公开(公告)号：US20180356327A1

公开(公告)日：2018-12-13

申请号：US15748393

申请日：2015-11-24

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： Robert MOLINE ,  Manish GIRI ,  Chantelle DOMINGUE

IPC: G01N15/06 ,  B01L3/00 ,  C12Q1/25 ,  G01N33/487 ,  G01N33/543 ,  G01N1/38

CPC classification number: G01N15/0656 ,  B01L3/502715 ,  B01L2200/027 ,  B01L2200/16 ,  B01L2300/0636 ,  B01L2300/0825 ,  B01L2300/0867 ,  B01L2300/1827 ,  B01L2400/0406 ,  B01L2400/0442 ,  B01L2400/0487 ,  C12Q1/25 ,  G01N1/38 ,  G01N33/48707 ,  G01N33/50 ,  G01N33/54366 ,  G01N2015/0065

Abstract: Examples herein provide a device. The device includes a sample delivery component, which includes: a reagent chamber to contain at least one reagent; a sample chamber to contain a fluid sample; and a delivery channel extending from the reagent chamber and in fluid communication with the sample chamber and an output port, wherein the delivery channel is conducive to mixing the at least one reagent and the fluid sample to form a mixture before the mixture reaches the output port and be discharged therefrom. The device includes a testing cassette detachable from the delivery component, which includes: an input port in fluid communication with a microfluidic reservoir, the input port to receive the discharged fluid sample from the output port; and a micro-fabricated integrated sensor in a microfluidic channel extending from the microfluidic reservoir.

公开(公告)号：US20190210025A1

公开(公告)日：2019-07-11

申请号：US16099172

申请日：2016-07-26

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： Chantelle DOMINGUE ,  Tod WOODFORD ,  Manish GIRI ,  Matthew David SMITH ,  George H CORRIGAN III ,  Masoud ZAVAREHI ,  Joshua M. YU

IPC: B01L3/00 ,  G01N15/10

CPC classification number: B01L3/502761 ,  B01L3/502715 ,  B01L3/5085 ,  B01L2200/0652 ,  B01L2300/0645 ,  B01L2300/0864 ,  B01L2400/043 ,  B01L2400/0439 ,  B01L2400/0442 ,  G01N15/1031 ,  G01N15/1056 ,  G01N35/1065 ,  G01N2015/1006 ,  G01N2015/1062 ,  G01N2015/1081

Abstract: According to an example, a microfluidic apparatus may include a fluid slot and a foyer that is in fluid communication with the fluid slot via a channel having a relatively smaller width than the foyer. The microfluidic apparatus may also include an electrical sensor to measure a change in an electrical field caused by a particle of interest in a fluid passing through the channel from the fluid slot to the foyer, an actuator to apply pressure onto fluid contained in the foyer, and a controller to receive the measured change in the electrical field from the electrical sensor, determine, from the received change in the electrical field, an electrical signature of the particle of interest, and control the actuator to control movement of the particle of interest based upon the determined electrical signature of the particle of interest.

公开(公告)号：US20200088715A1

公开(公告)日：2020-03-19

申请号：US16494473

申请日：2017-04-20

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Uranbileg DAALKHAIJAV ,  Rachel M. WHITE ,  Tod WOODFORD ,  Chantelle DOMINGUE

IPC: G01N33/49 ,  G01N33/86

Abstract: A microfluidic blood coagulation testing die includes a substrate, a slot in the substrate permitting entry of a sample of blood, a chamber in the substrate for collection of cells in the sample, and a pinch point that permits passage of sample from slot to chamber. The die includes a sensor in or near the at least one pinch point to test sample passing through the at least one pinch point. Activator, such as freeze-dried coagulation-initializing tissue factor, coats at least a portion of the interior surface of the slot, pinch point, and chamber.

