公开(公告)号：US20200368750A1

公开(公告)日：2020-11-26

申请号：US16768881

申请日：2018-10-03

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： Hilary ELY ,  Michael W. CUMBIE ,  Adam HIGGINS ,  Rachel M. WHITE ,  Erik D. TORNIAINEN

IPC: B01L7/00 ,  C12P19/34

Abstract: A fluid thermal processing device may include a substrate, a platform projecting from the substrate, a fluid heating element supported by the platform, a temperature sensing element, distinct from the fluid heating element, supported by the platform and an enclosure supported by and cooperating with the substrate to form a fluid chamber about the platform. The fluid chamber forms a volume of uniform thickness conforming to and about the platform.

公开(公告)号：US20200088715A1

公开(公告)日：2020-03-19

申请号：US16494473

申请日：2017-04-20

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Uranbileg DAALKHAIJAV ,  Rachel M. WHITE ,  Tod WOODFORD ,  Chantelle DOMINGUE

IPC: G01N33/49 ,  G01N33/86

Abstract: A microfluidic blood coagulation testing die includes a substrate, a slot in the substrate permitting entry of a sample of blood, a chamber in the substrate for collection of cells in the sample, and a pinch point that permits passage of sample from slot to chamber. The die includes a sensor in or near the at least one pinch point to test sample passing through the at least one pinch point. Activator, such as freeze-dried coagulation-initializing tissue factor, coats at least a portion of the interior surface of the slot, pinch point, and chamber.

公开(公告)号：US20180224425A1

公开(公告)日：2018-08-09

申请号：US15749116

申请日：2016-03-07

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： Shameed SAIT M A ,  Rachel M. WHITE ,  Chantelle DOMINGUE ,  Manish GIRI

IPC: G01N33/49 ,  G01N27/02

CPC classification number: G01N33/4915 ,  C12Q1/56 ,  G01N27/02 ,  G01N33/49 ,  G01N33/561 ,  G01N33/86

Abstract: Examples herein provide a method. The method includes applying an electrical potential difference over a blood sample in a testing cassette of a microfluidic device, the cassette including a microfluidic channel through which the blood sample flows. The method includes measuring, over a duration of time, an electrical signal passing through the blood sample as the blood sample flows from a first end and coagulates at a second end of the microfluidic channel to obtain a measurement function as a function of time. The method also includes correlating the measurement function to a characteristic of the blood sample.

公开(公告)号：US20200347437A1

公开(公告)日：2020-11-05

申请号：US16960045

申请日：2018-03-23

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： Rachel M. WHITE

IPC: C12Q1/686 ,  G01N21/64

Abstract: An example method includes introducing a nucleic acid sample, a fluorescent indicator, and an internal positive control into a reaction volume of a microfluidic device. The example method further includes conducting a nucleic acid amplification reaction in the reaction volume, and optically monitoring a fluorescent signal from the reaction volume over a duration. A concentration of the internal positive control is selected to exhibit an initial increase in the fluorescent signal within the duration. The initial increase is to occur prior to a subsequent increase to be exhibited by an amplification product of a target when the target is present in the nucleic acid sample.

公开(公告)号：US20200206734A1

公开(公告)日：2020-07-02

申请号：US16643264

申请日：2017-11-22

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Hilary ELY ,  Adam HIGGINS ,  Rachel M. WHITE ,  Erik D. TORNIAINEN ,  Tod WOODFORD ,  Michael W. CUMBIE ,  Chien-Hua CHEN

IPC: B01L3/00

Abstract: The present disclosure is drawn to microfluidic devices. A microfluidic device can include a substrate, a lid mounted to the substrate, and a microchip mounted to the substrate. The lid mounted to the substrate can form a discrete microfluidic chamber between structures including an interior surface of the lid and a portion of the substrate. The lid can include an inlet and a vent positioned relative to one another to facilitate loading of fluid to the discrete microfluidic chamber via capillary action. A portion of the microchip can be positioned within the discrete microfluidic chamber.

公开(公告)号：US20200096464A1

公开(公告)日：2020-03-26

申请号：US16618840

申请日：2017-07-17

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Rachel M. WHITE

IPC: G01N27/06 ,  G01N33/49

Abstract: An apparatus includes a die having a receiving area for a blood sample. A chamber is mounted on the die and fluidically coupled to the receiving area to process the blood sample. The chamber includes a set of electrodes that applies a voltage to the blood sample. A hematocrit level of the blood sample is determined based on a change in impedance across the set of electrodes after the voltage is applied.