公开(公告)号：US20070021534A1

公开(公告)日：2007-01-25

申请号：US11184128

申请日：2005-07-19

申请人： Gregory Glenn ,  Simon Hodson

发明人： Gregory Glenn ,  Simon Hodson

IPC分类号： D21H19/54

CPC分类号： C08L3/02 ,  C08L29/04 ,  C08L97/02 ,  C08L2666/02

摘要： A fiber-reinforced and starch-based composition can be prepared by combining two fractions. The first fraction can include a gelatinized starch, water, and fibers, wherein the fibers are substantially homogenously mixed with the starch in an amount sufficient to structurally reinforce the mechanical characteristics of the starch-based composition. The second fraction is then combined with the first fraction, wherein the second fraction can include non-gelatinized starch, non-volatile plasticizer, and a water-resistant polymer. The composition is mixed so as to form a thermoplastic composition being capable of expanding when rapidly heated to above the boiling point of water and the softening point of the plasticized starch. Additionally, fiber-reinforced articles can be prepared from a method of processing the starch-based compositions. Such a method includes introducing the fiber-reinforced starch-based composition into a mold, and molding the composition into a fiber-reinforced article.

摘要翻译： 纤维增强和基于淀粉的组合物可以通过组合两个级分来制备。 第一级分可以包括糊化淀粉，水和纤维，其中纤维基本上与淀粉均匀混合，其量足以在结构上增强淀粉基组合物的机械特性。 然后将第二级分与第一级分组合，其中第二馏分可包括非胶凝淀粉，非挥发性增塑剂和耐水聚合物。 将组合物混合以形成当快速加热至高于水的沸点和增塑淀粉的软化点时能够膨胀的热塑性组合物。 此外，纤维增强制品可以由加工淀粉基组合物的方法制备。 这种方法包括将纤维增强的淀粉基组合物引入模具中，并将组合物模塑成纤维增强制品。

公开(公告)号：US20070021515A1

公开(公告)日：2007-01-25

申请号：US11184614

申请日：2005-07-19

申请人： Gregory Glenn ,  Simon Hodson

发明人： Gregory Glenn ,  Simon Hodson

IPC分类号： C08J9/00

CPC分类号： C08J9/125 ,  C08J2201/03 ,  C08J2303/00

摘要： An expandable starch-based composition includes a starch, a volatile blowing agent, a non-volatile plasticizer, nucleating agent, and a water-resistant polymer. The expandable starch-based composition can be characterized by having a plasticized starch capable of expanding when rapidly heated to above the boiling point of the volatile blowing agent and the softening point of the plasticized starch. The composition can be used in a method of manufacturing an expandable starch-based bead, wherein the method includes: introducing the composition into an extruder; heating and mixing the composition in order to yield a thermoplastic melt; extruding the thermoplastic melt through a die opening to yield an extruded strand; cooling the extruded strand; and cutting the cooled strand in to beads. The beads can be used in a method of manufacturing a biodegradable article, the method includes: providing a plurality of expandable starch-based beads; placing the beads into a mold cavity; rapidly heating the beads to a temperature greater than the boiling point of the volatile blowing agent; causing at least a portion of the expanded beads to adhere together to form an intermediate molded body; and cooling the intermediate molded body to yield the article of manufacture.

摘要翻译： 一种可膨胀的淀粉基组合物包括淀粉，挥发性发泡剂，不挥发性增塑剂，成核剂和耐水聚合物。 可膨胀淀粉基组合物的特征在于具有当被快速加热到高于挥发性发泡剂的沸点以及增塑淀粉的软化点时能够膨胀的增塑淀粉。 该组合物可用于制造可膨胀淀粉基珠粒的方法，其中该方法包括：将组合物引入挤出机中; 加热和混合组合物以产生热塑性熔体; 通过模头挤出热塑性熔体以产生挤出的股线; 冷却挤出的股线; 并将冷却的线切割成珠。 珠粒可以用于制造可生物降解的制品的方法，该方法包括：提供多个可膨胀淀粉类珠粒; 将珠子放入模腔中; 将珠子快速加热至大于挥发性发泡剂沸点的温度; 使至少一部分发泡珠粒粘附在一起形成中间成型体; 并冷却中间成型体以产生制品。

