公开(公告)号：US09149388B2

公开(公告)日：2015-10-06

申请号：US12893149

申请日：2010-09-29

申请人： Guangyao Jia ,  Ahmad Salehi ,  Glenn Robert Sussman ,  Ann Yadlowsky

发明人： Guangyao Jia ,  Ahmad Salehi ,  Glenn Robert Sussman ,  Ann Yadlowsky

IPC分类号： A61F9/007 ,  A61B18/12 ,  A61B18/00 ,  A61B18/14

CPC分类号： A61F9/00754 ,  A61B2018/00321 ,  A61B2018/00702 ,  A61B2018/00726 ,  A61B2018/1407

摘要： A capsulorhexis apparatus includes a capsulorhexis probe configured for insertion into an eye through an incision and a pulse generator configured to deliver at least one radio-frequency (RF) pulse to the capsulorhexis probe. The delivered RF pulse has a pre-determined attenuation profile such that the power level of the delivered RF pulse is substantially attenuated over the RF pulse's duration. In some embodiments, the pulse generator is configured to deliver a series of two or more RF pulses to the eye, such that the energy of each of the second and subsequent pulses of the series is substantially attenuated relative to the energy of the immediately preceding pulse.

摘要翻译： 撕囊术装置包括被配置用于通过切口插入眼睛的撕囊切口探针和构造成将至少一个射频（RF）脉冲输送到撕囊切除探针的脉冲发生器。 递送的RF脉冲具有预定的衰减分布，使得所传送的RF脉冲的功率电平在RF脉冲的持续时间上基本上衰减。 在一些实施例中，脉冲发生器被配置为向眼睛递送一系列两个或更多个RF脉冲，使得该系列的第二个和后续脉冲中的每个的能量相对于紧接在前的脉冲的能量基本衰减 。

公开(公告)号：US20120078242A1

公开(公告)日：2012-03-29

申请号：US12893149

申请日：2010-09-29

申请人： Guangyao Jia ,  Ahmed Salehi ,  Glenn Robert Sussman ,  Ann Yadlowsky

发明人： Guangyao Jia ,  Ahmed Salehi ,  Glenn Robert Sussman ,  Ann Yadlowsky

IPC分类号： A61B18/04

CPC分类号： A61F9/00754 ,  A61B2018/00321 ,  A61B2018/00702 ,  A61B2018/00726 ,  A61B2018/1407

摘要： A capsulorhexis apparatus includes a capsulorhexis probe configured for insertion into an eye through an incision and a pulse generator configured to deliver at least one radio-frequency (RF) pulse to the capsulorhexis probe. The delivered RF pulse has a pre-determined attenuation profile such that the power level of the delivered RF pulse is substantially attenuated over the RF pulse's duration. In some embodiments, the pulse generator is configured to deliver a series of two or more RF pulses to the eye, such that the energy of each of the second and subsequent pulses of the series is substantially attenuated relative to the energy of the immediately preceding pulse.

摘要翻译： 撕囊术装置包括被配置用于通过切口插入眼睛的撕囊切口探针和构造成将至少一个射频（RF）脉冲输送到撕囊切除探针的脉冲发生器。 递送的RF脉冲具有预定的衰减分布，使得所传送的RF脉冲的功率电平在RF脉冲的持续时间上基本上衰减。 在一些实施例中，脉冲发生器被配置为向眼睛递送一系列两个或更多个RF脉冲，使得该系列的第二个和后续脉冲中的每一个的能量相对于紧接在前的脉冲的能量基本衰减 。

公开(公告)号：US20110202049A1

公开(公告)日：2011-08-18

申请号：US12707747

申请日：2010-02-18

申请人： Guangyao Jia ,  Glenn Robert Sussman

发明人： Guangyao Jia ,  Glenn Robert Sussman

IPC分类号： A61F9/007 ,  A61B18/08

CPC分类号： A61B18/08 ,  A61F9/00781 ,  A61F9/0079 ,  A61F2009/00868 ,  A61F2009/00891

摘要： An ablation probe for use in glaucoma surgery has a shaft, a heating element, and a pair of electrical connectors located on a distal end of the shaft. The pair of electrical connectors holds the heating element to the shaft. The heating element is sized and shaped to ablate a trabecular meshwork in a human eye. The ablation probe is advanced through a corneal incision until the heating element contacts the trabecular meshwork. An electrical current is passed through the heating element to ablate the trabecular meshwork.

