公开(公告)号：US20090024017A1

公开(公告)日：2009-01-22

申请号：US12107392

申请日：2008-04-22

申请人： Giulio Ruffini ,  Stephen Dunne ,  Esteve Farres

发明人： Giulio Ruffini ,  Stephen Dunne ,  Esteve Farres

IPC分类号： A61B5/05

CPC分类号： A61B5/0408 ,  A61B5/0478 ,  A61B5/0492 ,  A61B5/685 ,  A61B5/7232 ,  A61B2562/0215 ,  A61B2562/046

摘要： An electrophysiological sensor, weak electrical signal conditioning circuit and method for controlling the circuit as provided. The sensor includes rigid filiform conducting nanostructures connected to a conducting substrate and operable to penetrate an organic tissue. The circuit includes an instrumentation amplifier with an input connected to a first electrode in contact with a first area of a medium, and a second input; a voltage generating device connected to an electrode in contact with a second area of the medium for applying a continuous reference signal to it; a compensator, electrically insulated from the device, for compensating the direct current offsets of a weak electrical signal received by the first electrode, generating a signal with a reference voltage with a value which can be modified by a control system, and supplying it to the second input. A method is also provided for controlling the circuit.

摘要翻译： 一种电生理传感器，弱电信号调节电路及其控制方法。 传感器包括连接到导电基底并可操作以穿透有机组织的刚性丝状导电纳米结构。 该电路包括仪表放大器，其输入端连接到与介质的第一区域接触的第一电极和第二输入端; 连接到与介质的第二区域接触的电极的电压产生装置，用于向其施加连续的参考信号; 补偿器，与所述装置电绝缘，用于补偿由所述第一电极接收的弱电信号的直流偏移，产生具有可由控制系统修改的值的参考电压的信号，并将其提供给 第二个输入。 还提供了一种用于控制电路的方法。

公开(公告)号：US08660649B2

公开(公告)日：2014-02-25

申请号：US13058886

申请日：2009-10-13

申请人： Giulio Ruffini ,  Esteve Farres ,  Carles Grau

发明人： Giulio Ruffini ,  Esteve Farres ,  Carles Grau

IPC分类号： A61N1/00 ,  A61B5/04

CPC分类号： A61N1/36025 ,  A61B5/0476 ,  A61M21/00 ,  A61M2021/0055 ,  A61M2021/0072 ,  A61M2205/3569 ,  A61M2205/3592 ,  A61M2205/8206 ,  A61M2230/10 ,  A61N1/0529 ,  A61N1/0531 ,  A61N1/36014 ,  A61N1/36017 ,  A61N1/37252

摘要： The method includes applying individual stimuli to different regions of a brain the application of specific stimulus signals to corresponding stimulation elements arranged adjacent to the regions of the brain. The method includes constructing one or more simplified models of the brain, or of one or more sectors of the brain, considering the brain or the sector thereof, as appropriate, as a non-linear coupled oscillating system, and includes determining the stimulus signals so that the latter are suitable for exciting one or more natural vibration modes of the non-linear coupled oscillating system. The system includes stimulation elements (E1, E2 . . . En) arranged adjacent to regions of a brain, and an electronic system in connection with the stimulation elements (E1, E2 . . . En) and intended for applying thereto corresponding stimulus signals and for determining same by applying the proposed method.

摘要翻译： 该方法包括将特定刺激信号应用于大脑的不同区域的个体刺激施加到与脑区域相邻布置的相应刺激元件。 该方法包括构造一个或多个简化的大脑模型，或大脑的一个或多个部分，考虑到大脑或其部分，作为非线性耦合振荡系统，并且包括确定刺激信号 后者适合于激发非线性耦合振荡系统的一个或多个自然振动模式。 该系统包括邻近大脑区域布置的刺激元件（E1，E2 ... En），以及与刺激元件（E1，E2 ... En）结合并用于向其施加相应刺激信号的电子系统， 通过应用所提出的方法来确定它们。

公开(公告)号：US20110190846A1

公开(公告)日：2011-08-04

申请号：US13058886

申请日：2009-10-13

申请人： Giulio Ruffini ,  Esteve Farres ,  Carles Grau

发明人： Giulio Ruffini ,  Esteve Farres ,  Carles Grau

IPC分类号： A61N1/05 ,  A61N2/00

CPC分类号： A61N1/36025 ,  A61B5/0476 ,  A61M21/00 ,  A61M2021/0055 ,  A61M2021/0072 ,  A61M2205/3569 ,  A61M2205/3592 ,  A61M2205/8206 ,  A61M2230/10 ,  A61N1/0529 ,  A61N1/0531 ,  A61N1/36014 ,  A61N1/36017 ,  A61N1/37252

摘要： The method includes applying individual stimuli to different regions of a brain the application of specific stimulus signals to corresponding stimulation elements arranged adjacent to the regions of the brain. The method includes constructing one or more simplified models of the brain, or of one or more sectors of the brain, considering the brain or the sector thereof, as appropriate, as a non-linear coupled oscillating system, and includes determining the stimulus signals so that the latter are suitable for exciting one or more natural vibration modes of the non-linear coupled oscillating system. The system includes stimulation elements (E1, E2 . . . En) arranged adjacent to regions of a brain, and an electronic system in connection with the stimulation elements (E1, E2 . . . En) and intended for applying thereto corresponding stimulus signals and for determining same by applying the proposed method.

摘要翻译： 该方法包括将特定刺激信号应用于大脑的不同区域的个体刺激施加到与脑区域相邻布置的相应刺激元件。 该方法包括构造一个或多个简化的大脑模型，或大脑的一个或多个部分，考虑到大脑或其部分，作为非线性耦合振荡系统，并且包括确定刺激信号 后者适合于激发非线性耦合振荡系统的一个或多个自然振动模式。 该系统包括邻近大脑区域布置的刺激元件（E1，E2 ... En），以及与刺激元件（E1，E2 ... En）结合并用于向其施加相应刺激信号的电子系统， 通过应用所提出的方法来确定它们。