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公开(公告)号：US20220354873A1
公开(公告)日：2022-11-10
申请号：US17665724
申请日：2022-02-07
Applicant: Gilead Sciences, Inc.
Inventor： Steven Donald Axt , Pavel Robertovich Badalov , Katrien Brak , Silvio Campagna , Andrei Chtchemelinine , Edward Doerffler , Morin Mae Frick , Detian Gao , Lars V. Heumann , Brittanie Hoang , Willard Lew , Robert Ronald Milburn , Sean Timothy Neville , Bruce Ross , Erik Rueden , Robert William Scott , Dustin Siegel , Andrew C. Stevens , Clarissa Tadeus , Tiago Vieira , Andrew W. Waltman , Xianghong Wang , Mark Charles Whitcomb , Lydia Wolfe , Chia-Yun Yu
IPC: A61K31/685 , A61K31/706 , A61K31/7056 , A61K31/53 , C07H1/00 , C07H1/02 , C07H11/00 , C07H15/18 , A61K31/6615 , A61K31/665 , A61K31/683 , C07D487/04 , C07D519/00 , C07F9/24 , C07F9/6561 , A61K31/675 , A61K45/06 , A61K31/00
Abstract: Provided are methods of preparing compounds and pharmaceutical compositions for treating Filoviridae virus infections The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.
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Patent Agency Ranking
公开(公告)号：US11344565B2
公开(公告)日：2022-05-31
申请号：US14926063
申请日：2015-10-29
Applicant: Gilead Sciences, Inc.
Inventor： Steven Donald Axt , Pavel Robertovich Badalov , Katrien Brak , Silvio Campagna , Andrei Chtchemelinine , Edward Doerffler , Morin Mae Frick , Detian Gao , Lars V. Heumann , Brittanie Hoang , Willard Lew , Robert Ronald Milburn , Sean Timothy Neville , Bruce Ross , Erik Rueden , Robert William Scott , Dustin Siegel , Andrew C. Stevens , Clarissa Tadeus , Tiago Vieira , Andrew W. Waltman , Xianghong Wang , Mark Charles Whitcomb , Lydia Wolfe , Chia-Yun Yu
IPC: C07H5/06 , C07H7/06 , A61K31/685 , A61K31/706 , A61K31/7056 , A61K31/53 , C07H1/00 , C07H1/02 , C07H11/00 , C07H15/18 , A61K31/6615 , A61K31/665 , A61K31/683 , C07D487/04 , C07D519/00 , C07F9/24 , C07F9/6561 , A61K31/675 , A61K45/06 , A61K31/00
Abstract: Provided are methods of preparing compounds and pharmaceutical compositions comprising a compound Formula VIII for treating Filoviridae virus infections. In one aspect, the compound of Formula VIII is formed from a reaction mixture comprising the compound of Formula IX, the compound of Formula X, a coupling agent such as magnesium chloride and a non-nucleophilic base such as diisopropylethylamine. The compound of Formula IX can be formed from a compound of Formula V and a cyanating agent. The compound of Formula V can be synthesized from a reaction mixture comprising a deprotonating agent such as phenylmagnesium chloride; a silylating agent such as chlorotrimethylsilane; a coupling agent such as isopropylmagnesium chloride, an additive such as LaCl3-2LiCl, LaCl3, CeCl3, NdCl3, or YCl3; a compound of Formula VI; and 7-iodopyrrolo[2,1-f][1,2,4]triazin-4-amine. The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.
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公开(公告)号：US10030033B2
公开(公告)日：2018-07-24
申请号：US15227527
申请日：2016-08-03
Applicant: Gilead Sciences, Inc.
Inventor： Amy Cagulada , Johann Chan , Lina Chan , Denise A. Colby , Kapil Kumar Karki , Darryl Kato , Katie Ann Keaton , Sudha Kondappally , Chris Levins , Adam Littke , Ruben Martinez , Dominika Pcion , Troy Reynolds , Bruce Ross , Michael Sangi , Adam J. Schrier , Pamela Seng , Dustin Siegel , Nathan Shapiro , Donald Tang , James G. Taylor , Jonathan Tripp , Andrew W. Waltman , Lawrence Yu
IPC: C07D498/16 , C07D403/12 , C07D498/18 , C07C271/34 , C07D241/44 , C07C205/57 , C07C233/09 , C07C251/12 , C07C255/61
Abstract: The present disclosure provides processes for the preparation of a compound of formula I: which is useful as an antiviral agent. The disclosure also provides compounds and processes for the preparation of the compounds that are synthetic intermediates to the compound of formula I.
