利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

43 条记录 (耗时 0.029 秒)

    5′ triphosphate oligonucleotide with blunt end and uses thereof
    1.
    发明授权
    5′ triphosphate oligonucleotide with blunt end and uses thereof 有权

    公开(公告)号：US09409941B2

    公开(公告)日：2016-08-09

    申请号：US12993420

    申请日：2009-05-20

    申请人： Gunther Hartmann ,  Martin Schlee

    发明人： Gunther Hartmann ,  Martin Schlee

    IPC分类号： A61K31/713 ,  A61K48/00 ,  A61P31/12 ,  A61P37/04 ,  C07H21/00 ,  A61K31/7088 ,  C12N15/113 ,  C12N15/117

    摘要： The present invention provides an oligonucleotide which is capable of activating RIG-I and inducing an anti-viral, in particular, an IFN, response in cells expressing RIG-I. The present invention further provides an oligonucleotide which is capable of activating RIG-I and which has target gene-silencing activity. The oligonucleotide of the present invention has a double-stranded section of at least 19, preferably at least 21 bp, at least one 5′ triphosphate, and at least one blunt end which bears a 5′ triphosphate. The present invention further provides the use said oligonucleotide for inducing an anti-viral, in particular, an IFN, response in vitro and in vivo. The present invention additionally provides the use of said oligonucleotide for preventing and/or treating diseases or conditions such as infections, tumors/cancers, and immune disorders.

    5' TRIPHOSPHATE OLIGONUCLEOTIDE WITH BLUNT END AND USES THEREOF
    2.
    发明申请
    5' TRIPHOSPHATE OLIGONUCLEOTIDE WITH BLUNT END AND USES THEREOF 有权
    5'二磷酸二氢钠与BLUNT END和其用途

    公开(公告)号：US20110165123A1

    公开(公告)日：2011-07-07

    申请号：US12993420

    申请日：2009-05-20

    申请人： Gunther Hartmann ,  Martin Schlee

    发明人： Gunther Hartmann ,  Martin Schlee

    IPC分类号： A61K38/21 ,  C07H21/02 ,  A61K31/713 ,  A61K39/00 ,  C12N5/071 ,  C07H1/00 ,  A61P35/00 ,  A61P37/04 ,  A61P31/12 ,  A61P31/04

    CPC分类号： C12N15/1135 ,  A61K31/7088 ,  A61K31/713 ,  A61K45/06 ,  C07H21/00 ,  C12N15/113 ,  C12N15/1131 ,  C12N15/117 ,  C12N2310/14 ,  C12N2310/17 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/531 ,  C12N2320/31 ,  Y02A50/465

    摘要： The present invention provides an oligonucleotide which is capable of activating RIG-I and inducing an anti-viral, in particular, an IFN, response in cells expressing RIG-I. The present invention further provides an oligonucleotide which is capable of activating RIG-I and which has target gene-silencing activity. The oligonucleotide of the present invention has a double-stranded section of at least 19, preferably at least 21 bp, at least one 5′ triphosphate, and at least one blunt end which bears a 5′ triphosphate. The present invention further provides the use said oligonucleotide for inducing an anti-viral, in particular, an IFN, response in vitro and in vivo. The present invention additionally provides the use of said oligonucleotide for preventing and/or treating diseases or conditions such as infections, tumors/cancers, and immune disorders.

    摘要翻译： 本发明提供能够激活RIG-1并在表达RIG-1的细胞中诱导抗病毒特别是IFN的应答的寡核苷酸。 本发明还提供能够活化RIG-1并具有靶基因沉默活性的寡核苷酸。 本发明的寡核苷酸具有至少19个，优选至少21个碱基对，至少一个5'-三磷酸和至少一个带有5'三磷酸的平端的双链段。 本发明进一步提供所述寡核苷酸用于在体外和体内诱导抗病毒特别是IFN的应答。 本发明还提供了所述寡核苷酸用于预防和/或治疗疾病或病症如感染，肿瘤/癌症和免疫疾病的用途。

