公开(公告)号：US20060151438A1

公开(公告)日：2006-07-13

申请号：US11294579

申请日：2005-12-06

申请人： Hajime Urai ,  Youichi Ohshita ,  Makoto Koizumi ,  Naoki Osawa ,  Hiroaki Hashimoto ,  Junzo Kida

发明人： Hajime Urai ,  Youichi Ohshita ,  Makoto Koizumi ,  Naoki Osawa ,  Hiroaki Hashimoto ,  Junzo Kida

IPC分类号： H01H33/88

CPC分类号： H01H33/904

摘要： A puffer type gas circuit breaker has a piston, which is connected with a center shaft via a link mechanism. At an initial stage of an interruption operation, the link mechanism drives a puffer cylinder and the piston both in an interruption direction while maintaining an almost constant distance therebetween. Even when a pressure rise occurs in a compression chamber by the heat of an arc generated in accordance with opening between a fixed arc contact and a movable arc contact, the pressure rise does not become an operation counterforce to an operator. At a final stage of the interruption operation where the fixed arc contact is removed from a throat of an insulating nozzle, the link mechanism drives the piston in an almost stopped status.

摘要翻译： 吹气式气体断路器具有通过连杆机构与中心轴连接的活塞。 在中断操作的初始阶段，连杆机构在冲击缸和活塞两者都沿中断方向驱动，同时保持它们之间几乎恒定的距离。 即使当通过根据固定电弧触点和可动电弧触点之间的开口产生的电弧的热量在压缩室中发生压力升高时，压力升高也不会成为对操作者的操作反作用力。 在固定电弧接触从绝缘喷嘴的喉部移除的中断操作的最后阶段，连杆机构以几乎停止的状态驱动活塞。

公开(公告)号：US07339132B2

公开(公告)日：2008-03-04

申请号：US11294579

申请日：2005-12-06

申请人： Hajime Urai ,  Youichi Ohshita ,  Makoto Koizumi ,  Naoki Osawa ,  Hiroaki Hashimoto ,  Junzo Kida

发明人： Hajime Urai ,  Youichi Ohshita ,  Makoto Koizumi ,  Naoki Osawa ,  Hiroaki Hashimoto ,  Junzo Kida

IPC分类号： H01H33/90

CPC分类号： H01H33/904

摘要： A puffer type gas circuit breaker has a piston, which is connected with a center shaft via a link mechanism. At an initial stage of an interruption operation, the link mechanism drives a puffer cylinder and the piston both in an interruption direction while maintaining an almost constant distance therebetween. Even when a pressure rise occurs in a compression chamber by the heat of an arc generated in accordance with opening between a fixed arc contact and a movable arc contact, the pressure rise does not become an operation counterforce to an operator. At a final stage of the interruption operation where the fixed arc contact is removed from a throat of an insulating nozzle, the link mechanism drives the piston in an almost stopped status.

摘要翻译： 吹气式气体断路器具有通过连杆机构与中心轴连接的活塞。 在中断操作的初始阶段，连杆机构在冲击缸和活塞两者都沿中断方向驱动，同时保持它们之间几乎恒定的距离。 即使当通过根据固定电弧触点和可动电弧触点之间的开口产生的电弧的热量在压缩室中发生压力升高时，压力升高也不会成为对操作者的操作反作用力。 在固定电弧接触从绝缘喷嘴的喉部移除的中断操作的最后阶段，连杆机构以几乎停止的状态驱动活塞。

公开(公告)号：US09885036B2

公开(公告)日：2018-02-06

申请号：US13001714

申请日：2009-06-30

申请人： Makoto Koizumi ,  Yasuhide Hirota

发明人： Makoto Koizumi ,  Yasuhide Hirota

IPC分类号： C12N15/11 ,  A61K31/713

CPC分类号： C12N15/111 ,  A61K31/713 ,  C12N2310/14 ,  C12N2310/321 ,  C12N2310/343 ,  C12N2320/51 ,  C12N2310/3521

摘要： It is intended to provide a double-stranded polynucleotide that is resistant to RNase and has RNA interference effect, etc. The present invention provides a double-stranded polynucleotide comprising sense and antisense strands comprising polynucleotides comprising a nucleotide unit of DNAs and 2′-O-methyl RNAs alternately combined.