公开(公告)号：US07344177B1

公开(公告)日：2008-03-18

申请号：US11595460

申请日：2006-11-09

申请人： Gregory Glenn

发明人： Gregory Glenn

IPC分类号： B60J1/04

CPC分类号： B60J3/0208

摘要： A sun visor extender and CD holder includes a frame and a pair of longitudinal sides. A plurality of notches is formed along a top surface of the sides. Oppositely disposed ends are formed with the sides and oriented orthogonal thereto. Open top and bottom faces define a central region between the sides and the ends. Straps traverse across a width of the frame and are anchored thereto and span subjacent to the top and bottom faces. A storage rack is attached to the frame and has shoulders bulging outwardly from a bottom surface thereof. The rack is oppositely faced from the straps and extends along an entire surface area of the top surface of the frame. A sun-blocking plate has a body interfitted between the sides and the ends and is supported by the straps.

摘要翻译： 遮阳板延伸器和CD支架包括框架和一对纵向侧面。 沿着侧面的顶表面形成多个凹口。 相对设置的端部形成有侧面并且与其正交定向。 敞开的顶面和底面限定了侧面和端部之间的中心区域。 带横过框架的宽度并锚定在其上并跨越顶面和底面的下方。 存储架附接到框架并且具有从其底表面向外凸出的肩部。 机架相对地从带子面对并且沿框架顶表面的整个表面区域延伸。 防晒板具有在侧面和端部之间相互配合并由带支撑的身体。

公开(公告)号：US20060028336A1

公开(公告)日：2006-02-09

申请号：US11245360

申请日：2005-10-05

申请人： Gregory Glenn ,  Damon Silva ,  Timothy Henry

发明人： Gregory Glenn ,  Damon Silva ,  Timothy Henry

IPC分类号： G08B1/00 ,  G08B1/08 ,  G08C19/16

CPC分类号： G01F23/0061 ,  G08B21/182 ,  G08B25/10 ,  H04L67/12 ,  H04Q9/00 ,  H04Q2209/40 ,  H04W4/70 ,  H04W84/18

摘要： A remote monitoring system includes a sensor interface, a processor, and a wireless communication interface. The sensor interface receives sensor information from a sensor coupled to the sensor interface. The processor processes the sensor information into at least one data packet for transferring to a server. The wireless communication interface transfers the data packet over wireless communications to the server.

公开(公告)号：US20060002960A1

公开(公告)日：2006-01-05

申请号：US11007282

申请日：2004-12-09

申请人： Paul Zoeteweij ,  Gregory Glenn ,  Larry Ellingsworth

发明人： Paul Zoeteweij ,  Gregory Glenn ,  Larry Ellingsworth

IPC分类号： A61K39/02

CPC分类号： A61K39/0258 ,  A61K39/08 ,  A61K39/39 ,  A61K2039/54 ,  A61K2039/55544 ,  A61K2039/6037 ,  Y02A50/474

摘要： Addition of a bacterial ADP-ribosylating exotoxin (bARE) to a formulation (e.g., immunogen or vaccine) or a system (e.g., patch or kit) for immunization enhances the immune response in a subject to one or more components of the formulation. Binding of the B subunit of a bARE to ganglioside GM1 of the subject in vivo, however, mediates toxicity and limits the use of native bARE as adjuvants. Mutation or in vitro coupling of the B subunit to ligands such as GM1 inhibits binding to GM1 in vivo, thereby eliminating toxicity but retaining desired adjuvant activity. The use of such detoxified, GM-1 binding deficient exotoxins provides a safe and potent new strategy for development of effective formulation for immunization.

