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    System and method for plasma-mediated modification of tissue
    1.
    发明授权
    System and method for plasma-mediated modification of tissue 有权
    血浆介导的组织修饰的系统和方法

    公开(公告)号：US09278028B2

    公开(公告)日：2016-03-08

    申请号：US13023483

    申请日：2011-02-08

    Applicant: Neil Friedman ,  Barry Seibel ,  William Culbertson ,  Georg Schuele ,  Dan Andersen

    Inventor： Neil Friedman ,  Barry Seibel ,  William Culbertson ,  Georg Schuele ,  Dan Andersen

    IPC: A61B18/20 ,  A61F9/008

    CPC classification number: A61F9/00825 ,  A61F9/008 ,  A61F9/00834 ,  A61F2009/00851 ,  A61F2009/0087 ,  A61F2009/00887 ,  A61F2009/00897

    Abstract: A system for cataract surgery on an eye of a patient is described. In one embodiment, the system comprises a first laser source configured to deliver a first laser beam in a pulsed form at a first pulse energy; a second laser source configured to deliver a second laser beam in a pulsed form at a second pulse energy greater than the first pulse energy; an scanning optical system, configured to: receive the first and second laser beams; and adjust a first focus position of the first laser beam, and a second focus position of the second laser beam, in up to three dimensions to direct the first and second laser beams onto one or more targeted tissue structure portions of the eye of the patient; a controller operatively coupled to the scanning optical system and configured to cause the scanning optical system to adjust the first focus position to photodisrupt a first tissue structure portion with the first laser beam, and subsequently adjust the second focus position to further photodisrupt the first tissue structure portion with the second laser beam.

    Abstract translation: 描述了患者眼睛上的白内障手术系统。 在一个实施例中，该系统包括被配置为以第一脉冲能量传递脉冲形式的第一激光束的第一激光源; 第二激光源，被配置为以大于所述第一脉冲能量的第二脉冲能量递送脉冲形式的第二激光束; 扫描光学系统，被配置为：接收所述第一和第二激光束; 并且调整所述第一激光束的第一聚焦位置和所述第二激光束的第二聚焦位置，以最多三维来将所述第一和第二激光束引导到患者眼睛的一个或多个目标组织结构部分上 ; 控制器，其可操作地耦合到所述扫描光学系统并且被配置为使得所述扫描光学系统调整所述第一聚焦位置以用所述第一激光束光致破坏第一组织结构部分，并且随后调整所述第二聚焦位置以进一步光致破坏所述第一组织结构 部分与第二激光束。

    Method and device for non-invasive regulation of temperature with radiation, especially laser radiation of biological tissue
    3.
    发明授权
    Method and device for non-invasive regulation of temperature with radiation, especially laser radiation of biological tissue 有权
    用于辐射非特异性调节温度的方法和装置，特别是生物组织的激光辐射

    公开(公告)号：US06830567B2

    公开(公告)日：2004-12-14

    申请号：US10201250

    申请日：2002-07-24

    Applicant: Georg Schuele ,  Ralf Brinkmann

    Inventor： Georg Schuele ,  Ralf Brinkmann

    IPC: A61F9007

    CPC classification number: A61B5/01 ,  A61B5/0095 ,  A61B2017/00084 ,  A61B2017/00128 ,  A61F9/00727 ,  A61F9/008 ,  A61F9/00814 ,  A61F9/00821 ,  A61F9/009 ,  A61F2009/00844 ,  A61F2009/00863

    Abstract: A method and a system for the non-invasive temperature determination on biological tissue, particularly at the fundus of the eye, treated by a treatment radiation, particularly laser radiation, wherein, during the respective irradiation time, at essentially identical time intervals, additional radiation pulses of a shorter pulse duration and a lower energy are aimed at the treated biological tissue, the resulting tissue expansions and/or contractions being detected by a pressure measurement or optical measurement and, from the measuring signals, the absolute temperature values are determined and optionally the treatment radiation is controlled as a function thereof.

