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    CCR5-specific antibodies with HIV neutralizing activity that recognize a linear dodecapeptide that mimics a conformational epitope in the second extracellular loop of CCR5
    2.
    发明授权
    CCR5-specific antibodies with HIV neutralizing activity that recognize a linear dodecapeptide that mimics a conformational epitope in the second extracellular loop of CCR5 有权
    具有HIV中和活性的CCR5特异性抗体，其识别模拟CCR5的第二胞外环中的构象表位的线性十二肽

    公开(公告)号：US08282926B2

    公开(公告)日：2012-10-09

    申请号：US12647789

    申请日：2009-12-28

    申请人： Hana Golding ,  Surender Khurana

    发明人： Hana Golding ,  Surender Khurana

    IPC分类号： A61K39/395 ,  A61K39/42 ,  C12P21/08 ,  B01L3/00

    CPC分类号： C07K16/2866 ,  C07K2317/21 ,  C07K2317/622

    摘要： The present invention relates, e.g., to an isolated peptide comprising a sequence of contiguous amino acids that is at least about 60% identical (e.g., at least about 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 98% or 100% identical) to the sequence E-W-Q-K-E-G-L-V-T-L-W-L (SEQ ID NO:1), or an active variant of an isolated peptide comprising SEQ ID NO:1. Neutralizing antibodies generated by, or specific for, such peptides are also described, in particular antibodies which are specific for the HIV co-receptor, CCR5, and which inhibit infection of a host cell by HIV. Neutralizing single strand and complete human monoclonal antibodies against CCR5 are described. Methods of using such peptides or antibodies, for inhibiting infection by HIV, are also described.

    摘要翻译： 本发明涉及例如分离的肽，其包含至少约60％相同（例如，至少约60％，65％，70％，75％，80％，85％， 90％，95％，98％或100％相同）的序列，或包含SEQ ID NO：1的分离的肽的活性变体。 还描述了由这种肽产生或特异性的中和抗体，特别是针对HIV共受体CCR5特异的抗体，并且其通过HIV抑制宿主细胞的感染。 描述了针对CCR5的中和单链和完整的人单克隆抗体。 还描述了使用这些肽或抗体来抑制HIV感染的方法。

    Peptide That Elicits Neutralizing Antibodies Targeting the Hiv Co-Receptor
    4.
    发明申请
    Peptide That Elicits Neutralizing Antibodies Targeting the Hiv Co-Receptor 有权
    引发针对HIV共受体的中和抗体的肽

    公开(公告)号：US20080160010A1

    公开(公告)日：2008-07-03

    申请号：US11578122

    申请日：2005-04-11

    申请人： Hana Golding ,  Surender Khurana

    发明人： Hana Golding ,  Surender Khurana

    IPC分类号： A61K39/00 ,  C07K16/00 ,  C12Q1/70 ,  A61K38/00

    CPC分类号： C07K16/2866 ,  C07K2317/21 ,  C07K2317/622

    摘要： The present invention relates, e.g., to an isolated peptide comprising a sequence of contiguous amino acids that is at least about 60% identical (e.g., at least about 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 98% or 100% identical) to the sequence E-W-Q-K-E-G-L-V-T-L-W-L (SEQ ID NO:1), or an active variant of an isolated peptide comprising SEQ ID NO:1. Neutralizing antibodies generated by, or specific for, such peptides are also described, in particular antibodies which are specific for the HIV co-receptor, CCR5, and which inhibit infection of a host cell by HIV. Neutralizing single strand and complete human monoclonal antibodies against CCR5 are described. Methods of using such peptides or antibodies, for inhibiting infection by HIV, are also described.

    摘要翻译： 本发明涉及例如分离的肽，其包含至少约60％相同（例如，至少约60％，65％，70％，75％，80％，85％， 90％，95％，98％或100％相同）的序列，或包含SEQ ID NO：1的分离的肽的活性变体。 还描述了由这种肽产生或特异性的中和抗体，特别是针对HIV共受体CCR5特异的抗体，并且其通过HIV抑制宿主细胞的感染。 描述了针对CCR5的中和单链和完整的人单克隆抗体。 还描述了使用这些肽或抗体来抑制HIV感染的方法。

    Methods for the detection of HIV-1-specific antibodies employing GP41 polypeptides
    5.
    发明授权
    Methods for the detection of HIV-1-specific antibodies employing GP41 polypeptides 有权
    使用GP41多肽检测HIV-1特异性抗体的方法

    公开(公告)号：US08722324B2

    公开(公告)日：2014-05-13

    申请号：US12977320

    申请日：2010-12-23

    申请人： Hana Golding ,  Surender Khurana

    发明人： Hana Golding ,  Surender Khurana

    IPC分类号： C12Q1/70 ,  A61K39/21

    CPC分类号： G01N33/6854 ,  C07K14/005 ,  C07K14/161 ,  C07K14/162 ,  C07K14/163 ,  C12N2740/16111 ,  C12N2740/16122 ,  C12N2740/16222 ,  C12N2740/16322 ,  G01N33/56988 ,  G01N2333/162 ,  G01N2469/20

    摘要： This invention relates to compositions and methods or the detection of human immunodeficiency virus-1 (HIV-1) infection by conducting an immunoassay comprising the steps of: (a) contacting a biological sample containing HIV-1 antibody with a peptide, having an epitope, of one or more of SEQ ID 49-56 to form a peptide-anti-HIV-1 antibody complex; (b) contacting the formed complex with an anti-HIV-1 antibody binding molecule to permit the anti-HIV-1 antibody binding molecule to bind to the anti-HIV-1 antibody of the formed peptide-anti-HIV-1 antibody complex and form an extended complex that is immobilized on a solid support; (c) removing unbound anti-HIV-1 antibody and anti-HIV-1 antibody binding molecule from the extended complex; and (d) determining the presence or concentration of the anti-HIV-1 antibody in the biological sample.

