公开(公告)号：US4463188A

公开(公告)日：1984-07-31

申请号：US481946

申请日：1983-04-04

申请人： Gohfu Suzukamo ,  Masami Fukao ,  Yukio Yoneyoshi

发明人： Gohfu Suzukamo ,  Masami Fukao ,  Yukio Yoneyoshi

IPC分类号： C07C51/64 ,  C07B31/00 ,  C07B55/00 ,  C07C51/00 ,  C07C51/353 ,  C07C51/487 ,  C07C61/04 ,  C07C61/15 ,  C07C67/00 ,  C07C51/58 ,  C07C51/04

CPC分类号： C07C61/15 ,  C07C51/487

摘要： A method for racemization of optically active 2,2-dimethylcyclopropane-1-carboxylic acid by converting said acid to the corresponding halide thereof represented by the general formula; ##STR1## wherein X is a halogen atom, which is heated to a temperature of about 80.degree. C. to about 300.degree. C., preferably about 100.degree. C. to about 200.degree. C., and then, if desired, producing 2,2-dimethylcyclopropane-1-carboxylic acid by hydrolysis of the resultant acid halide.

摘要翻译： 通过将所述酸转化成由通式表示的相应的卤化物来使光学活性的2,2-二甲基环丙烷-1-羧酸外消旋化的方法; 其中X是卤原子，其被加热到约80℃至约300℃，优选约100℃至约200℃的温度，然后如果需要，产生2 ，2-二甲基环丙烷-1-羧酸，通过水解得到的酰卤。

公开(公告)号：US5831132A

公开(公告)日：1998-11-03

申请号：US549399

申请日：1995-10-27

申请人： Kenji Saito ,  Norio Kometani ,  Azusa Fujiwara ,  Yukio Yoneyoshi ,  Gohfu Suzukamo

发明人： Kenji Saito ,  Norio Kometani ,  Azusa Fujiwara ,  Yukio Yoneyoshi ,  Gohfu Suzukamo

IPC分类号： C07C29/143 ,  C07D317/54 ,  C07C33/46 ,  C07C27/00

CPC分类号： C07D317/54 ,  C07C29/143 ,  C07B2200/07

摘要： The present invention relates to a process for producing optically active halomethyl phenyl carbinols of the formula (1), comprising reducing halomethyl phenyl ketones of the formula (2) using an asymmetric reducing agent obtained from boranes and optically active .alpha.-phenyl-substituted-.beta.-amino alcohols of the formula (3) or optically active .alpha.-non-substituted-.beta.-amino alcohols of the formula (4). The present invention further relates to a process for producing optically active carbinols, comprising reacting a prochiral keytone with an asymmetric reducing agent obtained from optically active .beta.-amino alcohols of the formula (5), a metal boron hydride and Lewis acid or lower dialkyl sulfuric acid. All of the formulas (1) to (5) are the same as shown in the specification.

摘要翻译： 本发明涉及一种制备式（1）的光学活性卤代甲基苯基甲醇的方法，其包括使用由硼烷和光学活性的α-苯基取代的β取代的β-不饱和还原剂还原式（2）的卤代甲基苯基酮 （3）的氨基醇或式（4）的光学活性的α-壬基取代的β-氨基醇。 本发明还涉及一种光学活性甲醇的制造方法，其包括使前手性键控酮与由式（5）的光学活性β-氨基醇获得的不对称还原剂，金属硼氢化物和路易斯酸或低级二烷基硫酸 酸。 所有式（1）至（5）与说明书中所示的相同。

公开(公告)号：US5801280A

公开(公告)日：1998-09-01

申请号：US628154

申请日：1996-04-05

申请人： Yukio Yoneyoshi ,  Naoto Konya ,  Gohfu Suzukamo ,  Masashi Kamitamari ,  Takashi Miyawaki

发明人： Yukio Yoneyoshi ,  Naoto Konya ,  Gohfu Suzukamo ,  Masashi Kamitamari ,  Takashi Miyawaki