公开(公告)号：US20140316123A1

公开(公告)日：2014-10-23

申请号：US14258663

申请日：2014-04-22

申请人： Masafumi Matsuo ,  Yasuhiro Takeshima ,  DAIICHI SANKYO COMPANY, LIMITED ,  Makoto Koizumi ,  Orphan Disease Treatment Institute Co., Ltd.

发明人： Masafumi Matsuo ,  Yasuhiro Takeshima ,  Makoto Koizumi

IPC分类号： C12N15/113

CPC分类号： C07H21/04 ,  A61K38/00 ,  A61K48/00 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/3231 ,  C12N2320/33

摘要： Oligonucleotides having a nucleotide sequence complementary to nucleotide numbers such as 2571-2607, 2578-2592, 2571-2592, 2573-2592, 2578-2596, 2578-2601 or 2575-2592 of the dystrophin cDNA (Gene Bank accession No. NM_004006.1) and therapeutic agents for muscular dystrophy comprising such oligonucleotides.

摘要翻译： 具有与核苷酸序列互补的核苷酸序列的寡核苷酸，例如抗肌萎缩蛋白cDNA（Gene Bank登录号NM_004006）的2571-2607,2578-2592,2571-2592,2573-2592,2578-2596,2578-2601或2575-2592。 1）和包含这种寡核苷酸的肌营养不良的治疗剂。

公开(公告)号：US20130090465A1

公开(公告)日：2013-04-11

申请号：US13673466

申请日：2012-11-09

申请人： Masafumi MATSUO ,  Yasuhiro Takeshima ,  Makoto Koizumi

发明人： Masafumi MATSUO ,  Yasuhiro Takeshima ,  Makoto Koizumi

IPC分类号： C07H21/04

CPC分类号： C07H21/04 ,  A61K38/00 ,  A61K48/00 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/3231 ,  C12N2320/33

摘要： Oligonucleotides having a nucleotide sequence complementary to nucleotide numbers such as 2571-2607, 2578-2592, 2571-2592, 2573-2592, 2578-2596, 2578-2601 or 2575-2592 of the dystrophin cDNA (Gene Bank accession No. NM_004006.1) and therapeutic agents for muscular dystrophy comprising such oligonucleotides.

摘要翻译： 具有与核苷酸序列互补的核苷酸序列的寡核苷酸，例如抗肌萎缩蛋白cDNA（Gene Bank登录号NM_004006）的2571-2607,2578-2592,2571-2592,2573-2592,2578-2596,2578-2601或2575-2592。 1）和包含这种寡核苷酸的肌营养不良的治疗剂。

公开(公告)号：US20070195286A1

公开(公告)日：2007-08-23

申请号：US11646453

申请日：2006-12-28

申请人： Yoichi Hiramatsu ,  Yoshikazu Kidokoro ,  Kenichiro Utsumi ,  Makoto Koizumi

发明人： Yoichi Hiramatsu ,  Yoshikazu Kidokoro ,  Kenichiro Utsumi ,  Makoto Koizumi

IPC分类号： G03B21/22 ,  G03B21/28

CPC分类号： H04N9/3141 ,  G02B17/0621

摘要： Disclosed herein is a rear projection display apparatus including, a screen, a projection mirror; a video apparatus for projecting a picture, an optical unit including a projection lens, a light source, a drive and control circuit, and a structure body for holding the screen, wherein the projection mirror is adjustably provided on the structure body fitted with the screen or on a structure body holding the screen.

