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    Vascular smooth muscle cell growth factor
    5.
    发明授权
    Vascular smooth muscle cell growth factor 失效
    血管平滑肌细胞生长因子

    公开(公告)号：US06525023B1

    公开(公告)日：2003-02-25

    申请号：US09132769

    申请日：1998-08-12

    申请人： Motoo Yamasaki ,  Kenji Shibata ,  Nobuo Hanai ,  Akiko Furuya ,  Kaoru Miyamoto

    发明人： Motoo Yamasaki ,  Kenji Shibata ,  Nobuo Hanai ,  Akiko Furuya ,  Kaoru Miyamoto

    IPC分类号： A61K3818

    CPC分类号： C07K14/475 ,  A61K38/00

    摘要： The present invention provides a novel vascular smooth muscle cell growth factor, a DNA encoding VSGF, a vector containing the DNA, a method for producing a transformant obtained by transformation with the vector, a method for producing VSGF, an antibody specifically reactive to the VSGF and a method for producing the antibody. The VSGF of the present invention is useful for diagnosis and therapy of wound healing failure, intractable skin ulcer, or abnormal blood vessel forming disease by fibroblast growth factor.

    摘要翻译： 本发明提供新型的血管平滑肌细胞生长因子，编码VSGF的DNA，含有该载体的载体，通过载体转化获得的转化体的制造方法，VSGF的制造方法，与VSGF特异性反应的抗体 和抗体的制造方法。 本发明的VSGF可用于通过成纤维细胞生长因子诊断和治疗伤口愈合失败，难治性皮肤溃疡或异常血管形成疾病。

    Anti-fibroblast growth factor-8 monoclonal antibody
    6.
    发明授权
    Anti-fibroblast growth factor-8 monoclonal antibody 失效
    抗成纤维细胞生长因子-8单克隆抗体

    公开(公告)号：US06310184B1

    公开(公告)日：2001-10-30

    申请号：US09326590

    申请日：1999-06-07

    申请人： Nobuo Hanai ,  Motoo Yamasaki ,  Akiko Furuya ,  Akira Tanaka

    发明人： Nobuo Hanai ,  Motoo Yamasaki ,  Akiko Furuya ,  Akira Tanaka

    IPC分类号： C07K1600

    CPC分类号： C23C14/30 ,  C07K16/22 ,  C07K2317/73 ,  C23C26/00 ,  G02B1/105

    摘要： Described is a monoclonal antibody capable of specifically binding to fibroblast growth factor-8 (FGF-8) which is related to growth factors of hormone-dependent tumor cells such as prostatic cancer and breast cancer, and inhibits the FGF-8 activity. The monoclonal antibody is useful in analyzing the role and biological function of FGF-8 in hormone-dependent tumor cells such as prostatic cancer and breast cancer and can be beneficial in the treatment of these cancers.

    摘要翻译： 描述了能够特异性结合成纤维细胞生长因子-8（FGF-8）的单克隆抗体，其与激素依赖性肿瘤细胞如前列腺癌和乳腺癌的生长因子相关，并且抑制FGF-8活性。 单克隆抗体可用于分析FGF-8在激素依赖性肿瘤细胞如前列腺癌和乳腺癌中的作用和生物学功能，可有助于治疗这些癌症。

    Antibody against human insulin-like growth factor
    8.
    发明授权
    Antibody against human insulin-like growth factor 有权
    抗人类胰岛素样生长因子的抗体

    公开(公告)号：US07438911B2

    公开(公告)日：2008-10-21

    申请号：US10513148

    申请日：2003-04-30

    申请人： Kenya Shitara ,  Kazuyasu Nakamura ,  Akiko Furuya ,  Rinpei Niwa ,  Yuji Ohki ,  Nobuo Hanai

    发明人： Kenya Shitara ,  Kazuyasu Nakamura ,  Akiko Furuya ,  Rinpei Niwa ,  Yuji Ohki ,  Nobuo Hanai

    IPC分类号： A61K39/395 ,  G01N33/53 ,  C12N5/06 ,  C12N15/00 ,  C12P21/08 ,  C07K16/22

    CPC分类号： C07K16/22 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

    摘要： For the effective treatment of diseases such as cancer in which hIGF participates, there have been desired to be developed antibodies which strongly bind to both factors hIGF-I and hIGF-II and inhibit their functions and fragments of these antibodies. The present invention provides antibodies which have the ability to specifically bind to human IGF-I and IGF-II to thereby inhibit the functions of human IGF-I and IGF-II and have binding activity with a binding constant of 5×109 M−1 or more measured with a biosensor BIACORE. In addition, the present invention provides diagnostics, preventives and remedies for an hIGF-mediated disease and a disease showing pathological progressing due to abnormally promoted hIGF production, which use said antibodies.

    摘要翻译： 为了有效治疗诸如hIGF参与的癌症的疾病，期望开发出与hIGF-1和hIGF-II两者强烈结合并抑制其功能和这些抗体片段的抗体。 本发明提供具有特异性结合人IGF-I和IGF-II从而抑制人IGF-I和IGF-II的功能并具有结合常数为5×10 9的结合活性的抗体， 或者用生物传感器BIACORE测量的更高/更高。 此外，本发明提供了hIGF介导的疾病的诊断，预防措施和补救措施以及由于异常促进的hIGF产生导致使用所述抗体的病理进展的疾病。