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1.发明授权Antifungal agent produced by arthrinium arundinis ATCC 74359 失效由arthrinium arundinis ATCC 74359生产的抗真菌剂
公开(公告)号：US5712109A
公开(公告)日：1998-01-27
申请号：US789348
申请日：1997-01-27
申请人： Jerrold M. Liesch , Maria S. Meinz , Janet C. Onishi , Robert E. Schwartz , Gerald F. Bills , Robert A. Giacobbe , Deborah L. Zink , Angeles Cabello , Maria T. Diez , Isabella Martin , Fernando Pelaez , Francisca Vicente
发明人： Jerrold M. Liesch , Maria S. Meinz , Janet C. Onishi , Robert E. Schwartz , Gerald F. Bills , Robert A. Giacobbe , Deborah L. Zink , Angeles Cabello , Maria T. Diez , Isabella Martin , Fernando Pelaez , Francisca Vicente
CPC分类号： C07J9/00
摘要： There is disclosed a compound having the formula ##STR1## which is produced by the fungus, Arthrinium arundinis ATCC 74359, and exhibits antifungal activity.
摘要翻译： 公开了由真菌Arthrinium arundinis ATCC 74359产生的具有式（I）的化合物，并表现出抗真菌活性。
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公开(公告)号：US5756472A
公开(公告)日：1998-05-26
申请号：US789349
申请日：1997-01-27
申请人： Jerrold M. Liesch , Maria S. Meinz , Janet C. Onishi , Sandra A. Morris , Robert E. Schwartz , Gerald F. Bills , Robert A. Giacobbe , Wendy S. Horn , Deborah L. Zink , Angeles Cabello , Maria T. Diez , Isabella Martin , Fernando Pelaez , Francisca Vicente
发明人： Jerrold M. Liesch , Maria S. Meinz , Janet C. Onishi , Sandra A. Morris , Robert E. Schwartz , Gerald F. Bills , Robert A. Giacobbe , Wendy S. Horn , Deborah L. Zink , Angeles Cabello , Maria T. Diez , Isabella Martin , Fernando Pelaez , Francisca Vicente
IPC分类号： C07H15/24 , A61K31/70 , C07D315/00 , C12N1/14
CPC分类号： C07H15/24 , Y10S435/911
摘要： There is disclosed a novel compound having the formula ##STR1## which exhibits antifungal activity.
摘要翻译： 公开了具有抗真菌活性的具有式（I）＆lt; IMAGE＆gt;的式的新化合物。
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公开(公告)号：US5348970A
公开(公告)日：1994-09-20
申请号：US125432
申请日：1993-09-22
申请人： Robert E. Schwartz , Janet C. Onishi , Gerald F. Bills , Robert A. Giacobbe , Fernando Pelaez , Maria T. Diez , Francisca Vicente , Julian Gorrochategui , Gregory L. Helms , Barnali Pramanik
发明人： Robert E. Schwartz , Janet C. Onishi , Gerald F. Bills , Robert A. Giacobbe , Fernando Pelaez , Maria T. Diez , Francisca Vicente , Julian Gorrochategui , Gregory L. Helms , Barnali Pramanik
IPC分类号： C07D405/06 , A61K31/40
CPC分类号： C07D405/06
摘要： A compound of the formula 1: ##STR1## is produced via fermentation of a fungal isolate ATCC no. 74235. The organism is included herein, as well as a process for production of the compound, a pharmaceutical composition and a method of treatment.
摘要翻译： 通过真菌分离物ATCC号的发酵产生式1化合物：
1。 生物体包括在本文中，以及生产化合物的方法，药物组合物和治疗方法。 -
4.发明授权Bis-aryl ethers, compositions containing such compounds and methods of treatment 失效双芳基醚，含有这些化合物的组合物和处理方法
公开(公告)号：US5994412A
公开(公告)日：1999-11-30
申请号：US110006
申请日：1998-07-02
申请人： Seok H. Lee , Maria T. Diez , Fernando Pelaez , Marina Mojena Sanchez , M. Dolores Vilella Amils , Hans E. Huber , Denis R. Patrick , Otto D. Hensens , Rosalind G. Jenkins , Leeyuan Huang , Annie Z. Zhao , Deborah L. Zink , Anne Dombrowski , Gerald F. Bills
发明人： Seok H. Lee , Maria T. Diez , Fernando Pelaez , Marina Mojena Sanchez , M. Dolores Vilella Amils , Hans E. Huber , Denis R. Patrick , Otto D. Hensens , Rosalind G. Jenkins , Leeyuan Huang , Annie Z. Zhao , Deborah L. Zink , Anne Dombrowski , Gerald F. Bills
摘要： A compound represented by the formula I is disclosed: ##STR1## or a pharmaceutically acceptable salt or hydrate thereof. The compound has inhibitory activity against the oncoprotein Raf.Also included are pharmaceutical compositions, methods of treating cancer, cultures of the producing fungal microorganism and methods of fermentative production of the compound.
摘要翻译： 公开了由式I表示的化合物：或其药学上可接受的盐或水合物。 该化合物对癌蛋白Raf具有抑制活性。 还包括药物组合物，治疗癌症的方法，产生真菌微生物的培养物和化合物发酵生产的方法。
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公开(公告)号：US5200342A
公开(公告)日：1993-04-06
申请号：US715535
申请日：1991-06-14
CPC分类号： C12N9/1085 , C12P17/181 , C12P9/00 , C12R1/645 , Y10S435/911
摘要： This invention relates to strains of the species Curvularia lunata isolated from tree bark and useful in a fermentation process to form compounds of formula (I): ##STR1##
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公开(公告)号：US5250424A
公开(公告)日：1993-10-05
申请号：US990158
申请日：1992-12-14
CPC分类号： C12N9/1085 , C12P17/181 , C12P9/00 , C12R1/645 , Y10S435/911
摘要： This invention relates to strains of the species Curvularia lunata isolated from tree bark and useful in a fermentation process to form compounds of formula (I): ##STR1##
摘要翻译： 本发明涉及从树皮中分离出来的种类Curvularia lunata菌株，可用于形成式（I）化合物的发酵过程：
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7.发明授权Substituted hexahydrobenzopyran derivatives as angiotensin II antagonists 失效取代的六氢苯并吡喃衍生物作为血管紧张素II拮抗剂
公开(公告)号：US5276054A
公开(公告)日：1994-01-04
申请号：US961957
申请日：1992-10-16
申请人： Maria T. Diez , Michael A. Goetz , Robert A. Giacobbe , Otto D. Hensens , Leeyan Huang , Isabel Martin , E. Tracy T. Jones , Siobhan Stevens-Miles , Yu L. Kong
发明人： Maria T. Diez , Michael A. Goetz , Robert A. Giacobbe , Otto D. Hensens , Leeyan Huang , Isabel Martin , E. Tracy T. Jones , Siobhan Stevens-Miles , Yu L. Kong
IPC分类号： C07D311/74 , C07D493/10 , A61K31/35 , C07D311/72 , C07D311/78
CPC分类号： C07D493/10 , C07D311/74
摘要： Substituted hexahydrobenzopyran derivatives of the Formulae A, B, or C are useful as angiotensin II antagonists: ##STR1##
摘要翻译： 式A，B或C的取代的六氢苯并吡喃衍生物可用作血管紧张素II拮抗剂：（*化学结构*）A（*化学结构*）B（*化学结构*）C
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