IPC分类号： C07B53/00 ,  C07B57/00 ,  C07C29/143 ,  C07C33/34 ,  C07C209/40 ,  C07C213/02

CPC分类号： C07B53/00 ,  C07B57/00 ,  C07C209/40 ,  C07C213/02 ,  C07C29/143 ,  C07B2200/07

摘要： A process for preparing an optically active alcohol by reacting a prochiral ketone corresponding to the optically active alcohol and an acid with a mixture of (1) a boron-containing compound selected from the group consisting of i) a borane compound which is obtained from an optically active .beta.-aminoalcohol and a boron hydride; or obtained from the optically active .beta.-aminoalcohol, a metal borohydride and an acid and ii) an optically active oxazaborolidine and (2) a metal borohydride; and a process for preparing an optically active amine by reacting an oxime derivative and an acid with a mixture of (1) a boron-containing compound selected from the group consisting of i) a borane compound which is obtained from an optically active .beta.-aminoalcohol and a boron hydride, or obtained from said optically active .beta.-aminoalcohol, a metal borohydride and an acid and ii) an optically active oxazaborolidine, and (2) a metal borohydride.

公开(公告)号：US5717116A

公开(公告)日：1998-02-10

申请号：US624084

申请日：1996-03-29

申请人： Kenji Saito ,  Norio Kometani ,  Azusa Fujiwara ,  Yukio Yoneyoshi ,  Gohfu Suzukamo

发明人： Kenji Saito ,  Norio Kometani ,  Azusa Fujiwara ,  Yukio Yoneyoshi ,  Gohfu Suzukamo

IPC分类号： C07D301/26 ,  C07D303/02 ,  C12P7/62 ,  C12P41/00 ,  C07D301/24

CPC分类号： C07D303/02 ,  C07D301/26 ,  C12P41/004 ,  C12P7/62

摘要： The present invention provides a process for producing (R)-styrene oxides represented by the formula (1): ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and X are as defined in the specification, which comprises treating a mixture of (R)- and (S)-phenylhalogenomethylcarbinols with a lipase in the presence of a carboxylate to preferentially convert the (S)-phenylhalogenomethylcarbinols, and treating a mixture of the formed carbinol alkylates (3) and (R)-phenylhalogenomethylcarbinols with a base to cyclize the (R)-phenylhalogenomethylcarbinols, and also provides an industrially excellent process for producing (R)-styrene oxides (1) which comprises using a mixture enriched with (R)-phenylhalogenomethylcarbinols as the mixture of (R)- and (S)-phenylhalogenomethylcarbinols (2).

摘要翻译： 本发明提供一种由式（1）表示的（R） - 苯乙烯氧化物的制备方法：其中R 1，R 2，R 3和X如说明书中所定义，其包括将 R） - 和（S） - 苯基卤代甲基甲醇与羧酸酯存在下的脂肪酶以优先转化（S） - 苯基卤代甲基甲醇，并将形成的烷基醇烷基化物（3）和（R） - 苯基卤代甲基甲醇的混合物与碱反应 （R） - 苯基卤代甲基甲醇环化，并且还提供了工业上优异的（R） - 苯乙烯氧化物（1）的制备方法，其包括使用（R） - 苯基卤代甲基甲醇作为（R） - 和（S） - 苯基卤甲基甲醇（2）。

公开(公告)号：US6156940A

公开(公告)日：2000-12-05

申请号：US56797

申请日：1998-04-08

申请人： Kenji Saito ,  Norio Kometani ,  Azusa Fujiwara ,  Yukio Yoneyoshi ,  Gohfu Suzukamo

发明人： Kenji Saito ,  Norio Kometani ,  Azusa Fujiwara ,  Yukio Yoneyoshi ,  Gohfu Suzukamo

IPC分类号： C07C29/143 ,  C07D317/54 ,  C07C27/00

CPC分类号： C07D317/54 ,  C07C29/143 ,  C07B2200/07

摘要： The present invention relates to a process for producing optically active halomethyl phenyl carbinols of the formula (1), comprising reducing halomethyl phenyl ketones of the formula (2) using an asymmetric reducing agent obtained from boranes and optically active .alpha.-phenyl-substituted-.beta.-amino alcohols of the formula (3) or optically active .alpha.-non-substituted-.beta.-amino alcohols of the formula (4).The present invention further relates to a process for producing optically active carbinols, comprising reacting a prochiral ketone with, an asymmetric reducing agent obtained from optically active .beta.-amino alcohols of the formula (5), a metal boron hydride and Lewis acid or lower dialkyl sulfuric acid. All of the formulas (1) to (5) are the same as shown in the specification.

