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    Immunoglobulin-like variable chain binding polypeptides and methods of use
    2.
    发明申请
    Immunoglobulin-like variable chain binding polypeptides and methods of use 审中-公开
    免疫球蛋白样可变链结合多肽及其使用方法

    公开(公告)号：US20060263787A1

    公开(公告)日：2006-11-23

    申请号：US11126105

    申请日：2005-05-10

    申请人： Glen Evans ,  Katya McLane

    发明人： Glen Evans ,  Katya McLane

    IPC分类号： C12Q1/68 ,  G01N33/53 ,  C07K16/24 ,  C07K16/26 ,  C07K16/30

    CPC分类号： C07K14/47 ,  C07K16/00 ,  C07K2317/56 ,  G01N33/6857

    摘要： The invention provides an isolated diverse population of VH-like binding polypeptides. Each binding polypeptide within the population comprising an unascertained combination of an immunoglobulin VH region exon encoded polypeptide, a JH region exon encoded polypeptide and a D region exon encoded polypeptide, wherein the VH, D and JH region exon encoded polypeptides are joined in a single polypeptide forming an immunoglobulin VH-like binding polypeptide, or a functional fragment thereof.

    摘要翻译： 本发明提供了一种分离的不同种类的V H样结合多肽。 群体内的每个结合多肽包含免疫球蛋白V H区域外显子编码多肽，J H区外显子编码多肽和D区外显子编码多肽的未确定组合，其中 V H H区，D区和J H区外显子编码的多肽连接在形成免疫球蛋白H样结合多肽的单个多肽中，或 其功能片段。

    Method and apparatus for performing automated power plant battery backup capacity measurement
    3.
    发明申请
    Method and apparatus for performing automated power plant battery backup capacity measurement 审中-公开
    执行自动电厂电池备用容量测量的方法和装置

    公开(公告)号：US20070080692A1

    公开(公告)日：2007-04-12

    申请号：US11224172

    申请日：2005-09-12

    申请人： Glen Evans

    发明人： Glen Evans

    IPC分类号： G01N27/416

    CPC分类号： G01R31/392 ,  G01R31/3835 ,  G01R31/386

    摘要： A method and apparatus for automatically performing a measurement of a power plant's battery backup capacity. The process comprises reducing an output voltage of a rectifier and identifying a time when said output voltage has been so reduced, measuring the voltage (e.g., at the output of the battery) to determine when the battery has been discharged and identifying a time when the battery has been determined to be discharged, calculating the period of time for the battery to discharge based on the two identified times, restoring the output voltage of the rectifier, and comparing the calculated period of time for the battery to discharge to a predetermined minimum acceptable period of time for the battery to discharge. Advantageously, this process is performed automatically at predetermined intervals or in accordance with a predetermined scheduling algorithm, and is advantageously performed during known “off-peak” time periods (e.g., during the overnight hours).

    摘要翻译： 一种用于自动执行发电厂电池备用能力测量的方法和装置。 该过程包括降低整流器的输出电压并识别所述输出电压如此减小的时间，测量电压（例如，在电池的输出端），以确定电池何时已经放电，并且识别当 电池被确定放电，根据两个识别时间计算电池放电的时间，恢复整流器的输出电压，并将计算出的电池的时间段与放电的计算时间进行比较，使之达到预定的最小可接受 电池放电的一段时间。 有利地，该过程以预定的间隔或根据预定的调度算法自动执行，并且有利地在已知的“非高峰”时间段（例如，在隔夜时间）期间执行。

    Nanomachine compositions and methods of use
    4.
    发明申请
    Nanomachine compositions and methods of use 审中-公开