公开(公告)号：US20190151848A1

公开(公告)日：2019-05-23

申请号：US16099658

申请日：2016-07-26

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： Jeffrey A NIELSEN ,  Manish GIRI ,  Chantelle DOMINGUE ,  Kenneth WARD ,  Christie DUDENHOEFER ,  Matthew David SMITH ,  Joshua M. YU ,  Hilary ELY

IPC: B01L3/00 ,  G01N15/10 ,  G01N15/14

Abstract: According to an example, a microfluidic apparatus may include a fluid slot, a foyer in fluid communication with the fluid slot via a channel having a relatively smaller width than the foyer, a sensor to detect a presence of a particle of interest in a fluid passing through the channel, a nozzle in fluid communication with the foyer, and an actuator positioned in line with the nozzle. The microfluidic apparatus may also include a controller to receive information from the sensor, determine, from the received information, whether a particle of interest has passed through the channel, and control the actuator to expel fluid in the foyer through the nozzle based upon the determination.

公开(公告)号：US20200088716A1

公开(公告)日：2020-03-19

申请号：US16494528

申请日：2017-04-20

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Rachel M. White ,  Urartbileg DAALKHAIJAV ,  Tod WOODFORD ,  Chantelle DOMINGUE

IPC: G01N33/49 ,  G01N33/543 ,  G01N33/86 ,  B01L3/00 ,  C12M1/34

Abstract: A microfluidic blood coagulation testing die includes a substrate, a slot defined in the substrate permitting entry of a blood sample, a chamber defined in the substrate that collects red blood cells from the blood sample, and a microfluidic path that provides a fluid connection from the slot to the chamber. The microfluidic path includes a channel, an inlet disposed at one end of the channel and an outlet disposed at the other end of the channel.

公开(公告)号：US20190285564A1

公开(公告)日：2019-09-19

申请号：US16319026

申请日：2016-10-05

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： George H. CORRIGAN, III ,  Chantelle DOMINGUE ,  Sadiq BENGALI

IPC: G01N27/12

Abstract: The present disclosure is drawn to an insulated sensor including a silicon substrate with active circuitry on a surface thereof, an electrode disposed on the silicon substrate, a passivation layer having a thickness from greater than 500 Angstroms to 3,000 Angstroms disposed on the active circuitry, and an electrode insulating layer having a thickness from 10 Angstroms to 500 Angstroms disposed on the electrode.

公开(公告)号：US20190151849A1

公开(公告)日：2019-05-23

申请号：US16099668

申请日：2016-07-26

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： Jeffrey A NIELSEN ,  Manish GIRI ,  Chantelle DOMINGUE ,  Kenneth WARD ,  Christie DUDENHOEFER ,  Matthew David SMITH ,  Joshua M. YU ,  Diane R. HAMMERSTAD ,  Hilary ELY

IPC: B01L3/00 ,  B01L3/02

Abstract: According to an example, a microfluidic apparatus may include a channel, a foyer, in which the foyer is in fluid communication with the channel and in which the channel has a smaller width than the foyer, a sensor to sense a property of a fluid passing through the channel, a nozzle in fluid communication with the foyer, and an actuator positioned in line with the nozzle. The microfluidic apparatus may also include a controller to determine whether the sensed property of the fluid meets a predetermined condition and to perform a predefined action in response to the sensed property of the fluid meeting the predetermined condition.

公开(公告)号：US20180224425A1

公开(公告)日：2018-08-09

申请号：US15749116

申请日：2016-03-07

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： Shameed SAIT M A ,  Rachel M. WHITE ,  Chantelle DOMINGUE ,  Manish GIRI

IPC: G01N33/49 ,  G01N27/02

CPC classification number: G01N33/4915 ,  C12Q1/56 ,  G01N27/02 ,  G01N33/49 ,  G01N33/561 ,  G01N33/86

Abstract: Examples herein provide a method. The method includes applying an electrical potential difference over a blood sample in a testing cassette of a microfluidic device, the cassette including a microfluidic channel through which the blood sample flows. The method includes measuring, over a duration of time, an electrical signal passing through the blood sample as the blood sample flows from a first end and coagulates at a second end of the microfluidic channel to obtain a measurement function as a function of time. The method also includes correlating the measurement function to a characteristic of the blood sample.