摘要翻译： 本发明涉及一种制备式（1）的光学活性卤代甲基苯基甲醇的方法，其包括使用由硼烷和光学活性的α-苯基取代的β取代的β-不饱和还原剂还原式（2）的卤代甲基苯基酮 （3）的氨基醇或式（4）的光学活性的α-壬基取代的β-氨基醇。 本发明还涉及一种光学活性甲醇的制备方法，其包括使前手性酮与由式（5）的光学活性β-氨基醇获得的不对称还原剂，金属硼氢化物和路易斯酸或低级二烷基 硫酸。 所有式（1）至（5）与说明书中所示的相同。

公开(公告)号：US6025531A

公开(公告)日：2000-02-15

申请号：US89349

申请日：1998-06-03

申请人： Yukio Yoneyoshi ,  Naoto Konya ,  Gohfu Suzukamo

发明人： Yukio Yoneyoshi ,  Naoto Konya ,  Gohfu Suzukamo

IPC分类号： C07B53/00 ,  C07B57/00 ,  C07C29/143 ,  C07C33/34 ,  C07C209/40 ,  C07C213/02

CPC分类号： C07B53/00 ,  C07B57/00 ,  C07C209/40 ,  C07C213/02 ,  C07C29/143 ,  C07B2200/07

摘要： A process for preparing an optically active alcohol by reacting a prochiral ketone corresponding to the optically active alcohol and an acid with a mixture of (1) a boron-containing compound selected from the group consisting of i) a borane compound which is obtained from an optically active .beta.-aminoalcohol and a boron hydride; or obtained from the optically active .beta.-aminoalcohol, a metal borohydride and an acid and ii) an optically active oxazaborolidine and (2) a metal borohydride; and a process for preparing an optically active amine by reacting an oxime derivative and an acid with a mixture of (1) a boron-containing compound selected from the group consisting of i) a borane compound which is obtained from an optically active .beta.-aminoalcohol and a boron hydride, or obtained from said optically active .beta.-aminoalcohol, a metal borohydride and an acid and ii) an optically active oxazaborolidine, and (2) a metal borohydride.

摘要翻译： 通过使对应于光学活性醇的前手性酮与酸与（1）选自以下的混合物的混合物反应制备光学活性醇的方法：i）硼烷化合物，其由 光学活性β-氨基醇和硼氢化物; 或由光学活性β-氨基醇，金属硼氢化物和酸获得，和ii）光学活性的恶唑硼烷和（2）金属硼氢化物; 和通过使肟衍生物和酸与（1）选自以下的含硼化合物的混合物制备光学活性胺的方法：i）由光学活性β-氨基醇获得的硼烷化合物 和硼氢化物，或从所述光学活性β-氨基醇，金属硼氢化物和酸获得的硼氢化物，和ii）光学活性的恶唑硼烷，和（2）金属硼氢化物。

公开(公告)号：US4749809A

公开(公告)日：1988-06-07

申请号：US750255

申请日：1985-07-01

申请人： Yukio Yoneyoshi ,  Gohfu Suzukamo ,  Kazuhiko Hamada ,  Toshio Nishioka

发明人： Yukio Yoneyoshi ,  Gohfu Suzukamo ,  Kazuhiko Hamada ,  Toshio Nishioka

IPC分类号： C07B31/00 ,  C07B53/00 ,  C07C67/00 ,  C07D233/60 ,  C07D249/08 ,  C07D521/00 ,  C07F5/02

CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07F5/022

摘要： The present invention relates to an optically active borane complex represented by the general formula, ##STR1## wherein R.sup.1 represents an aryl group, R.sup.2 represents an alkyl group and a mark * means an asymmetric carbon, and a method for producing optically active alcohol derivatives by the reduction of prochiral ketones with said borane complex. The optically active alcohol derivative is useful for fungicides, herbicides or plant growth regulators.