摘要翻译： 用于青光眼手术的消融探针具有轴，加热元件和位于轴的远端上的一对电连接器。 一对电连接器将加热元件固定在轴上。 加热元件的尺寸和形状适于消除人眼中的小梁网。 消融探针通过角膜切口前进，直到加热元件接触小梁网。 电流通过加热元件以消融小梁网。

公开(公告)号：US08137344B2

公开(公告)日：2012-03-20

申请号：US12331800

申请日：2008-12-10

申请人： Guangyao Jia ,  Daniel J. Kao ,  Glenn Sussman

发明人： Guangyao Jia ,  Daniel J. Kao ,  Glenn Sussman

IPC分类号： A61B18/14

CPC分类号： A61F9/00754 ,  A61B18/14 ,  A61F9/0079

摘要： A capsularhexis electrode device and corresponding insertion tool are disclosed. A flexible capsulorhexis electrode device comprises an elastomeric ring, first and second electrically conductive traces disposed at a first face of the elastomeric ring and extending concentrically around the elastomeric ring, and first and second electrically conductive connectors. The first and second electrically conductive connectors are electrically connected to the first and second traces, respectively, and are disposed at opposing points across the elastomeric ring from one another. An insertion tool includes first and second stretcher bars with connectors for mating to the electrode device. One of the stretcher bars translates relative to the other to elongate the flexible electrode device for insertion into the anterior chamber of the eye through a small incision.

摘要翻译： 公开了一种胶囊切开电极装置和相应的插入工具。 柔性撕囊电极装置包括弹性体环，第一和第二导电迹线，设置在弹性体环的第一面处并且围绕弹性体环同心地延伸，以及第一和第二导电连接器。 第一和第二导电连接器分别电连接到第一和第二迹线，并且被布置在彼此穿过弹性体环的相对点处。 插入工具包括具有用于与电极装置配合的连接器的第一和第二担架杆。 一个拉伸杆相对于另一个平移，以伸长柔性电极装置，以通过小切口插入眼睛的前房。

公开(公告)号：US20110282335A1

公开(公告)日：2011-11-17

申请号：US12777820

申请日：2010-05-11

申请人： Guangyao Jia ,  Glenn R. Sussman

发明人： Guangyao Jia ,  Glenn R. Sussman

IPC分类号： A61B18/04

CPC分类号： A61B18/082 ,  A61B2018/00321 ,  A61B2018/141

摘要： Various embodiments of a capsule polishing device include a resistive-heating element including an electrically resistive, superelastic wire forming a loop between first and second ends of the superelastic wire. The first and second ends of the loop may at least partially extend from a planar face defined by the loop, to an insulating portion. In some embodiments, the capsule polishing device may be configured to perform active capsule polishing through a combination of hyperthermia of LECs and mechanical abrasion of the capsule surface. In some embodiments, at least a side and end portion of the loop of the capsule polishing device may be shaped to follow a contour of the capsule bag. The loop may be heated to approximately 40 to 47 degrees Celsius to destroy LECs (other temperatures are also possible). In some embodiments, the loop may include a roughened surface to increase mechanical abrasion.

摘要翻译： 胶囊抛光装置的各种实施例包括电阻加热元件，其包括形成在超弹性线的第一和第二端之间的环的电阻超弹性线。 环的第一和第二端可以至少部分地从由环限定的平面延伸到绝缘部分。 在一些实施例中，胶囊抛光装置可以被配置为通过LEC的热疗和胶囊表面的机械磨损的组合来执行活性胶囊抛光。 在一些实施例中，胶囊抛光装置的环的至少一个侧面和端部可以成形为跟随胶囊袋的轮廓。 环路可能被加热到大约40到47摄氏度以破坏LEC（其他温度也是可能的）。 在一些实施例中，环可以包括粗糙表面以增加机械磨损。

公开(公告)号：US20100312252A1

公开(公告)日：2010-12-09

申请号：US12477175

申请日：2009-06-03

申请人： Guangyao Jia ,  Glenn R. Sussman

发明人： Guangyao Jia ,  Glenn R. Sussman

IPC分类号： A61F9/00 ,  A61B18/04

CPC分类号： A61F9/00754 ,  A61B18/10 ,  A61B2018/00642 ,  A61F9/0079

摘要： Various embodiments of a capsularhexis device include a resistive-heating element comprising an electrically resistive, superelastic wire forming a loop between first and second ends of the superelastic wire. The loop may be retracted into a collapsed, retracted position or ejected into an expanded position. The first and second ends of the loop may at least partially extend at an angle from a planar face defined by the loop, to the insulating portion, to form a transitional neck between the loop and the insulating portion. The transitional neck may have a gap between the first and second ends at the insulating portion that is wider than a gap between the first and second ends on the opposing side of the transitional neck. The gap in the loop of superelastic wire may be sufficiently small to allow the loop to form a continuous cut in a capsule of an eye.

