公开(公告)号：US20220125626A1

公开(公告)日：2022-04-28

申请号：US17430035

申请日：2020-02-14

Applicant: HISAMITSU PHARMACEUTICAL CO.,INC.

Inventor： Kentaro NAKASHIMA ,  Keiichiro TSURUSHIMA ,  Takaaki YOSHINAGA

IPC: A61F7/02 ,  C09J129/04 ,  C08K5/12

Abstract: A cooling sheet comprising: a backing layer; an adhesive agent layer; and a liner layer for protecting the adhesive agent layer, wherein the adhesive agent layer contains water at 65 to 85% by mass based on a total mass of the adhesive agent layer, polyalkylene glycol monooleate at 0.12 to 0.7% by mass based on the total mass of the adhesive agent layer, polyvinyl alcohol at 3 to 10% by mass based on the total mass of the adhesive agent layer, polyacrylic acid at 0.5 to 5% by mass based on the total mass of the adhesive agent layer, and a parahydroxybenzoate at 0.01 to 1% by mass based on the total mass of the adhesive agent layer, and a mass ratio of a content of the polyvinyl alcohol to a content of the polyacrylic acid is in a range of 1.2:1 to 5:1.

公开(公告)号：US20230093050A1

公开(公告)日：2023-03-23

申请号：US17798412

申请日：2021-02-04

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Kentaro NAKASHIMA ,  Kento ICHINOHE ,  Keiichiro TSURUSHIMA ,  Takaaki YOSHINAGA

IPC: C09J133/02 ,  C09J11/06 ,  C09J11/08 ,  C09J7/30

Abstract: A method for producing an adhesive layer composition for producing a cooling sheet including a backing layer, an adhesive layer, and a liner layer, the method comprising the step of:
mixing a composition to be mixed containing water, an alum, sodium edetate, a polyacrylic acid, and a neutralized polyacrylic acid such that a mixing temperature becomes 5 to 23° C., to obtain an adhesive layer composition, wherein
in the composition to be mixed,
a content of the water is 69 to 938.24% by mass relative to a total mass of the composition to be mixed,
a content of the alum is 0.18 to 0.42% by mass relative to the total mass of the composition to be mixed,
a content of the sodium edetate is 0.08 to 0.18% by mass relative to the total mass of the composition to be mixed, and
a mass ratio between the content of the alum and the content of the sodium edetate (the content of the alum:the content of the sodium edetate) is 1:1 to 5.25:1.

公开(公告)号：US20250082591A1

公开(公告)日：2025-03-13

申请号：US18960714

申请日：2024-11-26

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Kentaro NAKASHIMA ,  Yusuke TANAKA ,  Keiichiro TSURUSHIMA

IPC: A61K31/167 ,  A61K9/70 ,  A61K47/10

Abstract: Disclosed is a patch comprising an adhesive layer on a backing layer, wherein the adhesive layer comprises lidocaine or a pharmaceutically acceptable salt thereof, propylene glycol, a rubber adhesive base and a terpene resin, wherein the content of the lidocaine or pharmaceutically acceptable salt thereof in the adhesive layer is 3 mass % to 5 mass % with respect to the total mass of the adhesive layer, the content of the terpene resin in the adhesive layer is 5 mass % to 18 mass % with respect to the total mass of the adhesive layer, and the content of propylene glycol in the adhesive layer is 3 mass % to 7 mass % with respect to the total mass of the adhesive layer, wherein crystals are not precipitated in the patch, and wherein the adhesive layer has an adhesive surface, and requires a force of 1.3 N or less to release the adhesive surfaces during self-adhesion.

公开(公告)号：US20230346720A1

公开(公告)日：2023-11-02

申请号：US18083793

申请日：2022-12-19

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Kentaro NAKASHIMA ,  Yusuke TANAKA ,  Keiichiro TSURUSHIMA

IPC: A61K9/70 ,  A61K31/167 ,  A61K47/10

CPC classification number: A61K31/167 ,  A61K9/7046 ,  A61K47/10

Abstract: Disclosed is a patch comprising an adhesive layer on a backing layer, wherein the adhesive layer comprises lidocaine or a pharmaceutically acceptable salt thereof, propylene glycol, a rubber adhesive base and a terpene resin, wherein the content of the lidocaine or a pharmaceutically acceptable salt thereof in the adhesive layer in terms of free form is 2 mass% to 6 mass% with respect to the total mass of the adhesive layer, wherein the ratio of the mass of the lidocaine or a pharmaceutically acceptable salt thereof in terms of free form to the mass of propylene glycol in the adhesive layer is 1:0.6 to 1:1.8, and wherein the content of the terpene resin in the adhesive layer is 5 mass% to 18 mass% with respect to a total mass of the adhesive layer.

公开(公告)号：US20180015049A1

公开(公告)日：2018-01-18

申请号：US15547645

申请日：2016-02-05

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Kentaro NAKASHIMA ,  Masahiro SATO ,  Yasuhisa KOSE ,  Takaaki YOSHINAGA

IPC: A61K9/70 ,  A61K31/045 ,  A61F13/00 ,  A61F13/02 ,  A61K47/34 ,  A61K31/618

CPC classification number: A61K9/7053 ,  A61F13/00063 ,  A61F13/0243 ,  A61F13/0253 ,  A61K9/7076 ,  A61K31/045 ,  A61K31/618 ,  A61K47/06 ,  A61K47/34 ,  A61L15/00 ,  B32B5/02 ,  B32B27/00

Abstract: Disclosed is an adhesive patch having a support and an adhesive agent layer laminated on the support, wherein the support consists of spunlace nonwoven fabric, the adhesive agent layer comprises an SIS block copolymer and liquid paraffin, the adhesive patch has a first direction, which is a predetermined reference axis direction, and a second direction, which is orthogonal to the first direction, and a bending resistance in the first direction of the adhesive patch is 18 to 30 mm.