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公开(公告)号：US5352800A
公开(公告)日：1994-10-04
申请号：US29745
申请日：1993-03-11
申请人： Gerard F. Bills , Michael A. Goetz , Robert A. Giacobbe , Lucia Herranz , E. Tracy Turner Jones , Fernando Pelaez , Yu L. Kong , Sheo B. Singh , Siobhan Stevens-Miles
发明人： Gerard F. Bills , Michael A. Goetz , Robert A. Giacobbe , Lucia Herranz , E. Tracy Turner Jones , Fernando Pelaez , Yu L. Kong , Sheo B. Singh , Siobhan Stevens-Miles
IPC分类号： C07D207/38 , C07D207/273
CPC分类号： C07D207/38 , Y10S435/911
摘要： Fermentation processes for the production of a compound of the Structural Formula I ##STR1## The compound of Structural Formula I has been shown to have endothelin antagonist activity and is therefore useful in treating cardiovascular disorders, such as hypertension, congestive heart failure, postischemic renal failure vasospasm, cerebral and cardia ischemia, myocardial infarction inflammatory diseases, Raynaud's disease, endotoxin shock and asthma.
摘要翻译： 用于制备结构式I化合物的发酵方法结构式I的化合物已显示具有内皮素拮抗剂活性，因此可用于治疗心血管疾病，例如高血压，充血性心力衰竭，缺血后肾脏 失败的血管痉挛，脑和贲门缺血，心肌梗塞炎症性疾病，雷诺氏病，内毒素休克和哮喘。
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公开(公告)号：US5789438A
公开(公告)日：1998-08-04
申请号：US924557
申请日：1997-09-05
申请人： Sheo B. Singh , Russell B. Lingham , Keith C. Silverman , Deborah L. Zink , Isabel Martin , Fernando Pelaez , Manuel Sanchez
发明人： Sheo B. Singh , Russell B. Lingham , Keith C. Silverman , Deborah L. Zink , Isabel Martin , Fernando Pelaez , Manuel Sanchez
IPC分类号： C07D311/78 , C07D493/04 , A61K31/365 , C07D493/06
CPC分类号： C07D493/04 , C07D311/78
摘要： The present invention is directed to steroidal or terpenoidal compounds which inhibit farnesyl-protein transferase (FPTase). The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and treatment of cancer.
摘要翻译： 本发明涉及抑制法呢基蛋白转移酶（FPTase）的甾族化合物或萜类化合物。 本发明进一步涉及含有本发明化合物的化疗组合物和抑制法呢基蛋白转移酶和治疗癌症的方法。
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公开(公告)号：US5663193A
公开(公告)日：1997-09-02
申请号：US682248
申请日：1996-07-17
申请人： Carmen Cascales , Russell B. Lingham , Fernando Pelaez , Jon D. Polishook , Keith C. Silverman , Sheo B. Singh , Deborah L. Zink
发明人： Carmen Cascales , Russell B. Lingham , Fernando Pelaez , Jon D. Polishook , Keith C. Silverman , Sheo B. Singh , Deborah L. Zink
IPC分类号： C07D493/04 , A61K31/535
CPC分类号： C07D493/04 , Y10S514/908
摘要： The present invention is directed to non-peptide compounds which inhibit farnesyl-protein transferase (FPTase) and the farnesylation of the oncogene protein Ras. The invention also relates to the process for the preparation of a compound of this invention by cultivating a culture of Phoma sp. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
摘要翻译： 本发明涉及抑制法呢基蛋白转移酶（FPTase）和致癌基因蛋白Ras的法呢基化的非肽化合物。 本发明还涉及通过培养Phoma sp。培养物来制备本发明化合物的方法。 本发明进一步涉及含有本发明化合物的化疗组合物和抑制法呢基蛋白转移酶的方法和癌基因蛋白Ras的法呢基化。
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公开(公告)号：US5801172A
公开(公告)日：1998-09-01
申请号：US890772
申请日：1997-07-11
申请人： Wendy H. Clapp-Shapiro , Bruce W. Burgess , Robert A. Giacobbe , Guy H. Harris , Suzanne Mandala , Jon Polishook , Mark Rattray , Rosemary A. Thornton , Deborah L. Zink , Angeles Cabello , Maria Teresa Diez , Isabel Martin , Fernando Pelaez
发明人： Wendy H. Clapp-Shapiro , Bruce W. Burgess , Robert A. Giacobbe , Guy H. Harris , Suzanne Mandala , Jon Polishook , Mark Rattray , Rosemary A. Thornton , Deborah L. Zink , Angeles Cabello , Maria Teresa Diez , Isabel Martin , Fernando Pelaez
IPC分类号： A01N43/90 , A01N63/04 , C07K5/097 , C07D471/00 , A01N43/58
CPC分类号： C07K5/0821 , A01N43/90 , A01N63/04
摘要： There is disclosed a novel compound having the formula ##STR1## which exhibits antifungal activity.
摘要翻译： 公开了具有抗真菌活性的具有式（I）＆lt; IMAGE＆gt;的式的新化合物。
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公开(公告)号：US5756472A
公开(公告)日：1998-05-26
申请号：US789349
申请日：1997-01-27
申请人： Jerrold M. Liesch , Maria S. Meinz , Janet C. Onishi , Sandra A. Morris , Robert E. Schwartz , Gerald F. Bills , Robert A. Giacobbe , Wendy S. Horn , Deborah L. Zink , Angeles Cabello , Maria T. Diez , Isabella Martin , Fernando Pelaez , Francisca Vicente
发明人： Jerrold M. Liesch , Maria S. Meinz , Janet C. Onishi , Sandra A. Morris , Robert E. Schwartz , Gerald F. Bills , Robert A. Giacobbe , Wendy S. Horn , Deborah L. Zink , Angeles Cabello , Maria T. Diez , Isabella Martin , Fernando Pelaez , Francisca Vicente
IPC分类号： C07H15/24 , A61K31/70 , C07D315/00 , C12N1/14
CPC分类号： C07H15/24 , Y10S435/911
摘要： There is disclosed a novel compound having the formula ##STR1## which exhibits antifungal activity.
