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    Torque transmitting bearing assembly
    2.
    发明授权
    Torque transmitting bearing assembly 失效
    扭矩传动轴承总成

    公开(公告)号：US4312545A

    公开(公告)日：1982-01-26

    申请号：US207427

    申请日：1980-11-17

    申请人： Gunter Blaurock ,  Ernst Albert ,  Klaus Reichert ,  Rudolf Schlereth

    发明人： Gunter Blaurock ,  Ernst Albert ,  Klaus Reichert ,  Rudolf Schlereth

    IPC分类号： F16C29/00 ,  F16C29/04 ,  F16C29/06 ,  F16D3/06

    CPC分类号： F16C29/10 ,  F16C29/0695 ,  F16D3/065

    摘要： A bearing assembly operatively interposed between a shaft and a housing having said shaft axially movably mounted therein for torque transmission therebetween includes a ball bushing inserted into a bushing receiving bore in the housing and guided through ball rings in ball races, with at least one of said ball rings being a load-transmitting ring including a load-transmitting ball ring section which rests radially inwardly against the shaft and radially outwardly against an external support surface defined by the ball bushing. The load bearing ball ring section of the at least one ball ring engages a race groove in the shaft on the shaft side of the ball ring and it engages a race groove of a bearing plate mounted in the ball bushing on the ball bushing side of the ball ring in a manner to transmit torque therebetween. The bearing plate may be pressed radially inwardly by means of a clamping device which presses against the ball bushing through contact surfaces which are oriented to intersect resultant planes generated by torque transmitting forces transmitted through the torque transmitting ball ring which are parallel to the bushing axis at an angle to insure a self-locking action.

    摘要翻译： 轴承组件可操作地插入在轴和壳体之间，所述轴与壳体轴向可移动地安装在其中，用于其间的扭矩传递，包括插入到壳体中的衬套容纳孔中的球轴套，并且通过球座中的至少一个引导， 球环是负载传递环，其包括负载传递滚珠环部分，其径向向内靠在轴上并径向向外抵靠由球轴承限定的外部支撑表面。 所述至少一个球环的所述承载滚珠环部分与所述滚珠轴的轴侧上的所述轴中的滚道槽接合，并且所述滚珠轴承与安装在所述滚珠衬套中的所述滚珠衬套中的所述滚珠轴承的滚道槽啮合， 球环以其间传递扭矩的方式。 承载板可以通过夹紧装置被径向向内按压，该夹紧装置通过接触表面压紧球轴套，该接触表面定向成与通过扭矩传递球环传递的扭矩传递力产生的相平面相交， 一个角度来确保自锁动作。

    Process for making antifusogenic fusion peptides that form inclusion bodies
    4.
    发明申请
    Process for making antifusogenic fusion peptides that form inclusion bodies 有权
    制造形成包涵体的抗融合融合肽的方法

    公开(公告)号：US20050058659A1

    公开(公告)日：2005-03-17

    申请号：US10969624

    申请日：2004-10-20

    申请人： Eva Hoess ,  Thomas Meier ,  Gabriele Pestlin ,  Friedrich Popp ,  Klaus Reichert ,  Rainer Schmuck ,  Bernd Schneidinger ,  Christoph Seidel ,  Wilhelm Tischer

    发明人： Eva Hoess ,  Thomas Meier ,  Gabriele Pestlin ,  Friedrich Popp ,  Klaus Reichert ,  Rainer Schmuck ,  Bernd Schneidinger ,  Christoph Seidel ,  Wilhelm Tischer

    IPC分类号： C12N15/09 ,  A61K38/00 ,  A61P31/12 ,  A61P31/18 ,  C07K14/155 ,  C07K14/16 ,  C12N1/21 ,  C12N15/62 ,  C12P21/02 ,  C12Q1/70 ,  A61K39/21 ,  C07H21/04

    CPC分类号： C07K14/005 ,  C07K2319/00 ,  C12N2740/15022 ,  C12N2740/16122 ,  C12P21/02

    摘要： A process is disclosed for the production of an antifusogenic peptide by producing a fusion peptide of a length of about 14 to 70 amino acids in a prokaryotic host cell, comprising the steps, under such conditions that inclusion bodies of said fusion peptide are formed, of: (a) expressing in said host cell a nucleic acid encoding said fusion peptide consisting of a first peptide which is an antifusogenic peptide of a length of about 10 to 50 amino acids and a second peptide of a length of about 4 to 30 amino acids, said first peptide being N-terminally linked to said second peptide; (b) cultivating said host cell to produce said inclusion bodies; and (c) recovering said antifusogenic peptide from said inclusion bodies, wherein said recovered antifusogenic peptide consists of said fusion peptide or a peptide comprising the antifusogenic peptide of about 10 to 50 amino acids and which is a fragment cleaved from said fusion peptide. Inclusion bodies of the peptides are disclosed. Also disclosed is a nucleic acid encoding the fusion peptide consisting of a first peptide which is an antifusogenic peptide selected from the group of SEQ ID NO: 7, SEQ ID NO: 8, SEQ ID NO: 9, SEQ ID NO: 10, and said sequences further consisting of glycine at the C terminal end, N-terminally linked to the second peptide.

    摘要翻译： 公开了通过在原核宿主细胞中产生约14至70个氨基酸长度的融合肽来生产抗融合肽的方法，包括以下步骤：在形成所述融合肽的包涵体的条件下， （a）在所述宿主细胞中表达编码所述融合肽的核酸，所述融合肽由长度为约10至50个氨基酸的抗融合肽的第一肽和长度为约4-30个氨基酸的第二个肽组成 所述第一肽与所述第二肽N-末端连接; （b）培养所述宿主细胞以产生所述包涵体; 和（c）从所述包涵体中回收所述抗融合肽，其中所述回收的抗融合肽由所述融合肽或包含约10至50个氨基酸的抗融合肽的肽组成，并且是从所述融合肽切割的片段。 公开了肽的包涵体。 还公开了编码由第一肽组成的融合肽的核酸，第一肽是选自SEQ ID NO：7，SEQ ID NO：8，SEQ ID NO：9，SEQ ID NO：10的抗融合肽， 所述序列进一步由C末端的甘氨酸组成，N-末端与第二肽连接。