-
公开(公告)号：US5756472A
公开(公告)日：1998-05-26
申请号：US789349
申请日：1997-01-27
申请人： Jerrold M. Liesch , Maria S. Meinz , Janet C. Onishi , Sandra A. Morris , Robert E. Schwartz , Gerald F. Bills , Robert A. Giacobbe , Wendy S. Horn , Deborah L. Zink , Angeles Cabello , Maria T. Diez , Isabella Martin , Fernando Pelaez , Francisca Vicente
发明人： Jerrold M. Liesch , Maria S. Meinz , Janet C. Onishi , Sandra A. Morris , Robert E. Schwartz , Gerald F. Bills , Robert A. Giacobbe , Wendy S. Horn , Deborah L. Zink , Angeles Cabello , Maria T. Diez , Isabella Martin , Fernando Pelaez , Francisca Vicente
IPC分类号： C07H15/24 , A61K31/70 , C07D315/00 , C12N1/14
CPC分类号： C07H15/24 , Y10S435/911
摘要： There is disclosed a novel compound having the formula ##STR1## which exhibits antifungal activity.
摘要翻译： 公开了具有抗真菌活性的具有式（I）＆lt; IMAGE＆gt;的式的新化合物。
-
2.发明授权Antifungal agent produced by arthrinium arundinis ATCC 74359 失效由arthrinium arundinis ATCC 74359生产的抗真菌剂
公开(公告)号：US5712109A
公开(公告)日：1998-01-27
申请号：US789348
申请日：1997-01-27
申请人： Jerrold M. Liesch , Maria S. Meinz , Janet C. Onishi , Robert E. Schwartz , Gerald F. Bills , Robert A. Giacobbe , Deborah L. Zink , Angeles Cabello , Maria T. Diez , Isabella Martin , Fernando Pelaez , Francisca Vicente
发明人： Jerrold M. Liesch , Maria S. Meinz , Janet C. Onishi , Robert E. Schwartz , Gerald F. Bills , Robert A. Giacobbe , Deborah L. Zink , Angeles Cabello , Maria T. Diez , Isabella Martin , Fernando Pelaez , Francisca Vicente
CPC分类号： C07J9/00
摘要： There is disclosed a compound having the formula ##STR1## which is produced by the fungus, Arthrinium arundinis ATCC 74359, and exhibits antifungal activity.
摘要翻译： 公开了由真菌Arthrinium arundinis ATCC 74359产生的具有式（I）的化合物，并表现出抗真菌活性。
-
公开(公告)号：US5543431A
公开(公告)日：1996-08-06
申请号：US449622
申请日：1995-05-24
申请人： Evon A. Bolessa , Robert E. Schwartz , Gerald F. Bills , Robert A. Giacobbe , Fernando Pelaez Perez , Angeles Cabello Arroyo , Teresa Diez Matas , Isabel Martin Fernandez , Francisca Vicente Perez , Suzanne M. Mandala , Deborah L. Zink , Rosemary Thornton , John R. Thompson , James E. Curotto
发明人： Evon A. Bolessa , Robert E. Schwartz , Gerald F. Bills , Robert A. Giacobbe , Fernando Pelaez Perez , Angeles Cabello Arroyo , Teresa Diez Matas , Isabel Martin Fernandez , Francisca Vicente Perez , Suzanne M. Mandala , Deborah L. Zink , Rosemary Thornton , John R. Thompson , James E. Curotto
IPC分类号： C07D207/12 , C07C233/09 , A61K31/16 , A61K31/695 , C07C233/20
CPC分类号： C07D207/12
摘要： A compound having the formula ##STR1## which is an anti-fungal agent is described. The producing organism Colletotricum accutatum is also described, along with a method of production.