    Method and apparatus for precision rolling of rotationally symmetrical components
    5.
    发明申请
    Method and apparatus for precision rolling of rotationally symmetrical components 有权
    旋转对称部件精密滚动的方法和装置

    公开(公告)号：US20060107717A1

    公开(公告)日：2006-05-25

    申请号：US11284454

    申请日：2005-11-21

    申请人： Gunther Hartmann ,  Wolfgang Sommer ,  Mario Braun ,  Matthias Becker

    发明人： Gunther Hartmann ,  Wolfgang Sommer ,  Mario Braun ,  Matthias Becker

    IPC分类号： B21H1/00

    CPC分类号： B21H1/00 ,  B21H3/00 ,  B21H3/02 ,  B21H3/06 ,  B21H5/00 ,  B21H5/022 ,  B21H9/02

    摘要： An apparatus (1) and a method serve for precision rolling of a surface area (2) of a rotationally symmetrical component (3), especially a screw. The apparatus (1) includes at least two spaced apart rolling tools (4, 5), a measuring unit (9) for determining an actual blank diameter of the component (3), an evaluating unit (10) for comparing the determined actual blank diameter of the component (3) with a predetermined blank diameter and for determining an adjustment value from the result of the comparison, and a control unit (11) for adjusting a distance between the at least two rolling tools (4, 5) in response to the adjustment value.

    摘要翻译： 一种装置（1）和一种用于精密滚动旋转对称部件（3）的表面区域（2）的方法，特别是螺杆。 所述设备（1）包括至少两个间隔开的滚动工具（4,5），用于确定所述部件（3）的实际坯料直径的测量单元（9），用于将所确定的实际空白 具有预定坯料直径的组件（3）的直径和用于根据比较结果确定调节值的控制单元（11），用于响应于调整至少两个轧制工具（4,5）之间的距离的控制单元（11） 到调整值。

    Method for operating an ion beam therapy system by monitoring the distribution of the radiation dose
    6.
    发明授权
    Method for operating an ion beam therapy system by monitoring the distribution of the radiation dose 有权
    通过监测辐射剂量分布来操作离子束治疗系统的方法

    公开(公告)号：US06736831B1

    公开(公告)日：2004-05-18

    申请号：US09913001

    申请日：2001-11-14

    申请人： Gunther Hartmann ,  Peter Heeg ,  Oliver Jaekel ,  Christian Karger

    发明人： Gunther Hartmann ,  Peter Heeg ,  Oliver Jaekel ,  Christian Karger

    IPC分类号： A61N100

    CPC分类号： G21K5/04 ,  A61N5/1043 ,  A61N5/1048 ,  A61N2005/1074 ,  A61N2005/1087

    摘要： A method for operation of an ion beam therapy system that comprises a grid scanner device, arranged in a beam guidance system (6, 8), having vertical deflection means (13) and horizontal deflection means (14) for the vertical and horizontal deflection of a treatment beam (11) perpendicular to its beam direction, with the result that the treatment beam (11) is deflected by the grid scanner device to an isocentre (10) of the irradiation site and scans a specific area surrounding the isocentre (10) using a specific radiation dose. Both the depth dose distribution and the transverse dose distribution of the grid scanner device (13, 14) at various positions in the region of the isocentre (10) are measured and evaluated, it being concluded that the radiation dose distribution is adequately homogeneous if the degree of variation in the radiation dose values measured at the individual positions does not exceed a specific tolerance limit value.

