摘要:
The present invention provides compounds of formula I wherein X and R1–R7 are as defined herein. Compositions containing these compounds, and methods for inhibiting HCV RNA-dependent RNA polymerase and treating hepatitis C and related disorders using these compounds and compositions are also provided
摘要:
Disclosed are the ERK inhibitors of formula 1.0: and the pharmaceutically acceptable salts, esters and solvates thereof. Q is a piperidine or piperazine ring that can have a bridge or a fused ring. The piperidine ring can have a double bond in the ring. All other substitutents are as defined herein. Also disclosed are methods of treating cancer using the compounds of formula 1.0.
摘要:
Disclosed are the ERK inhibitors of formula 1.0: and the pharmaceutically acceptable salts, esters and solvates thereof. Q is a piperidine or piperazine ring that can have a bridge or a fused ring. The piperidine ring can have a double bond in the ring. All other substitutents are as defined herein. Also disclosed are methods of treating cancer using the compounds of formula 1.0.
摘要:
The invention relates to the inhibition of hepatitis C virus (HCV) replication. In particular, embodiments of the invention provide compounds and methods for inhibiting HCV RNA-dependent RNA polymerase enzymatic activity. The invention also provides compositions and methods for the prophylaxis and treatment of HCV infection.
摘要:
Disclosed are the ERK inhibitors of formula 1.0: and the pharmaceutically acceptable salts and solvates thereof. Q is a piperidine or piperazine ring that can have a bridge or a fused ring. The piperidine ring can have a double bond in the ring. All other substituents are as defined herein. Also disclosed are methods of treating cancer using the compounds of formula 1.0.
摘要:
Disclosed are the ERK inhibitors of formula 1.0: [Formula (1.0)] and the pharmaceutically acceptable salts, esters and solvates thereof. Q is a piperidine or piperazine ring that can have a bridge or a fused ring. The piperidine ring can have a double bond in the ring. All other substitutents are as defined herein. Also disclosed are methods of treating cancer using the compounds of formula 1.0.
摘要:
The disclosure discloses a Generic Mapping Procedure (GMP) mapping method for an Optical channel Data Unit (ODU), including: caching low-level ODUk data to a memory according to the rate of low-level ODUk data stream; generating an adjustment byte in a mapping process and encoding the adjustment byte; generating read enable of the cached data by an algorithm according to the adjustment byte, reading the cached low-level ODUk data, and generating Optical channel Data Tributary Unit (ODTU) data according to the read data; and crossing a time slot of the ODTU data in multiple channels to that of a high-level ODU payload, and forming the data in the time slot of the high-level ODU payload and the encoded adjustment byte into a completed high-level ODU frame. The disclosure may further provide a GMP mapping apparatus for an ODU. According to a technical solution of the disclosure, the GMP mapping of the ODU can be implemented according to the dynamic change of a service rate.
摘要:
The invention encompasses a compound derived from hydroxamic acid that may be used to slow the expansion of cancer cells and thus is effective in the treatment of cancer. Generally, the disclosed compound includes a benzimidazole group coupled to a hydroxyamide of five or more unsubstituted carbon atoms and any pharmaceutically acceptable salts, solvates and chemically protected forms thereof. Also disclosed are pharmacological compositions including the compound and methods of using the compound to slow the expansion of cancer cells as well as methods of using the compound to treat cancer.
摘要:
This invention relates to a microwave oven lighting assembly. The lighting assembly has a LED lamp and one or more light-guiding members to collect and to condense the light of the lamp; the lighting assembly is placed outside of the microwave oven cavity, casting the light into the cavity through holes on the cavity wall. The invention requires significantly less energy consumption and provides greatly enhanced oven cavity illumination.
摘要:
According to one embodiment of the present invention, there is provided a high-frequency switching circuit including a first differential line and third line. The differential line includes a first line configured to have one end and an other end, a second line configured to have one end and an other end and a first switch configured to switch electrical connection between the one ends of the first and second lines. The differential line receives or outputs differential signals by the other ends of the first and second lines. The third line is configured to be electromagnetically coupled with the first differential line when the first switch is turned on. The first switch is arranged at a position where an electrical length from the other end of the first line and an electrical length from the other end of the second line are approximately equal.