公开(公告)号：US20250161265A1

公开(公告)日：2025-05-22

申请号：US18839471

申请日：2023-02-15

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Kimiko KAWAI ,  Tomohiro SHINODA ,  Takao KUROKAWA

IPC: A61K31/381 ,  A61K47/14 ,  A61K47/20

Abstract: A rotigotine-containing patch including a backing layer and an adhesive agent layer, wherein the adhesive agent layer comprises at least one selected from the group consisting of rotigotine and a pharmaceutically acceptable salt of rotigotine, and the adhesive agent layer further comprises an adhesive base agent, and at least one selected from the group consisting of thioglycolic acid and a pharmaceutically acceptable salt of thioglycolic acid.

公开(公告)号：US20250152502A1

公开(公告)日：2025-05-15

申请号：US19021981

申请日：2025-01-15

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Ryota HORI ,  Shinpei NISHIMURA

IPC: A61K9/00 ,  A61K31/4174 ,  A61K47/36 ,  A61M37/00

Abstract: The present invention aims to manufacture a microneedle device capable of carrying and administering a larger amount of biologically active substance per one microneedle. One aspect of the present invention is a method of manufacturing a microneedle device comprising coating microneedles with a coating liquid, wherein the coating liquid comprises a biologically active substance and a sulfated polysaccharide. The microneedle device manufactured by such a method comprises a substrate, microneedles disposed on the substrate, and a coating formed on the microneedles, wherein the coating comprises a biologically active substance and a sulfated polysaccharide.

公开(公告)号：US12233156B2

公开(公告)日：2025-02-25

申请号：US17253311

申请日：2019-06-20

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Ryota Hori ,  Shinpei Nishimura

IPC: A61M37/00 ,  A61K9/00 ,  A61K31/4174 ,  A61K47/36

Abstract: The present invention aims to manufacture a microneedle device capable of carrying and administering a larger amount of biologically active substance per one microneedle. One aspect of the present invention is a method of manufacturing a microneedle device comprising coating microneedles with a coating liquid, wherein the coating liquid comprises a biologically active substance and a sulfated polysaccharide. The microneedle device manufactured by such a method comprises a substrate, microneedles disposed on the substrate, and a coating formed on the microneedles, wherein the coating comprises a biologically active substance and a sulfated polysaccharide.

公开(公告)号：USD1062470S1

公开(公告)日：2025-02-18

申请号：US29916786

申请日：2023-11-15

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Designer： Tatsuaki Sakai ,  Kei Nishioka ,  Satoshi Ito

公开(公告)号：US11903915B2

公开(公告)日：2024-02-20

申请号：US17429683

申请日：2020-02-13

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Tatsuya Sakakura ,  Satoshi Kimura ,  Seiichiro Tsuru

IPC: A61K31/192 ,  A61K9/70 ,  A61K31/045 ,  A61K47/10

CPC classification number: A61K31/192 ,  A61K9/7038 ,  A61K31/045 ,  A61K47/10

Abstract: The present invention provides a gel patch having a paste layer on a support, wherein the paste layer comprising ketoprofen or a pharmaceutically acceptable salt thereof, propylene glycol, 1-menthol, and water, wherein the mass of propylene glycol in the paste layer is 3-fold the mass of ketoprofen or less, and wherein the content of 1-menthol based on a total mass of the paste layer is 0.1 to 0.5 mass %.

公开(公告)号：US20240016758A1

公开(公告)日：2024-01-18

申请号：US18034480

申请日：2021-10-21

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Naoyuki UCHIDA ,  Satoshi AMANO

IPC: A61K9/70 ,  A61K31/4045 ,  A61K47/12

CPC classification number: A61K9/7084 ,  A61K31/4045 ,  A61K47/12

Abstract: A ropinirole-containing patch comprising a backing layer and an adhesive agent layer, wherein



the adhesive agent layer comprising:
at least one selected from the group consisting of ropinirole and a pharmaceutically acceptable salt thereof;
at least one sodium carboxylate selected from the group consisting of sodium pentanoate, disodium glutarate, and sodium hexanoate; and
an adhesive agent.

