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    Method and device for non-invasive regulation of temperature with radiation, especially laser radiation of biological tissue
    2.
    发明授权
    Method and device for non-invasive regulation of temperature with radiation, especially laser radiation of biological tissue 有权
    用于辐射非特异性调节温度的方法和装置，特别是生物组织的激光辐射

    公开(公告)号：US06830567B2

    公开(公告)日：2004-12-14

    申请号：US10201250

    申请日：2002-07-24

    申请人： Georg Schuele ,  Ralf Brinkmann

    发明人： Georg Schuele ,  Ralf Brinkmann

    IPC分类号： A61F9007

    CPC分类号： A61B5/01 ,  A61B5/0095 ,  A61B2017/00084 ,  A61B2017/00128 ,  A61F9/00727 ,  A61F9/008 ,  A61F9/00814 ,  A61F9/00821 ,  A61F9/009 ,  A61F2009/00844 ,  A61F2009/00863

    摘要： A method and a system for the non-invasive temperature determination on biological tissue, particularly at the fundus of the eye, treated by a treatment radiation, particularly laser radiation, wherein, during the respective irradiation time, at essentially identical time intervals, additional radiation pulses of a shorter pulse duration and a lower energy are aimed at the treated biological tissue, the resulting tissue expansions and/or contractions being detected by a pressure measurement or optical measurement and, from the measuring signals, the absolute temperature values are determined and optionally the treatment radiation is controlled as a function thereof.

    摘要翻译： 一种用于通过治疗辐射，特别是激光辐射处理的生物组织，特别是眼睛的眼底上的非侵入性温度测定的方法和系统，其中在相应的照射时间期间，基本相同的时间间隔，附加辐射 短脉冲持续时间和较低能量的脉冲针对经处理的生物组织，通过压力测量或光学测量检测所得到的组织扩张和/或收缩，并且根据测量信号确定绝对温度值，并且任选地 作为其功能来控制治疗辐射。

    Device with an OCT system for examining and treating living tissue by means of heating of the tissue by absorbing electromagnetic radiation
    5.
    发明授权
    Device with an OCT system for examining and treating living tissue by means of heating of the tissue by absorbing electromagnetic radiation 有权
    具有OCT系统的装置，用于通过吸收电磁辐射来加热组织来检查和处理活组织

    公开(公告)号：US08774904B2

    公开(公告)日：2014-07-08

    申请号：US13642212

    申请日：2011-04-16

    申请人： Reginald Birngruber ,  Ralf Brinkmann ,  Gereon Huettmann ,  Heike Mueller

    发明人： Reginald Birngruber ,  Ralf Brinkmann ,  Gereon Huettmann ,  Heike Mueller

    IPC分类号： A61B6/00

    CPC分类号： A61B5/0066 ,  A61B5/0097 ,  A61B5/015 ,  A61B5/05 ,  A61B5/7225 ,  A61B5/742 ,  A61B18/20 ,  A61B2018/00636 ,  A61F9/008 ,  A61N5/00

    摘要： A device for examining or treating living tissue by means of local heating of the tissue by absorbing electromagnetic radiation, with at least one radiation source emitting electromagnetic radiation, a control unit for controlling the irradiation parameters of the radiation source, and at least one FD-OCT apparatus with a light source emitting a measurement light for illuminating that tissue region in which the electromagnetic radiation is absorbed by the tissue, characterized by a computational unit for carrying out the following steps: determining the depth-resolved tissue velocity in the radiation direction of the measurement light at a predetermined measurement point of the tissue from the phase information from the FD-OCT interference light, integrating the established tissue velocity over time, differentiating the calculated time integral with respect to space, and displaying the spatial derivative as a function of space and time and/or feeding the spatial derivative as a function of space and time to an evaluation module and/or feeding the spatial derivative as a function of space and time to the control unit.

    摘要翻译： 一种用于通过吸收电磁辐射的局部加热来检查或处理生物体组织的装置，具有至少一个发射电磁辐射的辐射源，用于控制辐射源的照射参数的控制单元和至少一个FD- OCT装置，具有发射用于照射组织区域的测量光的光源，其中电磁辐射被组织吸收，其特征在于用于执行以下步骤的计算单元：确定辐射方向上的深度分辨组织速度 根据来自FD-OCT干涉光的相位信息在组织的预定测量点处的测量光，将所建立的组织速度随时间积分，将所计算的时间积分与空间进行微分，并将空间导数作为 空间和时间和/或馈送空间导数作为功能 n到评估模块的空间和时间和/或将空间导数作为空间和时间的函数馈送到控制单元。

    Device for the Treatment of Biological Tissue Using Laser Radiation
    8.
    发明申请
    Device for the Treatment of Biological Tissue Using Laser Radiation 有权
    使用激光辐射处理生物组织的装置

    公开(公告)号：US20110184393A1

    公开(公告)日：2011-07-28

    申请号：US13062805

    申请日：2009-09-09

    申请人： Ralf Brinkmann

    发明人： Ralf Brinkmann

    IPC分类号： A61F9/008

    CPC分类号： A61F9/008 ,  A61B5/0095 ,  A61B2017/0011 ,  A61B2017/00128 ,  A61F2009/00863

    摘要： An apparatus for the treatment of biological, in particular living tissue comprising a treatment laser device 1 for generating a pulsed treatment radiation directed on to a target tissue, in an embodiment additionally including a measurement laser device 2, 3 for generating a pulsed measurement radiation directed on to the target tissue of lower energy and shorter pulse duration than the treatment radiation, a detector device 4 for measuring pressure transients induced by the measurement radiation and a control device 6 for controlling the treatment radiation in dependence on the pressure transients evaluated in respect of a tissue change, wherein a regulating or control algorithm for controlling the treatment radiation is formed from the pressure transients.

