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    Skin-sctive adjuvants for transcutaneous immuization
    2.
    发明申请
    Skin-sctive adjuvants for transcutaneous immuization 审中-公开
    用于经皮免疫的皮肤辅助剂

    公开(公告)号：US20060002959A1

    公开(公告)日：2006-01-05

    申请号：US11109948

    申请日：2005-04-20

    申请人： Gregory Glenn ,  Carl Alving

    发明人： Gregory Glenn ,  Carl Alving

    IPC分类号： A61K39/145

    CPC分类号： A61K39/39 ,  A61K9/0019 ,  A61K9/0021 ,  A61K39/00 ,  A61K2039/54 ,  A61K2039/55544 ,  C12N2760/16134

    摘要： Transcutaneous immunization can deliver antigen to the immune system through the stratum corneum without physical or chemical penetration to the dermis layer of the skin. This delivery system induces an antigen-specific immune response. Use of skin-active adjuvants is preferred. Although perforation of intact skin is not required, superficial penetration or micropenetration of the skin can act as an enhancer; similarly, hydration may enhance the immune response. This system can induce antigen-specific immune effectors after epicutaneous application of a formulation containing one or more antigen and adjuvant. The formulation may initiate processes such as antigen uptake, processing, and presentation; Langerhans cell activation, migration from the skin to other immune organs, and differentiation to mature dendritic cells; contacting antigen with lymphocytes bearing cognate antigen receptors on the cell surface and their stimulation; and combinations thereof. Systemic and/or regional immunity may be induced; immune responses that result in prophylaxis and/or therapeutic treatments are preferred. Antigen and adjuvant activities in the formulation may be found in the same molecule, two or more different molecules dissociated from each other, or multiple molecules in a complex formed by covalent or non-covalent bonds. For antigens and adjuvants which are proteinaceous, they may be provided in the formulation as a polynucleotide for transcutaneous genetic immunization. Besides simple application of a liquid formulation, patches or other medical devices may be used to deliver antigen for immunization.

    摘要翻译： 经皮免疫可通过角质层将免疫系统的抗原递送到皮肤真皮层，而不会物理或化学渗透到真皮层。 该递送系统诱导抗原特异性免疫应答。 优选使用皮肤活性佐剂。 虽然不需要完整皮肤的穿孔，但皮肤的表面渗透或微穿透可以作为增强剂; 类似地，水合可以增强免疫应答。 该系统在表皮施用含有一种或多种抗原和佐剂的制剂后可以诱导抗原特异性免疫效应物。 制剂可以引发诸如抗原摄取，加工和表达的过程; 朗格汉斯细胞活化，从皮肤迁移到其他免疫器官，并分化成成熟树突状细胞; 使抗原与淋巴细胞接触细胞表面的同源抗原受体及其刺激; 及其组合。 可能诱发全身和/或区域免疫; 导致预防和/或治疗性治疗的免疫应答是优选的。 制剂中的抗原和佐剂活性可以在相同的分子中发现，两个或更多个不同的分子彼此离解，或者是通过共价或非共价键形成的复合物中的多个分子。 对于蛋白质的抗原和佐剂，它们可以作为经皮基因免疫的多核苷酸提供在制剂中。 除了液体制剂的简单应用之外，可以使用贴片或其他医疗装置来递送用于免疫的抗原。

    Antibodies with simultaneous subsite specificities to protein and lipid epitopes
    6.
    发明申请
    Antibodies with simultaneous subsite specificities to protein and lipid epitopes 有权
    具有蛋白质和脂质表位同时亚位点特异性的抗体

    公开(公告)号：US20070072225A1

    公开(公告)日：2007-03-29

    申请号：US11525574

    申请日：2006-09-22

    申请人： Carl Alving

    发明人： Carl Alving

    IPC分类号： C12Q1/68 ,  C12P21/06 ,  C12N5/06 ,  C12N5/16

    CPC分类号： C07K16/1063 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/545 ,  A61K2039/55555 ,  A61K2039/55572 ,  A61K2039/6018 ,  C07K16/1045 ,  C07K16/18 ,  C07K16/468 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/76 ,  C12N2740/16034 ,  C12N2740/16134

    摘要： Antibodies and method of making antibodies, either monoclonal or polyclonal wherein said antibodies have dual or multi-specific binding capacity to more than one type of antigenic epitope. The antibodies have simultaneous or independent recognition subsites to each of the epitopes. Antigenic epitopes include lipids, peptides, proteins, amino acid sequences, sugars and carbohydrates. Monoclonal antibodies and a method of making monoclonal antibodies of the invention include monoclonal antibodies that are broadly neutralizing to HIV-1 or other envelop viruses wherein the monoclonal antibody has subsites that simultaneously recognize protein and lipid epitopes from the virus.