摘要翻译： 将细菌ADP-核糖基化外毒素（bARE）加入制剂（例如免疫原或疫苗）或用于免疫的系统（例如贴剂或试剂盒）增强受试者对制剂的一种或多种组分的免疫应答。 bARE的B亚基与受试者的体内神经节苷脂GM1的结合然而介导毒性并限制使用天然bARE作为佐剂。 B亚基与配体如GM1的突变或体外偶联在体内抑制与GM1的结合，从而消除毒性，但保留所需的佐剂活性。 使用这种解毒的GM-1结合缺失的外毒素提供了一种安全有效的新策略，用于开发有效的免疫制剂。

公开(公告)号：US20060002959A1

公开(公告)日：2006-01-05

申请号：US11109948

申请日：2005-04-20

申请人： Gregory Glenn ,  Carl Alving

发明人： Gregory Glenn ,  Carl Alving

IPC分类号： A61K39/145

CPC分类号： A61K39/39 ,  A61K9/0019 ,  A61K9/0021 ,  A61K39/00 ,  A61K2039/54 ,  A61K2039/55544 ,  C12N2760/16134

摘要： Transcutaneous immunization can deliver antigen to the immune system through the stratum corneum without physical or chemical penetration to the dermis layer of the skin. This delivery system induces an antigen-specific immune response. Use of skin-active adjuvants is preferred. Although perforation of intact skin is not required, superficial penetration or micropenetration of the skin can act as an enhancer; similarly, hydration may enhance the immune response. This system can induce antigen-specific immune effectors after epicutaneous application of a formulation containing one or more antigen and adjuvant. The formulation may initiate processes such as antigen uptake, processing, and presentation; Langerhans cell activation, migration from the skin to other immune organs, and differentiation to mature dendritic cells; contacting antigen with lymphocytes bearing cognate antigen receptors on the cell surface and their stimulation; and combinations thereof. Systemic and/or regional immunity may be induced; immune responses that result in prophylaxis and/or therapeutic treatments are preferred. Antigen and adjuvant activities in the formulation may be found in the same molecule, two or more different molecules dissociated from each other, or multiple molecules in a complex formed by covalent or non-covalent bonds. For antigens and adjuvants which are proteinaceous, they may be provided in the formulation as a polynucleotide for transcutaneous genetic immunization. Besides simple application of a liquid formulation, patches or other medical devices may be used to deliver antigen for immunization.

摘要翻译： 经皮免疫可通过角质层将免疫系统的抗原递送到皮肤真皮层，而不会物理或化学渗透到真皮层。 该递送系统诱导抗原特异性免疫应答。 优选使用皮肤活性佐剂。 虽然不需要完整皮肤的穿孔，但皮肤的表面渗透或微穿透可以作为增强剂; 类似地，水合可以增强免疫应答。 该系统在表皮施用含有一种或多种抗原和佐剂的制剂后可以诱导抗原特异性免疫效应物。 制剂可以引发诸如抗原摄取，加工和表达的过程; 朗格汉斯细胞活化，从皮肤迁移到其他免疫器官，并分化成成熟树突状细胞; 使抗原与淋巴细胞接触细胞表面的同源抗原受体及其刺激; 及其组合。 可能诱发全身和/或区域免疫; 导致预防和/或治疗性治疗的免疫应答是优选的。 制剂中的抗原和佐剂活性可以在相同的分子中发现，两个或更多个不同的分子彼此离解，或者是通过共价或非共价键形成的复合物中的多个分子。 对于蛋白质的抗原和佐剂，它们可以作为经皮基因免疫的多核苷酸提供在制剂中。 除了液体制剂的简单应用之外，可以使用贴片或其他医疗装置来递送用于免疫的抗原。

公开(公告)号：US20060002949A1

公开(公告)日：2006-01-05

申请号：US11141690

申请日：2005-06-01

申请人： Gregory Glenn ,  Carl Alving

发明人： Gregory Glenn ,  Carl Alving

IPC分类号： A61K39/00

CPC分类号： A61K39/08 ,  A61K39/008 ,  A61K39/015 ,  A61K39/0258 ,  A61K39/05 ,  A61K39/099 ,  A61K39/102 ,  A61K39/104 ,  A61K39/107 ,  A61K39/116 ,  A61K39/12 ,  A61K2039/5252 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/55505 ,  A61K2039/55522 ,  A61K2039/55533 ,  A61K2039/55544 ,  A61K2039/55555 ,  A61K2039/55561 ,  A61K2039/70 ,  C12N2740/16234 ,  C12N2760/16134 ,  C12N2760/16234 ,  C12N2760/20134 ,  Y02A50/474