摘要翻译： 胶囊切开装置的各种实施例包括电阻加热元件，其包括形成在超弹性线的第一和第二端之间的环的电阻的超弹性线。 环可以缩回到收缩的缩回位置或者弹出到展开位置。 环的第一和第二端可以至少部分地从由环限定的平面到绝缘部分成一定角度延伸，以在环与绝缘部之间形成过渡的颈部。 过渡颈部可以在绝缘部分处的第一和第二端之间的间隙宽于过渡颈部的相对侧上的第一和第二端之间的间隙。 超弹性线圈的间隙可能足够小以允许环在眼胶囊中形成连续切口。

公开(公告)号：US20100312232A1

公开(公告)日：2010-12-09

申请号：US12754119

申请日：2010-04-05

申请人： Guangyao Jia ,  Glenn R. Sussman

发明人： Guangyao Jia ,  Glenn R. Sussman

IPC分类号： A61B18/04

CPC分类号： A61F9/00754 ,  A61B18/10 ,  A61B2018/00642

摘要： Various embodiments of a capsulotomy repair device include a resistive-heating element comprising an electrically resistive, superelastic wire forming a loop between first and second ends of the superelastic wire. The first and second ends of the loop may at least partially extend at an angle from a planar face defined by the loop, to an insulating portion, to form a transitional neck between the loop and the insulating portion. The capsulotomy repair device may be positioned in the eye relative to a capsularhexis perimeter to overlap tears in the capsularhexis periemeter to remove the tears by forming an adjusted capsularhexis perimeter by burning around the tear.

摘要翻译： 囊切开术修复装置的各种实施例包括电阻加热元件，该电阻加热元件包括形成在超弹性线的第一和第二端之间的环的电阻超弹性线。 环的第一和第二端可以至少部分地从由环限定的平面到一绝缘部分的角度延伸，以在环与绝缘部之间形成过渡的颈部。 囊切开术修复装置可以相对于胶囊切开周边定位在眼睛中，以覆盖胶囊切开周界中的泪液，以通过在泪液周围燃烧形成调节的胶囊切口周边来除去眼泪。

公开(公告)号：US20080190503A1

公开(公告)日：2008-08-14

申请号：US11816746

申请日：2006-02-28

申请人： Jim V. Zoval ,  Marc J. Madou ,  Horacio Kido ,  Guangyao Jia ,  Jitae Kim

发明人： Jim V. Zoval ,  Marc J. Madou ,  Horacio Kido ,  Guangyao Jia ,  Jitae Kim

IPC分类号： F15C3/00

CPC分类号： F16K99/0021 ,  B01L3/50273 ,  B01L2300/0806 ,  B01L2300/0864 ,  B01L2400/0409 ,  B01L2400/0412 ,  B01L2400/0622 ,  F16K99/0001 ,  F16K2099/0078 ,  F16K2099/0084 ,  Y10T137/2202

摘要： A microfluidic switching device includes a planar substrate having a central axis of rotation and a radially-oriented microchannel disposed in the planar substrate that terminates at a junction. In one aspect, the junction is formed as a double-layered junction in which an upstream portion is vertically offset from a downstream portion. In addition, the upstream portion has a smaller effective center of cross-sectional area than the downstream portion. First and rotation second outlet chambers are coupled at one end to the junction. The device is rotated about the central axis in a clockwise direction so as to cause the fluid in the reservoir to flow into the first (right) outlet chamber or in a counter-clockwise direction so as to cause the fluid in the reservoir to flow into the second (left) outlet chamber.

摘要翻译： 微流体开关装置包括具有中心旋转轴线的平面基板和设置在平面基板中的径向取向的微通道，其终止于连接处。 一方面，接合部形成为双层结，其中上游部分与下游部分垂直偏移。 此外，上游部分具有比下游部分更小的有效截面面积中心。 第一和第二旋转第二出口腔室在一端连接到结点。 装置围绕中心轴线顺时针方向旋转，以使储存器中的流体流入第一（右）出口腔室或逆时针方向，从而使储存器中的流体流入 第二（左）出口室。