摘要翻译： 本发明涉及一种由通式表示的光学活性硼烷配合物，其中R1表示芳基，R2表示烷基，标记*表示不对称碳，以及通过以下方式制备光学活性醇衍生物的方法： 用所述硼烷络合物还原前手性酮。 光学活性醇衍生物可用于杀真菌剂，除草剂或植物生长调节剂。

公开(公告)号：US5145998A

公开(公告)日：1992-09-08

申请号：US593384

申请日：1990-10-02

申请人： Yoji Sakito ,  Gohfu Suzukamo ,  Yukio Yoneyoshi

发明人： Yoji Sakito ,  Gohfu Suzukamo ,  Yukio Yoneyoshi

IPC分类号： C07B53/00

CPC分类号： C07B53/00

摘要： A method for producing an optically active amine which is an important compound as a resolving agent for medicines, agricultural chemicals, intermediates thereof, etc is disclosed.

摘要翻译： 公开了作为药物用分解剂，农药，中间体等的重要化合物的光学活性胺的制造方法。

公开(公告)号：US5120853A

公开(公告)日：1992-06-09

申请号：US652607

申请日：1991-02-08

申请人： Yukio Yoneyoshi ,  Gohfu Suzukamo ,  Yoji Sakito

发明人： Yukio Yoneyoshi ,  Gohfu Suzukamo ,  Yoji Sakito

IPC分类号： B01J23/40 ,  B01J23/44 ,  B01J25/02 ,  B01J31/14 ,  C07B31/00 ,  C07B41/02 ,  C07B43/04 ,  C07B53/00 ,  C07B61/00 ,  C07C27/00 ,  C07C29/143 ,  C07C31/02 ,  C07C31/125 ,  C07C33/20 ,  C07C67/00 ,  C07C209/00 ,  C07C209/40 ,  C07C211/03 ,  C07C211/27 ,  C07C211/29 ,  C07C211/35 ,  C07C211/42 ,  C07C211/44 ,  C07C211/57 ,  C07C213/00 ,  C07C213/02 ,  C07C215/50 ,  C07C217/58 ,  C07C251/48 ,  C07D249/08 ,  C07D521/00 ,  C07F5/02

CPC分类号： C07D249/08 ,  C07C29/143 ,  C07D231/12 ,  C07D233/56 ,  C07B2200/07

摘要： The optically active benzylamine derivatives of the present invention are very useful for use as the asymmetric ligand of an asymmetric reducing agent. By using the optically active amine-boron complex prepared from the compound of the present invention, optically active products can be obtained in a specifically high optical yield. Moreover, the separation and recovery of the reaction products and asymmetric ligand can be easily achieved.

公开(公告)号：US4923999A

公开(公告)日：1990-05-08

申请号：US169056

申请日：1988-03-16

申请人： Yukio Yoneyoshi ,  Gohfu Suzukamo ,  Kazuhiko Hamada ,  Toshio Nishioka

发明人： Yukio Yoneyoshi ,  Gohfu Suzukamo ,  Kazuhiko Hamada ,  Toshio Nishioka

IPC分类号： C07B31/00 ,  C07B53/00 ,  C07C67/00 ,  C07D233/60 ,  C07D249/08 ,  C07D521/00 ,  C07F5/02

CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07F5/022

摘要： The present invention relates to an optically active borane complex represented by the general formula, ##STR1## wherein R.sup.1 represents an aryl group, R.sup.2 represents an alkyl group and a mark * means an asymmetric carbon, and a method for producing optically active alcohol derivatives by the reduction of prochiral ketones with said borane complex. The optically active alcohol derivative is useful for fungicides, herbicides or plant growth regulators.