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公开(公告)号:US07691987B2
公开(公告)日:2010-04-06
申请号:US10562324
申请日:2004-06-30
申请人: Gisela Greif , Ralf Hosse , Jürgen Krücken , Frank Wunderlich
发明人: Gisela Greif , Ralf Hosse , Jürgen Krücken , Frank Wunderlich
CPC分类号: C07K16/20 , A61K39/012 , A61K2039/505 , A61K2039/53 , C07K14/455
摘要: The invention relates to a novel oocyst sporocyst protein (EtOs22) belonging to the parasite of the species Eimeria tenella and to the polynucleotide encoding this protein, to vectors which contain this polynucleotide, to cells which are transformed with these vectors, to antibodies which are directed against the protein, to vaccines which comprise the polynucleotide, the protein, or fragments thereof, the abovementioned vectors or antibodies directed against the protein, and to the use of polynucleotide or of polypeptide for finding active compounds for treating an infection with Eimeria and active compounds which are suitable for the therapy of an infection with Eimeria.
摘要翻译: 本发明涉及属于艾美球虫种类的寄生虫和编码该蛋白质的多核苷酸的新型卵囊孢子蛋白(EtOs22)与含有该多核苷酸的载体对于被这些载体转化的细胞与被定向的抗体 针对蛋白质的疫苗,涉及包含多核苷酸,蛋白质或其片段的疫苗,针对蛋白质的上述载体或抗体,以及使用多核苷酸或多肽寻找用于治疗艾美球虫感染和活性化合物的活性化合物 其适用于艾美球虫感染的治疗。
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公开(公告)号:US20070184054A1
公开(公告)日:2007-08-09
申请号:US10562324
申请日:2004-06-30
申请人: Gisela Greif , Ralf Hosse , Jurgen Krucken , Frank Wunderlich
发明人: Gisela Greif , Ralf Hosse , Jurgen Krucken , Frank Wunderlich
IPC分类号: A61K39/395 , G01N33/569 , C07H21/04 , C12P21/06 , C07K16/18 , C07K14/44 , G01N33/53 , C12N5/06
CPC分类号: C07K16/20 , A61K39/012 , A61K2039/505 , A61K2039/53 , C07K14/455
摘要: The invention relates to a novel oocyst sporocyst protein (EtOs22) belonging to the parasite of the species Eimeria tenella and to the polynucleotide encoding this protein, to vectors which contain this polynucleotide, to cells which are transformed with these vectors, to antibodies which are directed against the protein, to vaccines which comprise the polynucleotide, the protein, or fragments thereof, the abovementioned vectors or antibodies directed against the protein, and to the use of polynucleotide or of polypeptide for finding active compounds for treating an infection with Eimeria and active compounds which are suitable for the therapy of an infection with Eimeria.
摘要翻译: 本发明涉及属于艾美球虫种类的寄生虫和编码该蛋白质的多核苷酸的新型卵囊孢子蛋白(EtOs22)与含有该多核苷酸的载体对于被这些载体转化的细胞与被定向的抗体 针对蛋白质的疫苗,涉及包含多核苷酸,蛋白质或其片段的疫苗,针对蛋白质的上述载体或抗体,以及使用多核苷酸或多肽寻找用于治疗艾美球虫感染和活性化合物的活性化合物 其适用于艾美球虫感染的治疗。
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公开(公告)号:US20120244112A1
公开(公告)日:2012-09-27
申请号:US13367843
申请日:2012-02-07
申请人: Oliver Ast , Peter Bruenker , Anne Freimoser-Grundschober , Sylvia Herter , Thomas U. Hofer , Ralf Hosse , Christian Klein , Ekkehard Moessner , Valeria G. Nicolini , Pablo Umana
发明人: Oliver Ast , Peter Bruenker , Anne Freimoser-Grundschober , Sylvia Herter , Thomas U. Hofer , Ralf Hosse , Christian Klein , Ekkehard Moessner , Valeria G. Nicolini , Pablo Umana
CPC分类号: C07K16/40 , A61K38/2013 , A61K47/6813 , A61K47/6849 , A61K47/6871 , A61K47/6891 , A61K2039/505 , C07K14/55 , C07K16/30 , C07K2319/00
摘要: The present invention generally relates to mutant interleukin-2 polypeptides that exhibit reduced affinity to the α-subunit of the IL-2 receptor, for use as immunotherapeutic agents. In addition, the invention relates to immunoconjugates comprising said mutant IL-2 polypeptides, polynucleotide molecules encoding the mutant IL-2 polypeptides or immunoconjugates, and vectors and host cells comprising such polynucleotide molecules. The invention further relates to methods for producing the mutant IL-2 polypeptides or immunoconjugates, pharmaceutical compositions comprising the same, and uses thereof.