摘要翻译： 公开了具有抗真菌活性的具有式（I）＆lt; IMAGE＆gt;的式的新化合物。
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6.发明授权Antifungal agent produced by arthrinium arundinis ATCC 74359 失效由arthrinium arundinis ATCC 74359生产的抗真菌剂
公开(公告)号：US5712109A
公开(公告)日：1998-01-27
申请号：US789348
申请日：1997-01-27
申请人： Jerrold M. Liesch , Maria S. Meinz , Janet C. Onishi , Robert E. Schwartz , Gerald F. Bills , Robert A. Giacobbe , Deborah L. Zink , Angeles Cabello , Maria T. Diez , Isabella Martin , Fernando Pelaez , Francisca Vicente
发明人： Jerrold M. Liesch , Maria S. Meinz , Janet C. Onishi , Robert E. Schwartz , Gerald F. Bills , Robert A. Giacobbe , Deborah L. Zink , Angeles Cabello , Maria T. Diez , Isabella Martin , Fernando Pelaez , Francisca Vicente
CPC分类号： C07J9/00
摘要： There is disclosed a compound having the formula ##STR1## which is produced by the fungus, Arthrinium arundinis ATCC 74359, and exhibits antifungal activity.
摘要翻译： 公开了由真菌Arthrinium arundinis ATCC 74359产生的具有式（I）的化合物，并表现出抗真菌活性。
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公开(公告)号：US5348970A
公开(公告)日：1994-09-20
申请号：US125432
申请日：1993-09-22
申请人： Robert E. Schwartz , Janet C. Onishi , Gerald F. Bills , Robert A. Giacobbe , Fernando Pelaez , Maria T. Diez , Francisca Vicente , Julian Gorrochategui , Gregory L. Helms , Barnali Pramanik
发明人： Robert E. Schwartz , Janet C. Onishi , Gerald F. Bills , Robert A. Giacobbe , Fernando Pelaez , Maria T. Diez , Francisca Vicente , Julian Gorrochategui , Gregory L. Helms , Barnali Pramanik
IPC分类号： C07D405/06 , A61K31/40
CPC分类号： C07D405/06
摘要： A compound of the formula 1: ##STR1## is produced via fermentation of a fungal isolate ATCC no. 74235. The organism is included herein, as well as a process for production of the compound, a pharmaceutical composition and a method of treatment.
摘要翻译： 通过真菌分离物ATCC号的发酵产生式1化合物：
1。 生物体包括在本文中，以及生产化合物的方法，药物组合物和治疗方法。 -
公开(公告)号：US5712151A
公开(公告)日：1998-01-27
申请号：US734702
申请日：1996-10-21
申请人： Sandra A. Morris , Gerald F. Bills , James E. Curotto , Sarah J. Dreikorn , Angela Basilio , Maria Teresa Diez , Fernando Pelaez , Francisca Vicente , Bruce W. Burgess , Stanley L. Streicher , Deborah L. Zink , John R. Thompson
发明人： Sandra A. Morris , Gerald F. Bills , James E. Curotto , Sarah J. Dreikorn , Angela Basilio , Maria Teresa Diez , Fernando Pelaez , Francisca Vicente , Bruce W. Burgess , Stanley L. Streicher , Deborah L. Zink , John R. Thompson
IPC分类号： A01N37/42 , C07D207/44 , C07D207/448 , C12P17/10 , C12N5/00 , C12N5/02
CPC分类号： C07D207/448 , A01N37/42 , C12P17/10 , C12R1/645
摘要： There is disclosed a novel compound having the formula ##STR1## which exhibits antifungal activity.
摘要翻译： 公开了具有抗真菌活性的具有式（I）的化合物。
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公开(公告)号：US5702929A
公开(公告)日：1997-12-30
申请号：US734704
申请日：1996-10-21
申请人： Sandra A. Morris , James E. Curotto , Gerald F. Bills , Sarah J. Dreikorn , Stanley L. Streicher , Deborah L. Zink , John R. Thompson , Angela Basilio , Fernando Pelaez , Maria Teresa Diez , Francisca Vicente
发明人： Sandra A. Morris , James E. Curotto , Gerald F. Bills , Sarah J. Dreikorn , Stanley L. Streicher , Deborah L. Zink , John R. Thompson , Angela Basilio , Fernando Pelaez , Maria Teresa Diez , Francisca Vicente
IPC分类号： C07D405/06 , C12P17/16 , C12N5/00 , C07D207/00
CPC分类号： C07D405/06 , C12P17/16
摘要： There is disclosed a novel compound having the formula ##STR1## which exhibits antifungal activity.
摘要翻译： 公开了具有抗真菌活性的具有式（I）的化合物。
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公开(公告)号：US06051597A
公开(公告)日：2000-04-18
申请号：US95244
申请日：1998-06-10
IPC分类号： A61K31/404 , A61K31/40
CPC分类号： A61K31/404
摘要： Indolylquinones are useful for the treatment and prevention of diabetes mellitus, and in particular, for the treatment or prevention of hyperglycemia in diabetic patients. Some of the indolylquinones are produced by fermentation of the novel fungus Pseudomassaria sp. ATCC 74411.
摘要翻译： 吲哚醌可用于治疗和预防糖尿病，特别是用于治疗或预防糖尿病患者的高血糖症。 一些吲哚基醌通过新型真菌假单胞菌属的发酵产生。 ATCC 74411。
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