公开(公告)号：US09921160B2

公开(公告)日：2018-03-20

申请号：US15324149

申请日：2015-06-23

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Takashi Anazawa ,  Yoshitaka Kodama ,  Motohiro Yamazaki ,  Kunio Harada

IPC: G01N21/64 ,  G01N21/01

CPC classification number: G01N21/6454 ,  B01L3/5027 ,  B01L2300/0861 ,  B01L2300/0877 ,  B01L2300/168 ,  G01N21/01 ,  G01N21/05 ,  G01N21/645 ,  G01N21/6452 ,  G01N2021/6463 ,  G01N2201/06113

Abstract: A laser beam 6 irradiated from a side face of a microchip 1 in which plural channels 2 fill ed with a member of a refractive index n2 in an inner portion of a member of a refractive index n1 (n2 lower base, and is deviated swiftly from a channel array. Hence, the laser beam 6 is made to be deviated gradually from the channel array by irradiating the laser beam 6 from the side face of the microchip 1 by being inclined relative to the same plane in a direction of being directed from the lower base to the upper base. As a result, a larger number of the channels 2 can efficiently be subjected to laser beam irradiation.

公开(公告)号：US11442016B2

公开(公告)日：2022-09-13

申请号：US16076212

申请日：2016-02-22

Applicant: Hitachi High-Technologies Corporation

Inventor： Takashi Anazawa ,  Motohiro Yamazaki

IPC: G01N21/64 ,  C12Q1/6869 ,  G02B3/00 ,  G02B27/14 ,  B01L3/00

Abstract: The invention is directed to a light-emission detection apparatus for individually condensing light emitted from each emission point of a emission-point array using each condensing lens of a condensing-lens array to form a light beam and detecting each light beam incident on a sensor in parallel, and the light-emission detection apparatus can be downsized and high sensitivity and low crosstalk can be simultaneously accomplished when a certain relation between the diameter of each emission point, a focal length of each condensing lens, an interval of condensing lenses, and an optical path length between each condensing lens and a sensor is satisfied.

公开(公告)号：US10753873B2

公开(公告)日：2020-08-25

申请号：US16205362

申请日：2018-11-30

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Takashi Anazawa ,  Satoshi Takahashi ,  Motohiro Yamazaki ,  Yoshitaka Kodama

IPC: G01N21/64 ,  G01J3/44 ,  G01N27/447 ,  G01J3/02 ,  G01J3/14 ,  G01J3/18 ,  C12Q1/6869 ,  G01J3/12

Abstract: A multicolor detection device includes: a condensing lens array 17 in which a plurality of condensing lenses 18, each of which turns light emitted from each of a plurality of light emitting points 1 individually into parallel light beams, are arranged, the light emitting points being arranged in a light emitting point array; at least one spectroscopic element on which the parallel light beams are incident in parallel, the at least one spectroscopic element being common; and at least one sensor on which light beams spectrally separated by the spectroscopic element are incident in parallel, the at least one sensor being common.

公开(公告)号：US10175172B2

公开(公告)日：2019-01-08

申请号：US15548432

申请日：2015-02-03

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Takashi Anazawa ,  Satoshi Takahashi ,  Motohiro Yamazaki ,  Yoshitaka Kodama

IPC: G01N21/64 ,  G01J3/44 ,  C12Q1/6869 ,  G01N27/447

Abstract: A multicolor detection device includes: a condensing lens array 17 in which a plurality of condensing lenses 18, each of which turns light emitted from each of a plurality of light emitting points 1 individually into parallel light beams, are arranged, the light emitting points being arranged in a light emitting point array; at least one spectroscopic element on which the parallel light beams are incident in parallel, the at least one spectroscopic element being common; and at least one sensor on which light beams spectrally separated by the spectroscopic element are incident in parallel, the at least one sensor being common.

公开(公告)号：US11860094B2

公开(公告)日：2024-01-02

申请号：US16480333

申请日：2017-02-20

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Takashi Anazawa

IPC: G01N21/64 ,  G01N27/447 ,  G01N30/86 ,  G01N30/88 ,  C12Q1/68

CPC classification number: G01N21/6428 ,  G01N21/6408 ,  G01N21/6458 ,  G01N27/44782 ,  G01N30/86 ,  C12Q1/68 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6441 ,  G01N2030/8827

Abstract: An analysis system includes an analyzer configured to separate a sample including a plurality of components labeled with any of M kinds of fluorescent substances by chromatography and acquire first time-series data of fluorescence signals detected in N kinds (M>N) of wavelength bands in a state in which at least a part of the plurality of components is not completely separated; and a computer configured to compare the first time-series data with the second time-series data, and determine which kind of fluorescent substance of M kinds of fluorescent substances individually labels each of the plurality of components.

公开(公告)号：US10253362B2

公开(公告)日：2019-04-09

申请号：US15029712

申请日：2014-11-04

Applicant: Hitachi High-Technologies Corporation

Inventor： Hiroshi Yoshida ,  Rena Akahori ,  Yasuhiko Tada ,  Shohei Terada ,  Takanobu Haga ,  Takashi Anazawa

IPC: C12Q1/68 ,  C12Q1/6869 ,  G01N33/487 ,  C12Q1/6872 ,  G01N15/00

Abstract: The purpose of the present invention is to provide a DNA transport control device having excellent reliability and durability, and a DNA sequencing device that uses the DNA transport control device. The present invention provides a DNA transport control device having a nanopore which allows for the passage of only the DNA strand of a single molecule, and a DNA sequencing device that uses the DNA transport control device. The DNA transport control device is characterized by the following: including a base material having openings and a thin film a block copolymer formed on the base material; the thin film including microdomains that are formed as a result of self-assembly of the block copolymer and that penetrate the thin film, and a matrix surrounding the microdomains; and the nanopore being formed from one opening in the base material and a single microdomain.