摘要翻译: 本发明一般涉及对IL-2受体的α亚基表现出降低的亲和力的突变白细胞介素-2多肽,用作免疫治疗剂。 此外,本发明涉及包含所述突变型IL-2多肽,编码突变型IL-2多肽或免疫缀合物的多核苷酸分子以及包含该多核苷酸分子的载体和宿主细胞的免疫缀合物。 本发明还涉及用于产生突变型IL-2多肽或免疫缀合物的方法,包含其的药物组合物及其用途。
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公开(公告)号:US20120276125A1
公开(公告)日:2012-11-01
申请号:US13457039
申请日:2012-04-26
申请人: Oliver Ast , Peter Bruenker , Thomas U. Hofer , Ralf Hosse , Christian Klein , Ekkehard Moessner , Pablo Umana
发明人: Oliver Ast , Peter Bruenker , Thomas U. Hofer , Ralf Hosse , Christian Klein , Ekkehard Moessner , Pablo Umana
IPC分类号: C07K16/46 , C12N15/13 , A61P37/04 , C12N5/10 , C12P21/00 , A61K39/44 , C07K14/55 , C12N15/63
CPC分类号: C07K16/40 , A61K38/2013 , A61K39/395 , A61K47/6813 , A61K47/6843 , A61K47/6849 , A61K47/6851 , A61K47/6853 , A61K2039/505 , C07K14/52 , C07K14/5434 , C07K14/55 , C07K16/18 , C07K16/283 , C07K16/2866 , C07K16/30 , C07K16/3007 , C07K16/46 , C07K2317/21 , C07K2317/41 , C07K2317/52 , C07K2317/524 , C07K2317/55 , C07K2317/56 , C07K2317/71 , C07K2317/732 , C07K2317/92 , C07K2319/00 , C07K2319/30 , C07K2319/33 , C07K2319/74
摘要: The present invention generally relates to antigen-specific immunoconjugates for selectively delivering effector moieties that influence cellular activity. More specifically, the invention provides novel immunoconjugates comprising a first antigen binding moiety, an Fc domain and a single effector moiety. In addition, the present invention relates to polynucleotides encoding such immunoconjugates, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the immunoconjugates of the invention, and to methods of using these immunoconjugates in the treatment of disease.
摘要翻译: 本发明一般涉及用于选择性递送影响细胞活性的效应部分的抗原特异性免疫偶联物。 更具体地,本发明提供了包含第一抗原结合部分,Fc结构域和单个效应子部分的新型免疫偶联物。 此外,本发明涉及编码这种免疫缀合物的多核苷酸,以及包含这种多核苷酸的载体和宿主细胞。 本发明还涉及本发明的免疫缀合物的制备方法,以及使用这些免疫缀合物治疗疾病的方法。
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公开(公告)号:US09011847B2
公开(公告)日:2015-04-21
申请号:US13205743
申请日:2011-08-09
申请人: Marina Bacac , Anne Freimoser-Grundschober , Ralf Hosse , Christian Klein , Ekkehard Moessner , Valeria G. Nicolini , Pablo Umaña
发明人: Marina Bacac , Anne Freimoser-Grundschober , Ralf Hosse , Christian Klein , Ekkehard Moessner , Valeria G. Nicolini , Pablo Umaña
IPC分类号: A61K39/395 , C07K16/40
CPC分类号: C07K16/40 , A61K47/6871 , A61K51/1075 , C07K16/30 , C07K2317/21 , C07K2317/33 , C07K2317/41 , C07K2317/55 , C07K2317/565 , C07K2317/732 , C07K2317/92
摘要: The invention provides antibodies against Fibroblast Activation Protein (FAP) and methods of using the same.
摘要翻译: 本发明提供了抗成纤维细胞活化蛋白(FAP)的抗体及其使用方法。
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公开(公告)号:US20120251529A1
公开(公告)日:2012-10-04
申请号:US13408171
申请日:2012-02-29
申请人: Thomas U. Hofer , Ralf Hosse , Ekkehard Moessner , Pablo Umana
发明人: Thomas U. Hofer , Ralf Hosse , Ekkehard Moessner , Pablo Umana
CPC分类号: C07K16/42 , A61K39/39566 , A61K45/06 , A61K2039/505 , A61N5/10 , C07K16/3007 , C07K2317/24 , C07K2317/41 , C07K2317/565 , C07K2317/732 , C07K2317/92 , C07K2317/94
摘要: The present invention provides antigen binding molecules (ABMs) which bind membrane-bound CEA, including ABMs with improved therapeutic properties, and methods of using the same.