    摘要翻译： 一种用于治疗生物，特别是生物体组织的装置，其包括用于产生针对目标组织的脉冲处理辐射的治疗激光装置1，该实施例另外包括用于产生脉冲测量辐射的测量激光装置2,3 对于目标组织的能量较低且脉冲持续时间短于治疗辐射，用于测量由测量辐射引起的压力瞬变的检测器装置4和用于根据关于以下方面评估的压力瞬变来控制治疗辐射的控制装置6 组织变化，其中用于控制治疗辐射的调节或控制算法由压力瞬变形成。

    APPARATUS FOR GENTLE LASER TREATMENT OF THE RETINA
    9.
    发明申请
    APPARATUS FOR GENTLE LASER TREATMENT OF THE RETINA 有权
    用于激光治疗的手术的装置

    公开(公告)号：US20100292763A1

    公开(公告)日：2010-11-18

    申请号：US12740530

    申请日：2008-10-24

    申请人： Ralf Brinkmann

    发明人： Ralf Brinkmann

    IPC分类号： A61F9/008

    CPC分类号： A61F9/008 ,  A61B18/20 ,  A61B2017/00084 ,  A61B2017/00106 ,  A61B2018/00636 ,  A61F9/00821 ,  A61F9/009 ,  A61F2009/00844 ,  A61F2009/00863

    摘要： Disclosed is an apparatus for treating living tissue with laser, comprising a therapeutic laser with a source of pulsed electromagnetic radiation, a control device for controlling the intensity and/or the duration of the therapeutic laser applied to the tissue, and a detection device for detecting optoacoustic signals triggered by irradiating the living tissue with the pulsed electromagnetic radiation. Said apparatus is characterized by an evaluation device that acts on the control device and is used for calculating a degree of quality B(t) from the optoacoustic signals detected by the detection device for individual laser pulses applied to a predetermined laser spot and determining a fit function f(t) at a predetermined point in time ?tl, said fit function f(t) approximating the mean curve of B(t) for 0 =t =?tl.; The intensity and/or the irradiation time of the therapeutic laser is defined by the parameters for the predetermined laser spot, said parameters being determined for the fit function f(t).

    摘要翻译： 公开了一种用激光治疗活组织的装置，包括具有脉冲电磁辐射源的治疗激光，用于控制施加到组织上的治疗激光的强度和/或持续时间的控制装置，以及用于检测 通过用脉冲电磁辐射照射活组织而触发的光声信号。 所述装置的特征在于作用在控制装置上的评估装置，用于根据由检测装置检测到的各个激光脉冲检测到的光声信号来计算质量B（t），该激光脉冲施加到预定的激光光斑并确定拟合 函数f（t）在预定时间点Δt1，所述拟合函数f（t）接近于0 = t =Δt1的B（t）的平均曲线。 治疗激光的强度和/或照射时间由预定激光光斑的参数定义，所述参数为拟合函数f（t）确定。

    Apparatus for gentle laser treatment of the retina
    10.
    发明授权
    Apparatus for gentle laser treatment of the retina 有权
    用于温和激光治疗视网膜的装置

    公开(公告)号：US09005261B2

    公开(公告)日：2015-04-14

    申请号：US12740530

    申请日：2008-10-24

    申请人： Ralf Brinkmann

    发明人： Ralf Brinkmann

    IPC分类号： A61F9/008 ,  A61B18/20 ,  A61B17/00 ,  A61B18/00 ,  A61F9/009

    CPC分类号： A61F9/008 ,  A61B18/20 ,  A61B2017/00084 ,  A61B2017/00106 ,  A61B2018/00636 ,  A61F9/00821 ,  A61F9/009 ,  A61F2009/00844 ,  A61F2009/00863

    摘要： A therapeutic laser with a source of pulsed electromagnetic radiation, a control device for controlling the intensity and/or the duration of the therapeutic laser applied to the tissue, and a detection device for detecting optoacoustic signals triggered by irradiating the living tissue with the pulsed electromagnetic radiation. The therapeutic laser is characterized by an evaluation device that acts on the control device and is used for calculating a degree of quality B(t) from the optoacoustic signals detected by the detection device for individual laser pulses applied to a predetermined laser spot and determining a fit function f(t) at a predetermined point in time Δt1, the fit function f(t) approximating the mean curve of B(t) for 0≦t≦Δt1. The intensity and/or the irradiation time of the therapeutic laser is defined by the parameters for the predetermined laser spot, the parameters being determined for the fit function f(t).

    摘要翻译： 具有脉冲电磁辐射源的治疗激光，用于控制施加到组织上的治疗激光的强度和/或持续时间的控制装置，以及用于检测通过用脉冲电磁辐射活体组织而触发的光声信号的检测装置 辐射。 治疗用激光器的特征在于作用在控制装置上的评价装置，用于根据由检测装置检测出的各个激光脉冲对预定的激光光斑所检测的光声信号计算出质量B（t）的程度， t（t）在预定时间点Dgr; t1，拟合函数f（t）近似于0（n）的平均曲线B（t）; t＆nlE;＆Dgr; t1。 治疗激光的强度和/或照射时间由预定激光光斑的参数定义，为拟合函数f（t）确定参数。