公开(公告)号：US20080110500A1

公开(公告)日：2008-05-15

申请号：US11816843

申请日：2006-03-08

申请人： Horacio Kido ,  Marc J. Madou ,  Jim V. Zoval ,  Jitae Kim ,  Guangyao Jia

发明人： Horacio Kido ,  Marc J. Madou ,  Jim V. Zoval ,  Jitae Kim ,  Guangyao Jia

IPC分类号： F15C1/04

CPC分类号： B01L3/502738 ,  B01L3/502723 ,  B01L2200/0621 ,  B01L2300/0806 ,  B01L2300/0864 ,  B01L2400/0409 ,  B01L2400/0694 ,  F16K99/0001 ,  F16K99/0028 ,  F16K2099/0084 ,  G01N35/00069 ,  G01N2035/00247 ,  Y10T137/0324 ,  Y10T137/0357 ,  Y10T137/2202

摘要： A microfluidic device for the splitting or sequencing of fluid flow includes a plurality of upstream and/or downstream chambers coupled via microfluidic channels. For splitting fluid, a substrate is provided that includes a main chamber and a plurality of downstream sub-chambers. Each sub-chamber is associated with a sealable vent hole. Fluid is selectively moved into the desired sub-chamber of interest by unsealing its associated vent hole. Fluid is then pumped into the sub-chamber, for example, by rotating the substrate. For flow sequencing, a substrate is provided that includes a plurality of upstream chambers coupled to at least one downstream chamber. Each upstream chamber has an associated vent hole that can be selectively opened. The substrate is then rotated and fluid contained in the upstream chamber with the valve in the unsealed state will then pass to the at least one downstream chamber.

摘要翻译： 用于分流或排序流体流的微流体装置包括通过微流体通道连接的多个上游和/或下游腔室。 为了分离流体，提供了包括主室和多个下游子室的基板。 每个子室与可密封的通气孔相关联。 通过开封其相关联的通气孔将流体选择性地移动到所需的感兴趣的子室中。 然后例如通过旋转衬底将流体泵送到子室中。 对于流顺序，提供了包括耦合到至少一个下游室的多个上游室的基板。 每个上游室具有可以选择性地打开的相关联的通气孔。 然后使衬底旋转，并且包含在上游室中的流体，其中阀处于未密封状态，然后将传递到至少一个下游室。

公开(公告)号：US20050255233A1

公开(公告)日：2005-11-17

申请号：US11057389

申请日：2005-02-11

申请人： Marc Madou ,  Chunlei Wang ,  Guangyao Jia ,  Lili Taherabadi ,  Benjamin Park ,  Rabih Zaouk

发明人： Marc Madou ,  Chunlei Wang ,  Guangyao Jia ,  Lili Taherabadi ,  Benjamin Park ,  Rabih Zaouk

IPC分类号： B05D5/12 ,  H01M4/58 ,  H01M4/583 ,  H01M4/66

CPC分类号： H01M4/583 ,  H01M4/663

摘要： C-MEMS architecture having high aspect ratio carbon structures and improved systems and methods for producing high aspect ratio C-MEMS structures are provided. Specifically, high aspect ratio carbon structures are microfabricated by pyrolyzing a patterned carbon precursor polymer. Pyrolysing the polymer preferably comprises a multi-step process in an atmosphere of inert and forming gas at high temperatures that trail the glass transit temperature (Tg) for the polymer. Multi-layer C-MEMS carbon structures are formed from multiple layers of negative photoresist, wherein a first layer forms carbon interconnects and the second and successive layers form high aspect ratio carbon structures. High-conductivity interconnect traces to connect C-MEMS carbon structures are formed by depositing a metal layer on a substrate, patterning a polymer precursor on top of the metal layer and pyrolyzing the polymer to create the final structure. The interconnects of a device with high aspect ratio electrodes are insulated using a self aligning insulation method.

摘要翻译： 提供了具有高纵横比碳结构的C-MEMS架构和用于生产高纵横比C-MEMS结构的改进的系统和方法。 具体地说，通过热解图案化的碳前体聚合物，高纵横比的碳结构被微制成。 热解聚合物优选包括在高温气氛中的惰性和形成气体的气氛中的多步骤过程，以达到聚合物的玻璃化转变温度（Tg）。 多层C-MEMS碳结构由多层负性光致抗蚀剂形成，其中第一层形成碳互连，第二层和连续层形成高纵横比碳结构。 用于连接C-MEMS碳结构的高导电性互连迹线通过在衬底上沉积金属层，在金属层的顶部上构图聚合物前体并热解聚合物以形成最终结构而形成。 具有高纵横比电极的器件的互连使用自对准绝缘方法绝缘。