-
公开(公告)号：US5348970A
公开(公告)日：1994-09-20
申请号：US125432
申请日：1993-09-22
申请人： Robert E. Schwartz , Janet C. Onishi , Gerald F. Bills , Robert A. Giacobbe , Fernando Pelaez , Maria T. Diez , Francisca Vicente , Julian Gorrochategui , Gregory L. Helms , Barnali Pramanik
发明人： Robert E. Schwartz , Janet C. Onishi , Gerald F. Bills , Robert A. Giacobbe , Fernando Pelaez , Maria T. Diez , Francisca Vicente , Julian Gorrochategui , Gregory L. Helms , Barnali Pramanik
IPC分类号： C07D405/06 , A61K31/40
CPC分类号： C07D405/06
摘要： A compound of the formula 1: ##STR1## is produced via fermentation of a fungal isolate ATCC no. 74235. The organism is included herein, as well as a process for production of the compound, a pharmaceutical composition and a method of treatment.
摘要翻译： 通过真菌分离物ATCC号的发酵产生式1化合物：
1。 生物体包括在本文中，以及生产化合物的方法，药物组合物和治疗方法。 -
公开(公告)号：US5686637A
公开(公告)日：1997-11-11
申请号：US371171
申请日：1995-01-10
申请人： Gerald F. Bills , James E. Curotto , S. Dreikorn , Robert A. Giacobbe , Guy H. Harris , Suzanne Miller Mandala , Rosemary A. Thornton , Deborah L. Zink , Angeles Cabello Arroyo , Fernando Pelaez Perez , Teresa Diez Matas , Francisca Vicente Perez
发明人： Gerald F. Bills , James E. Curotto , S. Dreikorn , Robert A. Giacobbe , Guy H. Harris , Suzanne Miller Mandala , Rosemary A. Thornton , Deborah L. Zink , Angeles Cabello Arroyo , Fernando Pelaez Perez , Teresa Diez Matas , Francisca Vicente Perez
IPC分类号： C07C69/738 , C12P7/64 , C07C59/147
CPC分类号： C12P7/6463 , C07C69/738
摘要： There is disclosed a novel compound having the formula ##STR1## which exhibits antifungal activity.
摘要翻译： 公开了具有抗真菌活性的具有式（I）＆lt; IMAGE＆gt;的式的新化合物。
-
公开(公告)号：US5461071A
公开(公告)日：1995-10-24
申请号：US326986
申请日：1994-10-21
申请人： Evon A. Bolessa , Robert E. Schwartz , Gerald F. Bills , Robert A. Giacobbe , Fernando Pelaez Perez , Angeles Cabello Arroyo , Teresa Diez Matas , Isabel Martin Fernandez , Francisca Vincente Perez , Suzanne M. Mandala , Deborah L. Zink , Rosemary Thornton , John R. Thompson , James E. Curotto
发明人： Evon A. Bolessa , Robert E. Schwartz , Gerald F. Bills , Robert A. Giacobbe , Fernando Pelaez Perez , Angeles Cabello Arroyo , Teresa Diez Matas , Isabel Martin Fernandez , Francisca Vincente Perez , Suzanne M. Mandala , Deborah L. Zink , Rosemary Thornton , John R. Thompson , James E. Curotto
IPC分类号： C07D207/12 , A61K31/40 , A61K31/445 , C07D211/40
CPC分类号： C07D207/12
摘要： A compound having the formula ##STR1## which is an anti-fungal agent is described. The producing organism Colletotricum accutatum is also described, along with a method of production.
摘要翻译： 描述了具有抗真菌剂的式“IMAGE”的化合物。 还描述了生产菌Colletotricum accutatum以及生产方法。
-
公开(公告)号：US5801172A
公开(公告)日：1998-09-01
申请号：US890772
申请日：1997-07-11
申请人： Wendy H. Clapp-Shapiro , Bruce W. Burgess , Robert A. Giacobbe , Guy H. Harris , Suzanne Mandala , Jon Polishook , Mark Rattray , Rosemary A. Thornton , Deborah L. Zink , Angeles Cabello , Maria Teresa Diez , Isabel Martin , Fernando Pelaez
发明人： Wendy H. Clapp-Shapiro , Bruce W. Burgess , Robert A. Giacobbe , Guy H. Harris , Suzanne Mandala , Jon Polishook , Mark Rattray , Rosemary A. Thornton , Deborah L. Zink , Angeles Cabello , Maria Teresa Diez , Isabel Martin , Fernando Pelaez
IPC分类号： A01N43/90 , A01N63/04 , C07K5/097 , C07D471/00 , A01N43/58
CPC分类号： C07K5/0821 , A01N43/90 , A01N63/04
摘要： There is disclosed a novel compound having the formula ##STR1## which exhibits antifungal activity.