    摘要翻译： 制备抗体的抗体和方法，单克隆或多克隆，其中所述抗体对多于一种类型的抗原表位具有双重或多特异性结合能力。 抗体对每个表位具有同时或独立的识别子。 抗原表位包括脂质，肽，蛋白质，氨基酸序列，糖和碳水化合物。 单克隆抗体和制备本发明的单克隆抗体的方法包括广泛中和HIV-1或其它包膜病毒的单克隆抗体，其中单克隆抗体具有同时从病毒识别蛋白质和脂质表位的亚群。

    Transcutaneous immunization without heterologous adjuvant
    8.
    发明申请
    Transcutaneous immunization without heterologous adjuvant 审中-公开
    没有异源佐剂的经皮免疫

    公开(公告)号：US20060002949A1

    公开(公告)日：2006-01-05

    申请号：US11141690

    申请日：2005-06-01

    申请人： Gregory Glenn ,  Carl Alving

    发明人： Gregory Glenn ,  Carl Alving

    IPC分类号： A61K39/00

    CPC分类号： A61K39/08 ,  A61K39/008 ,  A61K39/015 ,  A61K39/0258 ,  A61K39/05 ,  A61K39/099 ,  A61K39/102 ,  A61K39/104 ,  A61K39/107 ,  A61K39/116 ,  A61K39/12 ,  A61K2039/5252 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/55505 ,  A61K2039/55522 ,  A61K2039/55533 ,  A61K2039/55544 ,  A61K2039/55555 ,  A61K2039/55561 ,  A61K2039/70 ,  C12N2740/16234 ,  C12N2760/16134 ,  C12N2760/16234 ,  C12N2760/20134 ,  Y02A50/474

    摘要： Transcutaneous immunization can deliver antigen to the immune system through the stratum corneum without physical or chemical penetration to the dermis layer of the skin. This delivery system induces an antigen-specific immune response without the use of a heterologous adjuvant. Although perforation of intact skin is not required, superficial penetration or micropenetration of the skin can act as an enhancer; similarly, hydration may enhance the immune response. This system can induce antigen-specific immune effectors after epicutaneous application of a formulation containing one or more antigens. The formulation may initiate processes such as antigen uptake, processing, and presentation; Langerhans cell activation, migration from the skin to other immune organs, and differentiation to mature dendritic cells; contacting antigen with lymphocytes bearing cognate antigen receptors on the cell surface and their stimulation; and combinations thereof. Systemic and/or regional immunity may be induced. Immune responses that provide prophylactic and/or therapeutic treatments are preferred. Antigenic activities in the formulation may be found in the same molecule, two or more different molecules dissociated from each other, or multiple molecules in a complex formed by covalent or non-covalent bonds. For antigens which are proteinaceous, they may be provided in the formulation as a polynucleotide for transcutaneous genetic immunization. Besides simple application of a dry or liquid formulation to the skin, patches and other medical devices may be used to deliver antigen for immunization.

    摘要翻译： 经皮免疫可通过角质层将免疫系统的抗原递送到皮肤真皮层，而不会物理或化学渗透到真皮层。 该递送系统在不使用异源佐剂的情况下诱导抗原特异性免疫应答。 虽然不需要完整皮肤的穿孔，但皮肤的表面渗透或微穿透可以作为增强剂; 类似地，水合可以增强免疫应答。 该系统可以在外皮施用含有一种或多种抗原的制剂后诱导抗原特异性免疫效应物。 制剂可以引发诸如抗原摄取，加工和表达的过程; 朗格汉斯细胞活化，从皮肤迁移到其他免疫器官，并分化成成熟树突状细胞; 使抗原与淋巴细胞接触细胞表面的同源抗原受体及其刺激; 及其组合。 可诱导全身和/或区域免疫。 提供预防和/或治疗治疗的免疫应答是优选的。 制剂中的抗原活性可以在相同的分子中发现，两个或更多个不同的分子彼此解离，或者通过共价或非共价键形成的复合物中的多个分子。 对于蛋白质的抗原，它们可以作为经皮基因免疫的多核苷酸提供在制剂中。 除了干燥或液体制剂对皮肤的简单应用之外，还可以使用贴片和其它医疗装置来递送用于免疫的抗原。