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公开(公告)号：US20230102772A1
公开(公告)日：2023-03-30
申请号：US18057360
申请日：2022-11-21
Applicant: GLYCOM A/S
Inventor： Benjámin PODÁNYI , Pierre CHASSAGNE , Martin MATWIEJUK , Markus JONDELIUS HEDEROS
Abstract: It is provided i) an amorphous carbohydrate with improved chemical stability and/or physical features, ii) a method for producing an amorphous carbohydrate with improved chemical stability and/or physical features, and iii) a method for improving the chemical stability and/or the physical features of an amorphous carbohydrate.
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公开(公告)号：US20190248824A1
公开(公告)日：2019-08-15
申请号：US16346057
申请日：2017-10-31
Applicant: Glycom A/S
Inventor： Pierre CHASSAGNE , Martin MATWIEJUK , Nikolay KHANZHIN , Markus JONDELIUS HEDEROS
CPC classification number: C07H3/06 , A23L33/21 , A23V2002/00 , A61K31/702 , C07B2200/13 , C07H1/00 , C07H1/06 , C07H13/04 , F26B5/04 , F26B21/14
Abstract: The present invention relates to a method of removing residual organic solvent from crystalline oligosaccharides by the use of water vapour as well as the pharmaceutically and nutritionally suitable crystalline oligosaccharides obtained by said method.
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公开(公告)号：US20230099060A1
公开(公告)日：2023-03-30
申请号：US18057355
申请日：2022-11-21
Applicant: GLYCOM A/S
Inventor： Benjámin PODÁNYI , Pierre CHASSAGNE , Martin MATWIEJUK , Markus JONDELIUS HEDEROS
Abstract: It is provided i) an amorphous carbohydrate with improved chemical stability and/or physical features, ii) a method for producing an amorphous carbohydrate with improved chemical stability and/or physical features, and iii) a method for improving the chemical stability and/or the physical features of an amorphous carbohydrate.
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公开(公告)号：US20220119437A1
公开(公告)日：2022-04-21
申请号：US17646093
申请日：2021-12-27
Applicant: GLYCOM A/S
Inventor： Nikolay KHANZHIN , Markus JONDELIUS HEDEROS
IPC: C07H1/06 , B01D61/02 , B01D61/04 , B01D61/58 , B01D69/02 , B01D69/12 , B01D71/56 , B01D71/58 , C07H3/06 , C12P19/04 , C08B37/00 , C12P19/12 , A23L33/00 , C12P19/18
Abstract: This invention relates to a method for the enzymatic synthesis of oligosaccharides, preferably human milk oligosaccharides (HMOs) The method comprises the enzymatic transfer of a glycosyl moiety and subsequent removal of by-products, such as lactose, by nanofiltration using a membrane comprising an active polyamide layer.
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公开(公告)号：US20200299740A1
公开(公告)日：2020-09-24
申请号：US16895871
申请日：2020-06-08
Applicant: Glycom A/S
Inventor： Gyula DEKANY , Györgyi OSZTROVSZKY , Martin MATWIEJUK , Pierre CHASSAGNE , Markus JONDELIUS HEDEROS
Abstract: The invention relates to a method for selective crystallization of 2′-fucosyllactose (2′-FL) from an aqueous solution comprising 2′-FL and one or more other fucosylated carbohydrates by adding acetic acid to the solution. The aqueous solution is separated from an aqueous culture medium prior to crystallization.
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Patent Agency Ranking
公开(公告)号：US20200215486A1
公开(公告)日：2020-07-09
申请号：US16626245
申请日：2018-06-27
Applicant: GLYCOM A/S
Inventor： Nikolay KHANZHIN , Markus JONDELIUS HEDEROS
Abstract: This invention relates to a method for the enzymatic synthesis of oligosaccharides, preferably human milk oligosaccharides (HMOs) The method comprises the enzymatic transfer of a glycosyl moiety and subsequent removal of by-products, such as lactose, by nanofiltration using a membrane comprising an active polyamide layer.
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公开(公告)号：US20220395520A1
公开(公告)日：2022-12-15
申请号：US17821282
申请日：2022-08-22
Applicant: GLYCOM A/S
IPC: A61K31/702 , C12P19/04 , C12P1/04 , C12N9/10 , A61K31/716 , A61P31/04 , A61K31/7016 , A61K31/7032 , C07H1/00
Abstract: A mixture of human milk oligosaccharides that comprises or consists essentially of a) LNTri II, LNT, pLNH II and optionally lactose, or b) LNTri II, LNnT, pLNnH and optionally lactose, and is useful for preventing or treating viral or bacterial, intestinal and respiratory infections and for modulating the human gastrointestinal microbiota to increase Bifidobacterium abundance. A process for preparing the mixture and methods of crystallizing LNnT and LNT is also described.
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公开(公告)号：US20200148793A1
公开(公告)日：2020-05-14
申请号：US16626122
申请日：2018-06-27
Applicant: GLYCOM A/S
Inventor： Nikolay KHANZHIN , Markus JONDELIUS HEDEROS
Abstract: The invention relates to separation of disaccharides from tri- or higher oligosaccharides by nanofiltration.
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公开(公告)号：US20190175631A1
公开(公告)日：2019-06-13
申请号：US16312506
申请日：2017-06-23
Applicant: GLYCOM A/S
IPC: A61K31/702 , A61K31/7032 , A61K31/7016 , A61P31/04 , C07H1/00
Abstract: A mixture of human milk oligosaccharides that comprises or consists essentially of a) LNTri II, LNT, pLNH II and optionally lactose, or b) LNTri II, LNnT, pLNnH and optionally lactose, and is useful for preventing or treating viral or bacterial, intestinal and respiratory infections and for modulating the human gastrointestinal microbiota to increase Bifidobacterium abundance. A process for preparing the mixture and methods of crystallizing LNnT and LNT is also described.
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公开(公告)号：US20190119314A1
公开(公告)日：2019-04-25
申请号：US16094508
申请日：2017-04-19
Applicant: GLYCOM A/S
Inventor： Pierre CHASSAGNE , Nikolay KHANZHIN , Martin MATWIEJUK , Markus JONDELIUS HEDEROS , Niels BANKE
Abstract: The invention relates to a method for obtaining an N-acetylglucosamine containing neutral oligosaccharide from a fermentation broth, wherein said oligosaccharide is produced by culturing a genetically modified microorganism capable of producing said oligosaccharide from an internalized carbohydrate precursor, comprising the steps of: i) ultrafiltration (UF), preferably to separate biomass from the broth, ii) nanofiltration (NF), preferably to concentrate said oligosaccharide in the broth and/or reduce an inorganic salt content of the broth, and iii) treating the broth with an ion exchange resin, preferably to remove charged materials, and/or subjecting the broth to chromatography, preferably to remove hydrophobic impurities.
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