摘要翻译： 本文公开了一种背投显示装置，包括：屏幕，投影镜; 用于投影图像的视频设备，包括投影透镜的光学单元，光源，驱动和控制电路以及用于保持屏幕的结构体，其中投影镜可调节地设置在装配有屏幕的结构体上 或者在保持屏幕的结构体上。

公开(公告)号：US06262526B1

公开(公告)日：2001-07-17

申请号：US09492525

申请日：2000-01-27

申请人： Hiroshi Miyazawa ,  Makoto Koizumi ,  Mutsumi Maehara ,  Hidetoshi Kida

发明人： Hiroshi Miyazawa ,  Makoto Koizumi ,  Mutsumi Maehara ,  Hidetoshi Kida

IPC分类号： H01J2946

CPC分类号： H01J29/624 ,  H01J29/488 ,  H01J29/51 ,  H01J2229/4824

摘要： An in-line type color Braun tube having a fluorescent screen and a shield cup at an end of an electron gun, the shield cup including a cylindrical side wall and a bottom having a center electron beam passing hole and two side electron beam passing holes aligned in a horizontal direction. A convergence correcting member including a base and a pair of horizontal plates, the base and horizontal plates being a one piece member, and a bottom member of the base being cross-shaped and including two side electron beam passing holes and a center electron beam passing hole. A pair of horizontal plates sandwiches an electron beam passing through each of the side electron beam passing holes, in a direction vertical to the electron beam. The base is spot-welded to the bottom of the shield cup at an outer side of each of the side electron bottom beam passing holes proximate to a periphery of the bottom of the shield cup or at outer sides of the center electron beam passing hole along a branch of the cross-shaped base of the bottom member.

摘要翻译： 一种在电子枪的端部具有荧光屏和屏蔽杯的直列式彩色布朗管，该屏蔽杯包括圆柱形侧壁和具有中心电子束通过孔和两个侧面电子束通过孔对准的底部 在水平方向。 一种会聚校正构件，包括基座和一对水平板，所述基座和水平板是一体构件，并且所述基座的底部构件是十字形的，并且包括两个侧面电子束通过孔和中心电子束通过 孔。 一对水平板在垂直于电子束的方向上夹着通过每个侧电子束通过孔的电子束。 基座在靠近屏蔽杯底部的周边的每个侧面电子底部梁通过孔的外侧或在中心电子束通过孔的外侧点焊到屏蔽杯的底部 底部构件的十字形底座的分支。

公开(公告)号：US5572379A

公开(公告)日：1996-11-05

申请号：US305193

申请日：1994-09-13

申请人： Hajime Aoi ,  Toshiaki Tsuyoshi ,  Makoto Koizumi ,  Nobumasa Nishiyama ,  Yoshibumi Matsuda ,  Takuji Ogawa ,  Kazuhisa Shiraishi

发明人： Hajime Aoi ,  Toshiaki Tsuyoshi ,  Makoto Koizumi ,  Nobumasa Nishiyama ,  Yoshibumi Matsuda ,  Takuji Ogawa ,  Kazuhisa Shiraishi

IPC分类号： G11B5/02 ,  G11B5/00 ,  G11B5/012 ,  G11B5/09 ,  G11B5/39 ,  G11B5/40 ,  G11B5/55 ,  G11B5/596 ,  G11B19/02 ,  G11B19/04 ,  G11B27/30 ,  G11B27/36 ,  G11B5/03 ,  G11B5/127 ,  G11B5/33

CPC分类号： G11B19/04 ,  G11B19/02 ,  G11B27/3027 ,  G11B27/36 ,  G11B5/00 ,  G11B5/012 ,  G11B5/40 ,  G11B5/5547 ,  G11B2005/0016 ,  G11B2005/0018 ,  G11B5/59683

摘要： In a magnetic recording drive having a plurality of magnetic heads each employing a magnetoresistive sensor for the purpose of averaging the time required for sense currents to be caused to flow through the respective magnetoresistive sensors to shorten the longest reproducing time and to suppress the degradation of the characteristics due to the electromigration, thereby improving the reliability of the magnetic recording drive, the magnetic recording drive includes circuits for averaging the useful life depending on the currents caused to flow through the respective magnetoresistive sensors among the plurality of magnetic heads, whereby the time required for the sense current to be caused to flow through one MR reproducing head is greatly shortened. Therefore, the levels of outputs of the MR reproducing heads can be increased without reduction of the reliability and thus the reliability of the magnetic recording drive can be improved.