公开(公告)号：US11850311B2

公开(公告)日：2023-12-26

申请号：US17281621

申请日：2019-09-25

Applicant: Hisamitsu Pharmaceutical Co., Inc.

Inventor： Masaki Yukuhiro ,  Yuka Takagi ,  Satoshi Amano

IPC: A61K9/70 ,  A61K31/407

CPC classification number: A61K9/7069 ,  A61K31/407

Abstract: An object of the present invention is to provide an asenapine-containing patch having excellent adhesiveness and handleability, which can persistently provide sufficient medicinal effects by suppressing cold flow during storage or application while enhancing skin permeability using a silicone-based pressure-sensitive adhesive base, and thereby maintaining the stability of the drug in the patch during storage, and maintaining an appropriate administration form for a long period of time. The present invention relates to a patch having a support and a pressure-sensitive adhesive layer, wherein the pressure-sensitive adhesive layer comprises asenapine and a silicone-based pressure-sensitive adhesive base, and the loss tangent (tan δ) of the pressure-sensitive adhesive layer is 0.75 to 1.5 at 1.0 Hz.

公开(公告)号：US20230045891A1

公开(公告)日：2023-02-16

申请号：US17788019

申请日：2020-12-18

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Tatsuya SHIMIZU ,  Takako ESU ,  Shinpei NISHIMURA

IPC: A61M37/00 ,  A61L31/08 ,  A61L31/16 ,  A61K31/4174 ,  A61K9/00 ,  A61K31/137 ,  A61K47/18 ,  A61K47/36

Abstract: The present invention aims to provide a method for producing a microneedle device comprising a coating comprising dexmedetomidine and isoproterenol, in which the stability of isoproterenol during production and after production of the microneedle device is high. A method for producing a microneedle device according to one embodiment of the present invention comprises coating microneedles with a coating liquid to form a coating on the microneedles. The microneedle device comprises a substrate, microneedles disposed on the substrate, and a coating formed on the microneedles. The coating liquid comprises dexmedetomidine or a pharmaceutically acceptable salt thereof, isoproterenol or a pharmaceutically acceptable salt thereof, ethylenediaminetetraacetic acid or a pharmaceutically acceptable salt thereof, and a sulfated polysaccharide.

公开(公告)号：US20220273603A1

公开(公告)日：2022-09-01

申请号：US17682205

申请日：2022-02-28

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Kana IMAMURA ,  Naoko FUJITA ,  Yasunari MICHINAKA

IPC: A61K31/222 ,  A61K9/00 ,  A61K47/10 ,  A61K47/02

Abstract: A method for treating hyperhidrosis is disclosed. The method comprises administering a liquid topical preparation to a patient in need thereof. The liquid topical preparation comprises water and oxybutynin or a pharmaceutically acceptable salt thereof. The oxybutynin or pharmaceutically acceptable salt thereof is present in a range of, for example, from 10 mass % to 20 mass % based on a total mass of the liquid topical preparation.

公开(公告)号：US20220117906A1

公开(公告)日：2022-04-21

申请号：US17431303

申请日：2020-01-23

Applicant: Hisamitsu Pharmaceutical Co., Inc.

Inventor： Ryo Tanaka ,  Kazuya Kominami ,  Naoyuki Uchida ,  Takito Shima

IPC: A61K9/70 ,  A61K47/32

Abstract: The problem addressed by the present invention is to provide a method for suppressing cold flow during packaging or application, regardless of the properties or concentration of a drug, in a patch containing a drug and an acrylic adhesive base in an adhesive layer. The present invention relates to a method for suppressing cold flow of a patch equipped with a support layer and an adhesive layer containing a drug and an acrylic adhesive base, wherein the method causes calcium silicate to be contained in the adhesive layer.