摘要： Transcutaneous immunization can deliver antigen to the immune system through the stratum corneum without physical or chemical penetration to the dermis layer of the skin. This delivery system induces an antigen-specific immune response without the use of a heterologous adjuvant. Although perforation of intact skin is not required, superficial penetration or micropenetration of the skin can act as an enhancer; similarly, hydration may enhance the immune response. This system can induce antigen-specific immune effectors after epicutaneous application of a formulation containing one or more antigens. The formulation may initiate processes such as antigen uptake, processing, and presentation; Langerhans cell activation, migration from the skin to other immune organs, and differentiation to mature dendritic cells; contacting antigen with lymphocytes bearing cognate antigen receptors on the cell surface and their stimulation; and combinations thereof. Systemic and/or regional immunity may be induced. Immune responses that provide prophylactic and/or therapeutic treatments are preferred. Antigenic activities in the formulation may be found in the same molecule, two or more different molecules dissociated from each other, or multiple molecules in a complex formed by covalent or non-covalent bonds. For antigens which are proteinaceous, they may be provided in the formulation as a polynucleotide for transcutaneous genetic immunization. Besides simple application of a dry or liquid formulation to the skin, patches and other medical devices may be used to deliver antigen for immunization.

摘要翻译： 经皮免疫可通过角质层将免疫系统的抗原递送到皮肤真皮层，而不会物理或化学渗透到真皮层。 该递送系统在不使用异源佐剂的情况下诱导抗原特异性免疫应答。 虽然不需要完整皮肤的穿孔，但皮肤的表面渗透或微穿透可以作为增强剂; 类似地，水合可以增强免疫应答。 该系统可以在外皮施用含有一种或多种抗原的制剂后诱导抗原特异性免疫效应物。 制剂可以引发诸如抗原摄取，加工和表达的过程; 朗格汉斯细胞活化，从皮肤迁移到其他免疫器官，并分化成成熟树突状细胞; 使抗原与淋巴细胞接触细胞表面的同源抗原受体及其刺激; 及其组合。 可诱导全身和/或区域免疫。 提供预防和/或治疗治疗的免疫应答是优选的。 制剂中的抗原活性可以在相同的分子中发现，两个或更多个不同的分子彼此解离，或者通过共价或非共价键形成的复合物中的多个分子。 对于蛋白质的抗原，它们可以作为经皮基因免疫的多核苷酸提供在制剂中。 除了干燥或液体制剂对皮肤的简单应用之外，还可以使用贴片和其它医疗装置来递送用于免疫的抗原。

公开(公告)号：US20050083197A1

公开(公告)日：2005-04-21

申请号：US10684583

申请日：2003-10-15

申请人： Gregory Glenn ,  Damon Silva ,  Timothy Henry

发明人： Gregory Glenn ,  Damon Silva ,  Timothy Henry

IPC分类号： G05B23/02 ,  G08B25/10 ,  G08B1/08

CPC分类号： G01F23/0061 ,  G08B21/182 ,  G08B25/10 ,  H04L67/12 ,  H04Q9/00 ,  H04Q2209/40 ,  H04W4/70 ,  H04W84/18

摘要： An apparatus and method for efficiently collecting data at a remote device with a device that is able to use both analog and digital signals, especially those that are compliant with serial data interface twelve (SDI-12) protocol. The collected data is compressed into a packet and sent to a base station where it is made available. Additionally, the present invention is able to produce alarms in response to the detection of an alarm condition. This data is able to be viewed from virtually anywhere.

摘要翻译： 一种用于利用能够使用模拟和数字信号的设备，特别是符合串行数据接口十二（SDI-12）协议的设备在远程设备上有效收集数据的装置和方法。 收集的数据被压缩成一个数据包，并发送到一个可用的基站。 此外，本发明能够响应于警报状态的检测而产生警报。 这些数据可以从几乎任何地方查看。

公开(公告)号：US20050072457A1

公开(公告)日：2005-04-07

申请号：US10677191

申请日：2003-10-02

申请人： Gregory Glenn

发明人： Gregory Glenn

IPC分类号： H01L31/02 ,  H01L31/00

CPC分类号： H01L31/052 ,  H01L27/1421 ,  H01L31/0504 ,  Y02E10/50

摘要： A solar cell structure has a solar cell unit structure including a heat sink, and a solar cell having a front side, a back side, and a solar-cell projected area coverage on the heat sink. The solar cell has an active semiconductor structure that produces a voltage between the front side and the back side when the front side is illuminated. An intermediate structure is disposed between and joined to the back side of the solar cell and to the heat sink. The intermediate structure has an intermediate-structure projected area coverage on the heat sink and includes a by-pass diode having a diode projected area coverage on the heat sink. The diode projected area coverage on the heat sink may be substantially the same as the intermediate-structure projected coverage on the heat sink. Alternatively, the diode projected area coverage on the heat sink maybe less than the solar-cell projected area coverage on the heat sink, and the intermediate structure further includes a substrate coplanar with the by-pass diode.