摘要翻译： 在具有多个磁头的磁记录驱动器中，每个磁头采用磁阻传感器，用于平均要使感应电流流过各磁阻传感器所需的时间，以缩短最长再现时间并抑制 由于电迁移的特性，从而提高了磁记录驱动器的可靠性，磁记录驱动器包括用于根据流过多个磁头中的相应磁阻传感器的电流来平均使用寿命的电路，由此所需的时间 使得通过一个MR再现头流动的感测电流大大缩短。 因此，可以在不降低可靠性的情况下增加MR再现头的输出电平，从而可以提高磁记录驱动器的可靠性。

公开(公告)号：US20120220649A1

公开(公告)日：2012-08-30

申请号：US13505275

申请日：2010-10-29

申请人： Makoto Koizumi ,  Yasuhide Hirota

发明人： Makoto Koizumi ,  Yasuhide Hirota

IPC分类号： A61K31/713 ,  C07H21/00

CPC分类号： C12N15/1135 ,  A61K31/713 ,  C12N15/1136 ,  C12N2310/14 ,  C12N2310/321 ,  C12N2310/344 ,  C12N2310/3521

摘要： The present invention provides a double-stranded polynucleotide having a sense strand polynucleotide consisting of a nucleotide sequence complementary to a target sequence in a target gene, and an antisense strand polynucleotide having a nucleotide sequence complementary to the sense strand polynucleotide, wherein an aryl or heteroaryl compound is bound to a phosphate group at the 5′-end of the antisense strand polynucleotide.

摘要翻译： 本发明提供了一种双链多核苷酸，其具有由与靶基因中的靶序列互补的核苷酸序列组成的有义链多核苷酸和具有与有义链多核苷酸互补的核苷酸序列的反义链多核苷酸，其中芳基或杂芳基 化合物与反义链多核苷酸的5'末端的磷酸基结合。

公开(公告)号：US07906639B2

公开(公告)日：2011-03-15

申请号：US10577982

申请日：2004-11-04

申请人： Makoto Koizumi

发明人： Makoto Koizumi

IPC分类号： C07H21/04 ,  C12P19/34

CPC分类号： C12Q1/6853 ,  C07H21/04

摘要： The present invention relates to a method for detecting gene polymorphism by PCR, using, as a primer, an oligonucleotide, wherein the third nucleotide from the 3′-end thereof is a 2′-O,4′-C-ethylene nucleotide (ENA) unit, the other oligonucleotides are natural oligonucleotides, the 3′-end position thereof is a nucleotide complementary to the nucleotide of the reference sequence of a polymorphic sequence of a target gene, and the other positions are nucleotides complementary to the nucleotide sequence of the target gene, or an oligonucleotide, wherein the 3′-end of the nucleotide sequence thereof is a polymorphic position, the second nucleotide from the 3′-end thereof is a nucleotide having a base that is not complementary to a gene to be detected, and the third nucleotide from the 3′-end thereof is a 2′-O,4′-C-ethylene nucleotide (ENA) unit; oligonucleotides used in detection of gene polymorphism; and a kit for detecting gene polymorphism, comprising the above oligonucleotides.

摘要翻译： 本发明涉及一种利用PCR检测基因多态性的方法，使用寡核苷酸作为引物，其中3'末端的第3个核苷酸为2'-O，4'-C-亚乙基核苷酸（ENA ）单元，其它寡核苷酸是天然寡核苷酸，其3'端位置是与目标基因的多态性序列的参考序列的核苷酸互补的核苷酸，其它位置是与核苷酸序列的核苷酸互补的核苷酸 靶基因或寡核苷酸，其核苷酸序列的3'末端为多态性位置，其3'末端的第2个核苷酸为具有与待检测基因不互补的碱基的核苷酸， 并且其3'末端的第三个核苷酸是2'-O，4'-C-亚乙基核苷酸（ENA）单元; 用于检测基因多态性的寡核苷酸; 和用于检测基因多态性的试剂盒，其包含上述寡核苷酸。