    摘要翻译： 本发明涉及通过进行免疫测定的组合物和方法或人类免疫缺陷病毒-1（HIV-1）感染的检测，其包括以下步骤：（a）使含有HIV-1抗体的生物样品与具有表位 的一个或多个SEQ ID NO：49-56以形成肽 - 抗HIV-1抗体复合物; （b）使所形成的复合物与抗HIV-1抗体结合分子接触，以使抗HIV-1抗体结合分子与所形成的肽 - 抗HIV-1抗体复合物的抗HIV-1抗体结合 并形成固定在固体支持物上的扩展复合物; （c）从扩展的复合物中除去未结合的抗HIV-1抗体和抗HIV-1抗体结合分子; 和（d）测定生物样品中抗HIV-1抗体的存在或浓度。

    COMPOSITIONS AND METHODS FOR THE DETECTION OF HIV-1/HIV-2 INFECTION
    9.
    发明申请
    COMPOSITIONS AND METHODS FOR THE DETECTION OF HIV-1/HIV-2 INFECTION 有权
    用于检测HIV-1 / HIV-2感染的组合物和方法

    公开(公告)号：US20120196306A1

    公开(公告)日：2012-08-02

    申请号：US13321676

    申请日：2010-05-21

    申请人： Hana Golding ,  Surender Khurana

    发明人： Hana Golding ,  Surender Khurana

    IPC分类号： G01N33/53 ,  C07K17/02 ,  C07K14/16

    CPC分类号： G01N33/56988 ,  G01N2333/16 ,  G01N2469/20

    摘要： This invention relates to compositions and methods for the detection of immunodeficiency virus infection, especially immunodeficiency virus-1 (HIV-I) infection. The invention particularly concerns compositions and methods that may be used in HIV vaccine recipients whose sera may contain vaccine-generated anti-HIV-1 antibodies.

    摘要翻译： 本发明涉及用于检测免疫缺陷病毒感染，特别是免疫缺陷病毒-1（HIV-1）感染的组合物和方法。 本发明特别涉及可用于其血清可含有疫苗产生的抗HIV-1抗体的HIV疫苗受体中的组合物和方法。

    Methods for the detection of HIV-1 antibodies employing polypeptides obtained from gag P6 protein
    10.
    发明授权
    Methods for the detection of HIV-1 antibodies employing polypeptides obtained from gag P6 protein 失效
    使用从gag P6蛋白获得的多肽检测HIV-1抗体的方法

    公开(公告)号：US07888003B2

    公开(公告)日：2011-02-15

    申请号：US11662370

    申请日：2005-09-02

    申请人： Hana Golding ,  Surender Khurana

    发明人： Hana Golding ,  Surender Khurana

    IPC分类号： C12Q1/70 ,  A61K39/21

    CPC分类号： G01N33/6854 ,  C07K14/005 ,  C07K14/161 ,  C07K14/162 ,  C07K14/163 ,  C12N2740/16111 ,  C12N2740/16122 ,  C12N2740/16222 ,  C12N2740/16322 ,  G01N33/56988 ,  G01N2333/162 ,  G01N2469/20

    摘要： This invention relates to compositions and methods for the detection of HIV-1 antibodies employing polypeptides obtained from the Gag-p6 protein, the method comprising the steps of: (a) contacting a biological sample with a peptide having an epitope that is recognized by the anti-HIV-1 antibody where the contacting is under conditions sufficient to permit anti-HIV-1 present in the sample to bind to the epitope and form a peptide-anti-HIV-1 antibody complex; (b) contacting the formed peptide-anti-HIV-1 antibody complex with an anti-HIV-1 antibody binding molecule under conditions sufficient to permit the anti-HIV-1 antibody binding molecule to bind to anti-HIV-1 antibody of the formed peptide-anti-HIV-1 antibody complex and form an extended complex; said extended complex being immobilized on a solid support; and (c) removing unbound antibody from said extended complex; and (d) determining the presence or concentration of the anti-HIV-1 antibody in the biological sample by determining the presence or concentration of the formed extended complex.

    摘要翻译： 本发明涉及使用从Gag-p6蛋白获得的多肽检测HIV-1抗体的组合物和方法，所述方法包括以下步骤：（a）使生物样品与具有由所述 抗HIV-1抗体，其中接触条件足以使样品中存在的抗HIV-1与表位结合并形成肽 - 抗HIV-1抗体复合物; （b）在足以允许抗HIV-1抗体结合分子结合抗HIV-1抗体结合分子的抗HIV-1抗体的条件下，使所形成的肽 - 抗HIV-1抗体复合物与抗HIV-1抗体结合分子接触 形成肽 - 抗HIV-1抗体复合物并形成扩展复合物; 所述扩展的复合物被固定在固体支持物上; 和（c）从所述扩展复合物中除去未结合的抗体; 和（d）通过确定所形成的扩展复合物的存在或浓度来确定生物样品中抗HIV-1抗体的存在或浓度。