    Abstract translation: 一种用于通过治疗辐射，特别是激光辐射处理的生物组织，特别是眼睛的眼底上的非侵入性温度测定的方法和系统，其中在相应的照射时间期间，基本相同的时间间隔，附加辐射 短脉冲持续时间和较低能量的脉冲针对经处理的生物组织，通过压力测量或光学测量检测所得到的组织扩张和/或收缩，并且根据测量信号确定绝对温度值，并且任选地 作为其功能来控制治疗辐射。

    SYSTEM AND METHOD FOR PLASMA-MEDIATED MODIFICATION OF TISSUE
    4.
    发明申请
    SYSTEM AND METHOD FOR PLASMA-MEDIATED MODIFICATION OF TISSUE 有权
    用于血浆介导的组织修饰的系统和方法

    公开(公告)号：US20110196350A1

    公开(公告)日：2011-08-11

    申请号：US13023483

    申请日：2011-02-08

    Applicant: Neil Friedman ,  Barry Seibel ,  William Culbertson ,  Georg Schuele ,  Dan Andersen

    Inventor： Neil Friedman ,  Barry Seibel ,  William Culbertson ,  Georg Schuele ,  Dan Andersen

    IPC: A61B18/20

    CPC classification number: A61F9/00825 ,  A61F9/008 ,  A61F9/00834 ,  A61F2009/00851 ,  A61F2009/0087 ,  A61F2009/00887 ,  A61F2009/00897

    Abstract: A system for cataract surgery on an eye of a patient is described. In one embodiment, the system comprises a first laser source configured to deliver a first laser beam in a pulsed form at a first pulse energy; a second laser source configured to deliver a second laser beam in a pulsed form at a second pulse energy greater than the first pulse energy; an scanning optical system, configured to: receive the first and second laser beams; and adjust a first focus position of the first laser beam, and a second focus position of the second laser beam, in up to three dimensions to direct the first and second laser beams onto one or more targeted tissue structure portions of the eye of the patient; a controller operatively coupled to the scanning optical system and configured to cause the scanning optical system to adjust the first focus position to photodisrupt a first tissue structure portion with the first laser beam, and subsequently adjust the second focus position to further photodisrupt the first tissue structure portion with the second laser beam.

    Abstract translation: 描述了患者眼睛上的白内障手术系统。 在一个实施例中，该系统包括被配置为以第一脉冲能量传递脉冲形式的第一激光束的第一激光源; 第二激光源，被配置为以大于所述第一脉冲能量的第二脉冲能量递送脉冲形式的第二激光束; 扫描光学系统，被配置为：接收所述第一和第二激光束; 并且调整所述第一激光束的第一聚焦位置和所述第二激光束的第二聚焦位置，以最多三维来将所述第一和第二激光束引导到患者眼睛的一个或多个目标组织结构部分上 ; 控制器，其可操作地耦合到所述扫描光学系统并且被配置为使得所述扫描光学系统调整所述第一聚焦位置以用所述第一激光束光致破坏第一组织结构部分，并且随后调整所述第二聚焦位置以进一步光致破坏所述第一组织结构 部分与第二激光束。

    METHOD AND SYSTEM FOR MODIFYING EYE TISSUE AND INTRAOCULAR LENSES
    5.
    发明申请
    METHOD AND SYSTEM FOR MODIFYING EYE TISSUE AND INTRAOCULAR LENSES 有权
    用于修饰眼睛组织和眼科镜片的方法和系统

    公开(公告)号：US20110172649A1

    公开(公告)日：2011-07-14

    申请号：US12987069

    申请日：2011-01-07

    Applicant: Georg Schuele ,  Dan Andersen

    Inventor： Georg Schuele ,  Dan Andersen

    IPC: A61B18/20

    CPC classification number: A61F9/008 ,  A61F9/00812 ,  A61F9/00827 ,  A61F9/00834 ,  A61F2009/00842 ,  A61F2009/00853 ,  A61F2009/0087 ,  A61F2009/00872 ,  A61F2009/00889

    Abstract: As shown in the drawings for purposes of illustration, a method and system for making physical modifications to intraocular targets is disclosed. In varying embodiments, the method and system disclosed herein provide many advantages over the current standard of care. Specifically, linear absorption facilitated photodecomposition and linear absorption facilitated plasma generation to modify intraocular tissues and synthetic intraocular lenses.

