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公开(公告)号:US20250161265A1
公开(公告)日:2025-05-22
申请号:US18839471
申请日:2023-02-15
Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
Inventor: Kimiko KAWAI , Tomohiro SHINODA , Takao KUROKAWA
IPC: A61K31/381 , A61K47/14 , A61K47/20
Abstract: A rotigotine-containing patch including a backing layer and an adhesive agent layer, wherein the adhesive agent layer comprises at least one selected from the group consisting of rotigotine and a pharmaceutically acceptable salt of rotigotine, and the adhesive agent layer further comprises an adhesive base agent, and at least one selected from the group consisting of thioglycolic acid and a pharmaceutically acceptable salt of thioglycolic acid.
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公开(公告)号:US20250152502A1
公开(公告)日:2025-05-15
申请号:US19021981
申请日:2025-01-15
Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
Inventor: Ryota HORI , Shinpei NISHIMURA
IPC: A61K9/00 , A61K31/4174 , A61K47/36 , A61M37/00
Abstract: The present invention aims to manufacture a microneedle device capable of carrying and administering a larger amount of biologically active substance per one microneedle. One aspect of the present invention is a method of manufacturing a microneedle device comprising coating microneedles with a coating liquid, wherein the coating liquid comprises a biologically active substance and a sulfated polysaccharide. The microneedle device manufactured by such a method comprises a substrate, microneedles disposed on the substrate, and a coating formed on the microneedles, wherein the coating comprises a biologically active substance and a sulfated polysaccharide.
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公开(公告)号:US12233156B2
公开(公告)日:2025-02-25
申请号:US17253311
申请日:2019-06-20
Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
Inventor: Ryota Hori , Shinpei Nishimura
IPC: A61M37/00 , A61K9/00 , A61K31/4174 , A61K47/36
Abstract: The present invention aims to manufacture a microneedle device capable of carrying and administering a larger amount of biologically active substance per one microneedle. One aspect of the present invention is a method of manufacturing a microneedle device comprising coating microneedles with a coating liquid, wherein the coating liquid comprises a biologically active substance and a sulfated polysaccharide. The microneedle device manufactured by such a method comprises a substrate, microneedles disposed on the substrate, and a coating formed on the microneedles, wherein the coating comprises a biologically active substance and a sulfated polysaccharide.
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公开(公告)号:USD1062470S1
公开(公告)日:2025-02-18
申请号:US29916786
申请日:2023-11-15
Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
Designer: Tatsuaki Sakai , Kei Nishioka , Satoshi Ito
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公开(公告)号:US11903915B2
公开(公告)日:2024-02-20
申请号:US17429683
申请日:2020-02-13
Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
Inventor: Tatsuya Sakakura , Satoshi Kimura , Seiichiro Tsuru
IPC: A61K31/192 , A61K9/70 , A61K31/045 , A61K47/10
CPC classification number: A61K31/192 , A61K9/7038 , A61K31/045 , A61K47/10
Abstract: The present invention provides a gel patch having a paste layer on a support, wherein the paste layer comprising ketoprofen or a pharmaceutically acceptable salt thereof, propylene glycol, 1-menthol, and water, wherein the mass of propylene glycol in the paste layer is 3-fold the mass of ketoprofen or less, and wherein the content of 1-menthol based on a total mass of the paste layer is 0.1 to 0.5 mass %.
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公开(公告)号:US20240016758A1
公开(公告)日:2024-01-18
申请号:US18034480
申请日:2021-10-21
Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
Inventor: Naoyuki UCHIDA , Satoshi AMANO
IPC: A61K9/70 , A61K31/4045 , A61K47/12
CPC classification number: A61K9/7084 , A61K31/4045 , A61K47/12
Abstract: A ropinirole-containing patch comprising a backing layer and an adhesive agent layer, wherein
the adhesive agent layer comprising:
at least one selected from the group consisting of ropinirole and a pharmaceutically acceptable salt thereof;
at least one sodium carboxylate selected from the group consisting of sodium pentanoate, disodium glutarate, and sodium hexanoate; and
an adhesive agent.-
公开(公告)号:US11850311B2
公开(公告)日:2023-12-26
申请号:US17281621
申请日:2019-09-25
Applicant: Hisamitsu Pharmaceutical Co., Inc.
Inventor: Masaki Yukuhiro , Yuka Takagi , Satoshi Amano
IPC: A61K9/70 , A61K31/407
CPC classification number: A61K9/7069 , A61K31/407
Abstract: An object of the present invention is to provide an asenapine-containing patch having excellent adhesiveness and handleability, which can persistently provide sufficient medicinal effects by suppressing cold flow during storage or application while enhancing skin permeability using a silicone-based pressure-sensitive adhesive base, and thereby maintaining the stability of the drug in the patch during storage, and maintaining an appropriate administration form for a long period of time. The present invention relates to a patch having a support and a pressure-sensitive adhesive layer, wherein the pressure-sensitive adhesive layer comprises asenapine and a silicone-based pressure-sensitive adhesive base, and the loss tangent (tan δ) of the pressure-sensitive adhesive layer is 0.75 to 1.5 at 1.0 Hz.
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公开(公告)号:US20230045891A1
公开(公告)日:2023-02-16
申请号:US17788019
申请日:2020-12-18
Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
Inventor: Tatsuya SHIMIZU , Takako ESU , Shinpei NISHIMURA
IPC: A61M37/00 , A61L31/08 , A61L31/16 , A61K31/4174 , A61K9/00 , A61K31/137 , A61K47/18 , A61K47/36
Abstract: The present invention aims to provide a method for producing a microneedle device comprising a coating comprising dexmedetomidine and isoproterenol, in which the stability of isoproterenol during production and after production of the microneedle device is high. A method for producing a microneedle device according to one embodiment of the present invention comprises coating microneedles with a coating liquid to form a coating on the microneedles. The microneedle device comprises a substrate, microneedles disposed on the substrate, and a coating formed on the microneedles. The coating liquid comprises dexmedetomidine or a pharmaceutically acceptable salt thereof, isoproterenol or a pharmaceutically acceptable salt thereof, ethylenediaminetetraacetic acid or a pharmaceutically acceptable salt thereof, and a sulfated polysaccharide.
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公开(公告)号:US20220273603A1
公开(公告)日:2022-09-01
申请号:US17682205
申请日:2022-02-28
Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
Inventor: Kana IMAMURA , Naoko FUJITA , Yasunari MICHINAKA
IPC: A61K31/222 , A61K9/00 , A61K47/10 , A61K47/02
Abstract: A method for treating hyperhidrosis is disclosed. The method comprises administering a liquid topical preparation to a patient in need thereof. The liquid topical preparation comprises water and oxybutynin or a pharmaceutically acceptable salt thereof. The oxybutynin or pharmaceutically acceptable salt thereof is present in a range of, for example, from 10 mass % to 20 mass % based on a total mass of the liquid topical preparation.
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公开(公告)号:US20220117906A1
公开(公告)日:2022-04-21
申请号:US17431303
申请日:2020-01-23
Applicant: Hisamitsu Pharmaceutical Co., Inc.
Inventor: Ryo Tanaka , Kazuya Kominami , Naoyuki Uchida , Takito Shima
Abstract: The problem addressed by the present invention is to provide a method for suppressing cold flow during packaging or application, regardless of the properties or concentration of a drug, in a patch containing a drug and an acrylic adhesive base in an adhesive layer. The present invention relates to a method for suppressing cold flow of a patch equipped with a support layer and an adhesive layer containing a drug and an acrylic adhesive base, wherein the method causes calcium silicate to be contained in the adhesive layer.
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