    摘要翻译： 一种用于操作离子束治疗系统的方法，其包括布置在光束引导系统（6,8）中的网格扫描器装置，其具有垂直偏转装置（13）和用于垂直和水平偏转的水平偏转装置（14） 垂直于其光束方向的处理光束（11），结果是处理光束（11）被栅格扫描器装置偏转到照射部位的等角（10）并且扫描等中心（10）周围的特定区域， 使用特定的辐射剂量。 测量和评估在等中心（10）区域中的各种位置处的栅格扫描器装置（13,14）的深度剂量分布和横向剂量分布，得出如下结论：辐射剂量分布足够均匀 在各个位置测量的辐射剂量值的变化程度不超过特定的耐受极限值。

    Method of checking an isocentre and a patient-positioning device of an ion beam therapy system
    7.
    发明授权
    Method of checking an isocentre and a patient-positioning device of an ion beam therapy system 有权
    检查离子束治疗系统的等中心和患者定位装置的方法

    公开(公告)号：US06670618B1

    公开(公告)日：2003-12-30

    申请号：US09913109

    申请日：2001-11-20

    申请人： Gunther Hartmann ,  Peter Heeg ,  Oliver Jaekel ,  Christian Karger

    发明人： Gunther Hartmann ,  Peter Heeg ,  Oliver Jaekel ,  Christian Karger

    IPC分类号： G01N2300

    CPC分类号： A61N5/1049 ,  A61B2090/101 ,  A61N5/1043 ,  A61N5/1075 ,  A61N2005/1076 ,  A61N2005/1087

    摘要： The present invention relates to a method of checking an isocentre and a patient-positioning device of an ion beam therapy system that comprises a grid scanner device, arranged in a beam guidance system, having vertical deflection means and horizontal deflection means for the vertical and horizontal deflection of a treatment beam perpendicular to its beam direction, with the result that the treatment beam is deflected by the grid scanner device onto an isocentre of the irradiation site, and a specific area surrounding the isocentre is scanned, wherein a check of the isocentre and a patient-positioning device is carried out and the patient-positioning device comprises a patient table rotatable about an axis of rotation of the table. For the checking, a target point within a spherical phantom is represented by means of a special specimen body and the centre point of the specimen body is visibly represented by means of several image-forming methods. On departure of the measurement results in respect of the spatial position of the centre point under the image-forming methods from a predetermined intervention threshold, the ion beam therapy system is subjected to an inspection and/or maintenance.

    摘要翻译： 本发明涉及一种检查离子束治疗系统的等中心和患者定位装置的方法，其包括布置在光束引导系统中的网格扫描器装置，其具有垂直偏转装置和用于垂直和水平的水平偏转装置 处理光束垂直于其光束方向的偏转，结果是处理光束被栅格扫描器装置偏转到照射部位的等中心上，并且扫描周围等中心的特定区域，其中检查等中心和 执行患者定位装置，并且患者定位装置包括可围绕桌子的旋转轴线旋转的患者台。 对于检查，球形体模中的目标点通过特殊的样本体表示，并且通过几种成像方法可见地表示样本体的中心点。 在从图像形成方法的中心点的空间位置从预定干预阈值开始的测量结果离开时，对离子束治疗系统进行检查和/或维护。

    SILENCNG AND RIG-I ACTIVATION BY DUAL FUNCTION OLIGONUCLEOTIDES
    9.
    发明申请
    SILENCNG AND RIG-I ACTIVATION BY DUAL FUNCTION OLIGONUCLEOTIDES 审中-公开
    通过双功能寡核苷酸激活的保守和重组

    公开(公告)号：US20110184045A1

    公开(公告)日：2011-07-28

    申请号：US13002101

    申请日：2009-06-30

    申请人： Gunther Hartmann

    发明人： Gunther Hartmann

    IPC分类号： A61K31/713 ,  C12Q1/68 ,  A61P35/00

    CPC分类号： C12N15/111 ,  C12N2310/14 ,  C12N2320/11

    摘要： The invention describes a method of determining whether a double stranded RNA (dsRNA) silences gene expression in a cell in vivo by an RNA interference (RNAi) mechanism by performing 5′-rapid amplification of cDNA ends (5′RACE) to detect the cleavage site of the mRNA in the RNA sample.

    摘要翻译： 本发明描述了一种确定双链RNA（dsRNA）是否通过RNA干扰（RNAi）机制在细胞内沉默基因表达的方法，通过进行cDNA末端的5'快速扩增（5'RACE）以检测切割 RNA样品中mRNA的位点。