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    Tetracyclic condensed heterocyclic compounds and their use
    6.
    发明授权
    Tetracyclic condensed heterocyclic compounds and their use 失效
    四环稠合杂环化合物及其用途

    公开(公告)号：US5620973A

    公开(公告)日：1997-04-15

    申请号：US330133

    申请日：1994-10-25

    申请人： Giichi Goto ,  Yuji Ishihara ,  Masaomi Miyamoto

    发明人： Giichi Goto ,  Yuji Ishihara ,  Masaomi Miyamoto

    IPC分类号： C07D471/06 ,  C07D487/04 ,  A61K31/55

    CPC分类号： C07D471/06 ,  C07D487/04

    摘要： A novel compound of the formula ##STR1## wherein Ar represents a tetracyclic fused heterocyclic group which may be substituted; R.sup.1 represents H or a hydrocarbon group which may be substituted; Y represents an amino or nitrogen-containing saturated heterocyclic group which may be substituted, its salt, inhibiting excellent cholinesterase inhibitory activity and monoamine uptake inhibitory activity, thus being useful as therapeutic and/or prophylactic medicaments of senile dementia.

    摘要翻译： 式（Ⅰ）的新化合物，其中Ar表示可被取代的四环稠合杂环基; R1表示H或可被取代的烃基; Y表示可被取代的氨基或含氮饱和杂环基，其盐，抑制优异的胆碱酯酶抑制活性和单胺摄取抑制活性，因此可用作老年痴呆症的治疗和/或预防药物。

    Method for improving brain function using cholinesterase-inhibiting aminoketone compounds
    7.
    发明授权
    Method for improving brain function using cholinesterase-inhibiting aminoketone compounds 失效
    使用胆碱酯酶抑制性氨基酮化合物改善脑功能的方法

    公开(公告)号：US5434179A

    公开(公告)日：1995-07-18

    申请号：US215619

    申请日：1994-03-22

    申请人： Giichi Goto ,  Akinobu Nagaoka ,  Yuji Ishihara

    发明人： Giichi Goto ,  Akinobu Nagaoka ,  Yuji Ishihara

    IPC分类号： A61K31/135 ,  A61K31/40 ,  C07C225/16 ,  C07D295/108

    CPC分类号： C07D295/108 ,  A61K31/135 ,  A61K31/40 ,  C07C225/16

    摘要： An aminoketone compound of the formula ##STR1## wherein ring A' means a five through eight-membered cyclic group which may be substituted and may contain one or two hetero atom(s) of O, S, N, as the ring-constituents; R.sup.1' means a hydrogen atom or a hydrocarbon residue which may be substituted; R.sup.2' means a hydrogen atom or a lower alkyl group; R.sup.3' means an aromatic group which may be substituted; R.sup.4' means a hydrogen atom, a lower alkyl group or aromatic group which may be substituted; n' means an integer of 2 to 7, or a salt thereof, is useful as an cholinesterase inhibitors and a cerebral function ameliorating agent.

    摘要翻译： 式IMAMA的氨基酮化合物，其中环A'表示可以被取代的五至八元环基，并且可以含有一个或两个作为环组成的O，S，N的杂原子; R1'表示氢原子或可被取代的烃残基; R2'表示氢原子或低级烷基; R3'表示可被取代的芳基; R4'表示氢原子，可以被取代的低级烷基或芳基; n'表示2〜7的整数或其盐可用作胆碱酯酶抑制剂和脑功能改善剂。

    Heterocyclic compounds, their production and use
    8.
    发明授权
    Heterocyclic compounds, their production and use 失效
    杂环化合物，其生产和使用

    公开(公告)号：US06319916B1

    公开(公告)日：2001-11-20

    申请号：US08051831

    申请日：1993-04-23

    申请人： Giichi Goto ,  Masaomi Miyamoto ,  Yuji Ishihara

    发明人： Giichi Goto ,  Masaomi Miyamoto ,  Yuji Ishihara

    IPC分类号： C07D26702

    CPC分类号： C07D263/58 ,  C07D267/14 ,  C07D413/06

    摘要： A compound of the formula: wherein ring A is an optionally substituted benzene ring; ring B′ is an optionally substituted non-aromatic heterocyclic ring having, the same or different, two or more hetero atoms; R1 is a hydrogen atom or an optionally substituted hydrocarbon group, which may be different from one another in the repetition of n; Y is an optionally substituted amino group or an optionally substituted N-containing saturated heterocyclic group; n denotes an integer of 1 to 10, provided that when the ring B′ is a 5- to 7-membered ring, the ring B′ contains at least one nitrogen atom as hetero atom and n denotes an integer of 2 to 10, or a salt thereof. The compounds and salts thereof have an excellent cholinesterase inhibitory activity and antidepressant activity, and are useful as therapeutic and/or prophylactic medicaments of senile dementia.

    摘要翻译： 下式的化合物：其中环A是任选取代的苯环; 环B'是具有相同或不同的两个或更多个杂原子的任选取代的非芳族杂环; R1是氢原子或任选取代的烃基，其可以在重复n时彼此不同; Y是任选取代的氨基或任选取代的含N的饱和杂环基; n表示1〜10的整数，条件是当环B'为5-至7-元环时，环B'含有至少一个氮原子作为杂原子，n表示2至10的整数，或 其盐。 其化合物及其盐具有优异的胆碱酯酶抑制活性和抗抑郁活性，可用作老年性痴呆的治疗和/或预防药物。

    Tetracyclic condensed heterocyclic compounds their production, and use
    9.
    发明授权
    Tetracyclic condensed heterocyclic compounds their production, and use 失效
    四环稠合杂环化合物的生产和使用

    公开(公告)号：US5814642A

    公开(公告)日：1998-09-29

    申请号：US681911

    申请日：1996-07-30

    申请人： Giichi Goto ,  Yuji Ishihara ,  Masaomi Miyamoto

    发明人： Giichi Goto ,  Yuji Ishihara ,  Masaomi Miyamoto

    IPC分类号： C07D471/06 ,  C07D487/04 ,  C07D221/18 ,  A61K31/395 ,  A61K31/44 ,  C07D401/02

    CPC分类号： C07D471/06 ,  C07D487/04

    摘要： A novel compound of the formula ##STR1## wherein Ar represents a tetracyclic fused heterocyclic group which may be substituted; R.sup.1 represents H or a hydrocarbon group which may be substituted; Y represents an amino acid or nitrogen-containing saturated heterocyclic group which may be substituted, its salt, inhibiting excellent cholinesterase inhibitory activity and monoamine uptake inhibitory activity, thus being useful as therapeutic and/or prophylactic medicaments of senile dementia.

    摘要翻译： 式（Ⅰ）的新化合物，其中Ar表示可被取代的四环稠合杂环基; R1表示H或可被取代的烃基; Y表示可被取代的氨基酸或含氮饱和杂环基，其盐，抑制优异的胆碱酯酶抑制活性和单胺摄取抑制活性，因此可用作老年性痴呆的治疗和/或预防药物。