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    24-homo vitamin D derivatives, process for their production and pharmaceutical preparations obtained therefrom
    3.
    发明授权
    24-homo vitamin D derivatives, process for their production and pharmaceutical preparations obtained therefrom 失效
    24-homo维生素D衍生物，其制备方法和由其获得的药物制剂

    公开(公告)号：US5665716A

    公开(公告)日：1997-09-09

    申请号：US592017

    申请日：1990-10-02

    申请人： Gerald Kirsch ,  Gunter Neef ,  Katicia Schwarz ,  Matthias Brautigam ,  Ruth Thieroff-Ekerdt ,  Petra Rach

    发明人： Gerald Kirsch ,  Gunter Neef ,  Katicia Schwarz ,  Matthias Brautigam ,  Ruth Thieroff-Ekerdt ,  Petra Rach

    IPC分类号： A61K31/59 ,  A61P3/02 ,  A61P35/00 ,  A61P43/00 ,  C07C401/00

    CPC分类号： C07C401/00

    摘要： New 24-homo vitamin D derivatives of formula I ##STR1## are described, in which R.sup.1 means a hydrogen atom, a hydroxy, an alkanoyloxy group with 1 to 8 carbon atoms or an aralkanoyloxy group with up to 8 carbon atoms,R.sup.2 and R.sup.3, independently of one another, mean a linear or branched alkyl group with 1 to 4 carbon atoms, a trifluoromethyl group or together mean a saturated carbocyclic ring with 3 to 9 carbon atoms formed with carbon atom 25,R.sup.4 and R.sup.5, independently of one another, mean a hydrogen atom, an alkanoyl group with 1 to 8 carbon atoms or an aralkanoyl group with up to 8 carbon atoms, andA and B each mean a hydrogen or together a second bond, andn stands for 1, 2, 3,4 or 5.

    摘要翻译： 描述了式I（I）1的新的24-高维生素D衍生物，其中R 1表示氢原子，羟基，具有1至8个碳原子的烷酰氧基或具有至多8个碳原子的芳烷酰氧基 R2和R3彼此独立地表示具有1至4个碳原子的直链或支链烷基，三氟甲基或一起表示与碳原子25，R4和R5形成的具有3至9个碳原子的饱和碳环， 彼此独立地表示氢原子，具有1至8个碳原子的烷酰基或具有至多8个碳原子的芳烷酰基，A和B各自表示氢或一起形成第二键，n表示1， 2,3,4或5。

    20-methyl-substituted vitamin D derivatives
    7.
    发明授权
    20-methyl-substituted vitamin D derivatives 失效
    20-甲基取代的维生素D衍生物

    公开(公告)号：US5446035A

    公开(公告)日：1995-08-29

    申请号：US307081

    申请日：1994-09-16

    申请人： Gunter Neef ,  Andreas Steinmeyer ,  Gerald Kirsch ,  Katica Schwarz ,  Ruth Thieroff-Ekerdt ,  Herbert Wiesinger ,  Martin Haberey

    发明人： Gunter Neef ,  Andreas Steinmeyer ,  Gerald Kirsch ,  Katica Schwarz ,  Ruth Thieroff-Ekerdt ,  Herbert Wiesinger ,  Martin Haberey

    IPC分类号： A61K31/59 ,  A61P3/02 ,  A61P3/14 ,  A61P17/00 ,  A61P35/02 ,  A61P37/00 ,  A61P43/00 ,  C07C401/00

    CPC分类号： C07C401/00

    摘要： New 20-methyl-substituted vitamin D derivatives of general formula I ##STR1## are described in whichR.sup.1 means a hydrogen atom, a hydroxy group or an alkanoyloxy group with 1 to 12 carbon atoms or a benzoyloxy group,R.sup.2 means a hydrogen atom or an alkanoyl group with 1 to 12 carbon atoms or a benzoyl group andR.sup.3 means a saturated or unsaturated, straight-chain or branched hydrocarbon radical with up to 18 C atoms, which optionally contains carbocyclic structures, optionally substituted with one or more hydroxy, oxo, amino group(s) and/or one or more halogen atom(s) as well as optionally exhibits one or more oxygen, sulfur and/or nitrogen atom(s) as a bridging link or links in the hydrocarbon radical, and a process for their production.Relative to calcitriol, the new compounds exhibit a greatly improved induction of cell differentiation (HL-60) and are suitable for the production of pharmaceutical agents.

    摘要翻译： 描述了通式I的新的20-甲基取代的维生素D衍生物（I），其中R 1表示氢原子，羟基或具有1至12个碳原子的烷酰氧基或苯甲酰氧基，R2表示 氢原子或具有1至12个碳原子的烷酰基或苯甲酰基，R 3表示具有至多18个C原子的饱和或不饱和的直链或支链烃基，其任选地含有碳环结构，任选地被一个或多个 羟基，氧代，氨基和/或一个或多个卤素原子，以及任选地表现出一个或多个氧，硫和/或氮原子作为烃基中的桥连或连接， 及其生产过程。 相对于骨化三醇，新化合物表现出极大改善的细胞分化诱导（HL-60），适用于制药。