that use of lactose or other excipients are not needed. The dry powder formulation has a single active pharmaceutical compound having two major populations in particle size distribution: microfine particles of the active pharmaceutical, of 1-10 microns in diameter, and larger carrier particles, also of the active pharmaceutical compound. The carrier particles provide a long acting, delayed onset, and optionally therapeutic effect via the GI tract, while the microfine particles provide a fast onset effect via the lung.
摘要:
A threaded connection for a conduit includes a pin member and a box member. The pin member includes a pin thread having a pin thread crest, a pin thread root, a pin load flank oriented at a pin load flank angle, and a pin stab flank oriented at a pin stab flank angle. The box member includes a box thread having a box thread crest, a box thread root, a box load flank oriented at a box load flank angle, and a box stab flank oriented at a box stab flank angle. At least one of the pin load flank angle, the pin stab flank angle, the box load flank angle, and the box stab flank angle varies over at least part of the threaded connection.
摘要:
A system and method for thermal management of a die is disclosed wherein cooling of the die is controlled by controlling coolant flow to switch between laminar flow and turbulent flow as desired.
摘要:
In a method for creating an immune response, a vaccine is prepared in the form of a dry powder. The powder particles have an aerodynamic particle size range from 1-100 microns. A dose of powder is loaded into a dry powder inhaler. The dose is inhaled with an inspiratory flow rate of less than 60 liters per minute. A mucosal immune response is created via particles of the vaccine material depositing on the upper respiratory tract. A systemic immune response is created via particles of the vaccine material depositing into the deep lung. The vaccine material is size reduced by e.g., jet milling, into the desired range, yet vaccine potency is retained.
摘要:
A dry powder inhaler has a dispersion chamber containing beads. A dose of dry powder is released into the chamber, or into an inlet tangentially joining into the chamber. As the patient inhales on a nosepiece or mouthpiece, air moves circularly through the dispersion chamber to drive the beads. The beads roll, bounce, and collide repeatedly with the drug particles on the chamber surfaces or on the beads. The smaller active drug particles are separated from the larger carrier particles and from each other, and a powder aerosol is created and inhaled by the patient. The beads are preferably lightweight, so that they can be rapidly accelerated and moved, even with nominal inspiration. The flow resistance of the inhaler is also reduced via the beads, allowing greater air flow and powder dispersion, without any increased effort by the patient.
摘要:
A dry powder formulation for treatment of pulmonary conditions, via inhalation, includes an effective amount of formoterol or a salt or solvate thereof, in a dry powder form, an effective amount of fluticasone, in a dry powder form, and an excipient. A method for preparing a physically stable dry powder formulation for inhalation includes the steps of micronizing a first active polar drug, a second active non-polar drug, and a polar excipient. The second non-polar active drug is first blended with the excipient to form an intermediate mixture. The intermediate mixture is then blended with the first active polar drug. The increased separation of the polar drug and polar excipient stabilizes the formulation.
摘要:
Non-contiguous or tiled payload data are efficiently transferred between peers over a fabric. Specifically, a client transfers a byte enable message to a peer device via a mailbox mechanism, where the byte enable message specifies which bytes of the payload data being transferred via the data packet are to be written to the frame buffer on the peer device and which bytes are not to be written. The client transfers the non-contiguous or tiled payload payload data to the peer device. Upon receiving the payload data, the peer device writes bytes from the payload data into the target frame buffer for only those bytes enabled via the byte enable message. One advantage of the present invention is that non-contiguous or tiled data are transferred over a fabric with improved efficiency.
摘要:
A system for managing perishables in a supply chain, including at least one sensor module adapted to sense at least one parameter of at least one monitorable shipping unit of perishables through multiple stages in a supply chain, a plurality of sensed inputs integrator and communicators (SIICs), each communicating with the least one sensor module at least one different one of the multiple stages in the supply chain, for receiving information relating to the at least one parameter, a perishable lifecycle manager (PLM) communicating with at least some of the plurality of SIICs and a user interface providing to a user an indication of at least one of remaining lifetime prediction, supply chain link accountability and first expired, first out logistics outputs relating to the at least one monitorable shipping unit of perishables whose at least one parameter is sensed by the at least one sensor module.
摘要:
Cast-in-place cylinder bore liners are disclosed for use in casting of engine cylinder blocks, wherein a plurality of the cylinder bore liners are joined to form a cassette, and wherein an accuracy in positioning of each of the bore liners with respect to each other is maximized and a weight thereof is minimized.