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公开(公告)号：US20240253296A1
公开(公告)日：2024-08-01
申请号：US18559987
申请日：2021-05-11
发明人： Wei Long NG , Xi HUANG , Viktor SHKOLNIKOV , Roberto A. PUGLIESE , Mackenzie JOHNSON , Wai Yee YEONG
IPC分类号： B29C64/112 , B29C64/209 , B29C64/245 , B29C64/255 , B29K101/00 , B33Y10/00 , B33Y30/00 , B33Y70/10 , C12N5/00
CPC分类号： B29C64/112 , B29C64/209 , B29C64/245 , B29C64/255 , B33Y10/00 , B33Y30/00 , C12N5/0062 , B29K2101/00 , B33Y70/10 , C12N2513/00 , C12N2533/30
摘要： The present disclosure is drawn to bio-ink printer components, methods of printing bio-inks, and multi-fluid live cell printing systems. In one example, a bio-ink printer component can include a bio-ink and a bio-ink ejector fluidly connected or connectable to the bio-ink. The bio-ink can include a buffer solution that is suitable for live cells, and a polymer that includes polyvinylpyrrolidone, polyvinyl alcohol, polyvinyl sulfate, polyethylene glycol, polyester, poly(dimethylsiloxane), cellulose, polysaccharide, or a combination thereof. The bio-ink ejector can include an ejection nozzle and a thermal resistor positioned to heat the bio-ink to form a vapor bubble to eject a droplet of bio-ink from the ejection nozzle.
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公开(公告)号：US20230001692A1
公开(公告)日：2023-01-05
申请号：US17782875
申请日：2020-02-14
IPC分类号： B41J2/14
摘要： In example implementations, an apparatus is provided. The apparatus includes a channel, an opening in the channel, and a heating element aligned with the opening on opposite sides of the channel. The channel contains a droplet of a first liquid containing a particle, wherein the droplet is carried within a second liquid in the channel. The heating element is to heat the first liquid to generate a vapor in the first liquid to eject the droplet of the first liquid through the opening.
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公开(公告)号：US20220072535A1
公开(公告)日：2022-03-10
申请号：US17415839
申请日：2019-04-30
IPC分类号： B01L3/00
摘要： The present disclosure relates to a microfluidic device including a microfluidic substrate and dry reagent-containing polymer particles. The microfluidic substrate includes a microfluidic-retaining region within the microfluidic substrate that is fluidly coupled to multiple microfluidic channels. The dry reagent-containing polymer particles include reagent and a degradable polymer. The reagent is releasable from the degradable polymer when exposed to release fluid. The dry reagent-containing particles are retained within the microfluidic substrate at the microfluidic-retaining region in position to release reagent into the egress microfluidic channel upon flow of release fluid from the ingress microfluidic channel through the microfluidic-retaining region.
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公开(公告)号：US20190049386A1
公开(公告)日：2019-02-14
申请号：US16076344
申请日：2017-01-31
发明人： Ning GE , Viktor SHKOLNIKOV , Anita ROGACS , Steven J. SIMSKE
IPC分类号： G01N21/65
摘要： A surface enhanced luminescence (SEL) sensor may include a substrate and nano fingers projecting from the substrate. The nano fingers may include a nano finger extending along an axis. The nano finger may include a plasmonically active cap and a pillar supporting the plasmonically active cap. The pillar may have an asymmetric material composition with respect to the axis.
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公开(公告)号：US20230174908A1
公开(公告)日：2023-06-08
申请号：US17911553
申请日：2020-04-30
摘要： In example implementations, an apparatus is provided. The apparatus includes a channel, a reagent chamber, a synthetic jet channel, and an energy source. The channel is to hold a cell. The reagent chamber is coupled to the channel and stores a reagent. The synthetic jet channel is coupled to the channel and the reagent chamber. The energy source is located in the synthetic jet channel to heat a liquid in the synthetic jet channel to create a synthetic jet that carries the reagent through towards the cell to inject the reagent into the cell.
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公开(公告)号：US20230016934A1
公开(公告)日：2023-01-19
申请号：US17782805
申请日：2020-03-26
发明人： Viktor SHKOLNIKOV , Kenneth J. WARD
IPC分类号： G01N1/38 , G01N15/10 , G01N33/487
摘要： In one example in accordance with the present disclosure, a cell preparation system is described. The cell preparation system includes a fluidic channel to transport cells in single file past multiple detection devices. The cell preparation system also includes a series of detection devices. Each detection device includes 1) a constriction to deform a cell found therein and 2) a sensor to measure a state within the constriction. The cell preparation system also includes a controller. The controller analyzes outputs from multiple sensors to 1) verify a single file transport of cells through the system and 2) identify a cell that passes through the fluidic channel.
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公开(公告)号：US20210213451A1
公开(公告)日：2021-07-15
申请号：US16076074
申请日：2017-04-23
发明人： Viktor SHKOLNIKOV , Chien-Hua CHEN
摘要： A fluid entrained particle separator may include an inlet passage to direct particles entrained in a fluid, a first separation passage branching from the inlet passage, a second separation passage branching from the inlet passage and electrodes to create electric field exerting a dielectrophoretic force on the particles to direct the particles to the first separation passage or the second separation passage, wherein the first separation passage, the second separation passage, the electric field and the dielectrophoretic force extend in a plane.
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公开(公告)号：US20210197199A1
公开(公告)日：2021-07-01
申请号：US16076553
申请日：2017-07-12
IPC分类号： B01L3/00
摘要： A channel layer of a digital microfluidic device may include a number of sample wells located on a first side of the die, a number of first capillary channels fluidically coupled to each of the sample wells, the first capillary channels drawing a fluid from the sample wells using capillary forces, a capillary break fluidically coupled to each of the first capillary channels to dispense a portion of the fluid drawn from the sample wells through the capillary forces, a number of intermediate chambers fluidically coupled to the capillary break, a number of second capillary channels fluidically coupled to the intermediate chambers, the second capillary channels drawing the fluid from the intermediate chambers using capillary forces, and a number of mixing chambers fluidically coupled to the second capillary channels into which the capillary forces of the second capillary channels cause the fluid to enter the mixing chambers.
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公开(公告)号：US20210190694A1
公开(公告)日：2021-06-24
申请号：US16074298
申请日：2016-04-20
发明人： Ning GE , Anita ROGACS , Viktor SHKOLNIKOV , Alexander GOVYADINOV
IPC分类号： G01N21/65
摘要： A surface enhanced Raman scattering (SERS) sensor may include a substrate, an electrically conductive layer having a first portion spaced from a second portion by a gap, an electrically resistive layer in contact with and extending between the first portion and the second portion of the electrically conductive layer to form an electrically resistive bridge across the gap that heats the nano fingers in response to electrical current flowing across the bridge from the first portion to the second portion and nano fingers extending upward from the bridge.
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公开(公告)号：US20200038872A1
公开(公告)日：2020-02-06
申请号：US16494827
申请日：2017-04-21
IPC分类号： B01L3/00
摘要： An apparatus includes a polymer base layer having a surface. A die that includes a fluid manipulation surface that is substantially coplanar with the surface of the polymer base layer. The die includes a control electrode to generate an electric field to perform microfluidic manipulation of fluid across the fluid manipulation surface of the die.
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