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公开(公告)号：US20170210756A1
公开(公告)日：2017-07-27
申请号：US15227527
申请日：2016-08-03
Applicant: Gilead Sciences, Inc.
Inventor： Amy Cagulada , Johann Chan , Lina Chan , Denise A. Colby , Kapil Kumar Karki , Darryl Kato , Katie Ann Keaton , Sudha Kondapally , Christopher Levins , Adam Littke , Ruben Martinez , Dominika Pcion , Troy Reynolds , Bruce Ross , Michael Sangi , Adam J. Schrier , Pamela Seng , Dustin Siegel , Nathan Shapiro , Donald Tang , James G. Taylor , Jonathan Tripp , Andrew W. Waltman , Lawrence Yu
IPC: C07D498/18 , C07C271/34 , C07C255/61 , C07C205/57 , C07C233/09 , C07C251/12 , C07D403/12 , C07D241/44
CPC classification number: C07D498/18 , C07C51/09 , C07C205/57 , C07C209/00 , C07C227/02 , C07C233/09 , C07C251/12 , C07C255/61 , C07C271/34 , C07C2601/02 , C07D241/44 , C07D403/12 , C07D453/02 , C07D498/16 , C07K5/0808
Abstract: The present disclosure provides processes for the preparation of a compound of formula I: which is useful as an antiviral agent. The disclosure also provides compounds and processes for the preparation of the compounds that are synthetic intermediates to the compound of formula I.
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公开(公告)号：US20160122356A1
公开(公告)日：2016-05-05
申请号：US14926063
申请日：2015-10-29
Applicant: Gilead Sciences, Inc.
Inventor： Steven Donald Axt , Pavel Robertovich Badalov , Katrien Brak , Silvio Campagna , Andrei Chtchemelinine , Edward Doerffler , Morin Mae Frick , Detian Gao , Lars V. Heumann , Brittanie Hoang , Willard Lew , Robert Ronald Milburn , Sean Timothy Neville , Bruce Ross , Erik Rueden , Robert William Scott , Dustin Siegel , Andrew C. Stevens , Clarissa Tadeus , Tiago Vieira , Andrew W. Waltman , Xianghong Wang , Mark Charles Whitcomb , Lydia Wolfe , Chia-Yun Yu
IPC: C07D487/04 , C07F9/6561 , C07D519/00 , C07F9/24
CPC classification number: A61K31/685 , A61K31/00 , A61K31/53 , A61K31/6615 , A61K31/665 , A61K31/675 , A61K31/683 , A61K31/7056 , A61K31/706 , A61K45/06 , C07D487/04 , C07D519/00 , C07F9/2429 , C07F9/65616 , C07H1/00 , C07H1/02 , C07H11/00 , C07H15/18 , A61K2300/00
Abstract: Provided are methods of preparing compounds and pharmaceutical compositions for treating Filoviridae virus infections The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.
Abstract translation: 提供制备用于治疗丝状病毒科病毒感染的化合物和药物组合物的方法所提供的化合物，组合物和方法特别可用于治疗马尔堡病毒，埃博拉病毒和Cueva病毒感染。
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公开(公告)号：US09440991B2
公开(公告)日：2016-09-13
申请号：US14576143
申请日：2014-12-18
Applicant: GILEAD SCIENCES, INC.
Inventor： Amy Cagulada , Johann Chan , Lina Chan , Denise A. Colby , Kapil Kumar Karki , Darryl Kato , Katie Ann Keaton , Sudha Kondapally , Chris Levins , Adam Littke , Ruben Martinez , Dominika Pcion , Troy Reynolds , Bruce Ross , Michael Sangi , Adam J. Schrier , Pamela Seng , Dustin Siegel , Nathan Shapiro , Donald Tang , James G. Taylor , Jonathan Tripp , Andrew W. Waltman , Lawrence Yu
IPC: C07D403/12 , C07D413/14 , C07D498/16 , C07C227/02 , C07D453/02 , C07C209/00 , C07C51/09 , C07K5/083
CPC classification number: C07D498/18 , C07C51/09 , C07C205/57 , C07C209/00 , C07C227/02 , C07C233/09 , C07C251/12 , C07C255/61 , C07C271/34 , C07C2601/02 , C07D241/44 , C07D403/12 , C07D453/02 , C07D498/16 , C07K5/0808
Abstract: The present disclosure provides processes for the preparation of a compound of formula I: which is useful as an antiviral agent. The disclosure also provides compounds and processes for the preparation of the compounds that are synthetic intermediates to the compound of formula I.
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