摘要翻译: 本发明提供了结合膜结合CEA的抗原结合分子(ABM),其包括具有改善的治疗性质的ABM及其使用方法。
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公开(公告)号:US20120128591A1
公开(公告)日:2012-05-24
申请号:US13205743
申请日:2011-08-09
申请人: Marina Bacac , Anne Freimoser-Grundschober , Ralf Hosse , Christian Klein , Ekkehard Moessner , Valeria G. Nicolini , Pablo Umaña
发明人: Marina Bacac , Anne Freimoser-Grundschober , Ralf Hosse , Christian Klein , Ekkehard Moessner , Valeria G. Nicolini , Pablo Umaña
IPC分类号: A61K39/395 , C07H21/04 , C07K19/00 , A61P35/00 , C12P21/00 , C12N15/63 , C12N5/071 , C12N1/19 , C12N5/04 , C07K16/18 , A61K49/00
CPC分类号: C07K16/40 , A61K47/6871 , A61K51/1075 , C07K16/30 , C07K2317/21 , C07K2317/33 , C07K2317/41 , C07K2317/55 , C07K2317/565 , C07K2317/732 , C07K2317/92
摘要: The invention provides antibodies against Fibroblast Activation Protein (FAP) and methods of using the same.
摘要翻译: 本发明提供了抗成纤维细胞活化蛋白(FAP)的抗体及其使用方法。
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公开(公告)号:US20120039807A1
公开(公告)日:2012-02-16
申请号:US13207705
申请日:2011-08-11
申请人: Anne Freimoser-Grundschober , Ralf Hosse , Christian Klein , Ekkehard Moessner , Valeria G. Nicolini , Pablo Umana
发明人: Anne Freimoser-Grundschober , Ralf Hosse , Christian Klein , Ekkehard Moessner , Valeria G. Nicolini , Pablo Umana
IPC分类号: A61K39/395 , C12N15/13 , C12N5/10 , A61P35/00 , C12N1/15 , C12N1/19 , C12P21/00 , A61K49/00 , C07K16/18 , C12N1/21
CPC分类号: C07K16/18 , A61K47/6843 , A61K47/6851 , A61K49/0058 , A61K51/1018 , C07K16/30 , C07K2317/41 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/72 , C07K2317/92
摘要: The invention provides antibodies against the A2 domain of tenascin-C and methods of using the same.
摘要翻译: 本发明提供针对腱生蛋白C的A2结构域的抗体及其使用方法。
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公开(公告)号:US09156913B2
公开(公告)日:2015-10-13
申请号:US13207705
申请日:2011-08-11
申请人: Anne Freimoser-Grundschober , Ralf Hosse , Christian Klein , Ekkehard Moessner , Valeria G. Nicolini , Pablo Umaña
发明人: Anne Freimoser-Grundschober , Ralf Hosse , Christian Klein , Ekkehard Moessner , Valeria G. Nicolini , Pablo Umaña
CPC分类号: C07K16/18 , A61K47/6843 , A61K47/6851 , A61K49/0058 , A61K51/1018 , C07K16/30 , C07K2317/41 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/72 , C07K2317/92
摘要: The invention provides antibodies against the A2 domain of tenascin-C and methods of using the same.
摘要翻译: 本发明提供针对腱生蛋白C的A2结构域的抗体及其使用方法。
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公开(公告)号:US08642742B2
公开(公告)日:2014-02-04
申请号:US13408171
申请日:2012-02-29
申请人: Thomas U. Hofer , Ralf Hosse , Ekkehard Moessner , Pablo Umana
发明人: Thomas U. Hofer , Ralf Hosse , Ekkehard Moessner , Pablo Umana
IPC分类号: C07K16/30 , A61K39/395
CPC分类号: C07K16/42 , A61K39/39566 , A61K45/06 , A61K2039/505 , A61N5/10 , C07K16/3007 , C07K2317/24 , C07K2317/41 , C07K2317/565 , C07K2317/732 , C07K2317/92 , C07K2317/94
摘要: The present invention provides antigen binding molecules (ABMs) which bind membrane-bound CEA, including ABMs with improved therapeutic properties, and methods of using the same.
摘要翻译: 本发明提供了结合膜结合CEA的抗原结合分子(ABM),其包括具有改善的治疗性质的ABM及其使用方法。
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