公开(公告)号：US20230123792A1

公开(公告)日：2023-04-20

申请号：US17910130

申请日：2020-03-31

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Alexander Govyadinov ,  Dennis M. LAZAROFF ,  Brett E. DAHLGREN ,  Stefan Enr LUCCHINI ,  Tod WOODFORD

IPC: B01L3/00 ,  G01N21/64

Abstract: The present disclosure is drawn to microfluidic devices. The microfluidic device includes a microfluidic well, a layered composite stack, and an optical sensor. The layered composite stack includes an optical filter composited with an etch-stopping layer. The optical filter defines the microfluidic well. The optical sensor is associated with the microfluidic well and has the optical filter positioned therebetween.

公开(公告)号：US20200088715A1

公开(公告)日：2020-03-19

申请号：US16494473

申请日：2017-04-20

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Uranbileg DAALKHAIJAV ,  Rachel M. WHITE ,  Tod WOODFORD ,  Chantelle DOMINGUE

IPC: G01N33/49 ,  G01N33/86

Abstract: A microfluidic blood coagulation testing die includes a substrate, a slot in the substrate permitting entry of a sample of blood, a chamber in the substrate for collection of cells in the sample, and a pinch point that permits passage of sample from slot to chamber. The die includes a sensor in or near the at least one pinch point to test sample passing through the at least one pinch point. Activator, such as freeze-dried coagulation-initializing tissue factor, coats at least a portion of the interior surface of the slot, pinch point, and chamber.

公开(公告)号：US20200088716A1

公开(公告)日：2020-03-19

申请号：US16494528

申请日：2017-04-20

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Rachel M. White ,  Urartbileg DAALKHAIJAV ,  Tod WOODFORD ,  Chantelle DOMINGUE

IPC: G01N33/49 ,  G01N33/543 ,  G01N33/86 ,  B01L3/00 ,  C12M1/34

Abstract: A microfluidic blood coagulation testing die includes a substrate, a slot defined in the substrate permitting entry of a blood sample, a chamber defined in the substrate that collects red blood cells from the blood sample, and a microfluidic path that provides a fluid connection from the slot to the chamber. The microfluidic path includes a channel, an inlet disposed at one end of the channel and an outlet disposed at the other end of the channel.

公开(公告)号：US20200206734A1

公开(公告)日：2020-07-02

申请号：US16643264

申请日：2017-11-22

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Hilary ELY ,  Adam HIGGINS ,  Rachel M. WHITE ,  Erik D. TORNIAINEN ,  Tod WOODFORD ,  Michael W. CUMBIE ,  Chien-Hua CHEN

IPC: B01L3/00

Abstract: The present disclosure is drawn to microfluidic devices. A microfluidic device can include a substrate, a lid mounted to the substrate, and a microchip mounted to the substrate. The lid mounted to the substrate can form a discrete microfluidic chamber between structures including an interior surface of the lid and a portion of the substrate. The lid can include an inlet and a vent positioned relative to one another to facilitate loading of fluid to the discrete microfluidic chamber via capillary action. A portion of the microchip can be positioned within the discrete microfluidic chamber.

公开(公告)号：US20190210025A1

公开(公告)日：2019-07-11

申请号：US16099172

申请日：2016-07-26

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： Chantelle DOMINGUE ,  Tod WOODFORD ,  Manish GIRI ,  Matthew David SMITH ,  George H CORRIGAN III ,  Masoud ZAVAREHI ,  Joshua M. YU

IPC: B01L3/00 ,  G01N15/10

CPC classification number: B01L3/502761 ,  B01L3/502715 ,  B01L3/5085 ,  B01L2200/0652 ,  B01L2300/0645 ,  B01L2300/0864 ,  B01L2400/043 ,  B01L2400/0439 ,  B01L2400/0442 ,  G01N15/1031 ,  G01N15/1056 ,  G01N35/1065 ,  G01N2015/1006 ,  G01N2015/1062 ,  G01N2015/1081

Abstract: According to an example, a microfluidic apparatus may include a fluid slot and a foyer that is in fluid communication with the fluid slot via a channel having a relatively smaller width than the foyer. The microfluidic apparatus may also include an electrical sensor to measure a change in an electrical field caused by a particle of interest in a fluid passing through the channel from the fluid slot to the foyer, an actuator to apply pressure onto fluid contained in the foyer, and a controller to receive the measured change in the electrical field from the electrical sensor, determine, from the received change in the electrical field, an electrical signature of the particle of interest, and control the actuator to control movement of the particle of interest based upon the determined electrical signature of the particle of interest.

公开(公告)号：US20180224384A1

公开(公告)日：2018-08-09

申请号：US15749319

申请日：2016-01-29

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： Tod WOODFORD ,  Hilary ELY ,  Sadiq BENGALI

IPC: G01N27/02

CPC classification number: G01N27/02

Abstract: An electrode system and a method of using an electrode system to make an impedance measurement. The electrode system comprises a substrate that supports a first and second electrodes. The first electrode is located inside a cutout of the second electrode. The first and second electrodes are separated by an insulating layer.