摘要翻译： 公开了具有抗真菌活性的具有式（I）＆lt; IMAGE＆gt;的式的新化合物。
-
公开(公告)号：US4931352A
公开(公告)日：1990-06-05
申请号：US362647
申请日：1989-06-07
申请人： Robert A. Fromtling , Robert A. Giacobbe , Jerrold M. Liesch , Sagrario M. Del Val , Robert E. Schwartz , Carol F. Wichmann
发明人： Robert A. Fromtling , Robert A. Giacobbe , Jerrold M. Liesch , Sagrario M. Del Val , Robert E. Schwartz , Carol F. Wichmann
摘要： An antifungal agent produced by cultivation of a yet unidentified microorganism is a cyclic lipopeptide with very high activity against human pathogens and of very low mammalian toxicity. Its production and isolation are also described.
摘要翻译： 通过培养未鉴定的微生物产生的抗真菌剂是对人类病原体具有非常高的活性和非常低的哺乳动物毒性的环状脂肽。 还描述了其生产和分离。
-
公开(公告)号：US5276055A
公开(公告)日：1994-01-04
申请号：US963178
申请日：1992-10-19
申请人： Angeles Cabello , Guy Harris , Robert A. Giacobbe , Gregory L. Helms , Otto D. Hensens , Suzanne M. Mandala , E. Tracy T. Jones , Isabel Martin , Walter Rozdilsky
发明人： Angeles Cabello , Guy Harris , Robert A. Giacobbe , Gregory L. Helms , Otto D. Hensens , Suzanne M. Mandala , E. Tracy T. Jones , Isabel Martin , Walter Rozdilsky
IPC分类号： A61K31/12 , A61K31/215 , A61K31/22 , A61P31/04 , A61P31/10 , C07C49/743 , C07C69/013 , C07C69/21 , C12N1/14 , C12P7/26 , C12P7/62 , C12R1/645
CPC分类号： C12P7/26 , C07C49/743 , C07C69/013 , C12P7/62
摘要： Compounds having the formula ##STR1## wherein R and R.sup.1 may be H or COCH.sub.3 provided that when R.sup.1 is COCH.sub.3, R is COCH.sub.3 are described.
摘要翻译： 具有式（I）的化合物其中R和R 1可以是H或COCH 3，条件是当R 1是COCH 3时，R是COCH 3。
-
公开(公告)号：US5541208A
公开(公告)日：1996-07-30
申请号：US186197
申请日：1994-01-24
申请人： Maria L. Garcia , Robert A. Giacobbe , Otto D. Hensens , Seok H. Lee , Owen B. McManus , Deborah L. Zink
发明人： Maria L. Garcia , Robert A. Giacobbe , Otto D. Hensens , Seok H. Lee , Owen B. McManus , Deborah L. Zink
IPC分类号： A61K31/40 , A61K45/06 , A61P25/28 , A61P43/00 , C07D491/04 , C07D491/052 , C07D491/14 , C07D491/20 , C07D491/22 , C07D498/14 , C12P17/10 , C12P17/18 , C12R1/645 , A61K31/41 , A61K31/395 , C07D498/22
CPC分类号： C07D491/04 , C07D491/14 , C12P17/10 , C12P17/18
摘要： The present invention relates to compounds of the formula: ##STR1## and the pharmaceutically acceptable salts thereof which are useful as potassium channel antagonists, particularly Maxi-K channel antagonists, and thus useful in treating Alzheimer's Disease and other cognitive disorders. This invention is also related to a method of making the compound of formula (I).
摘要翻译： 本发明涉及下式的化合物及其药学上可接受的盐，其可用作钾通道拮抗剂，特别是Maxi-K通道拮抗剂，因此可用于治疗阿尔茨海默病和其他认知障碍。 本发明还涉及制备式（I）化合物的方法。
-
-
-
-
-
-
-
-
-
搜索结果
19 条记录 (耗时 0.048 秒)