    公开(公告)号：US20060252090A1

    公开(公告)日：2006-11-09

    申请号：US11485728

    申请日：2006-07-13

    申请人： Glen Evans

    发明人： Glen Evans

    IPC分类号： C12Q1/68

    CPC分类号： C12N15/10 ,  C12R1/01

    摘要： The invention provides a basic genetic operating system for an autonomous prototrophic nanomachine having a nanomachine genome encoding a minimal gene set sufficient for viability. Also provided is a basic genetic operating system for an autonomous auxotrophic nanomachine having a nanomachine genome encoding a minimal gene set sufficient for viability in the presence of an auxotrophic biomolecule. The minimal gene set encoded by the basic genetic operating system can contain the functional categories of transcription, translation, aerobic metabolism, glycolysis/pyruvate dehydrogenase/pentose phosphate pathways, carbohydrate metabolism, central intermediary metabolism, nucleotide metabolism, transport and binding proteins, and housekeeping functions. Functional categories can be arranged in a predetermined physical or temporal order. A prototrophic basic genetic operating system sufficient for autonomous viability can contain a minimal gene set of about 152 or less fundamental genes, orthologs or nonothorologous displacements thereof. An auxotrophic basic genetic operating system sufficient for autonomous viability in the presence of an auxotrophic biomolecule can contain about 151 or less fundamental genes, orthologs or nonothorologous displacements thereof. Also provided is a basic genetic operating system sufficient for autonomous prototrophic or auxotrophic viability which can have an expression control region for the production of a biomolecule. Viable autonomous prototrophic and auxotrophic nanomachines are also provided.

    Computer-directed assembly of a polynucleotide encoding a target polypeptide
    6.
    发明申请
    Computer-directed assembly of a polynucleotide encoding a target polypeptide 有权
    编码靶多肽的多核苷酸的计算机导向装配

    公开(公告)号：US20070054277A1

    公开(公告)日：2007-03-08

    申请号：US10969694

    申请日：2004-10-20

    申请人： Glen Evans

    发明人： Glen Evans

    IPC分类号： C12Q1/68 ,  G06F19/00 ,  C12P19/34

    CPC分类号： C07K1/00 ,  B01J2219/00659 ,  B01J2219/00689 ,  B01J2219/00695 ,  B01J2219/007 ,  B01J2219/00722 ,  C07B2200/11 ,  C12N15/10 ,  C12N15/66 ,  C40B40/06 ,  G06F19/22

    摘要： The present invention outlines a novel approach to utilizing the results of genomic sequence information by computer-directed polynucleotide assembly based upon information available in databases such as the human genome database. Specifically, the present invention may be used to select, synthesize and assemble a novel, synthetic target polynucleotide sequence encoding a target polypeptide. The target polynucleotide may encode a target polypeptide that exhibits enhanced or altered biological activity as compared to a model polypeptide encoded by a natural (wild-type) or model polynucleotide sequence.

    摘要翻译： 本发明概述了基于基于数据库（例如人类基因组数据库）中可得到的信息利用基于计算机的多核苷酸组装体的基因组序列信息的结果的新方法。 具体地，本发明可用于选择，合成和组装编码靶多肽的新型合成靶多核苷酸序列。 与由天然（野生型）或模型多核苷酸序列编码的模型多肽相比，靶多核苷酸可以编码显示增强或改变的生物活性的靶多肽。

    Nanomachine compositions and methods of use
    8.
    发明申请
    Nanomachine compositions and methods of use 审中-公开

    公开(公告)号：US20060078907A1

    公开(公告)日：2006-04-13

    申请号：US11143564

    申请日：2005-06-02

    申请人： Glen Evans

    发明人： Glen Evans

    IPC分类号： C12Q1/68 ,  C12P21/06 ,  C12N15/63

    CPC分类号： C12N15/10 ,  C12R1/01

    摘要： The invention provides a basic genetic operating system for an autonomous prototrophic nanomachine having a nanomachine genome encoding a minimal gene set sufficient for viability. Also provided is a basic genetic operating system for an autonomous auxotrophic nanomachine having a nanomachine genome encoding a minimal gene set sufficient for viability in the presence of an auxotrophic biomolecule. The minimal gene set encoded by the basic genetic operating system can contain the functional categories of transcription, translation, aerobic metabolism, glycolysis/pyruvate dehydrogenase/pentose phosphate pathways, carbohydrate metabolism, central intermediary metabolism, nucleotide metabolism, transport and binding proteins, and housekeeping functions. Functional categories can be arranged in a predetermined physical or temporal order. A prototrophic basic genetic operating system sufficient for autonomous viability can contain a minimal gene set of about 152 or less fundamental genes, orthologs or nonothorologous displacements thereof. An auxotrophic basic genetic operating system sufficient for autonomous viability in the presence of an auxotrophic biomolecule can contain about 151 or less fundamental genes, orthologs or nonothorologous displacements thereof. Also provided is a basic genetic operating system sufficient for autonomous prototrophic or auxotrophic viability which can have an expression control region for the production of a biomolecule. Viable autonomous prototrophic and auxotrophic nanomachines are also provided.