摘要翻译： 太阳能电池结构具有包括散热器的太阳能电池单元结构和在散热片上具有正面，背面和太阳能电池投影面积的太阳能电池。 太阳能电池具有有源半导体结构，当正面被照亮时，该半导体结构在正面和背面之间产生电压。 中间结构设置在太阳能电池的背面并连接到散热片。 中间结构在散热器上具有中间结构的投影面积，并且包括在散热器上具有二极管投影面积的旁路二极管。 散热片上的二极管投影面积可能与散热片上的中间结构投影覆盖基本相同。 或者，散热器上的二极管投影面积可以小于散热器上的太阳能电池投影面积，并且中间结构还包括与旁路二极管共面的衬底。

公开(公告)号：US20070088248A1

公开(公告)日：2007-04-19

申请号：US11516462

申请日：2006-09-05

申请人： Gregory Glenn ,  Kyle Doerksen ,  Larry Ellingsworth ,  Diane Epperson ,  David Frerichs ,  Mervyn Hamer ,  Aaron Henningsgaard ,  Matthew Inouye ,  Adrian James ,  Jonathan Kaplan ,  John Lai ,  Robert Lister ,  David Lubensky ,  Peter MacDonald ,  Sally Madsen ,  Brian Mason ,  Christine McElhaney ,  Lionel Mohri ,  Anthony Pigliacampo ,  Gina Romero ,  Charles Steeves ,  Christina Villar ,  Jianmei Yu

发明人： Gregory Glenn ,  Kyle Doerksen ,  Larry Ellingsworth ,  Diane Epperson ,  David Frerichs ,  Mervyn Hamer ,  Aaron Henningsgaard ,  Matthew Inouye ,  Adrian James ,  Jonathan Kaplan ,  John Lai ,  Robert Lister ,  David Lubensky ,  Peter MacDonald ,  Sally Madsen ,  Brian Mason ,  Christine McElhaney ,  Lionel Mohri ,  Anthony Pigliacampo ,  Gina Romero ,  Charles Steeves ,  Christina Villar ,  Jianmei Yu

IPC分类号： A61B17/20

CPC分类号： A61B17/20 ,  A61B17/205 ,  A61B2017/00115 ,  A61B2017/00761 ,  A61B2090/065 ,  A61M35/006 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0061

摘要： The invention provides devices for the disruption of one or more layers of skin and methods of their use to administer therapeutic agents, e.g., antigens or drugs. The devices are designed to disrupt a defined area of skin. The defined area can approximate the area that a patch or other suitable vehicle for therapeutic agent, e.g., drug or vaccine, delivery is designed to contact. Exemplary devices employ a mask to define the area to be disrupted. Other devices disrupt a defined area by rotating in place. For devices that employ a mask that is secured to the skin, the invention provides methods of disrupting the stratum corneum by first securing the mask to the skin and then disrupting the skin. For rotating devices, the disrupting member is simply placed against the skin and actuated to effect disruption.

摘要翻译： 本发明提供用于破坏一层或多层皮肤的装置及其用于施用治疗剂例如抗原或药物的方法。 这些设备旨在破坏定义的皮肤区域。 限定的面积可以近似用于治疗剂（例如药物或疫苗）递送被设计为接触的贴剂或其它合适载体的区域。 示例性设备使用掩模来限定待破坏的区域。 其他设备通过旋转到位来破坏定义的区域。 对于使用固定在皮肤上的面罩的装置，本发明提供了通过首先将面罩固定在皮肤上然后破坏皮肤来破坏角质层的方法。 对于旋转装置，干扰构件被简单地放置在皮肤上并被致动以实现中断。