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    Macromolecular neuraminidase-binding compounds
    2.
    发明授权
    Macromolecular neuraminidase-binding compounds 失效
    大分子神经氨酸酶结合化合物

    公开(公告)号：US06680054B1

    公开(公告)日：2004-01-20

    申请号：US09308076

    申请日：1999-07-16

    申请人： Phillip A. Reece ,  Keith Geoffrey Watson ,  Wen-Yang Wu ,  Betty Jin ,  Guy Y. Krippner

    发明人： Phillip A. Reece ,  Keith Geoffrey Watson ,  Wen-Yang Wu ,  Betty Jin ,  Guy Y. Krippner

    IPC分类号： A61K3944

    CPC分类号： G01N33/56983 ,  C08B37/0021 ,  C08F8/30 ,  G01N2333/11 ,  G01N2333/924

    摘要： The invention provides novel macromolecules, methods for their preparation, pharmaceutical formulations thereof and their use as anti-influenza agents. The invention also provides a novel diagnostic method which can be used for detection of all types of influenza A and B virus. The macromolecular compound of the invention has attached to it one or more molecules (neuraminidase binders) which bind to the active site of influenza virus neuraminidase but which are not cleaved by the neuraminidase.

    摘要翻译： 本发明提供新型大分子，其制备方法，药物制剂及其作为抗流感药物的用途。 本发明还提供了一种可用于检测所有类型的甲型和乙型流感病毒的新型诊断方法。 本发明的高分子化合物与其结合了一种或多种结合流感病毒神经氨酸酶的活性位点但不被神经氨酸酶切割的分子（神经氨酸酶结合剂）。

    Antiviral agents
    4.
    发明授权
    Antiviral agents 失效
    抗病毒剂

    公开(公告)号：US07078403B1

    公开(公告)日：2006-07-18

    申请号：US10018963

    申请日：2000-06-16

    申请人： Wen-Yang Wu ,  Keith Watson ,  Darryl McConnell ,  Betty Jin ,  Guy Krippner

    发明人： Wen-Yang Wu ,  Keith Watson ,  Darryl McConnell ,  Betty Jin ,  Guy Krippner

    IPC分类号： A61K31/53

    CPC分类号： C07D401/04 ,  C07D237/20 ,  C07D237/22 ,  C07D261/08 ,  C07D403/04 ,  C07D417/14

    摘要： Disclosed herein are compounds of formula II: wherein Alk, Z, X1, X2, R1, —R10 and R11 are defined herein, and their salts and pharmaceutically acceptable derivatives thereof, as well as other compounds of the general formula Het-A-Alk-W-Ar-C(X2)═NO-X2 where Het, A, W and Ar are also defined herein. These compounds are useful in treating picornavirus infections in mammals. Novel intermediates of these compounds, as well as pharmaceutical compositions and methods of use, are also disclosed herein.

    摘要翻译： 本文公开了式II的化合物：其中Alk，Z，X 1，X 2，R 1，R 10， 本文定义的本文及其盐及其药学上可接受的衍生物，以及通式Het-A-Alk-W-Ar-C（X

    Compositions for veterinary and medical applications
    10.
    发明授权
    Compositions for veterinary and medical applications 有权
    兽医和医疗应用的组成

    公开(公告)号：US08927565B2

    公开(公告)日：2015-01-06

    申请号：US10570509

    申请日：2004-08-26

    申请人： Betty Jin ,  Wen-Yang Wu

    发明人： Betty Jin ,  Wen-Yang Wu

    IPC分类号： A61K31/4745 ,  A61K31/717 ,  A23K1/16 ,  A23K1/17 ,  A23K1/18 ,  A23L1/30 ,  A61K31/47 ,  A61K31/718 ,  A61K31/78

    CPC分类号： A61K31/717 ,  A23K20/132 ,  A23K20/195 ,  A23K50/30 ,  A23K50/75 ,  A23L33/105 ,  A61K31/47 ,  A61K31/718 ,  A61K31/78 ,  A61K2300/00

    摘要： Compositions including polymeric dialdehydes and compounds of where R1, R2, R7, R8, R9, and R10 may be the same or different and are selected from H, CH3, OH, OCH3, C2H5, OC2H5OCH2Ph, OCH2PhNO2, F or Cl; R3, R4, R5, R6 may be the same or different and are selected from H, CH3, OCH3, C2H5, OC2H5OCH2Ph, OCH2PhNO2, F or Cl, or R5 and R6 are the same or different and are selected from H, CH3, OCH3, C2H5, OC2H5OCH2Ph, OCH2PhNO2, F or Cl and R3 and R4 together are ═O, or R4 and R6 are the same or different and are selected from H, CH3, OCH3, C2H5, OC2H5OCH2Ph, OCH2PhNO2, F or Cl and R3 and R5 together form a double bond or are ═O, or R3 and R4, are the same or different and are selected from H, CH3, OCH3, C2H5, OC2H5OCH2Ph, OCH2PhNO2, F or Cl and R5 and R6 together are ═O; R11 and R12 together form ═CH2, or R11 and R12 may be the same or different and are independently selected from the group consisting of H, CH3, CH2CH3 and CH2CH2CH3; and X is selected from the group consisting of Cl, Br, SO4, I and R13COO, where R13 is CH3 or poly acids, for the treatment of gastrointestinal functional disorders or related conditions as well as for the promotion of general health and weight gain in animals including humans.

    摘要翻译： 包括聚合二醛和其中R 1，R 2，R 7，R 8，R 9和R 10可以相同或不同并且选自H，CH 3，OH，OCH 3，C 2 H 5，OC 2 H 5 OCH 2 Ph，OCH 2 PhNO 2，F或Cl的化合物的组合物; R 3，R 4，R 5，R 6可以相同或不同，选自H，CH 3，OCH 3，C 2 H 5，OC 2 H 5 OCH 2 Ph，OCH 2 PhNO 2，F或Cl，或R 5和R 6相同或不同，选自H， OCH 3，C 2 H 5，OC 2 H 5 OCH 2 Ph，OCH 2 PhNO 2，F或Cl和R 3和R 4一起为=或者R 4和R 6相同或不同，并且选自H，CH 3，OCH 3，C 2 H 5，OC 2 H 5 OCH 2 Ph，OCH 2 PhNO 2，F或Cl和R 3 并且R 5和R 5一起形成双键，或者是=或者R 3和R 4相同或不同，并且选自H，CH 3，OCH 3，C 2 H 5，OC 2 H 5 OCH 2 Ph，OCH 2 PhNO 2，F或Cl和R 5和R 6一起是= R 11和R 12一起形成= CH 2，或者R 11和R 12可以相同或不同，并且独立地选自H，CH 3，CH 2 CH 3和CH 2 CH 2 CH 3; X选自Cl，Br，SO 4，I和R 13 COO，其中R 13为CH 3或多酸，用于治疗胃肠功能障碍或相关病症，以及促进一般健康和体重增加 动物包括人类。