    Abstract translation: 如图所示，为了说明的目的，公开了一种用于对眼内靶标进行物理修改的方法和系统。 在不同的实施例中，本文公开的方法和系统提供了超过目前护理标准的许多优点。 具体地，线性吸收促进光分解和线性吸收促进等离子体产生以修饰眼内组织和合成人工晶状体。

    Method and device for contactless temperature monitoring and temperature adjustment
    7.
    发明授权
    Method and device for contactless temperature monitoring and temperature adjustment 失效
    非接触温度监测和温度调节方法和装置

    公开(公告)号：US07357570B2

    公开(公告)日：2008-04-15

    申请号：US10542298

    申请日：2004-01-11

    Applicant: Georg Schuele

    Inventor： Georg Schuele

    IPC: G01J5/00 ,  A61B5/00 ,  G01N21/85 ,  G01N21/47 ,  G01N21/63

    CPC classification number: G01J5/58 ,  A61B5/0066 ,  A61B5/01 ,  A61F9/008 ,  A61F2009/00851 ,  A61F2009/00863 ,  G01J5/0022 ,  G01J5/0025 ,  G01J2005/583

    Abstract: A method and device for determining the temperature of a sample, wherein a probing light beam is directed onto the sample whereby at least two partial beams of the probing light pass through paths of different lengths inside the sample by backscattering or reflecting the beams from at least two different depths in the sample, returning the partial beams to an analysis unit, and producing an interference pattern in the analysis unit by means of an interferometric device which uses one light beam as a reference for evaluating the interference pattern in an evaluating unit, wherein the signal intensity of the partial beam is determined counter to the optical path and the temperature displacement and temperature of the sample are determined by the temperature adjustment of the signal intensity.

    Abstract translation: 一种用于确定样品的温度的方法和装置，其中探测光束被引导到样品上，由此探测光的至少两个部分光束通过后向散射或至少反射来自样品中的不同长度的路径 样本中的两个不同的深度，将部分光束返回到分析单元，并且通过使用一个光束作为评估单元中的干涉图案的参考的干涉测量装置在分析单元中产生干涉图案，其中 确定部分光束的信号强度与光路相反，并且通过信号强度的温度调节来确定样品的温度位移和温度。

    SYSTEM AND METHOD FOR PLASMA-MEDIATED MODIFICATION OF TISSUE
    9.
    发明申请
    SYSTEM AND METHOD FOR PLASMA-MEDIATED MODIFICATION OF TISSUE 有权
    用于血浆介导的组织修饰的系统和方法

    公开(公告)号：US20150230987A1

    公开(公告)日：2015-08-20

    申请号：US14701458

    申请日：2015-04-30

    Applicant: Neil Friedman ,  Barry Seibel ,  William Culbertson ,  Georg Schuele ,  Dan Andersen

    Inventor： Neil Friedman ,  Barry Seibel ,  William Culbertson ,  Georg Schuele ,  Dan Andersen

    IPC: A61F9/008

    CPC classification number: A61F9/00825 ,  A61F9/008 ,  A61F9/00834 ,  A61F2009/00851 ,  A61F2009/0087 ,  A61F2009/00887 ,  A61F2009/00897

    Abstract: A method for cataract surgery on an eye of a patient includes scanning a first focus position of a first pulsed laser beam at a first pulse energy of between one-half microjoule and 50 microjoules in a first scanning pattern to photodisrupt a first tissue structure portion with a plurality of pulses of the first laser beam to form an incised surface; and afterwards, scanning a second focus position of a second pulsed laser beam having a second pulse energy being between 50 microjoules and 5,000 microjoules in a second scanning pattern that is co-registered to the first scanning pattern to further photodisrupt the same first tissue structure portion with the second laser beam to further separate segments of the first tissue structure along the incised surface.

    Abstract translation: 用于患者眼睛的白内障手术的方法包括以第一扫描图案以第二脉冲激光束以1/2微焦耳和50微焦耳之间的第一脉冲能量扫描第一聚焦位置，以将第一组织结构部分以 所述第一激光束的多个脉冲以形成切割表面; 之后，扫描具有第二脉冲能量的第二脉冲激光束的第二焦点位置，该第二脉冲激光束在与第一扫描图案共同对准的第二扫描图案中在50微焦耳与5,000微焦耳之间，以进一步光致相同的第一组织结构部分 其中第二激光束沿切口表面进一步分离第一组织结构的段。

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